Gene

KWMTBOMO11692  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004140

Annotation

PREDICTED:_probable_methylcrotonoyl-CoA_carboxylase_beta_chain?_mitochondrial_[Amyelois_transitella]

Location

Bomo_Chr19(+):11369167-11371136      View in EpiBrowser

Full name

Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial      

Alternative Name

3-methylcrotonyl-CoA carboxylase 2
3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit
3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta

Location in the cell

Cytoplasmic   Reliability : 1.513 Mitochondrial   Reliability : 1.637 Peroxisomal   Reliability : 1.075

CDS

ATGTTTAAACTCGTCAGAAGCATACGCCGACTGAGCGCACAATGCCGGCACCACAGCCACGCGACCGTCATCGGTACTGAGCCGAACCGAAGTGATCCTTACTTTCAAGAGAATAAGGCGAAAATGGATGAACTGATCGACGAGCTTCAACAGAAAACCGGTGACGCTATCAGAGGTGGGCCAGAGGACGCAGTAAAGAGGCACACGGCGAGAGGAAAATTGCTTGTCAAAGACAGGATTAACCGGTTAGTGGACGAGGGCTCCGATGTATTGGAATTGAGCGCGCTCGCCGCCGCCGACATGTACAAGGGCCAGGTTCCGAGCGCCGGTATCGTCACCGCTATCGGCAAAGTTCACGGTCGCGATTGCATGATCGTCGCTAATGATGCAACCGTTAAAGGGGGAACTTATTTTCCGATTACCGTGAAGAAGCACTTACGCGCCCAGTCGATCGCACAGGAATGTCGGCTTCCGTGCATTTATCTTGTTGATTCTGGTGGAGCCCATCTCCCTGATCAGGCTGATGTGTTTCCGGACCGCGAACACTTCGGAAGAATATTTTACAATCAAGCTAATATGTCAGCTGAGGGTATACCGCAGATATCTGTTGTCATGGGATCGTGCACTGCGGGAGGAGCGTACATCCCTAGTATGTCAGACGAGAGTATTATAATAAAAAATCAAGGAACCATTTTCTTGGCCGGCCCTCCATTAGTCAAAGCCGCTACTGGTGAATCAGTTTCTGCTGAAGATTTAGGTGGAGCTGACCTACATTGCCGGCAATCAGGAGTAACGGATCATTATGCTCTAGATGATGAGCATGCTTTACATTTAGCTAGGAATGTCGTGGCCAACCTCAATTGGAACAATGACCAAAGAGCTAGAGTTTATTCCTCGAAAATTGAGGAGCCTGTTCATGACATTCAGGATTTACACGGAATAGTAGGTGCTAATATTCAGAGACCTTTCGACATTAGAGAGGTTATATCCCGGATAGTTGACGGAAGTAGATTTCATGAATTCAAGCAACTTTATGGGGACACTTTAGTCTGCGGCTTCGCCACATTGTATGGACACCCAGTAGGTGTAATCGGGAACAACGGCGTTCTTATGTCCGAATCAGCTTTGAAGGGATCCCATTTCATTCAGCTGTGCGCTGCTAGGAAGATTCCTTTAGTGTTCCTGCAAAACATTACAGGTTTTATGGTAGGAAAAGACGCTGAAGCTGGCGGTATTGCTAAAAATGGAGCTAAAATGGTAACTGCGGTCAGTTGTTTCAAAGGACCGAAAATAACTGTGATTGTTGGGGGAAGTTTCGGTGCTGGGAACTATGGAATGTGTGGGCGAGCGTATTCGCCGAGTTTTCTTTTCATGTGGCCCAACGCAAGAATATCCGTGATGGGGGGACCACAAGCTGCAACAGTTCTCTCCTTGGTCGCCAAAGAAAAGGCTCAGCGTGAAGGGAAACCGTGGACTGATGAAGATGAAAAGAAAGTCAGGGGTCCATTAGAAGCGCAATTTGAGAAAGAGGGTCTTCCTTACTACAGTACAGCAAGGCTGTGGGATGATGGCATTGTAGCTCCGAAAGATACGAGAAAAATTATAGGCCTAAGTTTATCGGCAGCTCTTAACGCACCGTTTAGAGAAAGCAAATTCGGCATCTTTAGAATGTGA

