Gene

KWMTBOMO11809  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013678

Annotation

vacuolar_ATP_synthase_subunit_G_[Bombyx_mori]

Location

Bomo_Chr20(+):548094-551982      View in EpiBrowser

Full name

V-type proton ATPase subunit G       + More
Dolichol-phosphate mannosyltransferase subunit 1      

Alternative Name

V-ATPase 13 kDa subunit
Vacuolar proton pump subunit G

Location in the cell

Cytoplasmic   Reliability : 1.256 Nuclear   Reliability : 1.776

CDS

ATGGCGAGTCAGACCCAAGGAATCCAACAGCTTCTAGCTGCTGAAAAACGCGCTGCGGAGAAAGTCAGCGAGGCAAGGAAGCGAAAAGCGAAACGCCTAAAGCAGGCCAAGGAGGAGGCTCAAGATGAAGTTGAAAAGTACAGACAGGAGCGTGAAAGGCAGTTCAAAGAATTTGAAGCCAAGCACATGGGTACCAGGGAAGGTGTTGCGGCCAAGATCGATGCCGAGACCAAAGTTAAGATCGAAGAGATGAACAAAATGGTCCAAACACAGAAGGAGGCGGTCATCAAAGACGTCTTGAATCTGGTGTATGACATCAAACCCGAACTCCACATCAACTACCGCTTAAATTAA

Protein

MASQTQGIQQLLAAEKRAAEKVSEARKRKAKRLKQAKEEAQDEVEKYRQERERQFKEFEAKHMGTREGVAAKIDAETKVKIEEMNKMVQTQKEAVIKDVLNLVYDIKPELHINYRLN

Description

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

Catalytic Activity

dolichyl phosphate + GDP-alpha-D-mannose = dolichyl beta-D-mannosyl phosphate + GDP

Subunit

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.
V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).
Component of the dolichol-phosphate mannose (DPM) synthase complex.

Similarity

Belongs to the V-ATPase G subunit family.
Belongs to the glycosyltransferase 2 family.

Keywords

Cell membrane   Hydrogen ion transport   Ion transport   Membrane   Transport  

Feature

chain  V-type proton ATPase subunit G

Uniprot

Q2F5J4   S4PD74   Q25532   I4DMP9   A0A0K8TAD3   A0A0N1I9D1   + More
I4DNL2   A0A3S2L356   A0A1E1W4X6   A0A2H1VRB7   M4MAW1   A0A212F4Z0   D6WPH6   N6UQI0   A0A1L8E0R3   A0A170XKW9   A0A1B6JVS1   A0A1B6G5S6   A0A2S2QVW8   A0A1Y1MM55   A0A069DNI7   Q173D4   Q1W2A2   J3JTX5   U5EYM1   T1DFJ5   A0A023EDV1   A0A232FCE5   K7J8J0   T1E2M7   A0A224Y1G5   A0A336MDG6   A0A1D1ZKP1   A0A2H8TFY3   Q1ZZQ2   B0X4I4   A0A1Q3FGW6   A0A1J1ITM7   E0VSA0   A0A1Q3FH29   A0A0J7KTV3   A0A1B6EDH8   A0A151ITA9   F4WSZ5   A0A195AZ43   A0A158NYI3   C4WWQ7   A0A2R7X2H8   E9IUT5   R4WCX8   A0A195F782   A0A151WQF9   A0A026WMX8   A0A195CWE3   A0A154PB12   U4U5F2   E2A665   B3LXQ4   A0A1S3DCD9   A0A0N0U4C1   A0A1W4W8V4   Q16JK6   E2C0Z3   J9JIR2   A0A0A9YQH2   A0A0F7R132   A0A2A3EEU9   V9IHI2   A0A087ZYW3   B4NFJ4   T1DPT7   A0A182F6W4   W5JSL1   A0A2M3Z5Q7   A0A2M4AG33   A0A2M4C4M3   A0A182FEA8   T1DFY3   A0A0A1XDT7   A0A2M3Z0Y4   A0A2M4A523   W5JCW8   A0A182JMU4   A0A084WJA3   X1X105   A0A0C9QYB4   G9LZB9   A0A0M4EVQ9   B4JYY7   B4K581   B4LYZ4   A0A182LVN6   A0A182RQ45   A0A182WML6   R4G878   T1PP66   A0A3B0JNC8   Q293M1   B4GLX5   A0A1L8EHT7  

