Gene

KWMTBOMO11784

Pre Gene Modal

BGIBMGA000197

Annotation

putative_uroporphyrinogen-III_synthase-like_protein_[Danaus_plexippus]

Location

Bomo_Chr19(-):14610293-14611233      View in EpiBrowser

Full name

Uroporphyrinogen-III synthase      

Alternative Name

Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase

Location in the cell

Extracellular   Reliability : 0.841

CDS

ATGAAAATAGTGCTATTCAAAGGTTTGGACGCGCTCGGGGCTACAGCAGGTAATGCAGAAAATTTATCGAAAATTATTCTAAAAGATAAGAAAAAAACATCAACATTTCTGTTTCCGTGTGGCAATTTAAGATCAGAGACCATCCCCAACATGCTACAATCTGAAGGAATCACATTAGATGCTATAACTGTGTATGAGACACAAGAGAATGAAAACTTAAAGGCCCTTTTAATGGAATTGAATAACTTGAATGATAGTCCAAGTGGCTTGGCATTCTTTAGTCCGTCAGGTTGTGAATACATACACAGACAACTACAGACATTTAGCAACAGATTGTCCTTACTACCTCACTTTGCTATTGGCAACTCAACAGCGCATAAAATTGAAAATCTTGGTGTGGAAATAGCTGGAGTCGCAGCAAAACCTAAAGCTGAGAGTTTAGTTGAATCTGTATTGAAATATTTTGCATTACAAGGTAGCTAG

Protein

MKIVLFKGLDALGATAGNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESVLKYFALQGS

Catalytic Activity

hydroxymethylbilane = H2O + uroporphyrinogen III

Subunit

Monomer.

Similarity

Belongs to the uroporphyrinogen-III synthase family.

Keywords

3D-structure   Complete proteome   Direct protein sequencing   Disease mutation   Heme biosynthesis   Lyase   Polymorphism   Porphyrin biosynthesis   Reference proteome  

Feature

chain  Uroporphyrinogen-III synthase
sequence variant  In CEP; no residual activity; dbSNP:rs773301339.

Uniprot

H9ISH0   A0A2H1VCC3   A0A2A4JM04   A0A1E1WUD6   A0A212EJW5   A0A2W1BWD8   + More
A0A194QZH2   A0A0L7LFK7   A0A194PP16   V4C5Y1   H0X3N6   A0A151P4B1   A0A1U7RNQ5   U3JE58   A7RZ79   A0A2K6UMU3   I3MI16   W4Z1L1   A0A091G7Z8   A0A1S2ZSJ8   A0A2P8XWE9   H0ZML1   R0LGG7   A0A087QZP7   A0A2K6KP03   U3IZ02   A0A1W7RBR8   A0A2K5YUQ3   A0A2K6RL81   A0A2B4RME7   A0A091K245   G1NGQ3   A0A2I0MEE2   A0A1W4XV75   A0A218UT61   A0A093C5K0   A0A2K5IX16   G1QIU6   A0A210QQI9   A0A0A0B280   A0A2J8W675   A0A3Q1HA14   G1K8Y2   A0A3Q1H362   A0A093IQD7   A0A3L8SJ28   E1BUH1   U5EV31   A0A287B8R7   A0A091KT19   A0A1S3FM13   F1SDM7   A0A0S2Z4T8   P10746   A0A1U7TQY7   I3LT93   A0A091MZU0   A0A2R9A8M7   H2Q2R3   A0A091PEW0   U3FDH5   A0A287B4K1   U3EZI4   W5MMG7   A0A3Q0DXN9   G3R707   A0A287AZN2   A0A3Q0E150   A0A091ELP1   A0A3B4XB67   A0A3M6U1B9   G7PEB9   G7N1D1   A0A2K6CJ18   H9FZC1   A0A096NSQ2   A0A2K5VG84   A0A1Y1K2M0   G3NDM0   K9IHC0   A0A3Q7WIB5   A0A384BNH9   A0A091IHW1   A0A091HJ86   A0A093HHW8   A0A250YDV3   A0A3B3RJQ4   A0A3Q3AM93   A0A0P7YB65   A0A1W5AL37   A0A087V5F5   A0A1W5AU47   H0V422   A0A1U8CB12   T2MHM2   A0A2K6FWH8   A0A2K5CIV5   A0A2D4HGU7   D2H3F0  

