Gene

KWMTBOMO11738

Pre Gene Modal

BGIBMGA004194

Annotation

beta-hexosaminidase_[Ostrinia_furnacalis]

Location

Bomo_Chr19(+):13055214-13075111      View in EpiBrowser

Full name

Beta-hexosaminidase      

Location in the cell

Cytoplasmic   Reliability : 1.318

CDS

ATGGTCGGCGCGATGGCGACGATGCTGCTCGTATCGGTTCTGAGTTTCTTTGCTGCACCGTCCGATTCGATTTATATTGTCGAGCCCGGACCGAAGTTCCCACCGACGCGAGGCGAGGTCTGGCCGAAGCCGCAAAAGGAAACGAAAAGCGATTATTTTTATTTATTTCGCCCGGACGTCATTCAAATAGAGATTGTAAACAAAAAGTGCAATCTACTGAATGAAACGATAGAACGATACACGGAAATCTGGCAGCGCCAATATATGATCGTAAAACGGTACAACAACATTTCGACTCATGTAGAACCGCACGACATTGAGAAGTATTTAGGTGTACTGAAAAGGCTTACAATTAACATGTCTGCTCCTTGTGAATATTATCCACATTTTGACATGGACGAGAGCTATAATCTGACAGTTGGTGCAAACTCACAGATGACAAGTTTATCTGTTTGGGGCATGATGCGAGCATTTGAGTCCTGGACGCATCTTTTGTATTTCACGGATGATTCAAAGGAAATCAGGATCAACAAAACGGAGATCCATGATTTCCCGCAGTACAAGCATCGAGGACTCCTATTGGACACCGGAAGACATTACCTGTCGTTGAATACAATTCAGAAAACCTTGGACGCGATGAGCATCAACAAAATGAACGTGCTACACTGGCACATAGTTGACGATCAAAGCTTTCCTTATAAGAGTGAAATTTTACCAAGTTTGAGCGAAAAGGGCGCTTTCCATCCATCAATGGTGTACACGAAGAAGGATATTAAAATGATAATAAACTACGCGAGAGATCGTGCTATCCGTGTAATACCAGAAATTGATGTGCCCGGTCACACTAGATCCTGGGGTGCTGCATATCCCACGCTGCTGACGAAATGCTACGAGAAAAATAAAGTTATAGCCTACGGTCCTTTGAATCCGATAAGGAGCACCACATACAAAATCCTCGGGGAATTAATCCGGGAGGTCCAGAATCTGTTTCCTGATCGATATTATCACGTTGGAGGCGATGAAGTGGATTTAAGCTGCTGGCAATCGAACCCCGAACTGAAGGAGTATATGAAACAACACAATTTGACCGCTAACGGTGTCCACGCTATGTTCATGAAAGAGGTTATTGGCCGAGTGAAGAAAACTACAGTTCCAATAGTTTGGCAAGAAGTGTACGATGAAAAAGTGCCAATTTCTAAGGACACTCTCATACAAGTTTGGAAGTACAAATGGATTGATGAAATGATAAAGATTCTAAATTCGGGTCACAAAGTCGTTTTTTCATCGTCATGGTATTTGGACTATTTGAACTTCAATTGGAACTCGTTTTATGGTGACGACCCTCGGCTTATGGTCTACCAGAAGAAGAAGAACGCTCGTCTGGAGAACATCGTTGGCGGTGAAGCTTGTATGTGGGGCGAGATGGCTGACGATACGAACGTCATTAGCAGGACGTGGCCGCGAACTAGTGCTGTAGCTGAACGATTGTGGTCAGGACTCGATTACAAACACCCGCCAAAAGATCCTGTCACTATTCACGTACGACAACGTATCGAGGAACACACTTGCCGGATGCTACGACGTGGTATAGCCGCTGAACCTCCCAACGGACCGGGATTCTGTGTCAACATTTAA

