Gene

KWMTBOMO11686  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004138

Annotation

PREDICTED:_activating_signal_cointegrator_1_[Papilio_machaon]

Location

Bomo_Chr19(+):11261853-11269978      View in EpiBrowser

Full name

Molybdenum cofactor sulfurase      

Alternative Name

Molybdenum cofactor sulfurtransferase
Protein maroon-like

Location in the cell

Nuclear   Reliability : 4.463

CDS

ATGGAGCAATGGATAAGGGAAAATCTATCTACAATTTTGGATTTTGAAGTGCCTGACGATTTAATAAAGTATGTTTCGTCAATAGATAATGAAGTAGATTTAACTGAATACATGAAAACTTTGATTGACTTCAATAATTCTGAACATAAAAACTTTTTCTCCGAATTCATAAGGCTGAAGTTTCCTATTAAAGGCGGGACATCTAAACAGCAAAAAAAGAAAATATCAAAAGGCAAGGTTCAACAAGAGGTGATCGTCAAGGAAACAGTGCCTACACAAAGCGAGCCTGAAAGTAAAACTAAGAAGAAAACAAAATATGTCAATCTATACTCACAAGAAGGGAAGAATGCCCAAGTTGTGATGCTCAAAGGAAGACACCGCTGTGAATGTCAAGCTTCAAAACATGAGCTGATCAACAACTGCCTACAGTGCGGACGAGTGGTCTGCAGGCAGGAAGGCTCGGGCCCCTGTCTGTTTTGTGGCAGCTTGGTTTGCACTCCAGAAGAACAAAGGGAGTTGAATGCCAAGACCAAAGCTAGTGCTAAATTGATGGAGTCGCTTATGGAGAAGAGTCGACCCAAGGGCTGGGAGGACGCTCTGGTGCATAGAAATAGACTTTTGGAATATGATAGGACAAGTGAGCGTCGCACCCGCGTCACTGACGACGACAGTGACTACTTCAACGCGAACAGCGTGTGGCTCAGCTCAGAGGAGCGCGCCAAACTCGACAAGTACCAGCGGTCGCTGCACGAGAAGAAGCACGCGTCCAAACTGAACAAGAAGATGACCTTCGATTTCGCCGGGCGGCAGATATTGGAAGACAAAACCATAGACCACGATGTGGACGAGGACAAGATCAGAGACATAACCGCGGGAGCACGGGCCGCCGGCGGGGCGCTGCAGACGCACGCGGCCGTCGCCGGGCCAACGGACCGGGACGTGGCGCCCGGGGTCAACGCACCACTCTTACTGTTCGATCCGTCAGTGGAAAATGAGGATTATGCGACTGTTGTTAGAGCCAACGGGTTCTCCCAGATGTCTCGTATACAAGACGCCGAGTTGCAGGAGATGAGCGACACCGGCAGGTGCCTCTCCATGCACCAGCCCTGGGCCTCGTTGCTCGTTGAAGGCATCAAACTCCACGAAGGTCGTACATGGTACACCAGCCACCGAGGGAGGCTGTGGGTCGCCGCCACAGTGAAGCCCCCAGACCAGGACGTCATCAAGGCGCTGGAGAACCAGTACAGGGTCCTGTATCCAGAAAAGCAATTGCAATTTCCCTCGTTCTACCCGACTGGATGTCTGCTGGGCTGCGTCAACGTCGACGACTGCCTGCCCCAGGAGGAGTATCGGAAGACGTACCCGGACGGTGAGAGCGACAGTCCGTACGTGTTTATTTGCTCTAATCCTGTCAGCCTGAGGCTTCGGTTTCCGATCAAAGGACAACATAAAATATATCAACTAGAAAAAACAATTCATCAAGCCGCAATGAAATGTATTCAAAAAATGTCCAAAATACAAGCCAACGCAGCTTAA

