Gene

KWMTBOMO11666  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003985

Annotation

transitional_endoplasmic_reticulum_ATPase_TER94_[Bombyx_mori]

Location

Bomo_Chr19(-):10984080-10998392      View in EpiBrowser

Full name

Transitional endoplasmic reticulum ATPase TER94      

Alternative Name

Valosin-containing protein homolog

Location in the cell

Cytoplasmic   Reliability : 3.024

CDS

ATGGCAGATAATAAAAGCCCTGATGATTTATCGACCGCGATCCTCCGTCGCAAGGACAGACCCAACCGTCTCATTGTCGAAGAAGCAGTCAGCGATGACAACTCAGTCGTGGCACTTTCACAGGCCAAAATGGAGCAACTTCAACTCTTCCGTGGTGACACAGTCTTGCTCAAGGGCAAACGCCGCAAGGAAACCGTTTGCATCGTGCTCTCAGACGATAATTGCCCTGATGAGAAAATTCGGATGAACCGTGTTGTGAGAAACAACCTTCGTGTGCGTCTTTCTGATGTGGTATCCATCGCTCCGTGTCCTTCAGTGAAATATGGAAAACGAGTCCACATACTGCCAATTGATGATTCAGTTGAGGGTCTTACTGGCAATCTATTCGAAGTATACTTGAAGCCGTACTTCATGGAGGCTTACCGTCCGATCCATCGTGACGACACCTTCATGGTCCGCGGGGGCATGCGCGCCGTCGAGTTCAAAGTGGTCGAAACAGATCCATCACCATTTTGCATCGTGGCTCCTGATACCGTAATACACTGTGACGGTGAACCGATTAAACGTGAGGAAGAAGAGGAAGCACTAAATGCTGTCGGCTATGATGACATCGGCGGTTGTCGCAAACAACTGGCGCAAATTAAGGAGATGGTGGAGTTGCCACTGCGTCATCCTTCACTGTTCAAGGCTATTGGAGTGAAGCCTCCACGCGGCATTCTCATGTATGGGCCGCCTGGTACCGGAAAAACACTCATTGCTCGTGCTGTTGCTAATGAAACAGGAGCTTTCTTCTTTTTAATTAATGGACCGGAGATCATGTCTAAGCTGGCGGGAGAATCGGAGTCAAACCTCCGTAAGGCGTTTGAGGAAGCCGACAAGAACTCTCCGGCTATTATCTTCATTGATGAACTCGATGCTATTGCACCAAAGAGAGAGAAAACCCACGGTGAAGTGGAAAGACGTATCGTTTCACAGTTATTGACGCTTATGGATGGCATGAAGAAGTCGTCCCACGTGATCGTGATGGCGGCCACGAACCGGCCGAACTCCATCGACCCGGCGCTGCGGCGCTTCGGGCGGTTCGACCGCGAGATCGACATCGGCATCCCCGACGCGACCGGCCGCCTCGAGATCCTGCGCATACACACCAAGAACATGAAGCTAGGAGACGACGTCGATCTAGAACAGATCGCAGCAGAGTCTCACGGTCACGTGGGCGCTGATCTCGCGTCTCTGTGCTCGGAGGCAGCCTTGCAGCAGATTCGTGAGAAGATGGATCTCATTGACCTCGAGGACGATCAGATTGACGCAGAGGTTCTCAATTCTCTGGCTGTCTCCATGGATAACTTCCGGTACGCAATGACGAAATCGTCTCCGTCGGCGTTACGTGAGACAGTGGTGGAAGTTCCCAACGTGACGTGGACCGACATCGGCGGGCTGGAGGGAGTGAAGCGTGAACTCCAAGAACTCGTGCAGTATCCGGTCGAACATCCCGACAAATTCCTGAAGTTCGGCATGCAGCCTTCGCGCGGTGTTCTCTTCTACGGACCTCCTGGTTGTGGTAAAACTTTGCTGGCAAAGGCCATCGCCAACGAGTGTCAGGCTAACTTTATATCAGTGAAGGGACCAGAGCTGCTCACCATGTGGTTCGGCGAGTCCGAGGCGAACGTACGCGACATCTTCGACAAGGCTCGATCGGCATCTCCGTGCGTGTTGTTCTTCGACGAGCTGGACTCCATCGCCAAGTCGCGCGGCGGCTCCGTGTCGGACGCGGGCGGGGCGGCGGACCGCGTCATCAACCAGATCCTCACCGAGATGGACGGCATGGGCGCCAAGAAGAACGTCTTCATCATCGGTGCCACAAACAGACCGGACATCATCGACCCGGCCATCCTGCGTCCCGGCCGTCTGGACCAGCTCATCTACATCCCGCTGCCGGACGAGAAGTCCCGCGAGGCCATCCTGCGCGCCAACCTTCGCAAATCGCCTATCGCTAAGGACGTTGACTTGTCTTACATCGCCAAGGTGACGCAAGGCTTCAGTGGCGCTGACCTGACGGAGATATGCCAGCGAGCCTGCAAGCTGGCCATTCGCCAGGCCATCGAGGCGGAGATCCATCGCGAGAGGAGTCGCCAGCAGCAAGCCGCCGCTGCCGTTATGGACATGGACGAGGAAGACCCCGTTCCGGAGATTAGCCGCGCTCACTTCGAGGAGGCGATGAAGTTCGCGCGCCGCTCCGTGTCCGACAACGACATCCGCAAGTACGAGATGTTCGCGCAGACCCTGCAGCAGAGCCGCGGCTTCGGAACCAACTTCAGATTCCCAACAAACGCGGGAGCTACAGGGGGCACGGGTACTTCAGCGGGCGACCAGCCCACGTTCCAGGAGGAGGGGGGTGACGACGACCTGTACAGCTAA