Protein

MFKLVRSIRRLSAQCRHHSHATVIGTEPNRSDPYFQENKAKMDELIDELQQKTGDAIRGGPEDAVKRHTARGKLLVKDRINRLVDEGSDVLELSALAAADMYKGQVPSAGIVTAIGKVHGRDCMIVANDATVKGGTYFPITVKKHLRAQSIAQECRLPCIYLVDSGGAHLPDQADVFPDREHFGRIFYNQANMSAEGIPQISVVMGSCTAGGAYIPSMSDESIIIKNQGTIFLAGPPLVKAATGESVSAEDLGGADLHCRQSGVTDHYALDDEHALHLARNVVANLNWNNDQRARVYSSKIEEPVHDIQDLHGIVGANIQRPFDIREVISRIVDGSRFHEFKQLYGDTLVCGFATLYGHPVGVIGNNGVLMSESALKGSHFIQLCAARKIPLVFLQNITGFMVGKDAEAGGIAKNGAKMVTAVSCFKGPKITVIVGGSFGAGNYGMCGRAYSPSFLFMWPNARISVMGGPQAATVLSLVAKEKAQREGKPWTDEDEKKVRGPLEAQFEKEGLPYYSTARLWDDGIVAPKDTRKIIGLSLSAALNAPFRESKFGIFRM

Description

Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism (By similarity). Vital for adult survival.

Catalytic Activity

3-methylbut-2-enoyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + phosphate + trans-3-methylglutaconyl-CoA

Similarity

Belongs to the bacterial ribosomal protein bL20 family.
Belongs to the AccD/PCCB family.

Keywords

ATP-binding   Complete proteome   Ligase   Mitochondrion   Nucleotide-binding   Reference proteome   Transit peptide  

Feature

chain  Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

Uniprot

H9J3Q3   A0A2A4JFV6   A0A2H1UZQ6   A0A194QCR8   A0A194QYT3   A0A0L7LN29   + More
A0A212FNK2   A0A182IU36   B0WSS2   A0A1Q3EXM2   A0A084VTA7   Q16HN6   A0A1S4G0N4   A0A182G411   A0A182RSY4   A0A2M4AF07   W5J6M0   A0A2M4AF18   A0A182GIX5   A0A182LV31   A0A182VZQ0   A0A182TRV2   A0A023F596   A0A182Y3W0   Q7QCQ8   A0A1I8JSV1   A0A182XIU1   A0A023EU43   A0A182LBZ0   A0A2M3Z8F4   A0A182UXG3   A0A2M4BI51   A0A224XE59   A0A182JW06   A0A1W4V2F0   A0A1B0CDN4   A0A182QJQ2   A0A2M4BI55   B4KNH7   A0A034WCJ5   H0RNI1   A0A034WG38   B4HQB5   B4QDC4   Q9V9A7   A0A182P505   A0A0V0GAJ7   T1IDW8   B3MIN7   A0A182NQG6   A0A0P4VNG7   T1PBE2   B3NB25   A0A0K8UDW6   A0A0L0BMS4   B4P109   A0A0A1XIC4   C3YKH0   B4MY47   A0A182TA99   A0A0M4EL13   A0A1L8E2U2   A0A2L2YBJ1   H2ZJ79   A0A131Y2P7   R7V6W0   A0A1S3J4A6   G3MGR3   A0A0P4VYB1   H2ZJ78   A0A0K8RLB7   A0A1L8E2B7   A0A026W3Y9   W8CE36   A0A023GNV0   A0A2J7R0N0   A0A1E1XFD9   B4GC88   A0A1I8P2J9   A0A0K2TCS0   B4LK16   A0A1A9V4S7   E2A1E4   Q292Y6   A0A336M791   D3TNT3   A0A1B0EUD2   U5ESP2   A0A067RIX1   A0A1A9ZX14   A0A1W4VFL1   A0A3B0J218   A0A1A9WNW0   A0A2R5LHB1   A0A1Z5LCR5   F6T882   A0A2I4CWA8   A0A226CX02   E0VID1   A0A1S3J3R7  

