Gene

KWMTBOMO11719

Pre Gene Modal

BGIBMGA004182

Annotation

putative_heat_shock_protein_70_HSP70_interacting_protein_[Danaus_plexippus]

Location

Bomo_Chr19(+):12694764-12722492      View in EpiBrowser

Full name

Serine protease       + More
Peroxisomal leader peptide-processing protease      

Alternative Name

Trypsin domain-containing protein 1

Location in the cell

Extracellular   Reliability : 1.544

CDS

ATGGATGAACCAAAAGTGGCAGTCGAATGTGTGATGGTCTCGTACAACTTCACCCAAGACCCTGAAAAGGCGAAGATCGTAATGGTCTCGGCGTCCGGACTGAGGTTCTTCGACCGCTGGGTCTTAACCCACGGATCGATCCTAGCTCCGTTGAAAGAAGCCGAAATATTCCAGCGCTCCAAAGGAAAACTGATCCTCAACGACGAATTCTACGCGAAACTACCAGAAGTCTATGTTTCGGGACAGCACAGCACCCAGGAGAAGAACGTTTACGACAATCTGGAGGTGCTCAGCAAAAATAGGCACGCCCAAAACGGGGCTGACTTGGAGCACAGCAGCTATTTAGTCCGGACGGTGATGGGCAGGATATGTCATATATGGCAATGTTCAGTTGTCGACCGCTGCGCGTCCGACGTCTTCTACAACTGGTCGATAGGACACCGCGAGGCTGGCGAGGACGAACAAACGTCCCTGGGGCACTCTCTGCTCTCCGTATTCGTGCTGATCGATCTCGAGGGATGCGACCAAGAATTCAAAACACTGAGACCACTATCGAGTCTGCTGGACATCGTGCATCCTCCGCCAGTGCGAGGATCGCAGCTGCTTGTATGCTCCACGCCGTTCGGATGCGAGGCGTTCCTGAATTCGGAAACTATTGGATACATTTGCGGCGAGGTCGGGGTTCGGCCCTCCTTGATCCTGACCGATGCAGCCACTTCTTTGGGGTCCGAGGGTGGCGCTGTATTCGCTACTGGCAAATCGTTAAGTTTAATTGGTATAGTGGCGTGCAGTGTGTCCTGGTGTCGGGGTGAATGGGTGGGTCTGACTCTGGTGGCGCCGCTGATGACAGTACTGTCCGCGAAACTAAACATGGACATGGCCAACCTAGCGAGACCTCGGACCAGGGATCCGTTGATGACAGTTCTTAACACTGTGGACCGAATGACCGTATTGGTACGTTGCGGTTCCACTTGGGGCTCCGGAGTGTATCTTGGAGATGGATACTTCATCACCTGCTCGCATTGTCTCAACGAGTACACGAACAGGAGAGTGGAAATATACTGCCAAGGGATCAAGGAGCACGCGGTGGTGGTGTACCGAACTGTCCAGGATCGGCCTTACGATCTGGCGGTGCTGTACTCCAGCCCAGCGAAGTGGAAGCATCTGCAGGTGGCCAAGCTCTCCGACAATCCGGCTTGGAAAGGAGAGCAAGTGATGGCGGTCGGGTTCCCGTATTACAGCGAGCACTCCGTGGACTCGCTGGTGCCCACTATGACGAATGGCTACGTCAATAACGTCTCGCCGTCGATGATTCAGACCTCGTGCTGTGTGCAGTCTGGGTTCAGCGGTGGTCCAATAATTCGTCTGACCAGTGGCATCGAAGTGGTCGGCATAATTGTGAGCAATGCCAAGAATGACGAGAACGCGTATTACCCGTACGTGAACATGGCGGTGCCGGCCACGGCCTTCAAGGACTCCGTGCAGAAGTTCATGATCAGCAAGGATCCGAACAGCCTTCAAAATTTGGAAAATCAAAGAGAAATCATTCAATCGCAATGGCGACTGTTGCCGTACCGGTCCAAAATATAA