Protein

MVGAMATMLLVSVLSFFAAPSDSIYIVEPGPKFPPTRGEVWPKPQKETKSDYFYLFRPDVIQIEIVNKKCNLLNETIERYTEIWQRQYMIVKRYNNISTHVEPHDIEKYLGVLKRLTINMSAPCEYYPHFDMDESYNLTVGANSQMTSLSVWGMMRAFESWTHLLYFTDDSKEIRINKTEIHDFPQYKHRGLLLDTGRHYLSLNTIQKTLDAMSINKMNVLHWHIVDDQSFPYKSEILPSLSEKGAFHPSMVYTKKDIKMIINYARDRAIRVIPEIDVPGHTRSWGAAYPTLLTKCYEKNKVIAYGPLNPIRSTTYKILGELIREVQNLFPDRYYHVGGDEVDLSCWQSNPELKEYMKQHNLTANGVHAMFMKEVIGRVKKTTVPIVWQEVYDEKVPISKDTLIQVWKYKWIDEMIKILNSGHKVVFSSSWYLDYLNFNWNSFYGDDPRLMVYQKKKNARLENIVGGEACMWGEMADDTNVISRTWPRTSAVAERLWSGLDYKHPPKDPVTIHVRQRIEEHTCRMLRRGIAAEPPNGPGFCVNI

Catalytic Activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Similarity

Belongs to the glycosyl hydrolase 20 family.

Feature

chain  Beta-hexosaminidase

Uniprot

H9J3V5   A4LAF9   A0A212F3V9   Q2Q1D3   Q3LS75   A4PHN7   + More
Q2Q1D2   H9JX51   Q3LS76   A0A194PM72   Q3L6N4   A0A194QY72   A0A194PMI9   A0A194QY01   A0A2H1WXN3   A0A2H1V9E6   Q3L6N3   B6CI24   A0A2A4JYB6   E0VQW8   A0A182QVJ5   A0A182KFH4   A0A182VFS0   A0A182Y637   B0XBN5   A0A182JLR9   A0A087ZUU5   A0A182HR23   A0A182L7V3   A0A3G5BIJ3   J9HI66   W5JJY2   A0A182W8J9   Q7Q0Z2   A0A1W6EW10   Q17BL1   U5ETX4   A0A1L8DQZ7   A0A182R1R5   A0A026WT31   A0A1B0CZC5   A0A154PNT4   E2BEQ0   B0XBN6   A0A2J7PCV4   A0A0J7KWU3   A0A0M8ZZH8   A0A336ML82   E2ARG4   A0A1D2MNV3   A0A084W3Y6   A0A2P8Y3J8   N6T5A7   A0A1Y1LY98   A0A1B6CMM3   U4TU30   V5ICC8   A0A0C5CE39   A0A1E1X944   K7J7D5   A0A151JLX5   V5HIZ5   A0A232EL87   A0A3M7R7F3   A0A182UFT6   U4U517   A0A067R5X1   D6WRR9   A0A182FN54   A0A0P5GM25   A0A0N8EDP2   D6WRR7   D6WRR8   A0A182XHA2   G3MIF9   A0A0P5A061   A0A224YRG6   A0A1J1HQF6   A0A1B6KBG0   A0A2P2I9J4   V5H217   A0A182PTQ9   V3ZMB9   A0A1B6KR81   L7M7P5   A0A1S3HGE0   A0A182NNT6   A0A1S3HJI4   A0A226EDE3   K7J7D4   A0A131YXB6   A0A131YVJ8   A0A131XIX2   A0A131XKM5   A0A224YPH5   R7VAX7   A0A0C9RX26  

EC Number

3.2.1.52

Pubmed

19121390    22118469    16427309    16684772    17617724    26354079    + More
20566863    25244985    20966253    30400621    17510324    20920257    23761445    12364791    24508170    30249741    20798317    27289101    24438588    29403074    23537049    28004739    25765539    25224926    28503490    20075255    28648823    30375419    24845553    18362917    19820115    22216098    28797301    23254933    25576852    26830274    28049606   

