Gene

KWMTBOMO11793

Pre Gene Modal

BGIBMGA013651

Annotation

PREDICTED:_facilitated_trehalose_transporter_Tret1-like_[Amyelois_transitella]

Location

Bomo_Chr20(-):131492-140943      View in EpiBrowser

Full name

Facilitated trehalose transporter Tret1-2 homolog       + More
Facilitated trehalose transporter Tret1-1      

Location in the cell

PlasmaMembrane   Reliability : 4.57

CDS

ATGACGTTCGCGTCCGCCATCTTATCATCGTTCGGCGTGACTGTCAGTCCGGAGCTGCAGGCGTTGAGCTTCCCTGCCGTGATGCTGCTCGCCTCCCTGCTGTCACTCTTCTACGTCGAAAGGCTGGGTAGGAAGGTAAGGCCGCCGACCCTGCAGATTAAGAGTGTCCTCACACCACCCGTATGTCAGCACTACAGCGGTAACCGGGATACAAAACTGCTCGGCTCGCGTACGAACATGTCCGAGCTTGAATACACACCGGCGTTTTTGGTAACGGCGGGCTCGCTGGTCTGCCTGGCGACCACCCTGCTCGCCCAGCAGCACGGCTGGGCGGCGCCGGCGTGGCTGCCCGCGGCCGCCATGGTGCTGTCGCTTGCGTCCGGAGTCTCGCCTGTGCCCTATATCATTATGTCTGAAATGTTTCATTTCCAGATTCGCGCCAAGGTGTTGGCTTGCGTGGTGACGCACGCGTGGTTCATGTCGTTCACCCAGCTGGCGGCGTTCGGCCCCTTGTCGGCCGCGCTGGGACTGCACTCCACGTTCTTCGCGTTCGCCGCGGTGAACCTCTGCGGGGCCCTTGTGTCTCTGACGCTCTTGCCCGAAACGAAAGGAAAGACTCTGGAACAAATCGAAATTTCGTTACGAGGGAAACATTTCTTTAGATAA

Protein

MTFASAILSSFGVTVSPELQALSFPAVMLLASLLSLFYVERLGRKVRPPTLQIKSVLTPPVCQHYSGNRDTKLLGSRTNMSELEYTPAFLVTAGSLVCLATTLLAQQHGWAAPAWLPAAAMVLSLASGVSPVPYIIMSEMFHFQIRAKVLACVVTHAWFMSFTQLAAFGPLSAALGLHSTFFAFAAVNLCGALVSLTLLPETKGKTLEQIEISLRGKHFFR

Description

Fails to transport trehalose.
Low-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.

Biophysicochemical Properties

10.94 mM for trehalose

Similarity

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.

Keywords

Cell membrane   Complete proteome   Glycoprotein   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Alternative splicing   Phosphoprotein   Sugar transport   Transport  

Feature

chain  Facilitated trehalose transporter Tret1-2 homolog
splice variant  In isoform B.

Uniprot

H9JVT8   A0A2A4J9N1   A0A2H1VLY6   A0A2A4JNL8   A0A194QBF3   A0A194Q5D6   + More
A0A0N1IJR5   A0A0L7L525   H9JW16   A0A212EZE7   A0A2H1X046   A0A212F0M2   A0A194Q5F7   A0A0N1IIG7   D4AHW6   A0A2A4J8P9   A0A2W1BRA6   A5Y0C3   A0A3S2TMD3   H9J4J6   A0A3S2TIH7   H9JFD4   A0A2H1WGI4   A0A2H1WM77   A0A2A4JKE4   A0A2A4JPP7   A0A2W1BU14   A0A2H1VB69   Q8MKK4   K7IP31   A0A232F7N7   A0A0T6B7J6   A1Z8N1-2   A0A1W4WZ04   A0A0J9RBH4   B4QBN3   A0A0N0PCI3   A0A212F416   A0A2P8ZLZ8   A0A194Q5B9   A0A0J9RAI5   B4HNS1   H9JVU3   A0A212FAG2   A0A194PLS6   A0A1W4WPV3   A0A0L7RBJ5   A0A3S2NG77   A0A0N1IGQ6  

Pubmed

19121390    26354079    26227816    22118469    20705135    28756777    + More
17916500    20035867    10731132    12537572    12537569    20075255    28648823    18327897    22936249    17994087    29403074   

