Gene

KWMTBOMO11657

Pre Gene Modal

BGIBMGA003990

Annotation

fused_lobes_[Bombyx_mori]

Location

Bomo_Chr19(-):10745073-10819197      View in EpiBrowser

Full name

Beta-hexosaminidase       + More
Probable beta-hexosaminidase fdl      

Alternative Name

Protein fused lobes

Location in the cell

Mitochondrial   Reliability : 1.129

CDS

ATGATGTCGTGGGGTGATGCATTATGGCTTGGCTTGACGGCGAGATTTGCGAGGGTGGGGCGGCTGCGACGAGCCGTGCTCATGCTAGCCGCGGCCGCCTGCACCGCTGCTGCTGTACTCTACTGGAAACAGCAGACTGACGACAGCGCCAACAGACCGCTTCACTCCATGTATTCGGGCATCGAACCTCAGTGGTCTTGGTTATGTCAACACGACCGATGCGAGAGGTATCAAGCATCGGATACGACGACGCTACAGTCGCTGCAGACTTGCAACATGCTGTGCGCCTCCACCCAGCTCTGGCCACAGCCGACGGGGCCTGTCAGCCTCGCATCGGCGGCTGTGCCCGTGAGATCGGACCGCTTCTCCCTCAAAGTTATAGCGTCACCATCACGCGACGTCACCAAACACTTAAACGAAGCGTTTATCGTGATGCAAAATCACATGCGAACTTTAGAACATGGCGTGGTCGGTGAAAACCGTCGATCTGACATAGGACCCCCGCGGGACGTACTGGTGAAGGTATCCGTGAACGGATCCGGCGACCCTCGTATGCGGCTCGACACGAACGAAAGCTACAAACTCGCCTTACGGCCCTCCGGCAATTCCCTCGTCGTAGACATCACAGCGCATTCGTTCTGCGGAGCGAGACACGGCCTCGAAACACTTTTGCAGGTCACCTGGCTGGATCCGTACGCCGGATCGCTACTCATACTAGAAGCGGCAACTGTAGTTGATGCCCCTCGTTTTCCTTACCGTGGCCTGCTTCTGGATACGGCTCGTAATTTTTTCCCCGTCAGTGAGCTTCTCCGCACCATAGACGCGATGGCCGCGAACAAACTAAATACGTTCCACTGGCACGTGAGCGATTCACAATCGTTTCCGTGGAAGTTAGACAGCGCACCCCAACTGGCGCAGCACGGCGCCTACGGACCGGGCGCAGTGTACACGTCCGACGACGTGAGAACAATTGTTAAATACGCACGCATCAGAGGAATCCGGGTGCTGATGGAAATAGACACACCGGCGCACGTCGGTCGAGCTTTCGGTTGGGGTCCGGAGGCTGGCCTCGGCCACTTAGCGCACTGCATAGAGGCGGAACCCTGGAGTTCCTACTGCGGAGAACCTCCGTGCGGCCAACTGAATCCTCGCAACCCTCACATATACGATTTACTAGAACACGTCTACAGGGAGATCATTCAATTAACTGGGGTCGACGACATCTTCCACCTTGGTGGCGATGAGGTGTCGGAACAGTGCTGGGCTAAGCACTTCAATGATACGGATCCGATGGATCTTTGGATGGAGTTCACGCGACAAGCCATGCACGTTCTCGAACGAGCGAATGGGGGTAAAGCGCCAGAGCTCACTCTGCTTTGGTCATCGCGATTGACGCGCTCCCCGTACCTCGAACGCCTCGACCCAAAACGCTTTGGCGTACATGTGTGGGGCGCGTCGCAGTGGCCCGAGTCGCGTGCGGTTTTGGACGCCGGCTTCCGATCGGTGATCTCGCACGTGGACGCCTGGTACCTCGACTGCGGGTTCGGGTCGTGGCGCGACAGCTCGGACGGACACTGCGGGCCGTACCGGTCGTGGCAGCAGGTGTACGAGCACCGACCGTGGGCGACGGAAACGCCCGAGAGCGCGGCATGGCCGGTGGAGGGTGGCGCAGCGTGCCAGTGGACGGAGCAGTTGGGTCCGGGCGGGTTGGACGCGCGCGTGTGGCCCCGGACGGCAGCTCTGGCGGAGCGGCTGTGGGCAGACCGTGCCGAGGGCGCCACGGCGGATGTGTACTTGCGGCTCGACACACAGCGGGCGCGGCTGGTGGCGCGGGGGGTGCGGGCGGCGCCGCTGTGGCCGCGCTGGTGCTCCCACAACCCGCACGCGTGCCTCTAG

