Gene

KWMTBOMO11796

Annotation

alcohol_dehydrogenase_3?_partial_[Helicoverpa_assulta]

Location

Bomo_Chr20(+):166354-168531      View in EpiBrowser

Full name

Reticulon-4-interacting protein 1, mitochondrial      

Alternative Name

NOGO-interacting mitochondrial protein

Location in the cell

Extracellular   Reliability : 1.32

CDS

ATGTCGGCGGACAGCGCGGCCGCCCTGCCCTGGAGCGGGACCAAGGTGCTGGCCACGCTGAGGAAACTCAAGCTCAACCAGGACAACCTCAAAGGGAAGCGCGTGGCGGTGTGCGGCGCGGCGCGGGCGGAGCTGTGCGCGGCCGTGCAGCTGCTGGCCCGCGCGGGCGCGCACGTGTCCGCACTGGCGCCGCGCCACGCCGCGCAGCTGCTGCGGGACCTCGGGGCGTCCGAGTTCATAGACCCGGCGGAGGGAGGGCTGCAGGGGGCGGCGCGGGTGCTGGAGCAGCACGCGCGGCGCGAGGGCTGCTGGGACGCCGTGCTGCTGTGCGCCGGCGCCCCCGCACCGCCCAGCCCCGCCGTGCTCAGGTGA

Protein

MSADSAAALPWSGTKVLATLRKLKLNQDNLKGKRVAVCGAARAELCAAVQLLARAGAHVSALAPRHAAQLLRDLGASEFIDPAEGGLQGAARVLEQHARREGCWDAVLLCAGAPAPPSPAVLR

Description

Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve (PubMed:26593267). Appears to be a potent inhibitor of regeneration following spinal cord injury (PubMed:12067236).

Subunit

Interacts with RTN4, UQCRC1 and UQCRC2.

Similarity

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Keywords

Complete proteome   Membrane   Mitochondrion   Mitochondrion outer membrane   Neurogenesis   Reference proteome   Transit peptide  

Feature

chain  Reticulon-4-interacting protein 1, mitochondrial

Uniprot

H9JVU6   A0A2H1WXY7   A0A0F6Q2L1   A0A2W1BQ56   A0A2A4JZT1   A0A3S2P4G7   + More
A0A194Q5W9   A0A091MZ90   R0LT17   A0A093D138   U3INN6   A0A0A0B3E4   A0A094KPZ7   A0A2I0UP60   G1NLA7   F1NL88   A0A3Q2UAN0   D5XME6   A0A091QTX0   A0A091I9W8   A0A091N326   A0A2I0MUR0   A0A091INN9   A0A091SI56   A0A1V4JNC5   A0A226PUM9   A0A091NW78   A0A0Q3RHX4   D8KW01   A0A091GAX0   A0A091V8S1   A0A091SFL0   H0ZPM1   A0A093R9P6   U3KAY0   A0A093PMT8   A0A099ZSX3   A0A091UY34   A0A093NYI8   A0A3Q0G6D8   A0A087QJN6   R4GCV2   A0A093G543   G1KEI7   U3DRX2   U3EDW8   A0A2Y9DDQ7   F7IQ43   A0A172ZI06   U3EJF4   A0A218UZY6   A0A2Y9HAY0   K7GIV0   A0A091HIP8   A0A091PGG4   A0A091SC03   A0A3P4MWA6   A0A0P7UAI3   A0A2K5PGB1   A0A2K6TSQ1   G9KM33   A0A091F142   W5NIM2   A0A1W4Z669   A0A287BQ49   G3SYS0   H3B721   F1RT48   F1RT47   A0A2K5F466   A0A2Y9FAY8   G1T5A5   B2GUZ6   A0A3Q2LLK9   W5NIL9   A0A2U4AW93   A0A1N6I6S9   A0A1U7QUE4   G3GXJ0   A0A1Q3Q3W3   Q924D0   A0A3Q2I8D0   A0A3Q2CK26   F6ZDF5   M3X977   G3WJI4   H0X7J6   Q28F11   A0A2U3V6L3   I3MD13   L5JPC1   A0A0R4J0S3   A0A340XWV1   A0A3M8DBP4  