EC Number

6.4.1.4

Pubmed

19121390    26354079    26227816    22118469    24438588    17510324    + More
26483478    20920257    23761445    25474469    25244985    12364791    14747013    17210077    24945155    20966253    17994087    25348373    22936249    10731132    12537572    12537569    9584098    27129103    25315136    26108605    17550304    25830018    18563158    26561354    23254933    22216098    24508170    30249741    24495485    28503490    20798317    15632085    20353571    24845553    28528879    17495919    20566863   

EMBL

BABH01021743    NWSH01001673    PCG70454.1    ODYU01000021    SOQ34085.1    KQ459185    + More
KPJ03214.1    KQ460949    KPJ10454.1    JTDY01000575    KOB76616.1    AGBW02005277    OWR55307.1    DS232075    EDS34031.1    GFDL01014986    JAV20059.1    ATLV01016287    KE525074    KFB41201.1    CH478156    EAT33766.1    JXUM01041704    JXUM01041705    KQ561294    KXJ79084.1    GGFK01006045    MBW39366.1    ADMH02002131    ETN58500.1    GGFK01006053    MBW39374.1    JXUM01067006    JXUM01067007    JXUM01067008    KQ562428    KXJ75934.1    AXCM01000485    GBBI01002448    JAC16264.1    AAAB01008859    EAA07889.3    GAPW01000700    JAC12898.1    GGFM01004056    MBW24807.1    GGFJ01003598    MBW52739.1    GFTR01007142    JAW09284.1    AJWK01008032    AXCN02001539    GGFJ01003599    MBW52740.1    CH933808    EDW08936.1    GAKP01005676    JAC53276.1    BT132903    AEV66553.1    GAKP01005675    JAC53277.1    CH480816    EDW46654.1    CM000362    CM002911    EDX05911.1    KMY91800.1    AE013599    AF006654    AY084145    AAM70824.1    GECL01001144    JAP04980.1    ACPB03019345    CH902619    EDV38113.1    GDKW01002112    JAI54483.1    KA645455    AFP60084.1    CH954177    EDV59790.1    GDHF01027568    JAI24746.1    JRES01001644    KNC21238.1    CM000157    EDW89083.1    GBXI01004054    JAD10238.1    GG666522    EEN59214.1    CH963894    EDW77036.1    CP012524    ALC42180.1    GFDF01001269    JAV12815.1    IAAA01012927    IAAA01012928    LAA05519.1    GEFM01003018    JAP72778.1    AMQN01000703    KB294417    ELU14608.1    JO841064    AEO32681.1    GDRN01108181    JAI57301.1    GADI01001922    JAA71886.1    GFDF01001270    JAV12814.1    KK107447    QOIP01000001    EZA50718.1    RLU26971.1    GAMC01000881    JAC05675.1    GBBM01000688    JAC34730.1    NEVH01008227    PNF34387.1    GFAC01001201    JAT97987.1    CH479181    EDW31406.1    HACA01005900    CDW23261.1    CH940648    EDW61670.1    GL435760    EFN72770.1    CM000071    EAL24725.1    UFQT01000494    SSX24739.1    EZ423085    ADD19361.1    CCAG010015290    GANO01002266    JAB57605.1    KK852657    KDR19223.1    OUUW01000001    SPP73032.1    GGLE01004743    MBY08869.1    GFJQ02001757    JAW05213.1    LNIX01000060    OXA37290.1    DS235196    EEB13137.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000037510    UP000007151    + More
UP000075880    UP000002320    UP000030765    UP000008820    UP000069940    UP000249989    UP000075900    UP000000673    UP000075883    UP000075920    UP000075902    UP000076408    UP000007062    UP000069272    UP000076407    UP000075882    UP000075903    UP000075881    UP000192221    UP000092461    UP000075886    UP000009192    UP000001292    UP000000304    UP000000803    UP000075885    UP000015103    UP000007801    UP000075884    UP000095301    UP000008711    UP000037069    UP000002282    UP000001554    UP000007798    UP000075901    UP000092553    UP000007875    UP000014760    UP000085678    UP000053097    UP000279307    UP000235965    UP000008744    UP000095300    UP000008792    UP000078200    UP000000311    UP000001819    UP000092444    UP000027135    UP000092445    UP000268350    UP000091820    UP000002280    UP000192220    UP000198287    UP000009046   