Protein

MMSWGDALWLGLTARFARVGRLRRAVLMLAAAACTAAAVLYWKQQTDDSANRPLHSMYSGIEPQWSWLCQHDRCERYQASDTTTLQSLQTCNMLCASTQLWPQPTGPVSLASAAVPVRSDRFSLKVIASPSRDVTKHLNEAFIVMQNHMRTLEHGVVGENRRSDIGPPRDVLVKVSVNGSGDPRMRLDTNESYKLALRPSGNSLVVDITAHSFCGARHGLETLLQVTWLDPYAGSLLILEAATVVDAPRFPYRGLLLDTARNFFPVSELLRTIDAMAANKLNTFHWHVSDSQSFPWKLDSAPQLAQHGAYGPGAVYTSDDVRTIVKYARIRGIRVLMEIDTPAHVGRAFGWGPEAGLGHLAHCIEAEPWSSYCGEPPCGQLNPRNPHIYDLLEHVYREIIQLTGVDDIFHLGGDEVSEQCWAKHFNDTDPMDLWMEFTRQAMHVLERANGGKAPELTLLWSSRLTRSPYLERLDPKRFGVHVWGASQWPESRAVLDAGFRSVISHVDAWYLDCGFGSWRDSSDGHCGPYRSWQQVYEHRPWATETPESAAWPVEGGAACQWTEQLGPGGLDARVWPRTAALAERLWADRAEGATADVYLRLDTQRARLVARGVRAAPLWPRWCSHNPHACL

Description

Involved in brain restructurization via hormonal control during metamorphosis. Implicated in N-glycan processing.

Catalytic Activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Similarity

Belongs to the glycosyl hydrolase 20 family.

Keywords

Alternative splicing   Complete proteome   Developmental protein   Glycoprotein   Glycosidase   Hydrolase   Reference proteome   Signal  

Feature

chain  Probable beta-hexosaminidase fdl
splice variant  In isoform B.

Uniprot

D3GGI9   E1CG96   D3GGI8   B1P868   D6PW84   A0A212FNK4   + More
A0A3S2NQV5   D3GGI7   A0A194QCU8   A0A0L7LFG8   A0A2A4JAM6   A0A0L7KQB6   A0A0G2RLW6   A0A194QYW8   A0A212F886   A0A0L7LKV0   A0A2H1VA55   A5YVX6   A0A194QZT5   A0A2A4JIQ5   A0A194QE79   J3JWB4   U4UHA8   H9J3A9   A0A1Y1MUX2   A0A1W4WN94   A0A1W4WN20   A0A1W4WM34   A0A1W4WC04   A0A0T6BB39   B4H544   Q28X77   A0A0R3NQ30   A0A0R3NWB6   E2AN60   A0A026VXS5   A0A154PQQ9   A0A0R3NVQ4   A0A088ANY0   A0A3L8D4R7   A0A0A7NXB7   A0A195FQK5   A0A3B0JFG0   F4WC87   A0A3B0JKP9   E2BWS6   A0A195C5C4   A0A151XJZ2   Q7QIU7   A0A2A3ES46   A0A1L8E264   A0A195BK61   A0A1J1I7Y3   A0A1J1I989   A0A158N9Y2   A0A1B0CI79   A0A0Q9XGJ7   B4KPZ8   A0A0R1DQK7   B4P590   B4QCX6   A0A0J9RB23   A0A0R1DWG8   A0A1Q3F2V3   A0A0J9RB31   A0A1Q3F2U8   A0A1W4UJA8   B4N602   A0A1W4U6H5   A0A0J9RC20   B0WNY9   A0A0R1DQ79   B4HPK0   A0A0P6IVH7   A0A0L7QN95   A0A232F8H7   K7INU6   A0A0P9AC23   A0A0P8XLY1   A0A0B4LG91   A0A0P8XLW9   Q8WSF3-2   H5V8F4   A0A0B4LF89   Q8WSF3   A0A0Q5W266   A0A0N8NZZ6   A0A0Q5VZG7   B3MEN4   A9UN21   A0A182GY98   B4MDU3   A0A0Q9W0E1   A0A0Q9W9B7   A0A0Q9W007   B3NRZ7   A0A0M4E7X0   A0A084WEE1   A0A336LPK8   A0A336MDZ8  

