Gene

KWMTBOMO11651  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003996

Annotation

hexosaminidase_[Danaus_plexippus]

Location

Bomo_Chr19(-):10667903-10669707      View in EpiBrowser

Full name

Beta-hexosaminidase       + More
Probable beta-hexosaminidase fdl      

Alternative Name

Protein fused lobes

Location in the cell

Cytoplasmic   Reliability : 1.438 PlasmaMembrane   Reliability : 1.036

CDS

ATGTTGTGTGCAGGAGGTCAAATTTGGCCTCAACCAAGGGGAGCGATCAGCCTTTCCACAACCGCTGTGCCAGTACACGCTGACTCTTTCAGATTGAAAATATTATTAACTCCATCCCGTACGGTTCAAGAATATCTACAAGAGTCCTTTGAATTATTTCGGGAAGATGTTAAAAGACTCGAACAGTCAGCATTTGGTTTCGAAGAGCGGCGAAGTGTACTCGTCCGGATTGCCATAAATGGTAGTGAAGATCCACGAATGCGTATAGATACTGAAGAAAACTACAAACTTGTAATTCGCCCTAATTCCGATGACGGTTTGATGCTCGTAGATATATCTGCATCTACGTTCTGTGGTGCACGTCATGGCTTAGAAACTTTAATACAATTAATATGGTTTGATCCTTACGTCGCATCACTGTTTATGCTAGAAGCTGCATCAGTTGACGATTCGCCTCGATTCAAATACCGGGGGCTGTTATTAGACACAGCGCGTAATTATTTTCCGGTTCGTGATCTCATGCGAACTATTGATGGTATGGCCATTTCTAAGCTTAACACCTTTCACTGGCATGTAACCGATACCCAAGCATTCCCTTTACAATTAGACAGTGTAAAACATTTATCAAAACGAGGAGCCTACAGTCTGAGAGATGTTTACACAAAAGATGACGTCAGAGCATTAGTGCATCGTGCGAGATTACGTGGGATACGAGTTCTGATAGAAATAGATGTACCATCTCATGTTGGTCCAACCTGGAGTTTCAGTTCAGATTCGGAAACTGATGATCTTTCTTTATGTACCAACGCTCAACCTTGGAGTCCATTATGTCATGAGCCTCCTTGTGGGCAATTAAATCCACGAAACACTGATTTGTTTTTACTTTTAGAGCAAGTTTTTACAGAAATCATCCAGCTCACTGGAGTCGATGATTTGTTTCACATGGGAGGCGACGATGTGTCACTAGAATGTTGGGAACATTATTTCAATGATACTAACAGTGAAAACTATTTGATAGAATTTACCCGGTCTTCGTTAGATCGGCTACGCTATGTCAATGGCCGATTACCCAATCTAACATTATTTTGGTTTTCTTCCATAAGCGACCGTATCAAGACTGATTTGAAAGAGTCCGCGGACTTTATAGGTTTGCAGTTACGAGAATTCACATGGAAACATAAGTCTATTAATGGAATACGAACAGTCATTTCACACGAAGACGCATGGGACCTGAATAATGGAATGGGAGCTTGGTATGACACTAATGGTGGTATCCCTTACAATTCATGGCAACATGTGTATGAACACCGGCCATGGGCGAAAGATGTCGCTAATATAGAAGGAGGGGAGGCAACAGTTTGGTCCTCGACTTTAAGTGATGATGATCTCGATGCCACGGTGTGGCCTAGGGCGGCTGCTTTAGCAGAAAGACTATGGACAGACCGTGCCGAAGGCGCGACCCGTCCGGTACATGCGAGGTTAGATTTGCATCGCTCTCGGTTGGTTGCGCGGGGTCTAAAAGCAGCACCTATATGGTCTATGTGGTGCACTCAAAACCCTTACACGTGTTAA

