Gene

KWMTBOMO11689  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003972

Annotation

selenophosphate_synthetase_1_[Bombyx_mori]

Location

Bomo_Chr19(-):11335351-11337766      View in EpiBrowser

Full name

Selenide, water dikinase       + More
GTP:AMP phosphotransferase, mitochondrial      

Alternative Name

Protein patufet
Selenium donor protein
Selenophosphate synthase
dSelD
Adenylate kinase 3

Location in the cell

Cytoplasmic   Reliability : 2.514

CDS

ATGTCTTATCAAACGAGTGTAGCGCAGGACTCTTTAGCTGCAGCTCAATTAGAAATGGCCGGTAACCCTAATTCAATAGCTTTACGTCGTCCGTTTGACCCGGTGGCGCACGATTTGGAGGCAAGTTTTCGGCTGACACGATTTGCTGATCTAAAGGGAAGAAGTTGCAAAGTACCTCAAGATGTTCTCGGAAAACTTGTTGAGTCTTTACAGCAAGACTATTCGCAAGCGGATCAAGACCAATTTATGCATGTGGCTATCCCGCGCATCGGCATCGGCTTGGACTGCTCGGTGACACCACTTAGACACGGTGGGCTCTGTTTAGTTCAAACTACTGACTTTTTTTACCCATTAGTGGATGACCCATATATGATGGGTAAGATTGCATGTGCCAATGTTCTTAGCGACCTATACGCGATGGGTGTTACGGAGTGCGACAATATGCTCATGTTGTTGGGTGTCTCAACGAAAATGACTGAAAAGGAACGCGACGTCGTTATTCCTCTTATAATGCGCGGGTTCAAAGATTCCGCTTTGGAGGCAGGAACGTCTGTCACTGGTGGGCAAACTGTCATCAACCCCTGGTGCACAATTGGTGGGGTTGCTACCACTATCTGCCAGCCTAATGAGTACATTGTACCTGATAATGCAGTGATGGGTGATGTATTGGTCTTGACAAAACCTCTTGGTACACAAGTTGCAGTAAATGCTCACCAATGGTTGGACCAACCTGAACGCTGGAACAGAATCAAATTAGTTGTATCTGAAGAAGACGTTCGTAAAGCATATCACAGAGCAATGGACTCTATGAGCAGACTCAATCGCATTGCAGCAAGATTGATGCACAAGTACAATGCTCACGGCTCAACAGATGTAACTGGTTTTGGTTTACTGGGTCATGCACAGAACTTGGCATCTCATCAAAAGAATGAAGTATCATTTGTAATCCATAATCTGCCTGTAATTGCCAAGATGGCAGCAGTAGCGAAAGCTTGTGGGAACATGTTTCAATTGCTACAAGGACACGCTCCAGAGACATCTGGTGGACTTCTAATCTGTCTGCCACGAGAACAGGCTGCTGCGTACTGTAAAGATATTGAGAAACAAGAAGGATATCAGGCTTGGATCATTGGTATTGTGGAGAAGGGTAACCGCACAGCCCGCATTATTGATAAACCTCGAGTCATTGAAGTGCCTGCTAAAGATTAA

Protein

MSYQTSVAQDSLAAAQLEMAGNPNSIALRRPFDPVAHDLEASFRLTRFADLKGRSCKVPQDVLGKLVESLQQDYSQADQDQFMHVAIPRIGIGLDCSVTPLRHGGLCLVQTTDFFYPLVDDPYMMGKIACANVLSDLYAMGVTECDNMLMLLGVSTKMTEKERDVVIPLIMRGFKDSALEAGTSVTGGQTVINPWCTIGGVATTICQPNEYIVPDNAVMGDVLVLTKPLGTQVAVNAHQWLDQPERWNRIKLVVSEEDVRKAYHRAMDSMSRLNRIAARLMHKYNAHGSTDVTGFGLLGHAQNLASHQKNEVSFVIHNLPVIAKMAAVAKACGNMFQLLQGHAPETSGGLLICLPREQAAAYCKDIEKQEGYQAWIIGIVEKGNRTARIIDKPRVIEVPAKD

Description

Synthesizes selenophosphate from selenide and ATP. Essential for progression of the cell cycle by controlling the synthesis of selenoproteins. Plays a role in apoptosis and consequently a role in imaginal disk patterning and growth.
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.

