Gene

KWMTBOMO11774  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000189

Annotation

PREDICTED:_protein_VAC14_homolog_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr19(+):14477971-14485469      View in EpiBrowser

Full name

Protein VAC14 homolog      

Location in the cell

Cytoplasmic   Reliability : 2.099

CDS

ATGTCCGAGCGAGACTACGCACCGCTGAGCATAGCTTGTGTTCGTGGGCTTTGCGACAAATTATATGAGAAGAGAAAAGTTGCTGGAGTCGAGATTGAGAAGATGGTGAAAGATTTTAATGATGCAAAAAATACTAGCCAAATAAAAAAATTGATCAAAGTCTTGGGCCAGGACTTGATGTCTTCAACTAATCCTAATATGAAAAACGGAGCACTTATGGGTCTGTCTACTGTAGCAGTGGGGCTTGGCAAGGCATCAGTAGATTACTTACCAGAATTAACAAATCCAATAGTGGCTTGCTTCAGCGAGAGCGAATCTCGTGTAAGGTACCAAGCAGCTGAGGCATTGTTCAACGTGCTGAAGATTGTCCGAGGCGCTTCTTTATCACAGTTCCCTGTAATTTTCGATGCGCTGGCTAAACTCGCTGCTGATCCTGAGCAGCAGGTGAAGCATGCTGCTGAATTGTTGGATAGATTGCTCAAGGACATCGTGACCGAGAGCGGGTCCGTGGAGCTGTCGTCGCTGGTGGGGCTGGTGCGAGAGCGCATGTACACGCGCTCGGCGCCGGCGCGCCAGCTCGCCGTGTCCTGGGTGGCGGTGCTGGACGCCGTGCCCGACCTCAACGTGCTGGCCCATCTCCCGGACTTACTGGACGGGCTCTTCAAGATGCTAGACGATCCTAACCCGGAGATCAGAAGGATGTGCGATGTCCAGCTGAACGAGTTCCTCCGCAGCATTAAGAAAGAGCCAGCCAAAGTAGACTTCCAAGCCATGATCAACATCCTTATCATACACGCGCAGTCGCCCGAGGAACTGCTGCAGCTGACGGCGATTACGTGGCTCAAGGAGTTCGTGGAGCTGGCCGGCGCCGCCATGCTGCCCTTCGCCTCGGGCATCCTGTGCGCCGTGCTGCCCTGCCACGCATACTCCGACGAGCCAAGGAAGAGCATACGGGAGACGGCGGCCACGGTCAACTTTCAACTGATCAAACTGTTGGCTGCCGAGAGCGAGGAGGCTGGTGGTGAGGAGGCGGCGGGCGAGGAGGGGGGCGCGCTCAACCTGGAGGCCGTGGTGGGGGTGCTGACGCAGATGCTGCACCACAGCTCCGTGCACACTAAAGTGGCCGCCCTGGATTGGATCCTTCACTTATACAATAAGCTCCCCAAACAGATGTGCGGCGAGACGGAGCGCGTGTGGGCGGGCGCGGTGGGCAGCCTCACGGACGCGGCGCACGACGTGCTGCGGCGCGCGCTCGCCGTGCTGGCAGAGATCTGCTCCGCCGCCGGAGATTTGCAGTCTAGTCCTTACTACTACAAGTTCCTACAAGCTTTATTGAGGCTTTTGGCGGCAGACGAGAACCTGTTGGAAGACAGAGGAGCTTTCATTATCAGGCAGCTGTGCGTCCTGCTGAACGCGGAGGACATATACAGGGCCCTAGCGAACATTCTGCAGCAGGAGAAGAATCTCCGCTTCGTGACCACCATGGTGGACATCCTCAACACCATACTGCTGACGTCCGCCGAGCTATACGAGCTGCGGGCGCTGCTGAAGGACCGCAGCAAGCCGTGGAGCCGCTCGCTGTTCCTGGCGCTGCACGGCTGCTGGTGCCACAGCCCCGTGTCGCTGCTGGCGCTGTGTCTGCTGGCGCACCACTACCGGCACTGCAACACGCTCATCGCCACCTTCGGCGACCTCGAGATAACCGTGGAGTTCCTGACGGAGGTGGACAAGCTGGTGCAGCTCATTGAGTCGCCCATATTCGCCTACCTGCGCCTGGAGCTGGTGGGCGAGCACAGCGCCGGCCTGCGCGCCGCGCTCCGCACCGCCCGCGGTACGGACAACCAACTACCTTCCTAA