Protein

MEQWIRENLSTILDFEVPDDLIKYVSSIDNEVDLTEYMKTLIDFNNSEHKNFFSEFIRLKFPIKGGTSKQQKKKISKGKVQQEVIVKETVPTQSEPESKTKKKTKYVNLYSQEGKNAQVVMLKGRHRCECQASKHELINNCLQCGRVVCRQEGSGPCLFCGSLVCTPEEQRELNAKTKASAKLMESLMEKSRPKGWEDALVHRNRLLEYDRTSERRTRVTDDDSDYFNANSVWLSSEERAKLDKYQRSLHEKKHASKLNKKMTFDFAGRQILEDKTIDHDVDEDKIRDITAGARAAGGALQTHAAVAGPTDRDVAPGVNAPLLLFDPSVENEDYATVVRANGFSQMSRIQDAELQEMSDTGRCLSMHQPWASLLVEGIKLHEGRTWYTSHRGRLWVAATVKPPDQDVIKALENQYRVLYPEKQLQFPSFYPTGCLLGCVNVDDCLPQEEYRKTYPDGESDSPYVFICSNPVSLRLRFPIKGQHKIYQLEKTIHQAAMKCIQKMSKIQANAA

Description

Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

Catalytic Activity

AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin

Cofactor

pyridoxal 5'-phosphate

Similarity

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.

Uniprot

H9J3Q1   A0A2H1VUL3   A0A2A4JRA8   A0A194QCS3   A0A1E1WTC4   A0A212FNJ3   + More
U5EU27   A0A182HFE2   A0A0K8TM87   Q16GG8   Q16P92   A0A1S4G1T0   A0A182QNA8   B0WQK0   A0A182Y7J0   A0A1Q3F612   A0A1Q3F4N2   A0A1Q3F3Z3   A0A084WQV2   A0A1Q3F418   A0A182LZA3   A0A182W4P4   A0A182JMU5   A0A182P7X1   A0A182N1H8   A0A182RBH3   A0A182K4H8   A0A2M4BJ98   A0A2M4BK05   A0A2M4BJ76   Q7PS17   W5JSK4   A0A182FEA0   A0A067QWU2   T1P8K6   A0A1I8MMJ2   A0A1I8QCR3   E0VGW2   A0A0K8U366   A0A034WHN0   A0A2J7R6K1   A0A0A1WJF3   A0A1J1HIQ0   A0A0L0C215   A0A1B6EYI7   K1R5U7   A0A0L7LPK0   A0A1A9VZM3   A0A1S3HGA7   E2BRE9   A0A1B6C1E5   A0A1B0FR62   A0A0L7RC76   A0A1W4VG59   R7T3K6   B3MW68   A0A2C9JJT8   A0A2C9JJT4   A0A0N0U590   B4PYH4   A0A2S2QIQ9   B3NY18   A0A2R2MMT0   A0A1B0C9F2   A0A1A9UEK6   A0A3S1B0D9   B4I684   Q9VRA1   A0A0B6ZWX8   A0A0C9R7G9   A0A182IA81   F7FX60   Q29GM2   A0A0M4ESR5   A0A3B0KKK2   A0A3M6TYR9   A0A2H8TGN7   A0A0B6ZW79   A0A182V472   G3VA38   J9JJC1   A0A0P5V261   A0A0N8D2Q7   A0A0N8AZN8   A0A0P4WD33   A0A336K089   A0A0P5WCT6   A0A210R4I4   A0A0P5XES7   A0A0A9XP76   A0A146LK62   A0A3Q3S910   A0A1B0ADQ0   B4NUT6   B4L337   A0A1B6C8K3   V4ABX4  

EC Number

2.8.1.9

Pubmed

19121390    26354079    22118469    26483478    26369729    17510324    + More
25244985    24438588    12364791    14747013    17210077    20920257    23761445    24845553    25315136    20566863    25348373    25830018    26108605    22992520    26227816    20798317    23254933    17994087    15562597    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17495919    15632085    30382153    21709235    28812685    25401762    26823975   