Protein

MADNKSPDDLSTAILRRKDRPNRLIVEEAVSDDNSVVALSQAKMEQLQLFRGDTVLLKGKRRKETVCIVLSDDNCPDEKIRMNRVVRNNLRVRLSDVVSIAPCPSVKYGKRVHILPIDDSVEGLTGNLFEVYLKPYFMEAYRPIHRDDTFMVRGGMRAVEFKVVETDPSPFCIVAPDTVIHCDGEPIKREEEEEALNAVGYDDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEADKNSPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGMKKSSHVIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEILRIHTKNMKLGDDVDLEQIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDQIDAEVLNSLAVSMDNFRYAMTKSSPSALRETVVEVPNVTWTDIGGLEGVKRELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSASPCVLFFDELDSIAKSRGGSVSDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSREAILRANLRKSPIAKDVDLSYIAKVTQGFSGADLTEICQRACKLAIRQAIEAEIHRERSRQQQAAAAVMDMDEEDPVPEISRAHFEEAMKFARRSVSDNDIRKYEMFAQTLQQSRGFGTNFRFPTNAGATGGTGTSAGDQPTFQEEGGDDDLYS

Description

Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in the ubiquitin-proteasome system. Important for oskar mRNA localization and/or anchoring during oogenesis. Involved in germ cell formation.

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Subunit

Homohexamer (PubMed:10564274). Interacts with tud, vas, papi and AGO3 (PubMed:18590813, PubMed:21447556). Interacts with Npl4 (PubMed:26471729).

Similarity

Belongs to the AAA ATPase family.

Keywords

3D-structure   Alternative splicing   ATP-binding   Complete proteome   Cytoplasm   Developmental protein   Differentiation   Direct protein sequencing   Hydrolase   Nucleotide-binding   Nucleus   Oogenesis   Phosphoprotein   Reference proteome   Transport   Ubl conjugation pathway  

Feature

chain  Transitional endoplasmic reticulum ATPase TER94
splice variant  In isoform D.