Pubmed

19121390    28756777    26354079    23749191    20838655    15592404    + More
23371554    24621616    20360741    25243066    26769366    17381049    23236062    30723633    9215903    21993624    15489334    15057822    15632090    19892987    21804562    23929341    12067236    16141072    21183079    26593267    17975172    21709235    23258410    12040188    19468303   

EMBL

BABH01040671    BABH01040672    ODYU01011921    SOQ57935.1    KP237888    AKD01741.1    + More
KZ149937    PZC77118.1    NWSH01000350    PCG77154.1    RSAL01000025    RVE52121.1    KQ459460    KPJ00759.1    KK840164    KFP82813.1    KB742848    EOB03563.1    KL470963    KFV18819.1    ADON01050840    KL884779    KGM00309.1    KL339941    KFZ52280.1    KZ505668    PKU47829.1    AADN05000003    DP001174    ADD70307.1    KK706044    KFQ30369.1    KL217557    KFO96560.1    KK526066    KFP68165.1    AKCR02000002    PKK33383.1    KK500575    KFP09020.1    KK472522    KFQ57978.1    LSYS01006902    OPJ73227.1    AWGT02000016    OXB83182.1    KL375806    KFP83715.1    LMAW01000836    KQK85273.1    DP001173    ADK26740.1    KL447977    KFO79118.1    KK733815    KFQ99731.1    KK818132    KFQ39045.1    ABQF01000466    KL435766    KFW92817.1    AGTO01011341    KL670081    KFW78118.1    KL897886    KGL84877.1    KL410285    KFQ95621.1    KL225240    KFW69853.1    KL225660    KFM01440.1    KL215352    KFV64243.1    GAMT01003837    GAMQ01006899    JAB08024.1    JAB34952.1    GAMS01003001    GAMR01005108    JAB20135.1    JAB28824.1    CP013023    ANF97274.1    GAMP01008068    JAB44687.1    MUZQ01000087    OWK59030.1    AGCU01087627    AGCU01087628    AGCU01087629    AGCU01087630    AGCU01087631    AGCU01087632    KL513424    KFO87218.1    KK658293    KFQ06456.1    KK946628    KFQ54891.1    CYRY02014007    VCW84356.1    JARO02006916    KPP64595.1    JP017364    AES05962.1    KK719263    KFO62284.1    AHAT01009251    AEMK02000001    DQIR01247130    HDC02608.1    AFYH01088847    AFYH01088848    AFYH01088849    AFYH01088850    AFYH01088851    AFYH01088852    AFYH01088853    AFYH01088854    DQIR01021830    HCZ77305.1    AAGW02029550    AAGW02029551    AAGW02029552    AABR07045484    AABR07045485    BC166465    CH474025    AAI66465.1    EDL99682.1    FSRJ01000005    SIO27732.1    JH000060    KE667827    EGV98822.1    ERE84751.1    MKSW01000012    OJV28537.1    AF336862    AK050324    AK085858    AK088029    BC024116    AANG04003966    AEFK01170339    AEFK01170340    AEFK01170341    AEFK01170342    AEFK01170343    AAQR03003278    AAQR03003279    AAQR03003280    AAQR03003281    AAQR03003282    AAQR03003283    AAQR03003284    AAQR03003285    AAQR03003286    CR762233    CAJ82526.1    AGTP01061063    KB031156    ELK00606.1    AC153536    AC158637    CH466540    EDL05027.1    RHHQ01000015    RNB85051.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000016666    UP000053858    + More
UP000001645    UP000000539    UP000054308    UP000053872    UP000053119    UP000190648    UP000198419    UP000051836    UP000053760    UP000053605    UP000007754    UP000016665    UP000053258    UP000053641    UP000053283    UP000054081    UP000189705    UP000053286    UP000001646    UP000053875    UP000248480    UP000008225    UP000078148    UP000197619    UP000248481    UP000007267    UP000034805    UP000233040    UP000233220    UP000052976    UP000018468    UP000192224    UP000008227    UP000007646    UP000008672    UP000233020    UP000248484    UP000001811    UP000002494    UP000002281    UP000245320    UP000184699    UP000189706    UP000001075    UP000030759    UP000186374    UP000000589    UP000265020    UP000011712    UP000007648    UP000005225    UP000005215    UP000010552    UP000265300    UP000271031   