Protein

MLCAGGQIWPQPRGAISLSTTAVPVHADSFRLKILLTPSRTVQEYLQESFELFREDVKRLEQSAFGFEERRSVLVRIAINGSEDPRMRIDTEENYKLVIRPNSDDGLMLVDISASTFCGARHGLETLIQLIWFDPYVASLFMLEAASVDDSPRFKYRGLLLDTARNYFPVRDLMRTIDGMAISKLNTFHWHVTDTQAFPLQLDSVKHLSKRGAYSLRDVYTKDDVRALVHRARLRGIRVLIEIDVPSHVGPTWSFSSDSETDDLSLCTNAQPWSPLCHEPPCGQLNPRNTDLFLLLEQVFTEIIQLTGVDDLFHMGGDDVSLECWEHYFNDTNSENYLIEFTRSSLDRLRYVNGRLPNLTLFWFSSISDRIKTDLKESADFIGLQLREFTWKHKSINGIRTVISHEDAWDLNNGMGAWYDTNGGIPYNSWQHVYEHRPWAKDVANIEGGEATVWSSTLSDDDLDATVWPRAAALAERLWTDRAEGATRPVHARLDLHRSRLVARGLKAAPIWSMWCTQNPYTC

Description

Involved in brain restructurization via hormonal control during metamorphosis. Implicated in N-glycan processing.

Catalytic Activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Similarity

Belongs to the glycosyl hydrolase 20 family.

Keywords

Alternative splicing   Complete proteome   Developmental protein   Glycoprotein   Glycosidase   Hydrolase   Reference proteome   Signal  

Feature

chain  Beta-hexosaminidase
splice variant  In isoform B.

Uniprot

H9J3A9   A0A2A4JIQ5   A0A212F886   A0A2H1VA55   A0A194QZT5   A0A194QE79   + More
A0A0L7LKV0   D6PW84   A0A212FNK4   D3GGI9   A0A3S2NQV5   A0A0L7LFG8   D3GGI8   E1CG96   B1P868   A0A194QCU8   A0A0L7KQB6   D3GGI7   A0A2A4JAM6   A0A0G2RLW6   A0A194QYW8   A5YVX6   J3JWB4   A0A1Y1MUX2   U4UHA8   A0A1W4WN94   A0A1W4WN20   A0A1W4WM34   A0A1W4WC04   A0A1L8E264   A0A1B0CI79   Q7QIU7   A0A0T6BB39   B4H544   A0A0R3NQ30   A0A3B0JFG0   A0A0R3NWB6   Q28X77   A0A0R3NVQ4   A0A3B0JKP9   B3MEN3   A0A182YEG5   A0A0P8XLW9   A0A0P9AC23   A0A0P8XLY1   B3MEN4   A0A182M0G9   A0A0N8NZZ6   A0A1W4UJA8   A0A1W4U6H5   A0A084WEE1   A0A0M4E7X0   A0A182WLD9   A0A182QIR3   B0WNY9   A0A1J1I989   A0A182UPQ2   A0A1J1I7Y3   A0A182TXY9   A0A182NJB7   A0A2P8Y7F7   A0A182JNH4   A0A182GY98   A0A182KQ83   A0A182I2E2   A0A182WWU6   A0A1Q3F2V3   A0A182PVM6   A0A182R4K8   A0A1Q3F2U8   A0A336MDZ8   A0A336LPK8   B4N602   A0A0L0C5J2   A0A0J9RB23   A0A0J9RB31   A0A1I8NSX2   B4QCX6   A0A1I8NSW4   A0A0R1DWG8   A0A0R1DQK7   A0A0J9RC20   B4P590   B4HPK0   B4KPZ8   A0A0Q9XGJ7   B4MDU3   A0A0Q5W266   A0A0Q5VZG7   K7INU6   Q8WSF3-2   B4J887   A0A0B4LG91   A0A0Q9W0E1   A0A0R1DQ79   A0A0B4LF89   Q8WSF3   H5V8F4   A0A0Q9W007   A0A232F8H7  