Catalytic Activity

ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate
a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP

Subunit

Monomer.

Similarity

Belongs to the selenophosphate synthase 1 family. Class II subfamily.
Belongs to the adenylate kinase family. AK3 subfamily.

Keywords

ATP-binding   Cell cycle   Complete proteome   Developmental protein   Kinase   Nucleotide-binding   Reference proteome   Selenium   Transferase  

Feature

chain  Selenide, water dikinase

Uniprot

H9J385   Q3HR35   A0A212FNP3   S4PIS4   A0A194QYB3   A0A194QID8   + More
F5CBM5   A0A0L7LN24   A0A2H1V151   C4NFK8   D6WQY1   A0A1W4XPA8   J3JZ15   A0A1Y1M7B0   A0A0K8TM22   A0A2J7RSV7   A0A1L8DM15   A0A1A9XPQ8   A0A1B0AM41   A0A1A9WIA8   A0A1A9V7P8   A0A2J7RDB1   A0A1A9ZPC6   D3TNX4   A0A0K8VRH3   A0A034WST6   A0A336KLL5   A0A2P8YTY2   A0A1I8PVW5   A0A0A1WYS7   A0A2P8ZH28   A0A0L0CB70   T1P7N8   A0A1B6FWM1   W8C155   A0A158NS94   B3MDY9   A0A1W4WBB6   B4P736   B3NR64   B4HRA6   B4QFF3   O18373   B4J758   B4LMH5   B4KSK6   B4H519   Q28X55   B4MJM5   A0A3Q0JDN0   A0A3B0JUA7   A0A023EQC1   A0A1J1HJS2   A0A1S3DEJ9   U5EUU9   Q16XK1   B0W2W4   A0A1Q3F0R0   A0A182IXD8   A0A182RJB0   A0A182QEQ1   A0A182W7I0   A0A182M2G5   A0A182XZU5   A0A182NTJ7   A0A182T8H0   Q7Q3N9   A0A1S4GWU2   A0A182USB2   A0A182JWN4   A0A182TUC4   A0A182WT47   A0A182L1Z5   A0A182HV42   A0A182PD02   A0A084WHB0   A0A182F301   R4FNR1   A0A2M4BQD9   W5JSF0   A0A2M4AT88   A0A1B6DYK4   A0A2S2PEK6   A0A2H8TFN3   A0A2S2Q2W3   A0A2A3ELU8   J9K9H8   A0A1B6CFT7   F5CBP8   E0VCB3   A0A146LHN0   A0A0K8S9W8   A0A0A9ZA82   E9ICW7   A0A3L8DKU4   A0A195CX57   A0A195FV21   A0A0P6JZ99   A0A0C9R999   A0A151J815  

EC Number

2.7.9.3
2.7.4.10

Pubmed

19121390    22118469    23622113    26354079    26227816    19442669    + More
18362917    19820115    22516182    23537049    28004739    26369729    20353571    25348373    29403074    25830018    26108605    25315136    24495485    21347285    17994087    17550304    22936249    9398525    9491069    10731132    12537572    12537569    10444382    11258485    15632085    23185243    24945155    17510324    25244985    12364791    20966253    24438588    20920257    23761445    21664929    20566863    26823975    25401762    21282665    30249741   

