Gene

KWMTBOMO11696

Pre Gene Modal

BGIBMGA003967

Annotation

PREDICTED:_putative_phosphatidate_phosphatase_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr19(-):11482550-11633266      View in EpiBrowser

Full name

Putative phosphatidate phosphatase      

Alternative Name

Germ cell guidance factor
Phosphatidic acid phosphatase type 2
Protein wunen

Location in the cell

PlasmaMembrane   Reliability : 3.147

CDS

ATGTGCCTGACGGAATGGATCAGACTGCGTGACGACAAGGCCCGCAGACCGCGTGCGCTTTTCGGCCGAGAGCTCCCGGCTTGGCTCTGGGAGTCTTACCAGGTCGTCGGCGTGTTCCTCTTCGGTTGCGCCTGTCAGCAGCTGACCACCGACGTGGCCAAGTATTCGATAGGAAGACTGAGGCCGCATTTCTTCGATGTCTGCCAGCCTGACATAAATTGCTCATTACCGGAGTATCGTTGGAAGTACATTGAAGTATTCGAATGCTTGGGCGAGAACAAAAAGCTGCTTAAGGAGATGCGACTGTCGTTTCCGAGCGGACACTCATCGTTCGCAACGTTTACCATGCTCTATTTCTGTATTTACCTTCAGAAGCGTTTTACGTGGCGCGGTTCTAAACTGCTTCGTCACGGTATCCAGTTCATCCTGCTCACGTTCACTTGGTACACGCTGATGACCCGCGTCTCCGACTACAAGCACCACTGGAGCGACGTTCTGGCCGGTTTCAGTATTGGAATTATATACGCATTTGTTATTTACGCTTGCGTCTCGAATCTCCGTAAGACTCGATCCTGCCGCTCTCACAACCACCACGAGGCAGAACTCCACGTGACCAACGGAAACAGCCACCCTCGCGTCCAAGTCTGA

Protein

MCLTEWIRLRDDKARRPRALFGRELPAWLWESYQVVGVFLFGCACQQLTTDVAKYSIGRLRPHFFDVCQPDINCSLPEYRWKYIEVFECLGENKKLLKEMRLSFPSGHSSFATFTMLYFCIYLQKRFTWRGSKLLRHGIQFILLTFTWYTLMTRVSDYKHHWSDVLAGFSIGIIYAFVIYACVSNLRKTRSCRSHNHHEAELHVTNGNSHPRVQV

Description

Responsible for guiding the germ cells early in the process of migration from the lumen of the developing gut towards the overlying mesoderm, where the germ cells enter the gonads. May be involved in lipid metabolism.

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate

Subunit

Homodimer. This complex seems not to be involved in substrate recognition, it may confer only structural or functional stability.

Similarity

Belongs to the DEAD box helicase family.
Belongs to the PA-phosphatase related phosphoesterase family.

Keywords

Alternative splicing   Complete proteome   Developmental protein   Glycoprotein   Hydrolase   Membrane   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Putative phosphatidate phosphatase
splice variant  In isoform Short.

Uniprot

A0A2A4JNX9   A0A212FNH6   A0A3S2LX18   E2ASD3   A0A195FSE8   A0A026WG83   + More
F4WBK7   A0A195C2I9   A0A151HZK1   A0A151X7U8   A0A0L7R4Y5   K7J4V2   A0A158NNZ1   A0A2J7R5L3   E0VQY9   A0A232FAM8   A0A2J7NKD3   A0A0V0G785   A0A1Y1MVF2   A0A224XH03   A0A067QTP7   A0A0K8TTU9   A0A1W4XGY0   E2BZ71   A0A0M4EKC2   A0A1B6GLP9   V5GT25   A0A1B6C395   A0A0J7L0N3   A0A1J1ISA8   A0A3B0J214   B3MFK0   B3N7H0   H9J381   B4GHS9   A0A0P9BY25   A0A1Q3FHC6   A0A0A9Y520   Q172P3   A0A1B6KNY2   B4MDV3   A0A1B6E443   W8BIL3   Q28ZG6   A0A023EPH9   A0A3B0IY91   A0A0K8S456   B0VZ03   B4J876   B4P418   A0A0Q5WNR8   Q9V576   B4QH88   A0A1B6CQX8   B4HSS1   Q9V576-2   A0A1W4VBV9   A0A146KZH3   A0A0A9Y9L2   A0A182HE45   A0A194Q9B3   T1HKB2   A0A0A1XTI2   A0A034VNU9   D3TMP7   A0A212FNI3   A0A0K8S5D9   A0A0Q9W0A7   B4MPQ4   A0A336MP79   A0A194R3N3   B4KQ09   A0A0J9R9Z7   C7LA91   A0A0B4K7K7   A0A0R1DMD4   U5EWL0   A0A0K8VEM0   A0A1W4VCA5   N6WBT2   A0A1B0AHS6   A0A182KBZ6   A0A1A9VVR2   W8CAT4   S4PY41   A0A1A9YH95   A0A1W4V011   A0A2P6L920   A0A182JFU0   A0A0Q9XJA5   A0A182HPH1   A0A182LGU3   A0A182WM77   D6WU10   A0A2M3ZJ04   A0A1B0AXB4  