EC Number

3.2.1.52

Pubmed

19121390    22118469    26354079    26227816    20547376    18303021    + More
18342252    18362917    19820115    22516182    28004739    23537049    12364791    17994087    15632085    25244985    18057021    24438588    29403074    26483478    20966253    26108605    22936249    17550304    20075255    10623899    10731132    12537572    12537569    12537568    12537573    12537574    16110336    17569856    17569867    28648823   

EMBL

BABH01021684    NWSH01001413    PCG71313.1    AGBW02009781    OWR49928.1    ODYU01001276    + More
SOQ37272.1    KQ460949    KPJ10490.1    KQ459185    KPJ03250.1    JTDY01000705    KOB76153.1    GU984637    ADF97235.1    AGBW02005277    OWR55318.1    BABH01021699    BABH01021700    FJ695481    ACV89847.1    RSAL01000352    RVE42263.1    JTDY01001324    KOB74197.1    FJ695480    ACV89846.1    AB540233    BAJ20189.1    EU334747    ODYU01005953    ACA30398.1    SOQ47378.1    KPJ03244.1    JTDY01007043    KOB65498.1    FJ695479    ACV89845.1    NWSH01002205    PCG68909.1    KP000851    AJG44546.1    KPJ10484.1    EF592539    KQ971354    ABQ95985.1    EFA06836.2    BT127532    AEE62494.1    GEZM01019981    JAV89483.1    KB632326    ERL92397.1    GFDF01001338    JAV12746.1    AJWK01013083    AAAB01008807    EAA03943.4    LJIG01002462    KRT84478.1    CH479210    EDW32880.1    CM000071    KRT03108.1    OUUW01000001    SPP74050.1    KRT03107.1    EAL26439.2    KRT03109.1    SPP74049.1    CH902619    EDV35497.2    KPU75704.1    KPU75705.1    KPU75706.1    EDV35498.2    AXCM01013128    KPU75708.1    ATLV01023205    KE525341    KFB48585.1    CP012524    ALC40696.1    AXCN02000449    DS232017    EDS32008.1    CVRI01000043    CRK96298.1    CRK96299.1    PYGN01000845    PSN40104.1    JXUM01097258    JXUM01097259    JXUM01097260    JXUM01097261    APCN01000152    GFDL01013164    JAV21881.1    GFDL01013165    JAV21880.1    UFQT01001050    SSX28632.1    UFQS01000102    UFQT01000102    SSW99622.1    SSX20002.1    CH964154    EDW79791.2    JRES01000960    KNC26699.1    CM002911    KMY93226.1    KMY93227.1    CM000362    EDX06787.1    KMY93230.1    CM000158    KRJ99443.1    KRJ99444.1    KMY93229.1    EDW90752.2    CH480816    EDW47584.1    CH933808    EDW08100.1    KRG03902.1    CH940662    EDW58708.1    CH954179    KQS62831.1    KQS62830.1    AF323977    AE013599    AY113418    AY061037    AAL28585.1    AAL55992.1    AAM29423.1    CH916367    EDW01224.1    AHN56149.1    KRF78418.1    KRJ99445.1    AHN56148.1    BT133255    AFC17499.1    KRF78419.1    NNAY01000660    OXU27126.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000037510    + More
UP000283053    UP000007266    UP000030742    UP000192223    UP000092461    UP000007062    UP000008744    UP000001819    UP000268350    UP000007801    UP000076408    UP000075883    UP000192221    UP000030765    UP000092553    UP000075920    UP000075886    UP000002320    UP000183832    UP000075903    UP000075902    UP000075884    UP000245037    UP000075881    UP000069940    UP000075882    UP000075840    UP000076407    UP000075885    UP000075900    UP000007798    UP000037069    UP000095300    UP000000304    UP000002282    UP000001292    UP000009192    UP000008792    UP000008711    UP000002358    UP000000803    UP000001070    UP000215335   