EMBL

BABH01021741    DQ202318    ABA43640.1    AGBW02005277    OWR55310.1    GAIX01000089    + More
JAA92471.1    KQ460949    KPJ10457.1    KQ459185    KPJ03216.1    JF505286    AED87507.1    JTDY01000575    KOB76611.1    ODYU01000021    SOQ34082.1    FJ550361    NWSH01000825    ACR07790.1    PCG73997.1    KQ971351    EFA06522.1    APGK01055449    BT128496    KB741266    KB631940    AEE63453.1    ENN71491.1    ERL87341.1    GEZM01038611    JAV81594.1    GDAI01002623    JAI14980.1    NEVH01000250    PNF43920.1    GFDF01006585    JAV07499.1    JXJN01000330    NEVH01005291    PNF38824.1    CCAG010018974    EZ423126    ADD19402.1    GDHF01010830    JAI41484.1    GAKP01001268    JAC57684.1    UFQS01000606    UFQT01000606    SSX05297.1    SSX25658.1    PYGN01000360    PSN47700.1    GBXI01010073    JAD04219.1    PYGN01000059    PSN55805.1    JRES01000644    KNC29663.1    KA644489    AFP59118.1    GECZ01015171    JAS54598.1    GAMC01003722    JAC02834.1    ADTU01024724    CH902619    EDV37534.1    CM000158    EDW91001.1    CH954179    EDV56053.1    CH480816    EDW47835.1    CM000362    CM002911    EDX07063.1    KMY93736.1    AJ000672    U91994    AE013599    AY095058    CH916367    EDW02076.1    CH940648    EDW62070.1    CH933808    EDW09511.1    CH479210    EDW32855.1    CM000071    EAL26461.1    KRT03116.1    CH963846    EDW72314.1    OUUW01000001    SPP74658.1    GAPW01001821    JAC11777.1    CVRI01000006    CRK88163.1    GANO01002165    JAB57706.1    CH477537    EAT39358.1    DS231829    EDS30323.1    GFDL01013926    JAV21119.1    AXCN02000699    AXCM01002571    AAAB01008964    EAA12847.3    APCN01002493    ATLV01023800    KE525346    KFB49604.1    GAHY01000478    JAA77032.1    GGFJ01006139    MBW55280.1    ADMH02000571    ETN65840.1    GGFK01010611    MBW43932.1    GEDC01031265    GEDC01026626    GEDC01011344    GEDC01006557    GEDC01003187    JAS06033.1    JAS10672.1    JAS25954.1    JAS30741.1    JAS34111.1    GGMR01015264    MBY27883.1    GFXV01001066    MBW12871.1    GGMS01002329    MBY71532.1    KZ288215    PBC32698.1    ABLF02024017    GEDC01024994    JAS12304.1    JF508489    AEB41038.1    DS235051    EEB10999.1    GDHC01012202    JAQ06427.1    GBRD01015862    JAG49964.1    GBHO01002788    JAG40816.1    GL762419    EFZ21587.1    QOIP01000007    RLU21064.1    KQ977171    KYN05137.1    KQ981241    KYN44308.1    GDIQ01002142    JAN92595.1    GBYB01003361    JAG73128.1    KQ979602    KYN20528.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000053268    UP000037510    UP000218220    + More
UP000007266    UP000192223    UP000019118    UP000030742    UP000235965    UP000092443    UP000092460    UP000091820    UP000078200    UP000092445    UP000092444    UP000245037    UP000095300    UP000037069    UP000095301    UP000005205    UP000007801    UP000192221    UP000002282    UP000008711    UP000001292    UP000000304    UP000000803    UP000001070    UP000008792    UP000009192    UP000008744    UP000001819    UP000007798    UP000079169    UP000268350    UP000183832    UP000008820    UP000002320    UP000075880    UP000075900    UP000075886    UP000075920    UP000075883    UP000076408    UP000075884    UP000075901    UP000007062    UP000075903    UP000075881    UP000075902    UP000076407    UP000075882    UP000075840    UP000075885    UP000030765    UP000069272    UP000000673    UP000242457    UP000007819    UP000009046    UP000279307    UP000078542    UP000078541    UP000078492   

PRIDE

H9J385    Q3HR35    O18373   

Pfam

PF00586   AIRS        + More
PF02769   AIRS_C
PF05191   ADK_lid

Interpro

IPR004536   SPS/SelD        + More
IPR016188   PurM-like_N       
IPR036676   PurM-like_C_sf       
IPR036921   PurM-like_N_sf       
IPR023061   SelD_I       
IPR010918   PurM-like_C_dom       
IPR036193   ADK_active_lid_dom_sf       
IPR006259   Adenyl_kin_sub       
IPR028586   AK3/Ak4_mitochondrial       
IPR007862   Adenylate_kinase_lid-dom       
IPR000850   Adenylat/UMP-CMP_kin       
IPR027417   P-loop_NTPase       
IPR033690   Adenylat_kinase_CS       

