Gene

KWMTBOMO11730  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004166

Annotation

cytidylate_kinase_[Bombyx_mori]

Location

Bomo_Chr19(-):12836574-12837353      View in EpiBrowser

Full name

UMP-CMP kinase      

Alternative Name

Deoxycytidylate kinase
Uridine monophosphate/cytidine monophosphate kinase

Location in the cell

Mitochondrial   Reliability : 1.224 Nuclear   Reliability : 1.891

CDS

ATGTTGAATAGCGTGTTGCGGCAGAGTTCGCGCTACATTAACAAAATGGTGCCTCAAGTAGTCTTCGTGTTGGGAGCTCCTGGCTCTGGCAAAGGTACACAGTGCTCAATGATTTCTAAAGAATATGATTATGTCCATTTGAGTGCAGGCGATTTACTCCGAGAAGAACGCCAGAGACCTGGTTCAGAATACGGAGAAATGATTGAAGAAAAGATTCGTAACGGTGAGATAGTTCCAGTGGAGGTTACTTGCTCCTTATTACACAAGGCCATGCAGAAATCCGGTAAAGAACGTTTCCTCATAGATGGCTTTCCGCGTAATCAAGATAATATGGATGGCTGGGAGCGCGTCATGTCCGACAAAACCAAGCTACTTTTCGTTTTGTTCTTCGAATGTTCGCGTGAAATATGTACCGAGAGATGCTTGAGACGCGGCGCTGCAGGCAGTGGACGAAGCGACGACAACGTAGAGAGCTTAAAGAAAAGATTCAACACATATCTGAATGATACAATGCCGATCATCAACTATTACGATAAATTAGGTCTTGTCCGCAGGATCAATGCTGAAGAAGAACCTGATCAGGTGTTTGACAAAGTTAAAGTAGCATTTGACGAGATTAAATTGAAATGA

Protein

MLNSVLRQSSRYINKMVPQVVFVLGAPGSGKGTQCSMISKEYDYVHLSAGDLLREERQRPGSEYGEMIEEKIRNGEIVPVEVTCSLLHKAMQKSGKERFLIDGFPRNQDNMDGWERVMSDKTKLLFVLFFECSREICTERCLRRGAAGSGRSDDNVESLKKRFNTYLNDTMPIINYYDKLGLVRRINAEEEPDQVFDKVKVAFDEIKLK

Description

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.

Catalytic Activity

ATP + CMP = ADP + CDP
ATP + UMP = ADP + UDP
ATP + dCMP = ADP + dCDP

Cofactor

Mg(2+)

Subunit

Monomer.

Similarity

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
Belongs to the adenylate kinase family.

Uniprot

Q1HQ94   H9J3S9   A0A2W1BCI8   A0A2A4K4P5   A0A2H1V246   S4PY15   + More
A0A3S2NUQ5   A0A194QZM2   A0A194PP77   A0A212F3U9   A0A0L7LNZ6   A0A0T6AV96   E9G508   A0A0P5BTZ1   A0A0P5WGV9   A0A0P6EKS4   A0A0P5KAB5   A0A0P5JEC8   A0A0P5B2F5   A0A0P5ASI3   A0A0P5GDS1   A0A0P5Q9N1   A0A0P5G8S7   A0A0P5KXV5   A0A0P5SFV0   A0A0N8DF98   A0A0P5WD26   A0A0P5BIF7   A0A0P5SAY6   A0A0P6H4E7   A0A0P4ZQI4   A0A0P4WXE1   A0A0P5U0M4   A0A0P5NDC8   A0A067RFI3   A0A0P6BV01   A0A1B6EIT6   D6W794   A0A1B6J0B0   W8BUI0   A0A2P8ZFJ0   A0A3R7QVL5   A0A0K8TT83   A0A0A9WZX2   A0A1B6KM82   A0A2M4AIC1   A0A2P2I3C4   A0A2M4AH04   A0A2M4AHV9   B4K6D7   A0A2M4AJ33   A0A1Z5LCF4   A0A1B6D2J4   A0A2M4BYD5   A0A1W7R9B7   A0A2M4BXE2   A0A2M3ZHT6   A0A2M4BXH1   A0A0K8W967   A0A2M3Z7H6   A0A2M4BXT4   A0A0L0C3C4   A0A2M3ZHS4   A0A034W2B2   A0A2M4CZQ5   A0A182FL53   W5JJ81   A0A1L8DY60   A0A1L8DXK7   A0A1L8DXP9   A0A1B0CHQ9   A0A1L8EE30   A0A1L8EE13   A0A1D2N326   A0A2M4CZH5   A0A182LWT4   B4LYS9   A0A2R5L8S2   A0A1I8NP92   A0A0P4WGW2   A0A182IQT3   A0A182RWW5   A0A293LKG2   B4GEF7   A0A1B0GF19   Q296Z5   A0A182UUV4   A0A182KMT2   A0A182XH35   Q7Q292   A0A182I8B7   L7M308   A0A182VQI3   A0A182XXN3   A0A182TPB0   A0A0P5TD14   L7M351   A0A131XCB7   A0A023FJ35   A0A023EKZ3  

