Gene

KWMTBOMO11731  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004165

Annotation

translation_elongation_factor_2_isoform_2_[Bombyx_mori]

Location

Bomo_Chr19(-):12844940-12854223      View in EpiBrowser

Full name

Translation elongation factor 2       + More
Elongation factor 2      

Location in the cell

Cytoplasmic   Reliability : 4.299

CDS

ATGGTGAATTTCACGGTAGACGAGATCCGTGGGATGATGGACAAGAAGCGGAATATCCGCAACATGTCTGTGATCGCCCACGTCGATCACGGCAAGTCAACCCTCACGGACTCGTTGGTTTCCAAGGCCGGTATCATTGCTGGTGCGAGAGCCGGAGAGACCCGTTTCACTGACACGCGTAAGGACGAACAAGACCGTTGCATCACCATTAAATCTACGGCCATCTCTATGTTCTTCGAGCTTGAAGAGAAAGATTTAGTATTCATCACAAACCCTGACCAGCGTGAAAAGAGTGAGAAAGGTTTCTTGATCAACTTGATTGACTCACCTGGACACGTTGATTTCTCTTCTGAAGTAACAGCTGCACTCCGTGTCACTGATGGAGCCCTTGTGGTTGTTGACTGTGTGTCTGGTGTGTGTGTACAAACTGAAACAGTACTGCGTCAGGCTATTGCCGAGCGCATCAAGCCTATTCTGTTCATGAACAAAATGGACCGTGCTCTTCTTGAGCTCCAACTTGAAGCTGAAGAACTATACCAGACGTTCCAGCGTATTGTAGAAAATGTTAACGTCATTATAGCCACATATAACGATGATGGTGGTCCCATGGGTGAGGTGCGTGTCGACCCTAGCAAGGGCTCTGTTGGTTTCGGGTCTGGTCTTCATGGGTGGGCTTTCACCCTCAAACAATTCTCTGAGATGTATGCTGACAAATTCAAGATTGACCTTGTCAAGCTTATGAACAGGTTATGGGGAGAAAACTTTTTCAACCCTCAAACGAAGAAGTGGTCAAAACAAAAGGATGATGACAACAAACGTTCATTTTGCATGTACGTTTTGGATCCTATCTACAAGGTGTTCGATGCCATCATGAAATTTAAGAAAGAGGAGATTGATGATCTTCTTAAGAAGATTGGAGTCACAATCAAGCATGAGGATTCCGACAAAGATGGCAAAGCTTTGCTGAAGGTTGTGATGCGCTCTTGGTTGCCTGCTGGTGAAGCTCTGCTTCAGATGATTGCCATTCATTTACCATCACCTGTAGTGGCCCAGAAATATCGTATGGAGATGTTATATGAGGGACCCCACGATGATGAAGCTGCCATTGGTATCAAGAGCTGTGATCCTGAAGCCCCACTGATGATGTACGTGAGCAAGATGGTGCCGACCTCCGACAAAGGTCGTTTCTACGCCTTTGGACGCGTTTTCTCTGGCAAGGTTGTTACCGGACAAAAAGCTCGCATCATGGGACCAAACTTTACACCTGGAAAGAAAGAGGACTTGTATGAGAAGACTATCCAGCGTACAATCCTTATGATGGGACGTTATGTTGAAGCTATTGAGGATGTGCCCTCTGGTAACATCTGTGGTCTTGTTGGAGTCGATCAGTTCTTAGTCAAGACTGGTACCATCACCACTTTCAAGAATGCCCACAACATGAAGGTGATGAAATTCAGTGTATCACCAGTCGTGCGTGTCGCTGTTGAGCCCAAAAACCCTGCTGATCTGCCCAAGCTAGTAGAAGGTCTTAAACGTCTGGCTAAATCTGACCCCATGGTGCAGTGTATTAATGAAGAATCAGGAGAACACATTGTCGCTGGTGCTGGAGAACTCCATCTTGAGATCTGTCTTAAGGATCTTGAGGAGGACCATGCTTGCATTCCAATCAAGAAGTCTGACCCTGTCGTGTCGTACCGTGAGACCGTAGCTGAGGAATCGGACCAGCTCTGTCTCTCAAAGTCGCCCAACAAGCACAACCGTCTGTTCATGAAGGCTCAGCCCATGCCTGATGGTCTGCCAGAGGACATTGATGAGGGTCGCGTGAATCCCCGCGATGACTTCAAGACTCGCGCTCGGTATCTTACAGAAAAGTACGAATATGATGTTACCGAAGCCCGTAAGATTTGGTGCTTTGGCCCCGAGGGTACCGGCCCCAACATCCTGGTGGATTGCTCCAAAGGAGTTCAGTACCTCAATGAAATTAAGGACTCTGTTGTGGCTGGATTCCAGTGGGCCGCTAAGGAAGGAGTTATGGCTGAAGAGAATTTGCGTGGTGTTAGATTCAACATCTATGATGTAACACTCCATACTGATGCCATCCATAGAGGTGGTGGCCAAATCATTCCAACAACTAGAAGATGCTTGTACGCATGTCTGCTAACTGCTCAGCCCCGTCTTATGGAGCCTGTATATCTTTGTGAAATTCAGTGTCCTGAAGTAGCTGTGGGTGGTATCTACGGTGTACTGAACAGACGTCGTGGTCACGTTTTCGAAGAGTCCCAGGTGGCAGGTACACCTATGTTCATTGTGAAGGCCTACCTACCTGTCAATGAGTCGTTCGGTTTTACTGCCGATTTGCGTTCCAACACCGGCGGACAGGCCTTCCCGCAGTGCGTATTCGACCATTGGCAGGTCCTCCCTGGAGACCCGTGCGAACCTCAGAGCAAGCCCTACAACGTTGTACAGGAAACGAGAAAGAGGAAAGGATTGAAGGAAGGTCTCCCAGACTTAACTCAATATTTGGACAAATTGTAA

