Gene

KWMTBOMO11751  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004202

Annotation

sec13-like_protein_[Bombyx_mori]

Location

Bomo_Chr19(+):13213104-13227574      View in EpiBrowser

Full name

Nucleoporin SEH1      

Alternative Name

GATOR complex protein SEH1
Nup107-160 subcomplex subunit seh1

Location in the cell

Extracellular   Reliability : 1.323

CDS

ATGAGTGAAAACATAGCTACGAACCTTTTCGAGGCCCAAACGATACATGCCGATCACAAAGACCTTATTCACGATGTCGCGTACGACTTCTACGGGGAGAGAATGGCCACTTGTTCCAGTGATCAATACGTAAAGATATGGGACACAGACGGGCATGGAGGCTGGCGGATGACAGCGAGCTGGAAGGCTCATCACGGCTCTGTTTGGAAAGTTACATGGGCCCACCCAGAGTTTGGACAGGTCATTGCGACTTGCTCCTTTGATAGAACAGCTGCTATTTGGGAGGAAGTGGGTGACACCACAGCAACAGGCTCTGAAAAGAGTTTACGTACATGGCTGAAGCGGTCAAACCTCGTTGATTCAAGAACTTCAGTAACAGATGTTAAATTTGGACCTAAACATTTAGGTCTACTACTAGTTACATGCTCAGCTGATGGCATTATAAGAATATATGAGGCTCCGGATGTGATGAATTTGGCACAATGGACCCTCCAGCACGAGATACCGACGAAAGTTTCAATTAGTTGTTTATCATGGAACCCTTCATTGTCTAGGGTAGGAAACCCACCAATGTTGGCAGTAGGCAGCGATGAACCTAACACAACAAATGCCTTAGCATCAGTACCATCTGATAAGAGCACAGCTTGTAATGGAAAAGTTTTTATTTATGAATACAGTGAAACGTCTCGTCGTTGGACGCGAACGGACTGTCTGTCATCCGTCCAGGAGCCGGTCAACGACCTCGCCTTCGCTCCGAACCTCGGCCGCTCGTTCCATCTCCTCGCCGTAGCCGCCAAGGACCTGAGAATCATTAAAATCGAACCACTTTCTGAATCGTCTATCTCCGCGAACGGTTTGGGCGTGCGGTTCAAGAGTGAAGTAATGGCGGCCTTCGACGAGCACTACTCGTGCGTGTGGAGGGTGTCGTGGAACCCCACCGGGACTCTGCTGGCCTCGTCGGGGGACGACAGCTGCGTCAGACTATGGAATATGCAATACTTGAATCAGTGGAAGTGCGTGGCCGTGTTCAAGAATGAGACGGTGGGCGGAGACAGCGCGCCCGCCGCCCGCGCGCACACCGCCTACACGCGCCTCGCCGCCATGGCCAACCCCGCGCACATGCCCGTGCACTGA

Protein

MSENIATNLFEAQTIHADHKDLIHDVAYDFYGERMATCSSDQYVKIWDTDGHGGWRMTASWKAHHGSVWKVTWAHPEFGQVIATCSFDRTAAIWEEVGDTTATGSEKSLRTWLKRSNLVDSRTSVTDVKFGPKHLGLLLVTCSADGIIRIYEAPDVMNLAQWTLQHEIPTKVSISCLSWNPSLSRVGNPPMLAVGSDEPNTTNALASVPSDKSTACNGKVFIYEYSETSRRWTRTDCLSSVQEPVNDLAFAPNLGRSFHLLAVAAKDLRIIKIEPLSESSISANGLGVRFKSEVMAAFDEHYSCVWRVSWNPTGTLLASSGDDSCVRLWNMQYLNQWKCVAVFKNETVGGDSAPAARAHTAYTRLAAMANPAHMPVH

Description

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.

Subunit

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). Probably part of the GATOR complex.

Similarity

Belongs to the WD repeat SEC13 family.

Keywords

Cell cycle   Cell division   Centromere   Chromosome   Chromosome partition   Complete proteome   Kinetochore   Lysosome   Membrane   Mitosis   mRNA transport   Nuclear pore complex   Nucleus   Protein transport   Reference proteome   Repeat   Translocation   Transport   WD repeat  