EC Number

2.4.1.83

Pubmed

19121390    23622113    8626552    22651552    26354079    22118469    + More
18362917    19820115    23537049    28004739    26334808    17510324    22516182    24330624    24945155    26483478    28648823    20075255    20566863    21719571    21347285    21282665    23691247    24508170    30249741    20798317    17994087    25401762    26823975    25937057    20920257    23761445    25830018    24438588    25348373    25315136    15632085   

EMBL

BABH01038712    BABH01038713    DQ311429    ABD36373.1    GAIX01003776    JAA88784.1    + More
X92805    AK402567    BAM19189.1    GBRD01003430    JAG62391.1    KQ460141    KPJ17484.1    AK402991    KQ459460    BAM19502.1    KPJ00747.1    RSAL01000195    RVE44574.1    GDQN01009028    JAT82026.1    ODYU01003960    SOQ43360.1    KC127673    AGG56525.1    AGBW02010297    OWR48779.1    KQ971354    EFA06225.1    APGK01020738    KB740234    ENN81002.1    GFDF01001999    JAV12085.1    GEMB01004301    JAR98971.1    GECU01004434    JAT03273.1    GECZ01011981    JAS57788.1    GGMS01012600    MBY81803.1    GEZM01027397    JAV86759.1    GBGD01003529    JAC85360.1    CH477426    EAT41152.1    DQ445525    GEBQ01018984    ABD98763.1    JAT20993.1    BT126685    AEE61647.1    GANO01001918    JAB57953.1    GALA01000562    JAA94290.1    JXUM01038565    GAPW01006121    KQ561170    JAC07477.1    KXJ79476.1    NNAY01000478    OXU28108.1    GALA01000564    JAA94288.1    GFTR01001963    JAW14463.1    UFQS01001008    UFQT01000381    UFQT01001008    SSX08526.1    SSX23761.1    SSX28442.1    GDJX01000468    JAT67468.1    GFXV01000827    MBW12632.1    DQ416024    AK340101    AK340102    AK340103    ABD76371.1    BAH70766.1    DS232342    EDS40401.1    GFDL01008280    JAV26765.1    CVRI01000059    CRL03464.1    DS235748    EEB16256.1    GFDL01008232    JAV26813.1    LBMM01003266    KMQ93731.1    GEDC01001358    JAS35940.1    KQ981029    KYN10197.1    GL888331    EGI62608.1    KQ976701    KYM77305.1    ADTU01003907    AK342213    BAH72327.1    KK856173    PTY25105.1    GL766050    EFZ15654.1    AK417253    BAN20468.1    KQ981768    KYN35929.1    KQ982843    KYQ50043.1    KK107151    QOIP01000003    EZA57293.1    RLU24325.1    KQ977220    KYN04857.1    KQ434864    KZC09099.1    KB632149    ERL89119.1    GL437108    EFN71124.1    CH902617    EDV41711.1    KQ435824    KOX72144.1    CH478004    EAT34456.1    GL451850    EFN78429.1    ABLF02040342    GBHO01010256    GBRD01006996    GDHC01007597    JAG33348.1    JAG58825.1    JAQ11032.1    LC026145    BAR72390.1    KZ288269    PBC30004.1    JR047989    AEY60553.1    CH964251    EDW83061.1    GAMD01003059    JAA98531.1    ADMH02000584    ETN65749.1    GGFM01003095    MBW23846.1    GGFK01006361    MBW39682.1    GGFJ01010787    MBW59928.1    GAMD01002981    JAA98609.1    GBXI01005664    JAD08628.1    GGFM01001429    MBW22180.1    GGFK01002585    MBW35906.1    ADMH02001524    ETN62197.1    ATLV01024003    KE525348    KFB50297.1    ABLF02017433    GBYB01008754    JAG78521.1    JQ218438    GAKP01000834    AEV43310.1    JAC58118.1    CP012526    ALC47467.1    CH916378    EDV98602.1    CH933806    EDW15081.1    CH940650    EDW68097.1    AXCM01002335    ACPB03022079    GAHY01001447    JAA76063.1    KA649786    KA649788    AFP64417.1    OUUW01000008    SPP83737.1    CM000070    EAL29193.1    CH479185    EDW38549.1    GFDG01000558    JAV18241.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000283053    UP000007151    UP000007266    + More
UP000019118    UP000008820    UP000069940    UP000249989    UP000215335    UP000002358    UP000002320    UP000183832    UP000009046    UP000036403    UP000078492    UP000007755    UP000078540    UP000005205    UP000078541    UP000075809    UP000053097    UP000279307    UP000078542    UP000076502    UP000030742    UP000000311    UP000007801    UP000079169    UP000053105    UP000192221    UP000008237    UP000007819    UP000242457    UP000005203    UP000007798    UP000069272    UP000000673    UP000075880    UP000030765    UP000092553    UP000001070    UP000009192    UP000008792    UP000075883    UP000075900    UP000075920    UP000015103    UP000095301    UP000268350    UP000001819    UP000008744   