EC Number

3.2.1.52

Pubmed

19121390    20547376    18303021    22118469    26354079    26227816    + More
18342252    18362917    19820115    22516182    23537049    28004739    17994087    15632085    20798317    24508170    30249741    25488985    21719571    12364791    21347285    17550304    22936249    26999592    28648823    20075255    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    18057021    10623899    12537569    26483478    24438588   

EMBL

BABH01021699    BABH01021700    FJ695481    ACV89847.1    AB540233    BAJ20189.1    + More
FJ695480    ACV89846.1    EU334747    ODYU01005953    ACA30398.1    SOQ47378.1    GU984637    ADF97235.1    AGBW02005277    OWR55318.1    RSAL01000352    RVE42263.1    FJ695479    ACV89845.1    KQ459185    KPJ03244.1    JTDY01001324    KOB74197.1    NWSH01002205    PCG68909.1    JTDY01007043    KOB65498.1    KP000851    AJG44546.1    KQ460949    KPJ10484.1    AGBW02009781    OWR49928.1    JTDY01000705    KOB76153.1    ODYU01001276    SOQ37272.1    EF592539    KQ971354    ABQ95985.1    EFA06836.2    KPJ10490.1    NWSH01001413    PCG71313.1    KPJ03250.1    BT127532    AEE62494.1    KB632326    ERL92397.1    BABH01021684    GEZM01019981    JAV89483.1    LJIG01002462    KRT84478.1    CH479210    EDW32880.1    CM000071    EAL26439.2    KRT03108.1    KRT03107.1    GL441088    EFN65124.1    KK107796    EZA47639.1    KQ435007    KZC13460.1    KRT03109.1    QOIP01000013    RLU15380.1    KJ786476    AIZ97749.1    KQ981305    KYN42860.1    OUUW01000001    SPP74050.1    GL888070    EGI68067.1    SPP74049.1    GL451188    EFN79790.1    KQ978292    KYM95386.1    KQ982052    KYQ60598.1    AAAB01008807    EAA03943.4    KZ288193    PBC34036.1    GFDF01001338    JAV12746.1    KQ976455    KYM85038.1    CVRI01000043    CRK96299.1    CRK96298.1    ADTU01009908    AJWK01013083    CH933808    KRG03902.1    EDW08100.1    CM000158    KRJ99444.1    EDW90752.2    CM000362    CM002911    EDX06787.1    KMY93230.1    KMY93226.1    KRJ99443.1    GFDL01013164    JAV21881.1    KMY93227.1    GFDL01013165    JAV21880.1    CH964154    EDW79791.2    KMY93229.1    DS232017    EDS32008.1    KRJ99445.1    CH480816    EDW47584.1    GDUN01000092    JAN95827.1    KQ414860    KOC60039.1    NNAY01000660    OXU27126.1    CH902619    KPU75705.1    KPU75706.1    AE013599    AHN56149.1    KPU75704.1    AF323977    AY113418    AY061037    AAL28585.1    AAL55992.1    AAM29423.1    BT133255    AFC17499.1    AHN56148.1    CH954179    KQS62831.1    KPU75708.1    KQS62830.1    EDV35498.2    BT031185    ABY20426.1    JXUM01097258    JXUM01097259    JXUM01097260    JXUM01097261    CH940662    EDW58708.1    KRF78418.1    KRF78417.1    KRF78419.1    EDV56299.2    CP012524    ALC40696.1    ATLV01023205    KE525341    KFB48585.1    UFQS01000102    UFQT01000102    SSW99622.1    SSX20002.1    UFQT01001050    SSX28632.1   

Proteomes

UP000005204    UP000007151    UP000283053    UP000053268    UP000037510    UP000218220    + More
UP000053240    UP000007266    UP000030742    UP000192223    UP000008744    UP000001819    UP000000311    UP000053097    UP000076502    UP000005203    UP000279307    UP000078541    UP000268350    UP000007755    UP000008237    UP000078542    UP000075809    UP000007062    UP000242457    UP000078540    UP000183832    UP000005205    UP000092461    UP000009192    UP000002282    UP000000304    UP000192221    UP000007798    UP000002320    UP000001292    UP000053825    UP000215335    UP000002358    UP000007801    UP000000803    UP000008711    UP000069940    UP000008792    UP000092553    UP000030765   