Protein

MSERDYAPLSIACVRGLCDKLYEKRKVAGVEIEKMVKDFNDAKNTSQIKKLIKVLGQDLMSSTNPNMKNGALMGLSTVAVGLGKASVDYLPELTNPIVACFSESESRVRYQAAEALFNVLKIVRGASLSQFPVIFDALAKLAADPEQQVKHAAELLDRLLKDIVTESGSVELSSLVGLVRERMYTRSAPARQLAVSWVAVLDAVPDLNVLAHLPDLLDGLFKMLDDPNPEIRRMCDVQLNEFLRSIKKEPAKVDFQAMINILIIHAQSPEELLQLTAITWLKEFVELAGAAMLPFASGILCAVLPCHAYSDEPRKSIRETAATVNFQLIKLLAAESEEAGGEEAAGEEGGALNLEAVVGVLTQMLHHSSVHTKVAALDWILHLYNKLPKQMCGETERVWAGAVGSLTDAAHDVLRRALAVLAEICSAAGDLQSSPYYYKFLQALLRLLAADENLLEDRGAFIIRQLCVLLNAEDIYRALANILQQEKNLRFVTTMVDILNTILLTSAELYELRALLKDRSKPWSRSLFLALHGCWCHSPVSLLALCLLAHHYRHCNTLIATFGDLEITVEFLTEVDKLVQLIESPIFAYLRLELVGEHSAGLRAALRTARGTDNQLPS

Description

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity (By similarity).

Subunit

Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold (By similarity).

Similarity

Belongs to the VAC14 family.

Keywords

Complete proteome   Endosome   Membrane   Reference proteome   Repeat  

Feature

chain  Protein VAC14 homolog

Uniprot

H9ISG2   A0A212EK04   D6WPN6   A0A154PKW1   E2BXH5   A0A1Y1MAW0   + More
A0A139WEA7   A0A151WJQ9   A0A0L7QNU0   A0A067QRT8   E2AC17   A0A2A3ELH5   F4X110   A0A195CKL6   A0A158NI19   A0A0J7L0B3   E0VQV6   A0A2J7R3P0   A0A1B6I0P4   A0A1Y1M3R9   A0A1B6LBW9   A0A026WYQ0   A0A0M8ZSI6   A0A2J7R3M5   A0A1W4X449   A0A151I4L1   A0A232FKC3   K7IZD8   A0A1D2N298   A0A195F638   A0A0P6B9K8   A0A0P5HIL8   A0A0P5HRA7   A0A1B6E9H2   A0A164Z729   A0A0P6IEE6   A0A147BD08   N6T3G4   A0A195EFY1   A0A2R5LB63   A0A0L7L1D0   A0A293MXF6   A0A023F269   U4UQF3   A0A069DWW3   A0A0A9X6L4   A0A1B0CQ03   A0A131YIN1   V4BVL4   A0A224ZBK8   A0A087TV22   W8CD00   A0A2L2YQZ5   A0A0P5D0A6   F1NWG6   A0A2T7NI13   A0A226P2M0   Q5ZIW5   F6U0G4   A0A1I8MR22   A0A0P5CLR2   A0A0A1XM24   T2MEF9   B4MBI2   A0A151MSN0   A0A0P5DFF2   A0A226MPI1   A0A182N0G7   G1S284   A0A2H8TUV5   A0A182Q8M2   J9JVA2   H2NRF6   A0A2K6KTU5   A0A0L0CBX0   E9GAP5   A0A0D9QWF5   A0A2K5ESF7   A0A1I8PF19   A0A2K6KTT9   A0A2K6RIM8   A0A2K6RIM0   A0A0K8U4B4   A0A034W6B7   A0A182P6U2   B3P4A7   A0A2K5R1D8   A0A0M4F3J9   Q16Q69   A0A084VV66   A0A182W468   A0A336M062   A0A182I9J8   Q7QE90   A0A182JYM5   A0A182V5G1   B4QS97   A0A182MFN2  