Protein

MDEPKVAVECVMVSYNFTQDPEKAKIVMVSASGLRFFDRWVLTHGSILAPLKEAEIFQRSKGKLILNDEFYAKLPEVYVSGQHSTQEKNVYDNLEVLSKNRHAQNGADLEHSSYLVRTVMGRICHIWQCSVVDRCASDVFYNWSIGHREAGEDEQTSLGHSLLSVFVLIDLEGCDQEFKTLRPLSSLLDIVHPPPVRGSQLLVCSTPFGCEAFLNSETIGYICGEVGVRPSLILTDAATSLGSEGGAVFATGKSLSLIGIVACSVSWCRGEWVGLTLVAPLMTVLSAKLNMDMANLARPRTRDPLMTVLNTVDRMTVLVRCGSTWGSGVYLGDGYFITCSHCLNEYTNRRVEIYCQGIKEHAVVVYRTVQDRPYDLAVLYSSPAKWKHLQVAKLSDNPAWKGEQVMAVGFPYYSEHSVDSLVPTMTNGYVNNVSPSMIQTSCCVQSGFSGGPIIRLTSGIEVVGIIVSNAKNDENAYYPYVNMAVPATAFKDSVQKFMISKDPNSLQNLENQREIIQSQWRLLPYRSKI

Description

Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids (By similarity).

Subunit

Homodimer. Forms a heterodimer with the C-terminal cleavage product (45 kDa form). Forms a heterodimer with the N-terminal cleavage product (15 kDa form). Interacts with PEX5. Interacts with LONP2.
Homodimer. Forms a heterodimer with the C-terminal cleavage product (49 kDa form). Forms a heterodimer with the N-terminal cleavage product (10 kDa form). Interacts with PEX5. Interacts with LONP2.

Similarity

Belongs to the peptidase S1B family.

Keywords

Alternative splicing   Complete proteome   Hydrolase   Peroxisome   Polymorphism   Protease   Reference proteome   Serine protease   Direct protein sequencing  

Feature

chain  Peroxisomal leader peptide-processing protease
splice variant  In isoform 2.
sequence variant  In dbSNP:rs4746970.

Uniprot

A0A212F3V1   A0A194QIB4   A0A151I1W3   F4WAC9   A0A158NKX4   A0A151WUU6   + More
A0A067QKJ1   E0VMF1   A0A195FS70   A0A3L8DKA4   K7JQ80   A0A195E444   A0A026WMB9   A0A310SAW7   E9IZ09   A0A195CSZ4   A0A232FIM1   E2BEK9   A0A0M8ZQY4   A0A0L7RIW5   A0A0T6BCR6   A0A1Y1MEU2   E2AWZ9   A0A1B6JAH7   G1K9F7   Q2T9J0   A0A1S3J3A2   U3DD42   U3CL05   V4B9Y7   G3RKH0   D6WQY8   U3ESH8   U3BP87   A0A286XHC5   A0A2J8NUV7   K7DLN1   K6ZBN2   H2R3X9   M7BXP1   Q9DBA6   F7CEH3   F7E3Y8   A0A1L8FJW0   A0A1V4KK85   A0A2C9KQE2   A0A2C9KQG1   A0A210QUG3   S4RM99   V8NW66   H3BC03  

EC Number

3.4.21.-

Pubmed

22118469    26354079    21719571    21347285    24845553    20566863    + More
30249741    20075255    24508170    21282665    28648823    20798317    28004739    15164054    15489334    22002062    25243066    23254933    22398555    18362917    19820115    21993624    16136131    23624526    16141072    17255948    21183079    17495919    20431018    27762356    15562597    28812685    24297900    9215903   