Feature

chain  Nucleoporin SEH1

Uniprot

Q1HPY4   A0A2A4K6T4   A0A2W1BA67   S4PLR4   A0A194QYN4   A0A194PTR1   + More
A0A212F3X1   H9J3W3   A0A1E1WHA5   A0A2H1VUZ4   A0A0C9R4A4   A0A232FLE1   A0A0C9R0X8   A0A0J7KVA7   A0A158NBX0   A0A151J3A9   A0A195BFY3   A0A195CBC7   A0A195FLY4   A0A310SY22   A0A026X0Z3   E9J690   F4WHZ0   A0A151X9M2   A0A2A3EJK6   A0A088A5X8   A0A154P403   A0A0M9AD32   A0A0L7R1X7   E2B8S7   A0A1Y1KZU5   A0A1Y1L2D2   E0VH27   E2A1U4   A0A1W4WVE0   A0A067R0L8   D6WQA5   E9HK16   A0A1B6G5Q6   A0A1B6LXB8   A0A1B6GAG0   A0A3B1KAU6   A0A3B4D6Y0   A0A182UFV9   Q7Q9L2   A0A182HP15   A0A0S7LR47   A0A182QEU1   A0A3B4D8C1   A0A1W4Y2Z1   W5USS2   A0A2I4BEY6   A0A182IXF2   A0A3Q3GIV9   A0A3B3R326   A0A3Q2PTT9   A0A182V901   A0A3B4BIP8   A0A182M235   A0A3B3R3N9   Q6TGU2   H3D712   A0A0P5RD97   A0A182SXE3   A0A0P5X6F0   A0A1W4Y2G6   A0A3B4TRF2   A0A182LBJ1   A0A3B4FD63   A0A3N0XZW7   A0A3P9DHW2   A0A3B3WTB7   A0A096M3U1   A0A146W0E4   A0A3B3R0L0   A0A3Q1EA48   A0A3Q0R8A7   A0A146MVD9   A0A3B5KH55   A0A3P8W0G8   A0A3B3W0I5   A0A3Q3EE56   A0A3Q1EXU2   A0A3Q3GE29   A0A2I4BEY3   A0A3B4BHT8   G3NHQ4   A0A1Y9H260   A0A3Q3XCZ2   A0A2M4AV38   A0A3Q3LBC1   A0A3P8W602   A0A3P9P519   A0A0F8ALG5   A0A3P9A534   A0A3Q3QSF4   A0A3B4XE45   A0A1A8SJL9   A0A1A8KU25   A0A1A8PP40  

Pubmed

28756777    23622113    26354079    22118469    19121390    28648823    + More
21347285    24508170    30249741    21282665    21719571    20798317    28004739    20566863    24845553    18362917    19820115    21292972    25329095    12364791    14747013    17210077    23127152    29240929    25463417    15520368    23594743    15496914    20966253    25186727    21551351    24487278    25835551    25069045   

EMBL

DQ443268    ABF51357.1    NWSH01000119    PCG79370.1    KZ150291    PZC71581.1    + More
GAIX01003895    JAA88665.1    KQ460949    KPJ10404.1    KQ459598    KPI94525.1    AGBW02010485    OWR48430.1    BABH01028867    BABH01028868    BABH01028869    GDQN01004684    JAT86370.1    ODYU01004598    SOQ44643.1    GBYB01001646    JAG71413.1    NNAY01000048    OXU31564.1    GBYB01001645    JAG71412.1    LBMM01002726    KMQ94427.1    ADTU01011439    KQ980286    KYN16938.1    KQ976500    KYM83114.1    KQ978068    KYM97506.1    KQ981491    KYN40999.1    KQ759828    OAD62654.1    KK107036    QOIP01000004    EZA61975.1    RLU23795.1    GL768230    EFZ11657.1    GL888170    EGI66219.1    KQ982373    KYQ57085.1    KZ288229    PBC31654.1    KQ434809    KZC06577.1    KQ435697    KOX80793.1    KQ414667    KOC64860.1    GL446373    EFN87899.1    GEZM01068507    JAV66922.1    GEZM01068508    JAV66921.1    DS235157    EEB12683.1    GL435806    EFN72583.1    KK853129    KDR11002.1    KQ971354    EFA06948.2    GL732666    EFX67912.1    GECZ01012001    GECZ01000040    JAS57768.1    JAS69729.1    GEBQ01026558    GEBQ01011631    JAT13419.1    JAT28346.1    GECZ01010359    JAS59410.1    AAAB01008900    EAA09566.2    APCN01002864    GBYX01154583    JAO91898.1    AXCN02000997    JT418312    AHH42688.1    AXCM01001086    AY398414    BX294130    GDIQ01102559    JAL49167.1    GDIP01076860    GDIP01017719    LRGB01000512    JAM26855.1    KZS18751.1    RJVU01057109    ROK35642.1    AYCK01003957    GCES01063287    GCES01063286    JAR23036.1    GCES01162833    JAQ23489.1    GGFK01011332    MBW44653.1    KQ041554    KKF25628.1    HAEH01012493    HAEI01015948    SBS18417.1    HAED01010875    HAEE01015663    SBR35713.1    HAEF01014728    HAEG01008875    SBR83018.1   

