SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO11719
Pre Gene Modal
BGIBMGA004182
Annotation
putative_heat_shock_protein_70_HSP70_interacting_protein_[Danaus_plexippus]
Full name
Serine protease       + More
Peroxisomal leader peptide-processing protease      
Alternative Name
Trypsin domain-containing protein 1
Location in the cell
Extracellular   Reliability : 1.544
 

Sequence

CDS
ATGGATGAACCAAAAGTGGCAGTCGAATGTGTGATGGTCTCGTACAACTTCACCCAAGACCCTGAAAAGGCGAAGATCGTAATGGTCTCGGCGTCCGGACTGAGGTTCTTCGACCGCTGGGTCTTAACCCACGGATCGATCCTAGCTCCGTTGAAAGAAGCCGAAATATTCCAGCGCTCCAAAGGAAAACTGATCCTCAACGACGAATTCTACGCGAAACTACCAGAAGTCTATGTTTCGGGACAGCACAGCACCCAGGAGAAGAACGTTTACGACAATCTGGAGGTGCTCAGCAAAAATAGGCACGCCCAAAACGGGGCTGACTTGGAGCACAGCAGCTATTTAGTCCGGACGGTGATGGGCAGGATATGTCATATATGGCAATGTTCAGTTGTCGACCGCTGCGCGTCCGACGTCTTCTACAACTGGTCGATAGGACACCGCGAGGCTGGCGAGGACGAACAAACGTCCCTGGGGCACTCTCTGCTCTCCGTATTCGTGCTGATCGATCTCGAGGGATGCGACCAAGAATTCAAAACACTGAGACCACTATCGAGTCTGCTGGACATCGTGCATCCTCCGCCAGTGCGAGGATCGCAGCTGCTTGTATGCTCCACGCCGTTCGGATGCGAGGCGTTCCTGAATTCGGAAACTATTGGATACATTTGCGGCGAGGTCGGGGTTCGGCCCTCCTTGATCCTGACCGATGCAGCCACTTCTTTGGGGTCCGAGGGTGGCGCTGTATTCGCTACTGGCAAATCGTTAAGTTTAATTGGTATAGTGGCGTGCAGTGTGTCCTGGTGTCGGGGTGAATGGGTGGGTCTGACTCTGGTGGCGCCGCTGATGACAGTACTGTCCGCGAAACTAAACATGGACATGGCCAACCTAGCGAGACCTCGGACCAGGGATCCGTTGATGACAGTTCTTAACACTGTGGACCGAATGACCGTATTGGTACGTTGCGGTTCCACTTGGGGCTCCGGAGTGTATCTTGGAGATGGATACTTCATCACCTGCTCGCATTGTCTCAACGAGTACACGAACAGGAGAGTGGAAATATACTGCCAAGGGATCAAGGAGCACGCGGTGGTGGTGTACCGAACTGTCCAGGATCGGCCTTACGATCTGGCGGTGCTGTACTCCAGCCCAGCGAAGTGGAAGCATCTGCAGGTGGCCAAGCTCTCCGACAATCCGGCTTGGAAAGGAGAGCAAGTGATGGCGGTCGGGTTCCCGTATTACAGCGAGCACTCCGTGGACTCGCTGGTGCCCACTATGACGAATGGCTACGTCAATAACGTCTCGCCGTCGATGATTCAGACCTCGTGCTGTGTGCAGTCTGGGTTCAGCGGTGGTCCAATAATTCGTCTGACCAGTGGCATCGAAGTGGTCGGCATAATTGTGAGCAATGCCAAGAATGACGAGAACGCGTATTACCCGTACGTGAACATGGCGGTGCCGGCCACGGCCTTCAAGGACTCCGTGCAGAAGTTCATGATCAGCAAGGATCCGAACAGCCTTCAAAATTTGGAAAATCAAAGAGAAATCATTCAATCGCAATGGCGACTGTTGCCGTACCGGTCCAAAATATAA
Protein
MDEPKVAVECVMVSYNFTQDPEKAKIVMVSASGLRFFDRWVLTHGSILAPLKEAEIFQRSKGKLILNDEFYAKLPEVYVSGQHSTQEKNVYDNLEVLSKNRHAQNGADLEHSSYLVRTVMGRICHIWQCSVVDRCASDVFYNWSIGHREAGEDEQTSLGHSLLSVFVLIDLEGCDQEFKTLRPLSSLLDIVHPPPVRGSQLLVCSTPFGCEAFLNSETIGYICGEVGVRPSLILTDAATSLGSEGGAVFATGKSLSLIGIVACSVSWCRGEWVGLTLVAPLMTVLSAKLNMDMANLARPRTRDPLMTVLNTVDRMTVLVRCGSTWGSGVYLGDGYFITCSHCLNEYTNRRVEIYCQGIKEHAVVVYRTVQDRPYDLAVLYSSPAKWKHLQVAKLSDNPAWKGEQVMAVGFPYYSEHSVDSLVPTMTNGYVNNVSPSMIQTSCCVQSGFSGGPIIRLTSGIEVVGIIVSNAKNDENAYYPYVNMAVPATAFKDSVQKFMISKDPNSLQNLENQREIIQSQWRLLPYRSKI