EMBL

AGBW02010485    OWR48404.1    KQ459185    KPJ03191.1    KQ976551    KYM80857.1    + More
GL888048    EGI68812.1    ADTU01018997    KQ982718    KYQ51700.1    KK853244    KDR09440.1    DS235307    EEB14557.1    KQ981281    KYN43308.1    QOIP01000007    RLU20613.1    AAZX01010094    KQ979701    KYN19677.1    KK107152    EZA57207.1    KQ775960    OAD52251.1    GL767078    EFZ14186.1    KQ977306    KYN03642.1    NNAY01000159    OXU30433.1    GL447829    EFN85843.1    KQ435969    KOX67833.1    KQ414583    KOC70805.1    LJIG01001817    KRT85123.1    GEZM01033804    JAV84111.1    GL443486    EFN62041.1    GECU01011591    JAS96115.1    AL731540    BC016840    BC030242    BC111501    GAMQ01005348    JAB36503.1    GAMS01004027    JAB19109.1    KB200255    ESP02417.1    CABD030070152    KQ971351    EFA06487.2    GAMR01005421    GAMP01009723    JAB28511.1    JAB43032.1    GAMT01004242    JAB07619.1    AAKN02021221    NBAG03000223    PNI75555.1    GABE01003519    JAA41220.1    GABC01009352    GABD01003870    JAA01986.1    JAA29230.1    AACZ04041179    GABF01010231    JAA11914.1    KB508622    EMP40605.1    AK005069    AK154513    BC119320    AAMC01051887    CM004478    OCT71872.1    LSYS01003057    OPJ84783.1    NEDP02001812    OWF52357.1    AZIM01001724    ETE65918.1    AFYH01033853   

Proteomes

UP000007151    UP000053268    UP000078540    UP000007755    UP000005205    UP000075809    + More
UP000027135    UP000009046    UP000078541    UP000279307    UP000002358    UP000078492    UP000053097    UP000078542    UP000215335    UP000008237    UP000053105    UP000053825    UP000000311    UP000001646    UP000005640    UP000085678    UP000030746    UP000001519    UP000007266    UP000008225    UP000005447    UP000002277    UP000031443    UP000000589    UP000002280    UP000008143    UP000186698    UP000190648    UP000076420    UP000242188    UP000245300    UP000008672   

PRIDE

Q2T9J0    Q9DBA6   

Pfam

PF13877   RPAP3_C        + More
PF13181   TPR_8

Interpro

IPR039245   TYSND1/DEG15        + More
IPR009003   Peptidase_S1_PA       
IPR008256   Peptidase_S1B       
IPR019734   TPR_repeat       
IPR011990   TPR-like_helical_dom_sf       
IPR013026   TPR-contain_dom       
IPR025986   RPAP3-like_C       
IPR001940   Peptidase_S1C       
IPR017345   Pept_S1A_Tysnd1       

SUPFAM

SSF50494   SSF50494        + More
SSF48452   SSF48452       

Gene 3D

1.25.40.10    

ProteinModelPortal

A0A212F3V1   A0A194QIB4   A0A151I1W3   F4WAC9   A0A158NKX4   A0A151WUU6   + More
A0A067QKJ1   E0VMF1   A0A195FS70   A0A3L8DKA4   K7JQ80   A0A195E444   A0A026WMB9   A0A310SAW7   E9IZ09   A0A195CSZ4   A0A232FIM1   E2BEK9   A0A0M8ZQY4   A0A0L7RIW5   A0A0T6BCR6   A0A1Y1MEU2   E2AWZ9   A0A1B6JAH7   G1K9F7   Q2T9J0   A0A1S3J3A2   U3DD42   U3CL05   V4B9Y7   G3RKH0   D6WQY8   U3ESH8   U3BP87   A0A286XHC5   A0A2J8NUV7   K7DLN1   K6ZBN2   H2R3X9   M7BXP1   Q9DBA6   F7CEH3   F7E3Y8   A0A1L8FJW0   A0A1V4KK85   A0A2C9KQE2   A0A2C9KQG1   A0A210QUG3   S4RM99   V8NW66   H3BC03  

PDB

5Y2D     E-value=4.79176e-05,     Score=113

KEGG

101744453    K23012 peroxisomal leader peptide-processing protease [EC:3.4.21.-] | (RefSeq) peroxisomal leader pe

GO

GO:0016485   GO:0004252   GO:0005777   GO:0016021   GO:0051260   GO:0031998   GO:0002020   GO:0005782   GO:0005829   GO:0006625   GO:0006508   GO:0042802   GO:0016020   GO:0046836   GO:0051861   GO:0042626   GO:0005737   GO:0006434   GO:0043564   GO:0006418   GO:0003824  

PANTHER

PTHR21004  

Subcellular location

Peroxisome  

Length:

529

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.16963

Exp number, first 60 AAs:

0.00279

Total prob of N-in:

0.00403

outside

1  -  529

 

 

Pi

23.454064

Theta

23.631481

Tajima's D

-0.88129

CLR

25.199768

CSRT

0.16209189540523

Interpretation

Uncertain