EMBL

BABH01028856    BABH01028857    EF469203    ABO65045.1    AGBW02010485    OWR48417.1    + More
DQ249307    ABB76924.1    DQ183187    ABA27427.1    AB286958    BAF52532.1    DQ249308    ABB76925.1    BABH01031930    BABH01031931    BABH01031932    DQ183186    DQ249309    ABA27426.1    ABB76926.1    KQ459598    KPI94536.1    AY601817    AAT99455.1    KQ460949    KPJ10417.1    KPI94537.1    KPJ10418.1    ODYU01011852    SOQ57833.1    ODYU01001373    SOQ37455.1    AY601818    AAT99456.1    EU180214    ABY57947.1    NWSH01000359    PCG77015.1    DS235442    EEB15774.1    AXCN02001981    DS232645    EDS44384.1    APCN01001633    MK075207    AYV99610.1    CH477320    EJY57559.1    ADMH02001300    ETN63089.1    AAAB01008980    EAA14547.4    KY563514    ARK19923.1    EAT43655.1    GANO01002584    JAB57287.1    GFDF01005290    JAV08794.1    KK107128    QOIP01000006    EZA58264.1    RLU21577.1    AJVK01009523    AJVK01009524    KQ435007    KZC13512.1    GL447845    EFN85825.1    EDS44385.1    NEVH01026403    PNF14160.1    LBMM01002481    KMQ94768.1    KQ435792    KOX74285.1    UFQT01001452    SSX30615.1    GL442063    EFN63973.1    LJIJ01000794    ODM94535.1    ATLV01020229    ATLV01020230    KE525296    KFB44930.1    PYGN01000972    PSN38811.1    APGK01052022    APGK01052023    KB741208    ENN72853.1    GEZM01046313    JAV77340.1    GEDC01022680    JAS14618.1    KB631654    ERL85064.1    GANP01013912    JAB70556.1    KM217121    AJO25046.1    GFAC01003401    JAT95787.1    AAZX01003868    KQ978966    KYN26909.1    GANP01000808    JAB83660.1    NNAY01003607    OXU19117.1    REGN01004092    RNA19155.1    ERL85065.1    KK852722    KDR17734.1    KQ971354    EFA07069.1    GDIQ01239846    JAK11879.1    GDIP01056793    GDIQ01036932    LRGB01000725    JAM46922.1    JAN57805.1    KZS16343.1    EFA05960.2    EFA05959.1    JO841660    AEO33277.1    GDIP01210180    JAJ13222.1    GFPF01008359    MAA19505.1    CVRI01000008    CRK88449.1    GEBQ01031184    JAT08793.1    IACF01005106    LAB70693.1    GANP01013509    JAB70959.1    KB202050    ESO92513.1    GEBQ01026015    JAT13962.1    GACK01004989    JAA60045.1    LNIX01000004    OXA55532.1    AAZX01003866    GEDV01004723    JAP83834.1    GEDV01005318    JAP83239.1    GEFH01002269    JAP66312.1    GEFH01001454    JAP67127.1    GFPF01008362    MAA19508.1    AMQN01005134    KB295185    ELU13491.1    GBYB01012436    JAG82203.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000053240    UP000218220    UP000009046    + More
UP000075886    UP000075881    UP000075903    UP000076408    UP000002320    UP000075880    UP000005203    UP000075840    UP000075882    UP000008820    UP000000673    UP000075920    UP000007062    UP000075900    UP000053097    UP000279307    UP000092462    UP000076502    UP000008237    UP000235965    UP000036403    UP000053105    UP000000311    UP000094527    UP000030765    UP000245037    UP000019118    UP000030742    UP000002358    UP000078492    UP000215335    UP000276133    UP000075902    UP000027135    UP000007266    UP000069272    UP000076858    UP000076407    UP000183832    UP000075885    UP000030746    UP000085678    UP000075884    UP000198287    UP000014760   

PRIDE

H9J3V5    A4PHN7    H9JX51    Q3L6N4    Q3L6N3   

Pfam

PF14845   Glycohydro_20b2        + More
PF00728   Glyco_hydro_20
PF03031   NIF
PF02931   Neur_chan_LBD
PF08543   Phos_pyr_kin

Interpro

IPR029019   HEX_eukaryotic_N        + More
IPR015883   Glyco_hydro_20_cat       
IPR029018   Hex-like_dom2       
IPR025705   Beta_hexosaminidase_sua/sub       
IPR017853   Glycoside_hydrolase_SF       
IPR036412   HAD-like_sf       
IPR004274   FCP1_dom       
IPR036734   Neur_chan_lig-bd_sf       
IPR006202   Neur_chan_lig-bd       
IPR004625   PyrdxlKinase       
IPR013749   PM/HMP-P_kinase-1       
IPR029056   Ribokinase-like       