EC Number

3.1.3.4

Pubmed

22118469    20798317    24508170    30249741    21719571    20075255    + More
21347285    20566863    28648823    28004739    24845553    26369729    17994087    18057021    19121390    25401762    26823975    17510324    24495485    15632085    24945155    26483478    17550304    8985246    10731132    12537572    10731138    12537569    12856002    14725715    22936249    26354079    25830018    25348373    20353571    12537568    12537573    12537574    16110336    17569856    17569867    23622113    20966253    18362917    19820115   

EMBL

NWSH01000947    PCG73418.1    AGBW02005277    OWR55302.1    RSAL01000136    RVE46217.1    + More
GL442284    EFN63667.1    KQ981285    KYN43217.1    KK107231    QOIP01000009    EZA55072.1    RLU18933.1    GL888065    EGI68412.1    KQ978344    KYM94805.1    KQ976693    KYM77648.1    KQ982431    KYQ56455.1    KQ414657    KOC65831.1    AAZX01007073    AAZX01015686    AAZX01017394    ADTU01002785    ADTU01002786    ADTU01002787    ADTU01002788    ADTU01002789    NEVH01006994    PNF36111.1    DS235442    EEB15795.1    NNAY01000614    OXU27387.1    NEVH01054087    PNE09438.1    GECL01002156    JAP03968.1    GEZM01023368    JAV88425.1    GFTR01004661    JAW11765.1    KK853284    KDR08980.1    GDAI01000228    JAI17375.1    GL451577    EFN78977.1    CP012524    ALC41817.1    GECZ01006414    JAS63355.1    GALX01005068    JAB63398.1    GEDC01029613    GEDC01020895    JAS07685.1    JAS16403.1    LBMM01001527    KMQ96138.1    CVRI01000059    CRL03032.1    OUUW01000001    SPP72963.1    CH902619    EDV36685.1    KPU76358.1    CH954177    EDV59375.1    BABH01021749    CH479183    EDW36049.1    KPU76359.1    GFDL01008088    JAV26957.1    GBHO01017401    GDHC01017279    GDHC01000397    JAG26203.1    JAQ01350.1    JAQ18232.1    CH477433    EAT41005.1    GEBQ01026846    JAT13131.1    CH940662    EDW58718.1    GEDC01028997    GEDC01004598    JAS08301.1    JAS32700.1    GAMC01005437    GAMC01005435    JAC01121.1    CM000071    EAL25647.2    JXUM01023906    JXUM01023907    JXUM01023908    JXUM01023909    GAPW01002201    KQ560674    JAC11397.1    KXJ81330.1    SPP72964.1    GBRD01017873    JAG47954.1    DS231813    EDS25757.1    CH916367    EDW01213.1    CM000157    EDW89501.1    KQS70778.1    U73822    AE013599    AF145595    BT001729    AY046533    CM000362    CM002911    EDX06342.1    KMY92508.1    GEDC01021603    GEDC01011468    JAS15695.1    JAS25830.1    CH480816    EDW47098.1    GDHC01018237    JAQ00392.1    GBHO01017402    GBHO01017399    JAG26202.1    JAG26205.1    JXUM01035044    JXUM01035045    JXUM01035046    JXUM01035047    JXUM01035048    JXUM01035049    KQ561046    KXJ79901.1    KQ459252    KPJ02102.1    ACPB03006494    GBXI01000199    JAD14093.1    GAKP01015462    JAC43490.1    EZ422699    ADD18975.1    OWR55304.1    GBRD01017872    JAG47955.1    KRF78429.1    CH963849    EDW74093.1    UFQT01001933    SSX32172.1    KQ460949    KPJ10451.1    CH933808    EDW08111.2    KMY92509.1    BT099641    ACU68950.1    AFH07978.1    KRJ98495.1    GANO01001369    JAB58502.1    GDHF01028491    GDHF01015052    JAI23823.1    JAI37262.1    ENO01639.1    GAMC01005436    JAC01120.1    GAIX01003948    JAA88612.1    MWRG01000899    PRD35084.1    KRG03912.1    APCN01003016    KQ971352    EFA07301.1    GGFM01007741    MBW28492.1    JXJN01005198    JXJN01005199   