EMBL

BABH01021739    ODYU01004536    SOQ44525.1    NWSH01000825    PCG73993.1    KQ459185    + More
KPJ03219.1    GDQN01000867    JAT90187.1    AGBW02005277    OWR55314.1    GANO01001664    JAB58207.1    JXUM01134079    KQ568069    KXJ69154.1    GDAI01002134    JAI15469.1    CH478278    EAT33331.1    CH477791    EAT36176.1    AXCN02001394    DS232041    EDS32875.1    GFDL01012137    JAV22908.1    GFDL01012566    JAV22479.1    GFDL01012770    JAV22275.1    ATLV01025759    KE525399    KFB52596.1    GFDL01012762    JAV22283.1    AXCM01001655    GGFJ01003986    MBW53127.1    GGFJ01003987    MBW53128.1    GGFJ01003985    MBW53126.1    AAAB01008846    EAA06293.6    ADMH02000584    ETN65739.1    KK853153    KDR10551.1    KA644994    AFP59623.1    DS235152    EEB12618.1    GDHF01031326    JAI20988.1    GAKP01003861    JAC55091.1    NEVH01006756    PNF36465.1    GBXI01015108    JAC99183.1    CVRI01000004    CRK87434.1    JRES01000996    KNC26311.1    GECZ01026868    JAS42901.1    JH817887    EKC41083.1    JTDY01000400    KOB77357.1    GL449962    EFN81727.1    GEDC01029967    JAS07331.1    CCAG010018611    KQ414615    KOC68597.1    AMQN01003670    KB312450    ELT87196.1    CH902625    EDV35213.1    KQ435791    KOX74371.1    CM000162    EDX03015.1    GGMS01008432    MBY77635.1    CH954180    EDV47539.1    AJWK01002278    RQTK01001159    RUS71782.1    CH480823    EDW56290.1    AE014298    AAF50902.1    AHN59962.1    HACG01025987    CEK72852.1    GBYB01002711    JAG72478.1    APCN01001132    CH379064    EAL32087.1    CP012528    ALC49402.1    OUUW01000011    SPP86316.1    RCHS01002679    RMX46532.1    GFXV01001450    MBW13255.1    HACG01025988    CEK72853.1    AEFK01007746    AEFK01007747    AEFK01007748    ABLF02018136    GDIP01105937    JAL97777.1    GDIP01074591    LRGB01000115    JAM29124.1    KZS20794.1    GDIQ01227155    JAK24570.1    GDRN01061753    JAI65171.1    UFQS01000005    UFQT01000005    SSW96915.1    SSX17302.1    GDIP01088710    JAM15005.1    NEDP02000447    OWF55937.1    GDIP01073346    JAM30369.1    GBHO01024694    JAG18910.1    GDHC01010770    JAQ07859.1    CH984241    EDX16367.1    CH933810    EDW06965.1    GEDC01027461    JAS09837.1    KB202050    ESO92590.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000069940    UP000249989    + More
UP000008820    UP000075886    UP000002320    UP000076408    UP000030765    UP000075883    UP000075920    UP000075880    UP000075885    UP000075884    UP000075900    UP000075881    UP000007062    UP000000673    UP000069272    UP000027135    UP000095301    UP000095300    UP000009046    UP000235965    UP000183832    UP000037069    UP000005408    UP000037510    UP000091820    UP000085678    UP000008237    UP000092444    UP000053825    UP000192221    UP000014760    UP000007801    UP000076420    UP000053105    UP000002282    UP000008711    UP000092461    UP000078200    UP000271974    UP000001292    UP000000803    UP000075840    UP000002280    UP000001819    UP000092553    UP000268350    UP000275408    UP000075903    UP000007648    UP000007819    UP000076858    UP000242188    UP000261640    UP000092445    UP000000304    UP000009192    UP000030746   

PRIDE

H9J3Q1    Q9VRA1   

Pfam

PF04266   ASCH        + More
PF06221   zf-C2HC5
PF03476   MOSC_N
PF00266   Aminotran_5
PF03473   MOSC
PF04423   Rad50_zn_hook
PF13476   AAA_23