PRIDE

H9J3A9    D3GGI9    D3GGI8    E1CG96    D3GGI7    Q8WSF3    + More
H5V8F4   

Pfam

PF14845   Glycohydro_20b2        + More
PF00728   Glyco_hydro_20
PF01490   Aa_trans

Interpro

IPR029019   HEX_eukaryotic_N        + More
IPR015883   Glyco_hydro_20_cat       
IPR029018   Hex-like_dom2       
IPR025705   Beta_hexosaminidase_sua/sub       
IPR017853   Glycoside_hydrolase_SF       
IPR013057   AA_transpt_TM       

SUPFAM

SSF51445   SSF51445        + More
SSF55545   SSF55545       

Gene 3D

3.30.379.10    

ProteinModelPortal

H9J3A9   A0A2A4JIQ5   A0A212F886   A0A2H1VA55   A0A194QZT5   A0A194QE79   + More
A0A0L7LKV0   D6PW84   A0A212FNK4   D3GGI9   A0A3S2NQV5   A0A0L7LFG8   D3GGI8   E1CG96   B1P868   A0A194QCU8   A0A0L7KQB6   D3GGI7   A0A2A4JAM6   A0A0G2RLW6   A0A194QYW8   A5YVX6   J3JWB4   A0A1Y1MUX2   U4UHA8   A0A1W4WN94   A0A1W4WN20   A0A1W4WM34   A0A1W4WC04   A0A1L8E264   A0A1B0CI79   Q7QIU7   A0A0T6BB39   B4H544   A0A0R3NQ30   A0A3B0JFG0   A0A0R3NWB6   Q28X77   A0A0R3NVQ4   A0A3B0JKP9   B3MEN3   A0A182YEG5   A0A0P8XLW9   A0A0P9AC23   A0A0P8XLY1   B3MEN4   A0A182M0G9   A0A0N8NZZ6   A0A1W4UJA8   A0A1W4U6H5   A0A084WEE1   A0A0M4E7X0   A0A182WLD9   A0A182QIR3   B0WNY9   A0A1J1I989   A0A182UPQ2   A0A1J1I7Y3   A0A182TXY9   A0A182NJB7   A0A2P8Y7F7   A0A182JNH4   A0A182GY98   A0A182KQ83   A0A182I2E2   A0A182WWU6   A0A1Q3F2V3   A0A182PVM6   A0A182R4K8   A0A1Q3F2U8   A0A336MDZ8   A0A336LPK8   B4N602   A0A0L0C5J2   A0A0J9RB23   A0A0J9RB31   A0A1I8NSX2   B4QCX6   A0A1I8NSW4   A0A0R1DWG8   A0A0R1DQK7   A0A0J9RC20   B4P590   B4HPK0   B4KPZ8   A0A0Q9XGJ7   B4MDU3   A0A0Q5W266   A0A0Q5VZG7   K7INU6   Q8WSF3-2   B4J887   A0A0B4LG91   A0A0Q9W0E1   A0A0R1DQ79   A0A0B4LF89   Q8WSF3   H5V8F4   A0A0Q9W007   A0A232F8H7  

PDB

3S6T     E-value=9.08887e-78,     Score=740

KEGG

101741195    K20730 beta-hexosaminidase Fdl [EC:3.2.1.52] | (RefSeq) probable beta-hexosaminidase fdl

PATHWAY

00511    Other glycan degradation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004563   GO:0102148   GO:0005975   GO:0016021   GO:0008152   GO:0006491   GO:0016231   GO:0005886   GO:0006517   GO:0005770   GO:0008375   GO:0007420   GO:0016063   GO:0004553   GO:0005216   GO:0006811   GO:0016020   GO:0043564   GO:0006418   GO:0003824  

Length:

523

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01394

Exp number, first 60 AAs:

0.00277

Total prob of N-in:

0.00108

outside

1  -  523

 

 

Pi

63.621355

Theta

148.694248

Tajima's D

-0.916425

CLR

0

CSRT

0.152892355382231

Interpretation

Uncertain