Uniprot

Q2V0H5   A0A212FAS0   S4PED7   A0A2H1V392   A0A2A4JT40   A0A194QYV6   + More
A0A2A4JU38   A0A194QE63   H9J398   A0A182ITU9   A0A182NGU8   A0A1W4WKA3   A0A182PHK8   T1DPQ2   A0A182UBH8   A0A2C9GPU4   A0A182VEX7   A0A182LJ59   A0A182XMY2   Q7PIQ3   A0A1L8DTT2   U5EX49   A0A182FDN4   A0A182JV76   A0A2M3YZU1   A0A182MBZ2   A0A084W9Z2   A0A2M4A0T6   A0A2M4BE36   W5JHN6   A0A182RF80   A0A1Y1LG86   A0A182Q6S3   A0A182WB37   A0A1B0DPG7   A0A182Y187   V5GMY8   A0A1B6CDP3   A0A195CCX0   A0A1B6FUT9   D6WTD3   A0A195DN43   F4W4F4   A0A158P375   A0A195BHF3   A0A195EZP1   A0A2J7R5F8   E2AP42   A0A151WYZ4   A0A1Q3F7V6   A0A0P4VTA9   A0A2M4BE76   A0A224XIV6   E9IAW4   A0A069DWX9   A0A182GAA5   A0A0V0G2R0   E0VGE9   A0A067QLL5   E2BAA9   A0A0C9PIQ2   A0A1J1I3P4   A0A1I9WLJ9   A0A1A9YE80   T1PEY4   A0A0A9Y2M0   Q16SH1   A0A2A3ECV7   B4J5A4   A0A0Q9WAA5   K7IY05   A0A1L8EDF3   B0WC89   A0A3B0JJL8   V9IJ68   A0A088AFM4   U4UU26   A0A034VZW3   A0A0L0CN70   A0A0A1WE44   B4LM11   B4MQW3   A0A0K8SW23   A0A1A9YE81   A0A1I8PBP9   A0A0M5IXE2   A0A232F249   A0A0K8V5Z3   A0A1W4VCS6   A0A0L7RI36   Q290U1   A0A034VXB1   J9JPU1   Q7KN62   A0A2S2P454   A0A034W1F6   B3MHI7   A0A0R3NSK5   B4HMA9   B4QHU8  

EC Number

3.6.4.6

Pubmed

22118469    23622113    26354079    19121390    20966253    12364791    + More
14747013    17210077    24438588    20920257    23761445    28004739    25244985    18362917    19820115    21719571    21347285    20798317    27129103    21282665    26334808    26483478    20566863    24845553    27538518    25315136    25401762    26823975    17510324    17994087    20075255    23537049    25348373    26108605    25830018    28648823    15632085    9639875    10656772    10731132    12537572    10731138    10564274    14657277    17372656    18590813    21447556    26471729    22936249   