EC Number

4.2.1.75

Pubmed

19121390    22118469    28756777    26354079    26227816    23254933    + More
22293439    17615350    29403074    20360741    23749191    26358130    25362486    20838655    23371554    28812685    30282656    15592404    30723633    26871637    3174619    11112350    14702039    15164054    15489334    8829650    11689424    2331520    1733834    1737856    7860775    8655129    9188670    9834209    9803266    11121156    12060141    15304101    21653323    22350154    22722832    16136131    25243066    22398555    30382153    22002653    17431167    25319552    28004739    24813606    28087693    29240929    21993624    24065732    20010809   

EMBL

BABH01040697    ODYU01001800    SOQ38499.1    NWSH01001101    PCG72604.1    GDQN01003781    + More
GDQN01000424    JAT87273.1    JAT90630.1    AGBW02014361    OWR41793.1    KZ149915    PZC77965.1    KQ460949    KPJ10375.1    JTDY01001264    KOB74343.1    KQ459598    KPI94489.1    KB201362    ESO97024.1    AAQR03106853    AAQR03106854    AKHW03001049    KYO43888.1    AGTO01001153    DS469556    EDO43184.1    AGTP01018902    AAGJ04026344    AAGJ04026345    AAGJ04026346    AAGJ04026347    KL447873    KFO78078.1    PYGN01001244    PSN36335.1    ABQF01039378    KB743340    EOA99337.1    KL226002    KFM06701.1    ADON01089446    GDAY02002882    JAV48585.1    LSMT01000437    PFX17989.1    KK501793    KFP17856.1    AKCR02000017    PKK28043.1    MUZQ01000141    OWK56953.1    KL233907    KFV07547.1    ADFV01103217    ADFV01103218    ADFV01103219    NEDP02002410    OWF51001.1    KL873581    KGL99430.1    ABGA01134046    ABGA01134047    ABGA01134048    NDHI03003398    PNJ65275.1    PNJ65278.1    KK596988    KFW03883.1    QUSF01000019    RLW02116.1    AADN05000306    GANO01002060    JAB57811.1    AEMK02000096    KK753230    KFP42465.1    DQIR01286773    HDC42251.1    KU178377    ALQ33835.1    J03824    AF230665    AH010036    AK314896    AL360176    CH471066    BC002573    KK840443    KFP83038.1    AJFE02055254    AJFE02055255    AACZ04039300    GABF01009619    GABD01006374    GABE01008170    NBAG03000436    JAA12526.1    JAA26726.1    JAA36569.1    PNI24666.1    PNI24670.1    KK672071    KFQ05788.1    GAMT01007737    GAMS01002703    GAMQ01003795    GAMP01005595    JAB04124.1    JAB20433.1    JAB38056.1    JAB47160.1    GAMR01006262    JAB27670.1    AHAT01004035    CABD030076659    CABD030076660    KK718883    KFO58858.1    RCHS01002416    RMX47495.1    CM001284    EHH65105.1    CM001261    EHH19456.1    JSUE03044537    JU336227    JU477063    JV048155    AFE79980.1    AFH33867.1    AFI38226.1    AHZZ02036211    AQIA01072901    AQIA01072902    GEZM01097273    JAV54300.1    GABZ01007470    JAA46055.1    KL217818    KFO99280.1    KL514043    KFO87403.1    KL206121    KFV79045.1    GFFW01002956    JAV41832.1    JARO02007913    KPP63418.1    KL480538    KFO07847.1    AAKN02002942    AAKN02002943    HAAD01005190    CDG71422.1    IACK01027143    IACK01027144    LAA71184.1    ACTA01114342    GL192462    EFB30103.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000037510    UP000053268    + More
UP000030746    UP000005225    UP000050525    UP000189705    UP000016665    UP000001593    UP000233220    UP000005215    UP000007110    UP000053760    UP000079721    UP000245037    UP000007754    UP000053286    UP000233180    UP000016666    UP000233140    UP000233200    UP000225706    UP000053119    UP000001645    UP000053872    UP000192223    UP000197619    UP000233080    UP000001073    UP000242188    UP000053858    UP000001595    UP000265040    UP000001646    UP000276834    UP000000539    UP000008227    UP000081671    UP000005640    UP000189704    UP000240080    UP000002277    UP000008225    UP000018468    UP000001519    UP000052976    UP000261360    UP000275408    UP000009130    UP000233120    UP000006718    UP000028761    UP000233100    UP000007635    UP000286642    UP000261680    UP000291021    UP000054308    UP000053584    UP000261540    UP000264800    UP000034805    UP000192224    UP000005447    UP000189706    UP000233160    UP000233020    UP000008912   