PRIDE

D3GGI9    E1CG96    D3GGI8    D3GGI7    H9J3A9    Q8WSF3    + More
H5V8F4    A9UN21   

Pfam

PF00728   Glyco_hydro_20        + More
PF14845   Glycohydro_20b2
PF01490   Aa_trans

Interpro

IPR029018   Hex-like_dom2        + More
IPR025705   Beta_hexosaminidase_sua/sub       
IPR017853   Glycoside_hydrolase_SF       
IPR029019   HEX_eukaryotic_N       
IPR015883   Glyco_hydro_20_cat       
IPR013057   AA_transpt_TM       

SUPFAM

SSF55545   SSF55545        + More
SSF51445   SSF51445       

Gene 3D

3.30.379.10    

ProteinModelPortal

D3GGI9   E1CG96   D3GGI8   B1P868   D6PW84   A0A212FNK4   + More
A0A3S2NQV5   D3GGI7   A0A194QCU8   A0A0L7LFG8   A0A2A4JAM6   A0A0L7KQB6   A0A0G2RLW6   A0A194QYW8   A0A212F886   A0A0L7LKV0   A0A2H1VA55   A5YVX6   A0A194QZT5   A0A2A4JIQ5   A0A194QE79   J3JWB4   U4UHA8   H9J3A9   A0A1Y1MUX2   A0A1W4WN94   A0A1W4WN20   A0A1W4WM34   A0A1W4WC04   A0A0T6BB39   B4H544   Q28X77   A0A0R3NQ30   A0A0R3NWB6   E2AN60   A0A026VXS5   A0A154PQQ9   A0A0R3NVQ4   A0A088ANY0   A0A3L8D4R7   A0A0A7NXB7   A0A195FQK5   A0A3B0JFG0   F4WC87   A0A3B0JKP9   E2BWS6   A0A195C5C4   A0A151XJZ2   Q7QIU7   A0A2A3ES46   A0A1L8E264   A0A195BK61   A0A1J1I7Y3   A0A1J1I989   A0A158N9Y2   A0A1B0CI79   A0A0Q9XGJ7   B4KPZ8   A0A0R1DQK7   B4P590   B4QCX6   A0A0J9RB23   A0A0R1DWG8   A0A1Q3F2V3   A0A0J9RB31   A0A1Q3F2U8   A0A1W4UJA8   B4N602   A0A1W4U6H5   A0A0J9RC20   B0WNY9   A0A0R1DQ79   B4HPK0   A0A0P6IVH7   A0A0L7QN95   A0A232F8H7   K7INU6   A0A0P9AC23   A0A0P8XLY1   A0A0B4LG91   A0A0P8XLW9   Q8WSF3-2   H5V8F4   A0A0B4LF89   Q8WSF3   A0A0Q5W266   A0A0N8NZZ6   A0A0Q5VZG7   B3MEN4   A9UN21   A0A182GY98   B4MDU3   A0A0Q9W0E1   A0A0Q9W9B7   A0A0Q9W007   B3NRZ7   A0A0M4E7X0   A0A084WEE1   A0A336LPK8   A0A336MDZ8  

PDB

3S6T     E-value=7.64911e-95,     Score=888

KEGG

100359364    K20730 beta-hexosaminidase Fdl [EC:3.2.1.52] | (RefSeq) FDL, Bmfdl; fused lobes

PATHWAY

00511    Other glycan degradation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005975   GO:0102148   GO:0016021   GO:0004563   GO:0008152   GO:0006491   GO:0016231   GO:0005886   GO:0006517   GO:0005770   GO:0008375   GO:0007420   GO:0016063   GO:0004553   GO:0005216   GO:0006811   GO:0016020   GO:0043564   GO:0006418   GO:0003824  

Length:

631

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

15.533

Exp number, first 60 AAs:

15.44789

Total prob of N-in:

0.73885

POSSIBLE N-term signal

sequence

inside

1  -  19

TMhelix

20  -  42

outside

43  -  631

 

 

Pi

222.117702

Theta

166.859805

Tajima's D

0.830436

CLR

0.31086

CSRT

0.611669416529174

Interpretation

Uncertain