Gene
KWMTBOMO11717
Pre Gene Modal
BGIBMGA004180
Annotation
PREDICTED:_NF-kappa-B_essential_modulator_isoform_X1_[Bombyx_mori]
Full name
Optineurin
Location in the cell
Nuclear Reliability : 3.152
Sequence
CDS
ATGATGGCAGCTAAACTAGAAAATCATGATGATGAATCTTTTATAATCCTCGGAACGTCACCGGGCTCTAGCTTGGACTTAAAATGTAATGGCATTCACAATGGCGAGAATTCTTTAGATAATACACAAATAGAGGAAGCAATGAAAGATCTACCAGCGGAGGCTAACATGGCTTTCAAAGCACATTTTAAGCTTGGAGATTGTCCATCACCGGCGAGCATGATGGTCGCGAGCACAATGATAACAGACGACAAGAGTACAGAGGAGTTGCAGAAACGATTCGGCGAGCTCTTAGATGAGAACTTGATACTGAAGGAAACTTTAAAGCAGAATAATGATTCGATGAAGGAACAGTTCCTGCTGATCGCCTCCTGTCAGGAGGACATGATGAAGACCCATATGCTGCACAAGGAGAAGTTCGAAGAGACCAAGGAACTGGTCGAGAGACTCCGTCAAGAGAACAAGAAGTTAAAGTTCGACATCCAGCATCTGGACGACAGCAGGCCTAGGGTCGCGGAGGGTCCGCCGGCGCGGTCCGGGCCGCCGTCCGCCGTGGAGTTCGTGTCGGCGCCCGACGACGACACCATGAACAAGCTCACGGCCCAACTGGCGCTCGTCGAGAAGCAAAGGCGACAGGTTATAGTTGAGAATGAGAAACTGACCTGGCAGAAGGAGTCCCTGGAGCATATAGTTGACGCAACGTCCAAGGAGAGGGACGACTTGAAGGAGAAACTGAAACGGGTCGAGCTTCAAATGTTGAGCCGGGAGACTGAGCACGCGCTTGAAACCGAGAAACTAAGCTTCACGATCAAGCAGCTTAAGGACCAGCTGCAAGCGGTCAGCGGAGACACGAGCGTGTCGTTAGAGGAAGTGAAGCGACGTGACGTCACGATACAGCAGCTGCAGAACAAGATAGCGATGTTGCAGAACGAGCTCAAGACCGCGCAGCTGAAGATTTTGGATCTGGAGAACGTGAAGCTGCAGTTCAGCAAGCACAAGTCCGACGCGAACGAAACCGTTAAAGTGTACAAGGATCAGATACAGGACCTGCAGAATAAACTCAAGGAGGCATCGACCATTGTGTTCCAGCCCGCTCGGATATCGTGCGGCGCGGCGGAGTCTGACCAGTCCAACGTCAACGCGAACGTGAAGCTGTACGACAGAACCTTGAAGCATCTAGCTGAGCTGCTCAACGTGCTAATATACGGGCTCTCCGACAGCCTGGCGGAGACGGTGGGGCTGCTGGGCAGTCTGAGCGACCTGGAGCTGGGCCGTTGCTCGGCGGGGCAGCTGCGCGCCGGGCTCGCCGAGCTCAAGCAGCAGCTGGAGAAGCAGCACAGCGCCGTGCTCAGCAACATCGGTCAAGTAAGGGGGACGTTGTCGATATTCGAAGGGATATTCAAAGATTGTAGTAACATCCTCGACAGCAAGGCCAAGGAAGCGAAGAATCCCGGAACTCCCAACATTGAGATGCTGACCTCGGCGCTTGTGGCCCGGGGACAGGAGCTGCAGATGCTGAAAGTTGAGATCGATAAGCTGAAGGAGGAGAAAGAGGACACGGAGCTTTTGAAAGCACAACTCGAGTTATACAAGAGCGACTTCGAAGCGGAACGAGAGTCTCGTCAAGAGATGGCCAGTGAAAAGGAAACCGTGCTCACGGACCTCAGGAAAACTCAACGAATGAACCAAGAGCTGACGCAACAGCTGGACGAGGTACGGAGGCTGAACTCGGACGTTTACCAGAGGGCCACAGCGAAGCGATCGGCGCCCTCCGCCGCCGCCCCCCGCCCCGCCGCGCCCTCCCCCCGCTCCCCCCCATCCAGCACCGGCAACATGGTGTACACGTGCCCGAAGTGCATACGGTTCTCCTGCGACCAGTACAAAGTCATGGAGGACCATTTCGATTTTTGCCTCGACGACTTTTAA
Protein
MMAAKLENHDDESFIILGTSPGSSLDLKCNGIHNGENSLDNTQIEEAMKDLPAEANMAFKAHFKLGDCPSPASMMVASTMITDDKSTEELQKRFGELLDENLILKETLKQNNDSMKEQFLLIASCQEDMMKTHMLHKEKFEETKELVERLRQENKKLKFDIQHLDDSRPRVAEGPPARSGPPSAVEFVSAPDDDTMNKLTAQLALVEKQRRQVIVENEKLTWQKESLEHIVDATSKERDDLKEKLKRVELQMLSRETEHALETEKLSFTIKQLKDQLQAVSGDTSVSLEEVKRRDVTIQQLQNKIAMLQNELKTAQLKILDLENVKLQFSKHKSDANETVKVYKDQIQDLQNKLKEASTIVFQPARISCGAAESDQSNVNANVKLYDRTLKHLAELLNVLIYGLSDSLAETVGLLGSLSDLELGRCSAGQLRAGLAELKQQLEKQHSAVLSNIGQVRGTLSIFEGIFKDCSNILDSKAKEAKNPGTPNIEMLTSALVARGQELQMLKVEIDKLKEEKEDTELLKAQLELYKSDFEAERESRQEMASEKETVLTDLRKTQRMNQELTQQLDEVRRLNSDVYQRATAKRSAPSAAAPRPAAPSPRSPPSSTGNMVYTCPKCIRFSCDQYKVMEDHFDFCLDDF
Summary
Description
Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis.
Keywords
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Endosome
Golgi apparatus
Metal-binding
Reference proteome
Zinc
Zinc-finger
Feature
chain Optineurin
splice variant In isoform 2.
splice variant In isoform 2.
Uniprot
EMBL
Proteomes
PRIDE
ProteinModelPortal
PDB
6F1U
E-value=0.086273,
Score=86
Ontologies
GO
PANTHER
Topology
Subcellular location
Cytoplasm
Perinuclear region
Golgi apparatus
trans-Golgi network
Cytoplasmic vesicle
Recycling endosome
Autophagosome
Perinuclear region
Golgi apparatus
trans-Golgi network
Cytoplasmic vesicle
Recycling endosome
Autophagosome
Length:
641
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00349
Exp number, first 60 AAs:
0.00018
Total prob of N-in:
0.00069
outside
1 - 641
Population Genetic Test Statistics
Pi
20.913371
Theta
16.947195
Tajima's D
-1.282705
CLR
1.565927
CSRT
0.0913954302284886
Interpretation
Uncertain