Protein

MVNFTVDEIRGMMDKKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGARAGETRFTDTRKDEQDRCITIKSTAISMFFELEEKDLVFITNPDQREKSEKGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPILFMNKMDRALLELQLEAEELYQTFQRIVENVNVIIATYNDDGGPMGEVRVDPSKGSVGFGSGLHGWAFTLKQFSEMYADKFKIDLVKLMNRLWGENFFNPQTKKWSKQKDDDNKRSFCMYVLDPIYKVFDAIMKFKKEEIDDLLKKIGVTIKHEDSDKDGKALLKVVMRSWLPAGEALLQMIAIHLPSPVVAQKYRMEMLYEGPHDDEAAIGIKSCDPEAPLMMYVSKMVPTSDKGRFYAFGRVFSGKVVTGQKARIMGPNFTPGKKEDLYEKTIQRTILMMGRYVEAIEDVPSGNICGLVGVDQFLVKTGTITTFKNAHNMKVMKFSVSPVVRVAVEPKNPADLPKLVEGLKRLAKSDPMVQCINEESGEHIVAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVAEESDQLCLSKSPNKHNRLFMKAQPMPDGLPEDIDEGRVNPRDDFKTRARYLTEKYEYDVTEARKIWCFGPEGTGPNILVDCSKGVQYLNEIKDSVVAGFQWAAKEGVMAEENLRGVRFNIYDVTLHTDAIHRGGGQIIPTTRRCLYACLLTAQPRLMEPVYLCEIQCPEVAVGGIYGVLNRRRGHVFEESQVAGTPMFIVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQVLPGDPCEPQSKPYNVVQETRKRKGLKEGLPDLTQYLDKL

Description

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).

Similarity

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

Keywords

Complete proteome   Cytoplasm   Direct protein sequencing   Elongation factor   GTP-binding   Nucleotide-binding   Phosphoprotein   Protein biosynthesis   Reference proteome   3D-structure  

Feature

chain  Translation elongation factor 2

Uniprot

F8SKB6   Q1HPK6   H9J3S8   A0A3G1T184   A0A2A4K5I8   Q86M26   + More
A0A3S2LAA0   I4DIN3   A0A194PNI0   I4DM49   A0A2A4K5U4   A0A2W1BBG8   A0A194QYQ6   A0A0C9RJ98   V5GJC6   A0A1B0CCP0   B4IIG4   A0A1W4VEY1   G9C5D4   B4KF22   A0A0N0BKR4   A0A1Y1MPS5   P13060   U5EVG5   B4Q4F6   B4P6G4   K7J0G8   A0A2J7RKQ6   B4LUQ2   A0A2A3EIV9   A0A088A5X7   V9IF19   A0A0U3SX64   B3NKS1   A0A0M3QTX3   A0A1L8DS92   A0A1B6M4W8   A0A067QUC2   A0A1B0BN33   A0A348G614   B4JB96   A0A1A9ZFD3   D3TP87   A0A1A9XQQ0   A0A1A9VF37   D6WRR0   B3ML86   A0A0J7KV60   A0A0A1XQE3   A0A1B6FPH2   A0A3B0JGU4   A0A034VQU3   E2C8M6   A0A310SX29   A0A1L8EET8   A0A1L8EHV8   A0A170Y4A6   A0A023FB32   A0A1B6DMG0   A0A069DWL1   R4FQU1   A0A336M255   A0A1L8EHS5   B4N128   A0A158NI82   F4X3C2   B5DK66   B4GKX8   A0A1L8EF33   A0A3L8D8X6   N6SVM6   A0A0L0C5C9   T1PHN3   A0A182GYZ5   A0A1I8PSD9   A0A154P3Q8   R4WCQ3   A0A1D1Z8P1   W8C9B5   A0A0K8TQ27   Q0IFN2   Q95P39   A0A0A9W869   E9JB57   Q9BME7   A0A151WR61   A0A182H5X9   A0A1Y9H9K7   A0A1Q3FDD7   A0A182F5A8   A0A1Q3FDD6   A0A1Q3FDC3   A0A182NEL2   A0A2M3ZY68   W5J5L8   Q8T4R9   A0A2M3YX25   B0W238   Q8T4S0   T1DJH7  