SUPFAM

SSF56042   SSF56042        + More
SSF55326   SSF55326       
SSF52540   SSF52540       
SSF57774   SSF57774       

Gene 3D

3.30.1330.10     3.90.650.10    

CDD

cd02195  SelD
cd01428  ADK

ProteinModelPortal

H9J385   Q3HR35   A0A212FNP3   S4PIS4   A0A194QYB3   A0A194QID8   + More
F5CBM5   A0A0L7LN24   A0A2H1V151   C4NFK8   D6WQY1   A0A1W4XPA8   J3JZ15   A0A1Y1M7B0   A0A0K8TM22   A0A2J7RSV7   A0A1L8DM15   A0A1A9XPQ8   A0A1B0AM41   A0A1A9WIA8   A0A1A9V7P8   A0A2J7RDB1   A0A1A9ZPC6   D3TNX4   A0A0K8VRH3   A0A034WST6   A0A336KLL5   A0A2P8YTY2   A0A1I8PVW5   A0A0A1WYS7   A0A2P8ZH28   A0A0L0CB70   T1P7N8   A0A1B6FWM1   W8C155   A0A158NS94   B3MDY9   A0A1W4WBB6   B4P736   B3NR64   B4HRA6   B4QFF3   O18373   B4J758   B4LMH5   B4KSK6   B4H519   Q28X55   B4MJM5   A0A3Q0JDN0   A0A3B0JUA7   A0A023EQC1   A0A1J1HJS2   A0A1S3DEJ9   U5EUU9   Q16XK1   B0W2W4   A0A1Q3F0R0   A0A182IXD8   A0A182RJB0   A0A182QEQ1   A0A182W7I0   A0A182M2G5   A0A182XZU5   A0A182NTJ7   A0A182T8H0   Q7Q3N9   A0A1S4GWU2   A0A182USB2   A0A182JWN4   A0A182TUC4   A0A182WT47   A0A182L1Z5   A0A182HV42   A0A182PD02   A0A084WHB0   A0A182F301   R4FNR1   A0A2M4BQD9   W5JSF0   A0A2M4AT88   A0A1B6DYK4   A0A2S2PEK6   A0A2H8TFN3   A0A2S2Q2W3   A0A2A3ELU8   J9K9H8   A0A1B6CFT7   F5CBP8   E0VCB3   A0A146LHN0   A0A0K8S9W8   A0A0A9ZA82   E9ICW7   A0A3L8DKU4   A0A195CX57   A0A195FV21   A0A0P6JZ99   A0A0C9R999   A0A151J815  

PDB

3FD6     E-value=2.10176e-168,     Score=1520

KEGG

692787    K01008 selenide, water dikinase [EC:2.7.9.3] | (RefSeq) Sps1; selenophosphate synthetase 1

PATHWAY

00450    Selenocompound metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016260   GO:0005524   GO:0004756   GO:0005737   GO:0070329   GO:0001887   GO:0007005   GO:0006541   GO:0008284   GO:0007444   GO:0008283   GO:2000378   GO:0007049   GO:0016301   GO:0046033   GO:0005525   GO:0006172   GO:0046039   GO:0004017   GO:0046899   GO:0046041   GO:0005759   GO:0006355   GO:0008270   GO:0004828   GO:0006434   GO:0043564   GO:0006418   GO:0003824  

PANTHER

PTHR10256  

Subcellular location

Mitochondrion matrix  

Length:

402

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0417100000000001

Exp number, first 60 AAs:

0.00017

Total prob of N-in:

0.02170

outside

1  -  402

 

 

Pi

213.679633

Theta

208.345833

Tajima's D

0.115702

CLR

0.225304

CSRT

0.402129893505325

Interpretation

Uncertain