PRIDE

Q2F5J4    A0A087ZYW3   

Pfam

PF03179   V-ATPase_G        + More
PF00535   Glycos_transf_2

Interpro

IPR005124   V-ATPase_G        + More
IPR039528   DPM1-like       
IPR001173   Glyco_trans_2-like       
IPR029044   Nucleotide-diphossugar_trans       

SUPFAM

SSF53448   SSF53448       

Gene 3D

3.90.550.10    

CDD

cd06442  DPM1_like

ProteinModelPortal

Q2F5J4   S4PD74   Q25532   I4DMP9   A0A0K8TAD3   A0A0N1I9D1   + More
I4DNL2   A0A3S2L356   A0A1E1W4X6   A0A2H1VRB7   M4MAW1   A0A212F4Z0   D6WPH6   N6UQI0   A0A1L8E0R3   A0A170XKW9   A0A1B6JVS1   A0A1B6G5S6   A0A2S2QVW8   A0A1Y1MM55   A0A069DNI7   Q173D4   Q1W2A2   J3JTX5   U5EYM1   T1DFJ5   A0A023EDV1   A0A232FCE5   K7J8J0   T1E2M7   A0A224Y1G5   A0A336MDG6   A0A1D1ZKP1   A0A2H8TFY3   Q1ZZQ2   B0X4I4   A0A1Q3FGW6   A0A1J1ITM7   E0VSA0   A0A1Q3FH29   A0A0J7KTV3   A0A1B6EDH8   A0A151ITA9   F4WSZ5   A0A195AZ43   A0A158NYI3   C4WWQ7   A0A2R7X2H8   E9IUT5   R4WCX8   A0A195F782   A0A151WQF9   A0A026WMX8   A0A195CWE3   A0A154PB12   U4U5F2   E2A665   B3LXQ4   A0A1S3DCD9   A0A0N0U4C1   A0A1W4W8V4   Q16JK6   E2C0Z3   J9JIR2   A0A0A9YQH2   A0A0F7R132   A0A2A3EEU9   V9IHI2   A0A087ZYW3   B4NFJ4   T1DPT7   A0A182F6W4   W5JSL1   A0A2M3Z5Q7   A0A2M4AG33   A0A2M4C4M3   A0A182FEA8   T1DFY3   A0A0A1XDT7   A0A2M3Z0Y4   A0A2M4A523   W5JCW8   A0A182JMU4   A0A084WJA3   X1X105   A0A0C9QYB4   G9LZB9   A0A0M4EVQ9   B4JYY7   B4K581   B4LYZ4   A0A182LVN6   A0A182RQ45   A0A182WML6   R4G878   T1PP66   A0A3B0JNC8   Q293M1   B4GLX5   A0A1L8EHT7  

KEGG

692985    K02152 V-type H+-transporting ATPase subunit G | (RefSeq) vacuolar ATP synthase subunit G

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04145    Phagosome - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0042626   GO:1902600   GO:0016471   GO:0016324   GO:0006811   GO:0008553   GO:0006486   GO:0004582   GO:0005783   GO:0033181   GO:0007430   GO:0015992   GO:0016820   GO:0008270   GO:0005524   GO:0006139   GO:0019205   GO:0043564   GO:0006418   GO:0003824  

PANTHER

PTHR12713   PTHR43398  

Subcellular location

Apical cell membrane  
Endoplasmic reticulum  

Length:

117

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.43422

outside

1  -  117

 

 

Pi

268.288902

Theta

185.816058

Tajima's D

1.244431

CLR

0.263425

CSRT

0.723713814309284

Interpretation

Uncertain