Pubmed

19121390    22118469    18362917    19820115    20798317    28004739    + More
24845553    21719571    21347285    20566863    24508170    30249741    28648823    20075255    27289101    29652888    23537049    26227816    25474469    26334808    25401762    26823975    26830274    23254933    28797301    24495485    26561354    15592404    24621616    15642098    17431167    25315136    25830018    24065732    17994087    22293439    26108605    21292972    25362486    25348373    17510324    24438588    12364791    14747013    17210077   

EMBL

BABH01040702    BABH01040703    AGBW02014361    OWR41800.1    KQ971354    EFA06197.2    + More
KQ434938    KZC12114.1    GL451254    EFN79623.1    GEZM01041344    JAV80497.1    KYB26276.1    KQ983039    KYQ48064.1    KQ414855    KOC60156.1    KK853035    KDR12240.1    GL438389    EFN69035.1    KZ288223    PBC32009.1    GL888520    EGI59870.1    KQ977622    KYN01270.1    ADTU01016184    ADTU01016185    LBMM01001650    KMQ95944.1    DS235442    EEB15762.1    NEVH01007819    PNF35435.1    GECU01027261    JAS80445.1    GEZM01041346    JAV80494.1    GEBQ01018798    JAT21179.1    KK107078    QOIP01000011    EZA60269.1    RLU16468.1    KQ435867    KOX70260.1    PNF35433.1    KQ976456    KYM84873.1    NNAY01000078    OXU31191.1    LJIJ01000285    ODM99378.1    KQ981763    KYN36055.1    GDIP01024456    JAM79259.1    GDIQ01226943    JAK24782.1    GDIQ01223442    JAK28283.1    GEDC01002728    JAS34570.1    LRGB01000781    KZS16018.1    GDIQ01012602    JAN82135.1    GEGO01006758    JAR88646.1    APGK01045645    KB741037    ENN74689.1    KQ978957    KYN27148.1    GGLE01002582    MBY06708.1    JTDY01003648    KOB69220.1    GFWV01020071    MAA44799.1    GBBI01003030    JAC15682.1    KB632319    ERL92270.1    GBGD01000692    JAC88197.1    GBHO01030884    GBRD01016792    GDHC01008895    GDHC01008399    JAG12720.1    JAG49035.1    JAQ09734.1    JAQ10230.1    AJWK01022899    GEDV01010162    JAP78395.1    KB201977    ESO93069.1    GFPF01013268    MAA24414.1    KK116858    KFM68961.1    GAMC01002811    JAC03745.1    IAAA01041532    LAA10503.1    GDIP01164638    JAJ58764.1    AADN05000561    PZQS01000012    PVD20795.1    AWGT02000192    OXB74071.1    AJ720669    JSUE03026554    JSUE03026555    GDIP01168675    JAJ54727.1    GBXI01002382    JAD11910.1    HAAD01004078    CDG70310.1    CH940656    EDW58453.1    AKHW03005169    KYO27514.1    GDIP01158293    JAJ65109.1    MCFN01000563    OXB57223.1    ADFV01127321    ADFV01127322    ADFV01127323    ADFV01127324    ADFV01127325    ADFV01127326    ADFV01127327    GFXV01005925    MBW17730.1    AXCN02001412    ABLF02035835    ABGA01059396    ABGA01059397    ABGA01059398    ABGA01059399    ABGA01059400    ABGA01059401    ABGA01059402    ABGA01059403    ABGA01059404    ABGA01059405    NDHI03003408    PNJ61738.1    JRES01000634    KNC29750.1    GL732537    EFX83292.1    AQIB01129532    GDHF01031169    JAI21145.1    GAKP01009639    JAC49313.1    CH954181    EDV49352.1    CP012526    ALC45820.1    CH477759    EAT36537.1    ATLV01017157    KE525157    KFB41860.1    UFQT01000350    SSX23450.1    APCN01000987    AAAB01008847    EAA06890.5    CM000364    EDX13193.1    AXCM01001219   