SUPFAM

SSF51445   SSF51445        + More
SSF55545   SSF55545       
SSF56784   SSF56784       
SSF63712   SSF63712       
SSF53613   SSF53613       

Gene 3D

3.30.379.10     2.70.170.10     3.40.1190.20    

CDD

cd01173  pyridoxal_pyridoxamine_kinase

ProteinModelPortal

H9J3V5   A4LAF9   A0A212F3V9   Q2Q1D3   Q3LS75   A4PHN7   + More
Q2Q1D2   H9JX51   Q3LS76   A0A194PM72   Q3L6N4   A0A194QY72   A0A194PMI9   A0A194QY01   A0A2H1WXN3   A0A2H1V9E6   Q3L6N3   B6CI24   A0A2A4JYB6   E0VQW8   A0A182QVJ5   A0A182KFH4   A0A182VFS0   A0A182Y637   B0XBN5   A0A182JLR9   A0A087ZUU5   A0A182HR23   A0A182L7V3   A0A3G5BIJ3   J9HI66   W5JJY2   A0A182W8J9   Q7Q0Z2   A0A1W6EW10   Q17BL1   U5ETX4   A0A1L8DQZ7   A0A182R1R5   A0A026WT31   A0A1B0CZC5   A0A154PNT4   E2BEQ0   B0XBN6   A0A2J7PCV4   A0A0J7KWU3   A0A0M8ZZH8   A0A336ML82   E2ARG4   A0A1D2MNV3   A0A084W3Y6   A0A2P8Y3J8   N6T5A7   A0A1Y1LY98   A0A1B6CMM3   U4TU30   V5ICC8   A0A0C5CE39   A0A1E1X944   K7J7D5   A0A151JLX5   V5HIZ5   A0A232EL87   A0A3M7R7F3   A0A182UFT6   U4U517   A0A067R5X1   D6WRR9   A0A182FN54   A0A0P5GM25   A0A0N8EDP2   D6WRR7   D6WRR8   A0A182XHA2   G3MIF9   A0A0P5A061   A0A224YRG6   A0A1J1HQF6   A0A1B6KBG0   A0A2P2I9J4   V5H217   A0A182PTQ9   V3ZMB9   A0A1B6KR81   L7M7P5   A0A1S3HGE0   A0A182NNT6   A0A1S3HJI4   A0A226EDE3   K7J7D4   A0A131YXB6   A0A131YVJ8   A0A131XIX2   A0A131XKM5   A0A224YPH5   R7VAX7   A0A0C9RX26  

PDB

3LMY     E-value=2.07695e-104,     Score=970

KEGG

101745028    K12373 hexosaminidase [EC:3.2.1.52] | (RefSeq) beta-hexosaminidase subunit beta-like

PATHWAY

00511    Other glycan degradation - Bombyx mori (domestic silkworm)
00520    Amino sugar and nucleotide sugar metabolism - Bombyx mori (domestic silkworm)
00531    Glycosaminoglycan degradation - Bombyx mori (domestic silkworm)
00603    Glycosphingolipid biosynthesis - globo and isoglobo series - Bombyx mori (domestic silkworm)
00604    Glycosphingolipid biosynthesis - ganglio series - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0102148   GO:0004563   GO:0005975   GO:0016021   GO:0005230   GO:0009443   GO:0008478   GO:0008152   GO:0004553   GO:0005615   GO:0005524   GO:0006139   GO:0019205   GO:0043564   GO:0006418   GO:0003824  

SignalP

Position:   1 - 23,         Likelihood:  0.990456

 

 

Length:

544

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.83319

Exp number, first 60 AAs:

1.8274

Total prob of N-in:

0.08664

outside

1  -  544

 

 

Pi

3.06878

Theta

13.880194

Tajima's D

-1.059595

CLR

3.288314

CSRT

0.125293735313234

Interpretation

Uncertain