EMBL

BABH01040665    BABH01040666    BABH01040667    NWSH01002244    PCG68837.1    ODYU01003284    + More
SOQ41841.1    NWSH01001033    PCG73010.1    KQ459460    KPJ00761.1    KPJ00762.1    KQ459838    KPJ19754.1    JTDY01002946    KOB70431.1    BABH01036553    AGBW02011317    OWR46831.1    ODYU01012350    SOQ58622.1    AGBW02011050    OWR47308.1    KPJ00778.1    KPJ19742.1    AB549994    BAI83415.1    NWSH01002620    PCG67830.1    KZ149924    PZC77632.1    EF028238    ABM01870.1    RSAL01000053    RVE50024.1    BABH01021836    RSAL01000114    RVE46930.1    BABH01038299    ODYU01008186    SOQ51574.1    ODYU01009532    SOQ54032.1    NWSH01001270    PCG71903.1    NWSH01000916    PCG73554.1    KZ149936    PZC77145.1    ODYU01001615    SOQ38089.1    AB369551    AE013599    AY122079    AAM52591.1    AAM68715.1    BAF96745.1    NNAY01000793    OXU26469.1    LJIG01009574    KRT82807.1    AB369552    AB369553    BT003466    BT010286    AAF58632.2    AAQ23604.1    BAF96746.1    CM002911    KMY93024.1    CM000362    EDX06650.1    KQ460569    KPJ13961.1    AGBW02010450    OWR48486.1    PYGN01000019    PSN57528.1    KPJ00738.1    KMY93022.1    CH480816    EDW47436.1    BABH01040655    AGBW02009482    OWR50710.1    KQ459601    KPI93689.1    KQ414617    KOC68302.1    RSAL01000118    RVE46763.1    KQ459910    KPJ19331.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000037510    UP000007151    + More
UP000283053    UP000000803    UP000002358    UP000215335    UP000192223    UP000000304    UP000245037    UP000001292    UP000053825   

PRIDE

H9JVT8    H9JW16    H9J4J6    H9JFD4    Q8MKK4    A1Z8N1    + More
H9JVU3   

Pfam

PF00083   Sugar_tr

Interpro

IPR005828   MFS_sugar_transport-like        + More
IPR005829   Sugar_transporter_CS       
IPR020846   MFS_dom       
IPR036259   MFS_trans_sf       
IPR003663   Sugar/inositol_transpt       

SUPFAM

SSF103473   SSF103473       

CDD

cd06174  MFS

ProteinModelPortal

H9JVT8   A0A2A4J9N1   A0A2H1VLY6   A0A2A4JNL8   A0A194QBF3   A0A194Q5D6   + More
A0A0N1IJR5   A0A0L7L525   H9JW16   A0A212EZE7   A0A2H1X046   A0A212F0M2   A0A194Q5F7   A0A0N1IIG7   D4AHW6   A0A2A4J8P9   A0A2W1BRA6   A5Y0C3   A0A3S2TMD3   H9J4J6   A0A3S2TIH7   H9JFD4   A0A2H1WGI4   A0A2H1WM77   A0A2A4JKE4   A0A2A4JPP7   A0A2W1BU14   A0A2H1VB69   Q8MKK4   K7IP31   A0A232F7N7   A0A0T6B7J6   A1Z8N1-2   A0A1W4WZ04   A0A0J9RBH4   B4QBN3   A0A0N0PCI3   A0A212F416   A0A2P8ZLZ8   A0A194Q5B9   A0A0J9RAI5   B4HNS1   H9JVU3   A0A212FAG2   A0A194PLS6   A0A1W4WPV3   A0A0L7RBJ5   A0A3S2NG77   A0A0N1IGQ6  

PDB

6N3I     E-value=0.000153497,     Score=104

KEGG

101735554    K08145 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member

GO

GO:0016021   GO:0022857   GO:0008643   GO:0005886   GO:0015771   GO:0016020   GO:0015574   GO:0005215   GO:0005524   GO:0006139   GO:0019205   GO:0043564   GO:0006418   GO:0003824   GO:0055085  

Subcellular location

Cell membrane  

Length:

221

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

106.42864

Exp number, first 60 AAs:

20.3189

Total prob of N-in:

0.00469

POSSIBLE N-term signal

sequence

outside

1  -  19

TMhelix

20  -  39

inside

40  -  84

TMhelix

85  -  104

outside

105  -  113

TMhelix

114  -  136

inside

137  -  148

TMhelix

149  -  171

outside

172  -  180

TMhelix

181  -  200

inside

201  -  221

 

 

Pi

292.206904

Theta

198.416057

Tajima's D

1.65777

CLR

0.15449

CSRT

0.821908904554772

Interpretation

Uncertain