EMBL

DQ443348    AB244027    ABF51437.1    BAE54254.1    AGBW02009432    OWR50834.1    + More
GAIX01003236    JAA89324.1    ODYU01000315    SOQ34842.1    NWSH01000623    PCG75207.1    KQ460949    KPJ10474.1    PCG75208.1    KQ459185    KPJ03235.1    BABH01021718    GAMD01003149    JAA98441.1    APCN01001538    AAAB01008960    EAA44058.3    GFDF01004236    JAV09848.1    GANO01001130    JAB58741.1    GGFM01001033    MBW21784.1    AXCM01000869    ATLV01021973    KE525326    KFB47036.1    GGFK01001072    MBW34393.1    GGFJ01002175    MBW51316.1    ADMH02001494    ETN62319.1    GEZM01060701    JAV70955.1    AXCN02000366    AJVK01018258    GALX01003007    JAB65459.1    GEDC01025813    JAS11485.1    KQ977935    KYM98709.1    GECZ01016006    JAS53763.1    KQ971352    EFA07465.1    KQ980713    KYN14252.1    GL887532    EGI70849.1    ADTU01007770    KQ976467    KYM84186.1    KQ981905    KYN33586.1    NEVH01006994    PNF36062.1    GL441452    EFN64778.1    KQ982649    KYQ53104.1    GFDL01011477    JAV23568.1    GDKW01000852    JAI55743.1    GGFJ01002176    MBW51317.1    GFTR01008046    JAW08380.1    GL762073    EFZ22299.1    GBGD01000514    JAC88375.1    JXUM01050828    JXUM01050829    KQ561664    KXJ77875.1    GECL01003705    JAP02419.1    DS235140    EEB12455.1    KK853284    KDR08983.1    GL446696    EFN87364.1    GBYB01000823    JAG70590.1    CVRI01000036    CRK92985.1    KU932383    APA34019.1    KA647357    AFP61986.1    GBHO01016312    GDHC01010367    JAG27292.1    JAQ08262.1    CH477673    EAT37428.1    KZ288301    PBC28851.1    CH916367    EDW01746.1    CH940648    KRF79159.1    GFDG01002038    JAV16761.1    DS231886    EDS43334.1    OUUW01000001    SPP73639.1    JR050054    AEY61163.1    KB632367    ERL93660.1    GAKP01010988    JAC47964.1    JRES01000160    KNC33736.1    GBXI01017341    JAC96950.1    EDW59931.1    CH963849    EDW74502.1    GBRD01008451    GBRD01008450    JAG57371.1    CP012524    ALC41144.1    NNAY01001254    OXU24600.1    GDHF01018038    JAI34276.1    KQ414588    KOC70458.1    CM000071    EAL25271.2    GAKP01010986    JAC47966.1    ABLF02038030    AF047037    AF202034    AE013599    AF132553    GGMR01011379    MBY23998.1    GAKP01010987    JAC47965.1    CH902619    EDV37987.1    KRT02029.1    CH480816    EDW47186.1    CM000362    CM002911    EDX06432.1    KMY92633.1   

Proteomes

UP000007151    UP000218220    UP000053240    UP000053268    UP000005204    UP000075880    + More
UP000075884    UP000192223    UP000075885    UP000075902    UP000075840    UP000075903    UP000075882    UP000076407    UP000007062    UP000069272    UP000075881    UP000075883    UP000030765    UP000000673    UP000075900    UP000075886    UP000075920    UP000092462    UP000076408    UP000078542    UP000007266    UP000078492    UP000007755    UP000005205    UP000078540    UP000078541    UP000235965    UP000000311    UP000075809    UP000069940    UP000249989    UP000009046    UP000027135    UP000008237    UP000183832    UP000092443    UP000095301    UP000008820    UP000242457    UP000001070    UP000008792    UP000002358    UP000002320    UP000268350    UP000005203    UP000030742    UP000037069    UP000007798    UP000095300    UP000092553    UP000215335    UP000192221    UP000053825    UP000001819    UP000007819    UP000000803    UP000007801    UP000001292    UP000000304   

PRIDE

Q2V0H5    H9J398    Q7KN62   

Pfam

PF09336   Vps4_C        + More
PF00004   AAA
PF17862   AAA_lid_3
PF02359   CDC48_N
PF02933   CDC48_2
PF09773   Meckelin
PF00400   WD40

Interpro

IPR015415   Vps4_C        + More
IPR003338   CDC4_N-term_subdom       
IPR003959   ATPase_AAA_core       
IPR005938   AAA_ATPase_CDC48       
IPR029067   CDC48_domain_2-like_sf       
IPR009010   Asp_de-COase-like_dom_sf       
IPR027417   P-loop_NTPase       
IPR003960   ATPase_AAA_CS       
IPR004201   Cdc48_dom2       
IPR041569   AAA_lid_3       
IPR003593   AAA+_ATPase       
IPR019170   Meckelin       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR020472   G-protein_beta_WD-40_rep       
IPR036322   WD40_repeat_dom_sf       
IPR019775   WD40_repeat_CS       