Proteomes

UP000005204    UP000007151    UP000007266    UP000076502    UP000008237    UP000075809    + More
UP000053825    UP000027135    UP000000311    UP000242457    UP000007755    UP000078542    UP000005205    UP000036403    UP000009046    UP000235965    UP000053097    UP000279307    UP000053105    UP000192223    UP000078540    UP000215335    UP000002358    UP000094527    UP000078541    UP000076858    UP000019118    UP000078492    UP000037510    UP000030742    UP000092461    UP000030746    UP000054359    UP000000539    UP000245119    UP000198419    UP000006718    UP000095301    UP000008792    UP000050525    UP000198323    UP000075884    UP000001073    UP000075886    UP000007819    UP000001595    UP000233180    UP000037069    UP000000305    UP000029965    UP000233020    UP000095300    UP000233200    UP000075885    UP000008711    UP000233040    UP000092553    UP000008820    UP000030765    UP000075920    UP000075840    UP000007062    UP000075881    UP000075903    UP000000304    UP000075883   

PRIDE

H9ISG2    Q5ZIW5   

Pfam

PF11916   Vac14_Fig4_bd        + More
PF12755   Vac14_Fab1_bd

Interpro

IPR026825   Vac14        + More
IPR011989   ARM-like       
IPR021841   VAC14_Fig4p-bd       
IPR016024   ARM-type_fold       
IPR032878   Vac14_Fab1-bd       
IPR021133   HEAT_type_2       

SUPFAM

SSF48371   SSF48371       

Gene 3D

1.25.10.10    

ProteinModelPortal

H9ISG2   A0A212EK04   D6WPN6   A0A154PKW1   E2BXH5   A0A1Y1MAW0   + More
A0A139WEA7   A0A151WJQ9   A0A0L7QNU0   A0A067QRT8   E2AC17   A0A2A3ELH5   F4X110   A0A195CKL6   A0A158NI19   A0A0J7L0B3   E0VQV6   A0A2J7R3P0   A0A1B6I0P4   A0A1Y1M3R9   A0A1B6LBW9   A0A026WYQ0   A0A0M8ZSI6   A0A2J7R3M5   A0A1W4X449   A0A151I4L1   A0A232FKC3   K7IZD8   A0A1D2N298   A0A195F638   A0A0P6B9K8   A0A0P5HIL8   A0A0P5HRA7   A0A1B6E9H2   A0A164Z729   A0A0P6IEE6   A0A147BD08   N6T3G4   A0A195EFY1   A0A2R5LB63   A0A0L7L1D0   A0A293MXF6   A0A023F269   U4UQF3   A0A069DWW3   A0A0A9X6L4   A0A1B0CQ03   A0A131YIN1   V4BVL4   A0A224ZBK8   A0A087TV22   W8CD00   A0A2L2YQZ5   A0A0P5D0A6   F1NWG6   A0A2T7NI13   A0A226P2M0   Q5ZIW5   F6U0G4   A0A1I8MR22   A0A0P5CLR2   A0A0A1XM24   T2MEF9   B4MBI2   A0A151MSN0   A0A0P5DFF2   A0A226MPI1   A0A182N0G7   G1S284   A0A2H8TUV5   A0A182Q8M2   J9JVA2   H2NRF6   A0A2K6KTU5   A0A0L0CBX0   E9GAP5   A0A0D9QWF5   A0A2K5ESF7   A0A1I8PF19   A0A2K6KTT9   A0A2K6RIM8   A0A2K6RIM0   A0A0K8U4B4   A0A034W6B7   A0A182P6U2   B3P4A7   A0A2K5R1D8   A0A0M4F3J9   Q16Q69   A0A084VV66   A0A182W468   A0A336M062   A0A182I9J8   Q7QE90   A0A182JYM5   A0A182V5G1   B4QS97   A0A182MFN2  

KEGG

101737997    K15305 vacuole morphology and inheritance protein 14 | (RefSeq) protein VAC14 homolog

GO

GO:0070772   GO:0006661   GO:0000306   GO:0010008   GO:0016021   GO:0005488   GO:0008270   GO:0016567   GO:0005524   GO:0006139   GO:0019205   GO:0043564   GO:0006418   GO:0003824  

PANTHER

PTHR16023  

Subcellular location

Endosome membrane  

Length:

618

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.11232

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00591

outside

1  -  618

 

 

Pi

7.117504

Theta

12.855282

Tajima's D

-0.595289

CLR

0.095795

CSRT

0.217339133043348

Interpretation

Possibly Positive selection