Interpro

IPR009349   Znf_C2HC5        + More
IPR007374   ASCH_domain       
IPR039128   TRIP4-like       
IPR015947   PUA-like_sf       
IPR015421   PyrdxlP-dep_Trfase_major       
IPR000192   Aminotrans_V_dom       
IPR005303   MOSC_N       
IPR015424   PyrdxlP-dep_Trfase       
IPR028886   MoCo_sulfurase       
IPR005302   MoCF_Sase_C       
IPR015422   PyrdxlP-dep_Trfase_dom1       
IPR011037   Pyrv_Knase-like_insert_dom_sf       
IPR013134   Zn_hook_RAD50       
IPR004584   Rad50_eukaryotes       
IPR027417   P-loop_NTPase       
IPR038729   Rad50/SbcC_AAA       

SUPFAM

SSF88697   SSF88697        + More
SSF53383   SSF53383       
SSF50800   SSF50800       
SSF52540   SSF52540       

Gene 3D

3.40.640.10     3.90.1150.10    

ProteinModelPortal

H9J3Q1   A0A2H1VUL3   A0A2A4JRA8   A0A194QCS3   A0A1E1WTC4   A0A212FNJ3   + More
U5EU27   A0A182HFE2   A0A0K8TM87   Q16GG8   Q16P92   A0A1S4G1T0   A0A182QNA8   B0WQK0   A0A182Y7J0   A0A1Q3F612   A0A1Q3F4N2   A0A1Q3F3Z3   A0A084WQV2   A0A1Q3F418   A0A182LZA3   A0A182W4P4   A0A182JMU5   A0A182P7X1   A0A182N1H8   A0A182RBH3   A0A182K4H8   A0A2M4BJ98   A0A2M4BK05   A0A2M4BJ76   Q7PS17   W5JSK4   A0A182FEA0   A0A067QWU2   T1P8K6   A0A1I8MMJ2   A0A1I8QCR3   E0VGW2   A0A0K8U366   A0A034WHN0   A0A2J7R6K1   A0A0A1WJF3   A0A1J1HIQ0   A0A0L0C215   A0A1B6EYI7   K1R5U7   A0A0L7LPK0   A0A1A9VZM3   A0A1S3HGA7   E2BRE9   A0A1B6C1E5   A0A1B0FR62   A0A0L7RC76   A0A1W4VG59   R7T3K6   B3MW68   A0A2C9JJT8   A0A2C9JJT4   A0A0N0U590   B4PYH4   A0A2S2QIQ9   B3NY18   A0A2R2MMT0   A0A1B0C9F2   A0A1A9UEK6   A0A3S1B0D9   B4I684   Q9VRA1   A0A0B6ZWX8   A0A0C9R7G9   A0A182IA81   F7FX60   Q29GM2   A0A0M4ESR5   A0A3B0KKK2   A0A3M6TYR9   A0A2H8TGN7   A0A0B6ZW79   A0A182V472   G3VA38   J9JJC1   A0A0P5V261   A0A0N8D2Q7   A0A0N8AZN8   A0A0P4WD33   A0A336K089   A0A0P5WCT6   A0A210R4I4   A0A0P5XES7   A0A0A9XP76   A0A146LK62   A0A3Q3S910   A0A1B0ADQ0   B4NUT6   B4L337   A0A1B6C8K3   V4ABX4  

PDB

2E5O     E-value=5.44621e-44,     Score=448

KEGG

101744062    K23398 activating signal cointegrator 1 | (RefSeq) activating signal cointegrator 1

GO

GO:0005634   GO:0006355   GO:0008270   GO:0003713   GO:0045893   GO:0016021   GO:0102867   GO:0030151   GO:0006777   GO:0030170   GO:0016829   GO:0008265   GO:0002020   GO:0035035   GO:0019901   GO:0005737   GO:0045661   GO:0044389   GO:0016604   GO:0030520   GO:0030331   GO:0005813   GO:0099053   GO:0031594   GO:1901998   GO:0016887   GO:0006281   GO:0030870   GO:0000723   GO:0005524   GO:0004828   GO:0006434   GO:0043564   GO:0006418   GO:0003824  

PANTHER

PTHR12963  

Length:

511

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00109

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00282

outside

1  -  511

 

 

Pi

230.307196

Theta

183.84663

Tajima's D

1.168225

CLR

0.122825

CSRT

0.706114694265287

Interpretation

Uncertain