PRIDE

H9J3Q3    H0RNI1    Q9V9A7   

Pfam

PF01039   Carboxyl_trans        + More
PF00453   Ribosomal_L20
PF02958   EcKinase

Interpro

IPR029045   ClpP/crotonase-like_dom_sf        + More
IPR011762   COA_CT_N       
IPR034733   AcCoA_carboxyl       
IPR011763   COA_CT_C       
IPR035566   Ribosomal_protein_L20_C       
IPR005813   Ribosomal_L20       
IPR004119   EcKinase-like       
IPR011009   Kinase-like_dom_sf       
IPR015897   CHK_kinase-like       

SUPFAM

SSF52096   SSF52096        + More
SSF74731   SSF74731       
SSF56112   SSF56112       

Gene 3D

1.10.1900.20    

CDD

cd07026  Ribosomal_L20

ProteinModelPortal

H9J3Q3   A0A2A4JFV6   A0A2H1UZQ6   A0A194QCR8   A0A194QYT3   A0A0L7LN29   + More
A0A212FNK2   A0A182IU36   B0WSS2   A0A1Q3EXM2   A0A084VTA7   Q16HN6   A0A1S4G0N4   A0A182G411   A0A182RSY4   A0A2M4AF07   W5J6M0   A0A2M4AF18   A0A182GIX5   A0A182LV31   A0A182VZQ0   A0A182TRV2   A0A023F596   A0A182Y3W0   Q7QCQ8   A0A1I8JSV1   A0A182XIU1   A0A023EU43   A0A182LBZ0   A0A2M3Z8F4   A0A182UXG3   A0A2M4BI51   A0A224XE59   A0A182JW06   A0A1W4V2F0   A0A1B0CDN4   A0A182QJQ2   A0A2M4BI55   B4KNH7   A0A034WCJ5   H0RNI1   A0A034WG38   B4HQB5   B4QDC4   Q9V9A7   A0A182P505   A0A0V0GAJ7   T1IDW8   B3MIN7   A0A182NQG6   A0A0P4VNG7   T1PBE2   B3NB25   A0A0K8UDW6   A0A0L0BMS4   B4P109   A0A0A1XIC4   C3YKH0   B4MY47   A0A182TA99   A0A0M4EL13   A0A1L8E2U2   A0A2L2YBJ1   H2ZJ79   A0A131Y2P7   R7V6W0   A0A1S3J4A6   G3MGR3   A0A0P4VYB1   H2ZJ78   A0A0K8RLB7   A0A1L8E2B7   A0A026W3Y9   W8CE36   A0A023GNV0   A0A2J7R0N0   A0A1E1XFD9   B4GC88   A0A1I8P2J9   A0A0K2TCS0   B4LK16   A0A1A9V4S7   E2A1E4   Q292Y6   A0A336M791   D3TNT3   A0A1B0EUD2   U5ESP2   A0A067RIX1   A0A1A9ZX14   A0A1W4VFL1   A0A3B0J218   A0A1A9WNW0   A0A2R5LHB1   A0A1Z5LCR5   F6T882   A0A2I4CWA8   A0A226CX02   E0VID1   A0A1S3J3R7  

PDB

3U9T     E-value=0,     Score=1762

KEGG

101744540    K01969 3-methylcrotonyl-CoA carboxylase beta subunit [EC:6.4.1.4] | (RefSeq) probable methylcrotonoy

PATHWAY

00280    Valine, leucine and isoleucine degradation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016874   GO:0016740   GO:0005840   GO:0006412   GO:0019843   GO:0003735   GO:0005739   GO:0006552   GO:1905202   GO:0016021   GO:0007563   GO:0005759   GO:0005524   GO:0004485   GO:0006551   GO:0004658   GO:0006355   GO:0008270   GO:0004828   GO:0005737   GO:0006434   GO:0043564   GO:0006418   GO:0003824  

Subcellular location

Mitochondrion matrix  

Length:

557

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.40089

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00803

outside

1  -  557

 

 

Pi

231.050436

Theta

223.008837

Tajima's D

0.219368

CLR

0.013185

CSRT

0.432328383580821

Interpretation

Uncertain