Pubmed

11280994    19121390    12542638    22651552    26354079    28756777    + More
17994087    21835214    28004739    2508059    10731132    12537572    12537569    23636399    22936249    17550304    20075255    26694822    24845553    20353571    18362917    19820115    25830018    25348373    20798317    25474469    26334808    21347285    21719571    15632085    30249741    23537049    26108605    25315136    26483478    23691247    24495485    26369729    17510324    25401762    26823975    21282665    20920257    23761445   

EMBL

HQ638206    AEH16569.1    DQ515926    DQ443396    ABF51485.1    ABF71565.1    + More
BABH01028837    MG846894    AXY94746.1    NWSH01000149    PCG79043.1    AY078407    AAL83698.1    RSAL01000070    RVE49182.1    AK401151    BAM17773.1    KQ459598    KPI94543.1    AK402367    BAM18989.1    PCG79042.1    KZ150162    PZC72689.1    KQ460949    KPJ10424.1    GBYB01008285    GBYB01014149    JAG78052.1    JAG83916.1    GALX01004272    JAB64194.1    AJWK01006930    CH480843    EDW49714.1    HQ851375    AEV89753.1    CH933807    EDW11991.1    KQ435697    KOX80791.1    GEZM01024973    JAV87662.1    X15805    AE014134    AY075481    GANO01001036    JAB58835.1    CM000361    CM002910    EDX05753.1    KMY91369.1    CM000158    EDW89921.1    NEVH01002717    PNF41379.1    CH940649    EDW63220.1    KZ288229    PBC31657.1    JR040732    JR040733    AEY59267.1    AEY59268.1    KU218666    ALX00046.1    CH954179    EDV54375.1    CP012523    ALC39663.1    GFDF01004775    JAV09309.1    GEBQ01009006    JAT30971.1    KK853253    KDR09305.1    JXJN01017195    FX985553    BBF97887.1    CH916368    EDW02901.1    CCAG010016184    EZ423239    ADD19515.1    KQ971354    EFA05965.1    CH902620    EDV31704.1    LBMM01002919    KMQ94183.1    GBXI01001192    JAD13100.1    GECZ01017671    JAS52098.1    OUUW01000006    SPP81577.1    GAKP01015014    JAC43938.1    GL453666    EFN75756.1    KQ759828    OAD62656.1    GFDG01001635    JAV17164.1    GFDG01000565    JAV18234.1    GEMB01003680    JAR99539.1    GBBI01000579    JAC18133.1    GEDC01010435    JAS26863.1    GBGD01000461    JAC88428.1    GAHY01000224    JAA77286.1    UFQT01000346    SSX23431.1    GFDG01000568    JAV18231.1    CH963920    EDW78190.1    ADTU01016076    GL888609    EGI59103.1    CH379062    EDY70690.2    CH479184    EDW37294.1    GFDG01001600    JAV17199.1    QOIP01000012    RLU16339.1    APGK01054910    APGK01054911    KB741253    KB632340    ENN71809.1    ERL92951.1    JRES01000973    KNC26644.1    KA647398    AFP62027.1    JXUM01098525    JXUM01098526    JXUM01098527    KQ564427    KXJ72294.1    KQ434809    KZC06579.1    AK417058    BAN20273.1    GDJX01004676    JAT63260.1    GAMC01002304    JAC04252.1    GDAI01001362    JAI16241.1    CH477306    EAT44110.1    EAT44111.1    AY040342    AAK77225.1    GBHO01040921    GDHC01016664    JAG02683.1    JAQ01965.1    GL770938    EFZ09897.1    AF331798    AAK01430.1    KQ982813    KYQ50291.1    JXUM01112929    KQ565638    KXJ70824.1    AXCN02000850    GFDL01009460    JAV25585.1    GFDL01009459    JAV25586.1    GFDL01009464    JAV25581.1    GGFK01000091    MBW33412.1    ADMH02002093    ETN59286.1    AY064104    AAL85605.1    GGFM01000070    MBW20821.1    DS231825    EDS28166.1    AY064103    AAL85604.1    GAMD01001436    JAB00155.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000053240    UP000092461    + More
UP000001292    UP000192221    UP000009192    UP000053105    UP000000803    UP000000304    UP000002282    UP000002358    UP000235965    UP000008792    UP000242457    UP000005203    UP000008711    UP000092553    UP000027135    UP000092460    UP000001070    UP000092445    UP000092444    UP000092443    UP000078200    UP000007266    UP000007801    UP000036403    UP000268350    UP000008237    UP000007798    UP000005205    UP000007755    UP000001819    UP000008744    UP000279307    UP000019118    UP000030742    UP000037069    UP000095301    UP000069940    UP000249989    UP000095300    UP000076502    UP000008820    UP000075809    UP000075886    UP000069272    UP000075884    UP000000673    UP000002320   