PRIDE

H9JVU6    F1RT47    G3GXJ0    Q924D0   

Pfam

PF08240   ADH_N        + More
PF12777   MT
PF00107   ADH_zinc_N

Interpro

IPR036291   NAD(P)-bd_dom_sf        + More
IPR011032   GroES-like_sf       
IPR020843   PKS_ER       
IPR013154   ADH_N       
IPR026975   DNAH1       
IPR024743   Dynein_HC_stalk       
IPR026983   DHC_fam       
IPR037397   RTN4I1       
IPR002364   Quin_OxRdtase/zeta-crystal_CS       
IPR013149   ADH_C       

SUPFAM

SSF50129   SSF50129        + More
SSF51735   SSF51735       

CDD

cd08248  RTN4I1

ProteinModelPortal

H9JVU6   A0A2H1WXY7   A0A0F6Q2L1   A0A2W1BQ56   A0A2A4JZT1   A0A3S2P4G7   + More
A0A194Q5W9   A0A091MZ90   R0LT17   A0A093D138   U3INN6   A0A0A0B3E4   A0A094KPZ7   A0A2I0UP60   G1NLA7   F1NL88   A0A3Q2UAN0   D5XME6   A0A091QTX0   A0A091I9W8   A0A091N326   A0A2I0MUR0   A0A091INN9   A0A091SI56   A0A1V4JNC5   A0A226PUM9   A0A091NW78   A0A0Q3RHX4   D8KW01   A0A091GAX0   A0A091V8S1   A0A091SFL0   H0ZPM1   A0A093R9P6   U3KAY0   A0A093PMT8   A0A099ZSX3   A0A091UY34   A0A093NYI8   A0A3Q0G6D8   A0A087QJN6   R4GCV2   A0A093G543   G1KEI7   U3DRX2   U3EDW8   A0A2Y9DDQ7   F7IQ43   A0A172ZI06   U3EJF4   A0A218UZY6   A0A2Y9HAY0   K7GIV0   A0A091HIP8   A0A091PGG4   A0A091SC03   A0A3P4MWA6   A0A0P7UAI3   A0A2K5PGB1   A0A2K6TSQ1   G9KM33   A0A091F142   W5NIM2   A0A1W4Z669   A0A287BQ49   G3SYS0   H3B721   F1RT48   F1RT47   A0A2K5F466   A0A2Y9FAY8   G1T5A5   B2GUZ6   A0A3Q2LLK9   W5NIL9   A0A2U4AW93   A0A1N6I6S9   A0A1U7QUE4   G3GXJ0   A0A1Q3Q3W3   Q924D0   A0A3Q2I8D0   A0A3Q2CK26   F6ZDF5   M3X977   G3WJI4   H0X7J6   Q28F11   A0A2U3V6L3   I3MD13   L5JPC1   A0A0R4J0S3   A0A340XWV1   A0A3M8DBP4  

PDB

2VN8     E-value=1.8238e-07,     Score=125

KEGG

101736480    no KO assigned | (RefSeq) uncharacterized LOC101736480

GO

GO:0016491   GO:0016021   GO:0008270   GO:0005739   GO:0005741   GO:0050773  

PANTHER

PTHR10676   PTHR10676:SF358  

Subcellular location

Mitochondrion   Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria.   With evidence from 1 publications.
Mitochondrion outer membrane   Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria.   With evidence from 1 publications.

Length:

123

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0178

Exp number, first 60 AAs:

0.01333

Total prob of N-in:

0.09196

outside

1  -  123

 

 

Pi

316.749137

Theta

174.271877

Tajima's D

4.568282

CLR

0.300808

CSRT

0.99990000499975

Interpretation

Uncertain