Proteomes

UP000218220    UP000007151    UP000283053    UP000000311    UP000078541    UP000053097    + More
UP000279307    UP000007755    UP000078542    UP000078540    UP000075809    UP000053825    UP000002358    UP000005205    UP000235965    UP000009046    UP000215335    UP000027135    UP000192223    UP000008237    UP000092553    UP000036403    UP000183832    UP000268350    UP000007801    UP000008711    UP000005204    UP000008744    UP000008820    UP000008792    UP000001819    UP000069940    UP000249989    UP000002320    UP000001070    UP000002282    UP000000803    UP000000304    UP000001292    UP000192221    UP000053268    UP000015103    UP000007798    UP000053240    UP000009192    UP000092445    UP000075881    UP000078200    UP000092443    UP000075880    UP000075840    UP000075882    UP000075920    UP000007266    UP000092460   

PRIDE

H9J381    Q9V576    C7LA91   

Pfam

PF01569   PAP2        + More
PF00271   Helicase_C
PF00270   DEAD

Interpro

IPR000326   P_Acid_Pase_2/haloperoxidase        + More
IPR036938   P_Acid_Pase_2/haloperoxi_sf       
IPR014014   RNA_helicase_DEAD_Q_motif       
IPR011545   DEAD/DEAH_box_helicase_dom       
IPR014001   Helicase_ATP-bd       
IPR000629   RNA-helicase_DEAD-box_CS       
IPR001650   Helicase_C       
IPR027417   P-loop_NTPase       

SUPFAM

SSF48317   SSF48317        + More
SSF52540   SSF52540       

CDD

cd00079  HELICc

ProteinModelPortal

A0A2A4JNX9   A0A212FNH6   A0A3S2LX18   E2ASD3   A0A195FSE8   A0A026WG83   + More
F4WBK7   A0A195C2I9   A0A151HZK1   A0A151X7U8   A0A0L7R4Y5   K7J4V2   A0A158NNZ1   A0A2J7R5L3   E0VQY9   A0A232FAM8   A0A2J7NKD3   A0A0V0G785   A0A1Y1MVF2   A0A224XH03   A0A067QTP7   A0A0K8TTU9   A0A1W4XGY0   E2BZ71   A0A0M4EKC2   A0A1B6GLP9   V5GT25   A0A1B6C395   A0A0J7L0N3   A0A1J1ISA8   A0A3B0J214   B3MFK0   B3N7H0   H9J381   B4GHS9   A0A0P9BY25   A0A1Q3FHC6   A0A0A9Y520   Q172P3   A0A1B6KNY2   B4MDV3   A0A1B6E443   W8BIL3   Q28ZG6   A0A023EPH9   A0A3B0IY91   A0A0K8S456   B0VZ03   B4J876   B4P418   A0A0Q5WNR8   Q9V576   B4QH88   A0A1B6CQX8   B4HSS1   Q9V576-2   A0A1W4VBV9   A0A146KZH3   A0A0A9Y9L2   A0A182HE45   A0A194Q9B3   T1HKB2   A0A0A1XTI2   A0A034VNU9   D3TMP7   A0A212FNI3   A0A0K8S5D9   A0A0Q9W0A7   B4MPQ4   A0A336MP79   A0A194R3N3   B4KQ09   A0A0J9R9Z7   C7LA91   A0A0B4K7K7   A0A0R1DMD4   U5EWL0   A0A0K8VEM0   A0A1W4VCA5   N6WBT2   A0A1B0AHS6   A0A182KBZ6   A0A1A9VVR2   W8CAT4   S4PY41   A0A1A9YH95   A0A1W4V011   A0A2P6L920   A0A182JFU0   A0A0Q9XJA5   A0A182HPH1   A0A182LGU3   A0A182WM77   D6WU10   A0A2M3ZJ04   A0A1B0AXB4  

KEGG

101745361    K01080 phosphatidate phosphatase [EC:3.1.3.4] | (RefSeq) putative phosphatidate phosphatase

PATHWAY

00561    Glycerolipid metabolism - Bombyx mori (domestic silkworm)
00564    Glycerophospholipid metabolism - Bombyx mori (domestic silkworm)
00565    Ether lipid metabolism - Bombyx mori (domestic silkworm)
00600    Sphingolipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0008195   GO:0003676   GO:0005524   GO:0004386   GO:0035233   GO:0019991   GO:0005918   GO:0045177   GO:0007424   GO:0016791   GO:0007280   GO:0050829   GO:0045824   GO:0016311   GO:0008354   GO:0009880   GO:0042803   GO:0035234   GO:0006644   GO:0042577   GO:0005887   GO:0046839  

Subcellular location

Membrane  

Length:

215

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

61.59355

Exp number, first 60 AAs:

4.11957

Total prob of N-in:

0.29912

outside

1  -  103

TMhelix

104  -  123

inside

124  -  134

TMhelix

135  -  152

outside

153  -  161

TMhelix

162  -  184

inside

185  -  215

 

 

Pi

22.280355

Theta

21.967112

Tajima's D

-1.198485

CLR

1.225521

CSRT

0.105244737763112

Interpretation

Uncertain