PRIDE

Q1HPK6    H9J3S8    P13060    A0A088A5X7   

Pfam

PF00679   EFG_C        + More
PF00009   GTP_EFTU
PF03144   GTP_EFTU_D2
PF03764   EFG_IV
PF14492   EFG_II

Interpro

IPR027417   P-loop_NTPase        + More
IPR035647   EFG_III/V       
IPR020568   Ribosomal_S5_D2-typ_fold       
IPR005517   Transl_elong_EFG/EF2_IV       
IPR041095   EFG_II       
IPR004161   EFTu-like_2       
IPR009000   Transl_B-barrel_sf       
IPR005225   Small_GTP-bd_dom       
IPR000640   EFG_V-like       
IPR014721   Ribosomal_S5_D2-typ_fold_subgr       
IPR000795   TF_GTP-bd_dom       
IPR031157   G_TR_CS       

SUPFAM

SSF54980   SSF54980        + More
SSF52540   SSF52540       
SSF50447   SSF50447       
SSF54211   SSF54211       

Gene 3D

3.30.230.10    

ProteinModelPortal

F8SKB6   Q1HPK6   H9J3S8   A0A3G1T184   A0A2A4K5I8   Q86M26   + More
A0A3S2LAA0   I4DIN3   A0A194PNI0   I4DM49   A0A2A4K5U4   A0A2W1BBG8   A0A194QYQ6   A0A0C9RJ98   V5GJC6   A0A1B0CCP0   B4IIG4   A0A1W4VEY1   G9C5D4   B4KF22   A0A0N0BKR4   A0A1Y1MPS5   P13060   U5EVG5   B4Q4F6   B4P6G4   K7J0G8   A0A2J7RKQ6   B4LUQ2   A0A2A3EIV9   A0A088A5X7   V9IF19   A0A0U3SX64   B3NKS1   A0A0M3QTX3   A0A1L8DS92   A0A1B6M4W8   A0A067QUC2   A0A1B0BN33   A0A348G614   B4JB96   A0A1A9ZFD3   D3TP87   A0A1A9XQQ0   A0A1A9VF37   D6WRR0   B3ML86   A0A0J7KV60   A0A0A1XQE3   A0A1B6FPH2   A0A3B0JGU4   A0A034VQU3   E2C8M6   A0A310SX29   A0A1L8EET8   A0A1L8EHV8   A0A170Y4A6   A0A023FB32   A0A1B6DMG0   A0A069DWL1   R4FQU1   A0A336M255   A0A1L8EHS5   B4N128   A0A158NI82   F4X3C2   B5DK66   B4GKX8   A0A1L8EF33   A0A3L8D8X6   N6SVM6   A0A0L0C5C9   T1PHN3   A0A182GYZ5   A0A1I8PSD9   A0A154P3Q8   R4WCQ3   A0A1D1Z8P1   W8C9B5   A0A0K8TQ27   Q0IFN2   Q95P39   A0A0A9W869   E9JB57   Q9BME7   A0A151WR61   A0A182H5X9   A0A1Y9H9K7   A0A1Q3FDD7   A0A182F5A8   A0A1Q3FDD6   A0A1Q3FDC3   A0A182NEL2   A0A2M3ZY68   W5J5L8   Q8T4R9   A0A2M3YX25   B0W238   Q8T4S0   T1DJH7  

PDB

4V6W     E-value=0,     Score=4092

KEGG

733027    K03234 elongation factor 2 | (RefSeq) tef2; translation elongation factor 2

GO

GO:0003924   GO:0003746   GO:0005525   GO:0005737   GO:0005829   GO:0006414   GO:0043022   GO:1990904   GO:0006221   GO:0009041   GO:0005524   GO:0006139   GO:0019205   GO:0043564   GO:0006418   GO:0003824  

Subcellular location

Cytoplasm  

Length:

844

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02486

Exp number, first 60 AAs:

0.00083

Total prob of N-in:

0.00082

outside

1  -  844

 

 

Pi

23.246398

Theta

21.731521

Tajima's D

0.19095

CLR

1.023891

CSRT

0.431578421078946

Interpretation

Uncertain