PRIDE

H9ISH0    A0A0S2Z4T8    P10746    I3LT93   

Pfam

PF02602   HEM4

Interpro

IPR003754   4pyrrol_synth_uPrphyn_synth        + More
IPR039793   UROS/Hem4       
IPR036108   4pyrrol_syn_uPrphyn_synt_sf       

SUPFAM

SSF69618   SSF69618       

CDD

cd06578  HemD

ProteinModelPortal

H9ISH0   A0A2H1VCC3   A0A2A4JM04   A0A1E1WUD6   A0A212EJW5   A0A2W1BWD8   + More
A0A194QZH2   A0A0L7LFK7   A0A194PP16   V4C5Y1   H0X3N6   A0A151P4B1   A0A1U7RNQ5   U3JE58   A7RZ79   A0A2K6UMU3   I3MI16   W4Z1L1   A0A091G7Z8   A0A1S2ZSJ8   A0A2P8XWE9   H0ZML1   R0LGG7   A0A087QZP7   A0A2K6KP03   U3IZ02   A0A1W7RBR8   A0A2K5YUQ3   A0A2K6RL81   A0A2B4RME7   A0A091K245   G1NGQ3   A0A2I0MEE2   A0A1W4XV75   A0A218UT61   A0A093C5K0   A0A2K5IX16   G1QIU6   A0A210QQI9   A0A0A0B280   A0A2J8W675   A0A3Q1HA14   G1K8Y2   A0A3Q1H362   A0A093IQD7   A0A3L8SJ28   E1BUH1   U5EV31   A0A287B8R7   A0A091KT19   A0A1S3FM13   F1SDM7   A0A0S2Z4T8   P10746   A0A1U7TQY7   I3LT93   A0A091MZU0   A0A2R9A8M7   H2Q2R3   A0A091PEW0   U3FDH5   A0A287B4K1   U3EZI4   W5MMG7   A0A3Q0DXN9   G3R707   A0A287AZN2   A0A3Q0E150   A0A091ELP1   A0A3B4XB67   A0A3M6U1B9   G7PEB9   G7N1D1   A0A2K6CJ18   H9FZC1   A0A096NSQ2   A0A2K5VG84   A0A1Y1K2M0   G3NDM0   K9IHC0   A0A3Q7WIB5   A0A384BNH9   A0A091IHW1   A0A091HJ86   A0A093HHW8   A0A250YDV3   A0A3B3RJQ4   A0A3Q3AM93   A0A0P7YB65   A0A1W5AL37   A0A087V5F5   A0A1W5AU47   H0V422   A0A1U8CB12   T2MHM2   A0A2K6FWH8   A0A2K5CIV5   A0A2D4HGU7   D2H3F0  

PDB

1JR2     E-value=5.44047e-19,     Score=226

KEGG

101737021    K01719 uroporphyrinogen-III synthase [EC:4.2.1.75] | (RefSeq) uroporphyrinogen-III synthase

PATHWAY

00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004852   GO:0006780   GO:0006783   GO:0005829   GO:0071418   GO:0071243   GO:0070541   GO:0048037   GO:0046677   GO:0005739   GO:0006782   GO:0016021   GO:0033014   GO:0007186   GO:0005524   GO:0006139   GO:0019205   GO:0043564   GO:0006418   GO:0003824  

PANTHER

PTHR12390  

Length:

160

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00158

Exp number, first 60 AAs:

0.0012

Total prob of N-in:

0.04963

outside

1  -  160

 

 

Pi

0.281291

Theta

2.218835

Tajima's D

-2.1207

CLR

149.033382

CSRT

0.00384980750962452

Interpretation

Possibly Positive selection