SUPFAM

SSF52540   SSF52540        + More
SSF54585   SSF54585       
SSF50692   SSF50692       
SSF50978   SSF50978       

Gene 3D

2.130.10.10    

ProteinModelPortal

Q2V0H5   A0A212FAS0   S4PED7   A0A2H1V392   A0A2A4JT40   A0A194QYV6   + More
A0A2A4JU38   A0A194QE63   H9J398   A0A182ITU9   A0A182NGU8   A0A1W4WKA3   A0A182PHK8   T1DPQ2   A0A182UBH8   A0A2C9GPU4   A0A182VEX7   A0A182LJ59   A0A182XMY2   Q7PIQ3   A0A1L8DTT2   U5EX49   A0A182FDN4   A0A182JV76   A0A2M3YZU1   A0A182MBZ2   A0A084W9Z2   A0A2M4A0T6   A0A2M4BE36   W5JHN6   A0A182RF80   A0A1Y1LG86   A0A182Q6S3   A0A182WB37   A0A1B0DPG7   A0A182Y187   V5GMY8   A0A1B6CDP3   A0A195CCX0   A0A1B6FUT9   D6WTD3   A0A195DN43   F4W4F4   A0A158P375   A0A195BHF3   A0A195EZP1   A0A2J7R5F8   E2AP42   A0A151WYZ4   A0A1Q3F7V6   A0A0P4VTA9   A0A2M4BE76   A0A224XIV6   E9IAW4   A0A069DWX9   A0A182GAA5   A0A0V0G2R0   E0VGE9   A0A067QLL5   E2BAA9   A0A0C9PIQ2   A0A1J1I3P4   A0A1I9WLJ9   A0A1A9YE80   T1PEY4   A0A0A9Y2M0   Q16SH1   A0A2A3ECV7   B4J5A4   A0A0Q9WAA5   K7IY05   A0A1L8EDF3   B0WC89   A0A3B0JJL8   V9IJ68   A0A088AFM4   U4UU26   A0A034VZW3   A0A0L0CN70   A0A0A1WE44   B4LM11   B4MQW3   A0A0K8SW23   A0A1A9YE81   A0A1I8PBP9   A0A0M5IXE2   A0A232F249   A0A0K8V5Z3   A0A1W4VCS6   A0A0L7RI36   Q290U1   A0A034VXB1   J9JPU1   Q7KN62   A0A2S2P454   A0A034W1F6   B3MHI7   A0A0R3NSK5   B4HMA9   B4QHU8  

PDB

5C1B     E-value=0,     Score=3281

KEGG

692552    K13525 transitional endoplasmic reticulum ATPase | (RefSeq) Ter94; transitional endoplasmic reticulu

PATHWAY

04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0016787   GO:0005524   GO:0010826   GO:0036038   GO:0060271   GO:0016021   GO:0051228   GO:0071712   GO:0031593   GO:0016236   GO:0005634   GO:0005829   GO:0005737   GO:0097352   GO:0016887   GO:0034098   GO:0030970   GO:0030433   GO:0006530   GO:0046598   GO:0046716   GO:0007040   GO:0048477   GO:0032436   GO:0045786   GO:0006511   GO:0016320   GO:0007317   GO:0000502   GO:0035096   GO:0007279   GO:0000226   GO:0005886   GO:0090090   GO:0043523   GO:0045169   GO:0098586   GO:0031965   GO:0048813   GO:0006508   GO:0044754   GO:0007029   GO:0043186   GO:0043525   GO:0007030   GO:0042246   GO:0008152   GO:0005216   GO:0006811   GO:0016020   GO:0043564   GO:0006418   GO:0003824  

Subcellular location

Cytoplasm   Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (PubMed:18590813).   With evidence from 8 publications.
Nucleus   Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (PubMed:18590813).   With evidence from 8 publications.

Length:

805

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00468999999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00028

outside

1  -  805

 

 

Pi

234.137472

Theta

151.661668

Tajima's D

0.295754

CLR

0.198258

CSRT

0.449627518624069

Interpretation

Uncertain