EC Number

2.7.4.14

Pubmed

19121390    28756777    23622113    26354079    22118469    26227816    + More
21292972    24845553    18362917    19820115    24495485    29403074    26369729    25401762    26823975    17994087    28528879    26108605    25348373    20920257    23761445    27289101    15632085    20966253    12364791    14747013    17210077    25576852    25244985    28049606    24945155   

EMBL

DQ443158    ABF51247.1    BABH01028835    KZ150162    PZC72688.1    NWSH01000149    + More
PCG79039.1    ODYU01000338    SOQ34915.1    GAIX01004078    JAA88482.1    RSAL01000070    RVE49181.1    KQ460949    KPJ10425.1    KQ459598    KPI94544.1    AGBW02010485    OWR48407.1    JTDY01000489    KOB76946.1    LJIG01022763    KRT78843.1    GL732532    EFX85389.1    GDIP01195095    JAJ28307.1    GDIQ01210524    GDIP01099410    LRGB01000568    JAK41201.1    JAM04305.1    KZS17867.1    GDIQ01074920    JAN19817.1    GDIQ01188180    JAK63545.1    GDIQ01203623    JAK48102.1    GDIP01195094    JAJ28308.1    GDIP01195096    JAJ28306.1    GDIQ01247914    GDIP01136955    JAK03811.1    JAL66759.1    GDIQ01117654    JAL34072.1    GDIQ01247913    GDIP01136956    JAK03812.1    JAL66758.1    GDIQ01178481    JAK73244.1    GDIQ01094112    JAL57614.1    GDIP01039463    JAM64252.1    GDIP01088613    JAM15102.1    GDIP01199091    JAJ24311.1    GDIQ01096114    JAL55612.1    GDIQ01024281    JAN70456.1    GDIP01209444    JAJ13958.1    GDIP01251139    JAI72262.1    GDIP01119453    JAL84261.1    GDIQ01154440    JAK97285.1    KK852539    KDR21793.1    GDIP01010484    JAM93231.1    GECZ01031929    GECZ01026144    GECZ01025885    GECZ01006883    GECZ01001675    JAS37840.1    JAS43625.1    JAS43884.1    JAS62886.1    JAS68094.1    KQ971307    EFA11131.1    GECU01015088    JAS92618.1    GAMC01001560    JAC04996.1    PYGN01000075    PSN55220.1    QCYY01001177    ROT79886.1    GDAI01000240    JAI17363.1    GBHO01033204    GBRD01009771    GBRD01009766    GDHC01013997    JAG10400.1    JAG56053.1    JAQ04632.1    GEBQ01027437    JAT12540.1    GGFK01007209    MBW40530.1    IACF01002893    LAB68528.1    GGFK01006745    MBW40066.1    GGFK01007016    MBW40337.1    CH933806    EDW15210.2    GGFK01007297    MBW40618.1    GFJQ02001874    JAW05096.1    GEDC01027108    GEDC01017394    JAS10190.1    JAS19904.1    GGFJ01008607    MBW57748.1    GFAH01000665    JAV47724.1    GGFJ01008609    MBW57750.1    GGFM01007373    MBW28124.1    GGFJ01008608    MBW57749.1    GDHF01004914    JAI47400.1    GGFM01003721    MBW24472.1    GGFJ01008610    MBW57751.1    JRES01000953    KNC26840.1    GGFM01007310    MBW28061.1    GAKP01010125    GAKP01010123    JAC48829.1    GGFL01006533    MBW70711.1    ADMH02001344    ETN62945.1    GFDF01002889    JAV11195.1    GFDF01002887    JAV11197.1    GFDF01002888    JAV11196.1    AJWK01012598    GFDG01001914    JAV16885.1    GFDG01001915    JAV16884.1    LJIJ01000266    ODM99640.1    GGFL01006548    MBW70726.1    AXCM01004676    CH940650    EDW67006.2    GGLE01001691    MBY05817.1    GDRN01053500    GDRN01053499    JAI66164.1    GFWV01002570    MAA27300.1    CH479182    EDW33992.1    CCAG010012732    CM000070    EAL28311.1    AAAB01008978    EAA13639.5    APCN01002694    GACK01007516    JAA57518.1    GDIP01127857    JAL75857.1    GACK01007515    JAA57519.1    GEFH01004559    JAP64022.1    GBBK01003824    GBBK01003823    JAC20658.1    GAPW01003725    JAC09873.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000053268    UP000007151    + More
UP000037510    UP000000305    UP000076858    UP000027135    UP000007266    UP000245037    UP000283509    UP000009192    UP000037069    UP000069272    UP000000673    UP000092461    UP000094527    UP000075883    UP000008792    UP000095300    UP000075880    UP000075900    UP000008744    UP000092444    UP000001819    UP000075903    UP000075882    UP000076407    UP000007062    UP000075840    UP000075920    UP000076408    UP000075902   

PRIDE

Q1HQ94    H9J3S9   

Interpro

IPR006266   UMP_CMP_kinase        + More
IPR027417   P-loop_NTPase       
IPR033690   Adenylat_kinase_CS       
IPR000850   Adenylat/UMP-CMP_kin       

SUPFAM

SSF52540   SSF52540       

CDD

cd01428  ADK

ProteinModelPortal

Q1HQ94   H9J3S9   A0A2W1BCI8   A0A2A4K4P5   A0A2H1V246   S4PY15   + More
A0A3S2NUQ5   A0A194QZM2   A0A194PP77   A0A212F3U9   A0A0L7LNZ6   A0A0T6AV96   E9G508   A0A0P5BTZ1   A0A0P5WGV9   A0A0P6EKS4   A0A0P5KAB5   A0A0P5JEC8   A0A0P5B2F5   A0A0P5ASI3   A0A0P5GDS1   A0A0P5Q9N1   A0A0P5G8S7   A0A0P5KXV5   A0A0P5SFV0   A0A0N8DF98   A0A0P5WD26   A0A0P5BIF7   A0A0P5SAY6   A0A0P6H4E7   A0A0P4ZQI4   A0A0P4WXE1   A0A0P5U0M4   A0A0P5NDC8   A0A067RFI3   A0A0P6BV01   A0A1B6EIT6   D6W794   A0A1B6J0B0   W8BUI0   A0A2P8ZFJ0   A0A3R7QVL5   A0A0K8TT83   A0A0A9WZX2   A0A1B6KM82   A0A2M4AIC1   A0A2P2I3C4   A0A2M4AH04   A0A2M4AHV9   B4K6D7   A0A2M4AJ33   A0A1Z5LCF4   A0A1B6D2J4   A0A2M4BYD5   A0A1W7R9B7   A0A2M4BXE2   A0A2M3ZHT6   A0A2M4BXH1   A0A0K8W967   A0A2M3Z7H6   A0A2M4BXT4   A0A0L0C3C4   A0A2M3ZHS4   A0A034W2B2   A0A2M4CZQ5   A0A182FL53   W5JJ81   A0A1L8DY60   A0A1L8DXK7   A0A1L8DXP9   A0A1B0CHQ9   A0A1L8EE30   A0A1L8EE13   A0A1D2N326   A0A2M4CZH5   A0A182LWT4   B4LYS9   A0A2R5L8S2   A0A1I8NP92   A0A0P4WGW2   A0A182IQT3   A0A182RWW5   A0A293LKG2   B4GEF7   A0A1B0GF19   Q296Z5   A0A182UUV4   A0A182KMT2   A0A182XH35   Q7Q292   A0A182I8B7   L7M308   A0A182VQI3   A0A182XXN3   A0A182TPB0   A0A0P5TD14   L7M351   A0A131XCB7   A0A023FJ35   A0A023EKZ3  

PDB

1TEV     E-value=7.62561e-59,     Score=572

KEGG

732890    K13800 UMP-CMP kinase [EC:2.7.4.14] | (RefSeq) cytidylate kinase

PATHWAY

00240    Pyrimidine metabolism - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004127   GO:0005524   GO:0006221   GO:0009041   GO:0005737   GO:0005634   GO:0006207   GO:0006139   GO:0019205   GO:0043564   GO:0006418   GO:0003824  

PANTHER

PTHR23359  

Subcellular location

Cytoplasm  
Nucleus  

Length:

209

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.09394

Exp number, first 60 AAs:

0.09394

Total prob of N-in:

0.07174

outside

1  -  209

 

 

Pi

23.601479

Theta

26.433559

Tajima's D

-0.328846

CLR

1.550996

CSRT

0.287285635718214

Interpretation

Uncertain