Proteomes

UP000218220    UP000053240    UP000053268    UP000007151    UP000005204    UP000215335    + More
UP000036403    UP000005205    UP000078492    UP000078540    UP000078542    UP000078541    UP000053097    UP000279307    UP000007755    UP000075809    UP000242457    UP000005203    UP000076502    UP000053105    UP000053825    UP000008237    UP000009046    UP000000311    UP000192223    UP000027135    UP000007266    UP000000305    UP000018467    UP000261440    UP000075902    UP000007062    UP000075840    UP000075886    UP000192224    UP000192220    UP000075880    UP000261660    UP000261540    UP000265000    UP000075903    UP000261520    UP000075883    UP000000437    UP000007303    UP000075901    UP000076858    UP000261420    UP000075882    UP000261460    UP000265160    UP000261480    UP000028760    UP000257200    UP000261340    UP000005226    UP000265120    UP000261500    UP000264800    UP000007635    UP000075884    UP000261620    UP000261640    UP000242638    UP000265140    UP000261600    UP000261360   

PRIDE

Q1HPY4    H9J3W3    Q6TGU2   

Pfam

PF00400   WD40

Interpro

IPR036322   WD40_repeat_dom_sf        + More
IPR017986   WD40_repeat_dom       
IPR037597   Nucleoporin_Seh1       
IPR019775   WD40_repeat_CS       
IPR037363   Sec13/Seh1_fam       
IPR020472   G-protein_beta_WD-40_rep       
IPR001680   WD40_repeat       
IPR015943   WD40/YVTN_repeat-like_dom_sf       

SUPFAM

SSF50978   SSF50978       

Gene 3D

2.130.10.10    

ProteinModelPortal

Q1HPY4   A0A2A4K6T4   A0A2W1BA67   S4PLR4   A0A194QYN4   A0A194PTR1   + More
A0A212F3X1   H9J3W3   A0A1E1WHA5   A0A2H1VUZ4   A0A0C9R4A4   A0A232FLE1   A0A0C9R0X8   A0A0J7KVA7   A0A158NBX0   A0A151J3A9   A0A195BFY3   A0A195CBC7   A0A195FLY4   A0A310SY22   A0A026X0Z3   E9J690   F4WHZ0   A0A151X9M2   A0A2A3EJK6   A0A088A5X8   A0A154P403   A0A0M9AD32   A0A0L7R1X7   E2B8S7   A0A1Y1KZU5   A0A1Y1L2D2   E0VH27   E2A1U4   A0A1W4WVE0   A0A067R0L8   D6WQA5   E9HK16   A0A1B6G5Q6   A0A1B6LXB8   A0A1B6GAG0   A0A3B1KAU6   A0A3B4D6Y0   A0A182UFV9   Q7Q9L2   A0A182HP15   A0A0S7LR47   A0A182QEU1   A0A3B4D8C1   A0A1W4Y2Z1   W5USS2   A0A2I4BEY6   A0A182IXF2   A0A3Q3GIV9   A0A3B3R326   A0A3Q2PTT9   A0A182V901   A0A3B4BIP8   A0A182M235   A0A3B3R3N9   Q6TGU2   H3D712   A0A0P5RD97   A0A182SXE3   A0A0P5X6F0   A0A1W4Y2G6   A0A3B4TRF2   A0A182LBJ1   A0A3B4FD63   A0A3N0XZW7   A0A3P9DHW2   A0A3B3WTB7   A0A096M3U1   A0A146W0E4   A0A3B3R0L0   A0A3Q1EA48   A0A3Q0R8A7   A0A146MVD9   A0A3B5KH55   A0A3P8W0G8   A0A3B3W0I5   A0A3Q3EE56   A0A3Q1EXU2   A0A3Q3GE29   A0A2I4BEY3   A0A3B4BHT8   G3NHQ4   A0A1Y9H260   A0A3Q3XCZ2   A0A2M4AV38   A0A3Q3LBC1   A0A3P8W602   A0A3P9P519   A0A0F8ALG5   A0A3P9A534   A0A3Q3QSF4   A0A3B4XE45   A0A1A8SJL9   A0A1A8KU25   A0A1A8PP40  

PDB

5A9Q     E-value=1.40288e-110,     Score=1021

KEGG

732957    K14299 nucleoporin SEH1 | (RefSeq) sec13-like protein

PATHWAY

03013    RNA transport - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005198   GO:1904263   GO:0015031   GO:0031080   GO:0035859   GO:0034629   GO:0051028   GO:0051315   GO:0000777   GO:0051301   GO:0007080   GO:0006999   GO:0005765   GO:0005515   GO:0016788   GO:0006396   GO:0005615   GO:0005524   GO:0006139   GO:0019205   GO:0043564   GO:0006418   GO:0003824  

PANTHER

PTHR11024   PTHR11024:SF3  

Subcellular location

Chromosome  
Centromere  
Kinetochore  
Nucleus  
Nuclear pore complex  
Lysosome membrane  

Length:

377

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00441

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00678

outside

1  -  377

 

 

Pi

20.517581

Theta

17.539517

Tajima's D

-0.877931

CLR

10.405925

CSRT

0.16409179541023

Interpretation

Uncertain