Summary

Description
Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids (By similarity).
Subunit
Homodimer. Forms a heterodimer with the C-terminal cleavage product (45 kDa form). Forms a heterodimer with the N-terminal cleavage product (15 kDa form). Interacts with PEX5. Interacts with LONP2.
Homodimer. Forms a heterodimer with the C-terminal cleavage product (49 kDa form). Forms a heterodimer with the N-terminal cleavage product (10 kDa form). Interacts with PEX5. Interacts with LONP2.
Similarity
Belongs to the peptidase S1B family.
Keywords
Alternative splicing   Complete proteome   Hydrolase   Peroxisome   Polymorphism   Protease   Reference proteome   Serine protease   Direct protein sequencing  
Feature
chain  Peroxisomal leader peptide-processing protease
splice variant  In isoform 2.
sequence variant  In dbSNP:rs4746970.
EC Number
3.4.21.-
EMBL
AGBW02010485    OWR48404.1    KQ459185    KPJ03191.1    KQ976551    KYM80857.1    + More
GL888048    EGI68812.1    ADTU01018997    KQ982718    KYQ51700.1    KK853244    KDR09440.1    DS235307    EEB14557.1    KQ981281    KYN43308.1    QOIP01000007    RLU20613.1    AAZX01010094    KQ979701    KYN19677.1    KK107152    EZA57207.1    KQ775960    OAD52251.1    GL767078    EFZ14186.1    KQ977306    KYN03642.1    NNAY01000159    OXU30433.1    GL447829    EFN85843.1    KQ435969    KOX67833.1    KQ414583    KOC70805.1    LJIG01001817    KRT85123.1    GEZM01033804    JAV84111.1    GL443486    EFN62041.1    GECU01011591    JAS96115.1    AL731540    BC016840    BC030242    BC111501    GAMQ01005348    JAB36503.1    GAMS01004027    JAB19109.1    KB200255    ESP02417.1    CABD030070152    KQ971351    EFA06487.2    GAMR01005421    GAMP01009723    JAB28511.1    JAB43032.1    GAMT01004242    JAB07619.1    AAKN02021221    NBAG03000223    PNI75555.1    GABE01003519    JAA41220.1    GABC01009352    GABD01003870    JAA01986.1    JAA29230.1    AACZ04041179    GABF01010231    JAA11914.1    KB508622    EMP40605.1    AK005069    AK154513    BC119320    AAMC01051887    CM004478    OCT71872.1    LSYS01003057    OPJ84783.1    NEDP02001812    OWF52357.1    AZIM01001724    ETE65918.1    AFYH01033853   
Pfam
PF13877   RPAP3_C        + More
PF13181   TPR_8
Interpro
IPR039245   TYSND1/DEG15        + More
IPR009003   Peptidase_S1_PA       
IPR008256   Peptidase_S1B       
IPR019734   TPR_repeat       
IPR011990   TPR-like_helical_dom_sf       
IPR013026   TPR-contain_dom       
IPR025986   RPAP3-like_C       
IPR001940   Peptidase_S1C       
IPR017345   Pept_S1A_Tysnd1       
SUPFAM
SSF50494   SSF50494        + More
SSF48452   SSF48452       
Gene 3D
PDB
5Y2D     E-value=4.79176e-05,     Score=113

Ontologies

Topology

Subcellular location
Peroxisome  
Length:
529
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.16963
Exp number, first 60 AAs:
0.00279
Total prob of N-in:
0.00403
outside
1  -  529
 
 

Population Genetic Test Statistics

Pi
23.454064
Theta
23.631481
Tajima's D
-0.88129
CLR
25.199768
CSRT
0.16209189540523
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
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