Silkworm Genome Informatics Database

Gene

KWMTBOMO11684

Annotation

tyrosine-protein_kinase_receptor_torso_[Bombyx_mori]

Location

Bomo_Chr19(-):11230354-11235962 View in EpiBrowser

Full name

Tyrosine-protein kinase receptor torso

Location in the cell

Cytoplasmic Reliability : 1.936

CDS

ATGGAACATGATAACTTCGATCCAATACCATTCACGCTAATCGAACCAAATAATGTATTCGGAGAACTGATAACGACCGCAAATAAAGAATACCAGATCTGGTCGACCTATTTGGACGAGTATGGGACGCTTCAGGATTGGATGGAAGGTCCGATCGTTTTAAAGTTTGATCAGCGCAATCAACAACCGGACGATATAAAGTACAACGTGACGCAGGAGTTCCAATACATAATCTTAGGCAACGATTCCTATACGATCAACGGAAAATTCGTTTGGAACACCACAGGTGATCGGGACCTATGCTTTGATATCGCGAATATTTGCCAAAACACGAACATGAAGCACGCTAAGATATGGCCAACAGCACACCCCAGCTTTGATGTGGAAAATCTAGTTTTGAATGACGAATGTGAAATTCACGTGAAGGGTATTCACGGAACCACGAAACACAAATACAAAACTCCATCCTGTTTCGAATTGCCCGAATGTTTTTTAAATAACATGGAACCGGAGATTCCACAAGACGTGGCCATAGCCGCCGATCAAGATTTGCGGGGCTGGTGGAACATCAACGTAGCGTGGGCGAAGCCACATTTTCAACCGGAGATTTATAATGTGACCGTTCGAGCTAATATGATAAGATCGATTATTTTACCCGGGGTATGTATATAA

Protein

MEHDNFDPIPFTLIEPNNVFGELITTANKEYQIWSTYLDEYGTLQDWMEGPIVLKFDQRNQQPDDIKYNVTQEFQYIILGNDSYTINGKFVWNTTGDRDLCFDIANICQNTNMKHAKIWPTAHPSFDVENLVLNDECEIHVKGIHGTTKHKYKTPSCFELPECFLNNMEPEIPQDVAIAADQDLRGWWNINVAWAKPHFQPEIYNVTVRANMIRSIILPGVCI

Description

Probable receptor tyrosine kinase. During postembryonic development, involved in the initiation of metamorphosis probably by inducing the production of ecdysone in response to prothoracicotropic hormone (PTTH) (By similarity). Binding to PTTH stimulates activation of canonical MAPK signaling leading to ERK phosphorylation (PubMed:19965758, PubMed:26928300).

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Cofactor

Mg(2+)

Subunit

Homodimer; disulfide-linked.

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Keywords

3D-structure ATP-binding Cell membrane Complete proteome Developmental protein Disulfide bond Glycoprotein Kinase Magnesium Membrane Metal-binding Nucleotide-binding Phosphoprotein Reference proteome Signal Transferase Transmembrane Transmembrane helix Tyrosine-protein kinase

Feature

chain Tyrosine-protein kinase receptor torso

Uniprot

D2IYS2 A0A2A4JQG1 A0A2H1VVK8 A0A194QCN2 A0A194QZR5 A0A0M3VGH2 + More

EC Number

2.7.10.1

Pubmed

19965758 26928300 26698662 26354079 26745499

EMBL

GQ477743 ACZ81657.1 NWSH01000825 PCG74006.1 ODYU01004535 SOQ44522.1 + More
KQ459185 KPJ03227.1 KQ460949 KPJ10470.1 LC076477 BAS29645.2

Proteomes

UP000005204 UP000218220 UP000053268 UP000053240

PRIDE

D2IYS2

Pfam

PF07714 Pkinase_Tyr

Interpro

IPR008266   Tyr_kinase_AS        + More
IPR020635   Tyr_kinase_cat_dom
IPR000719   Prot_kinase_dom
IPR001245   Ser-Thr/Tyr_kinase_cat_dom
IPR011009   Kinase-like_dom_sf
IPR017441   Protein_kinase_ATP_BS
IPR036116   FN3_sf

SUPFAM

SSF56112 SSF56112 + More
SSF49265 SSF49265

ProteinModelPortal

D2IYS2 A0A2A4JQG1 A0A2H1VVK8 A0A194QCN2 A0A194QZR5 A0A0M3VGH2 + More

PDB

5AOQ E-value=6.80378e-107, Score=987

KEGG

101743525 K12378 tyrosine-protein kinase receptor torso [EC:2.7.10.1] | (RefSeq) Torso; mast/stem cell growth

PATHWAY

04013 MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0005524 GO:0005886 GO:0046872 GO:0004714 GO:0007275 GO:0016021 GO:0004713

Subcellular location

Cell membrane

Length:

223

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00137

Exp number, first 60 AAs:

0.0004

Total prob of N-in:

0.02046

outside

1 - 223

Pi

149.86617

Theta

133.832268

Tajima's D

0.219404

CLR

0.376746

CSRT

0.424928753562322

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics