Gene

KWMTBOMO11646  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004000

Annotation

alpha-N-acetylgalactosaminidase_precursor_[Bombyx_mori]

Location

Bomo_Chr19(-):10456652-10471292      View in EpiBrowser

Full name

Alpha-galactosidase      

Location in the cell

Cytoplasmic   Reliability : 2.502

CDS

ATGATAAGGTTGATTTTAGTTTTTTTAACAATATCGCACAGCTACGCCTTGAATAATGGATTAGCAATGACACCACCAATGGGCTGGCTGACATGGGAACGTTTTAGGTGTATAACCGACTGCGAGAAATATCCTAACGAATGCATAAGCGAGAGCCTAATAAAAAGGACAGCAGATTTGATGGTCAGCGAAGGATATCTAGATGCAGGATATGAATATTTAGGTATCGACGATTGTTGGTTAGAGAAGACACGCGATGATAAAGGTCGGCTGGTACCCGACAGGAAACGATTTCCAAATGGGATGAAGGCCATAGCTGATTATATCCACAGCAAAGGCTTAAAGTTCGGCATGTACGAAGATTATGGAAACCTCACATGTGCCGGTTACCCCGGGGTGCTTGGAAACGAAAAAATCGATATCAACACATTTGTCGAATGGGAAATCGATTATTTGAAGCTCGATGGATGTTATATTGACCCGATACAAATGGATAAAGGCTATCCAGACTTCGGTAAATTGTTGAACGCTACTGGACGATCCATCTTGTACTCCTGTAGCTGGCCAGCATATCAAGAGGAAAAAAAGATATTGCCAAACTATGCATCGATAGCAGAGCACTGTAACCTTTGGCGCAATTATGATGATATAGAAGACTCTTGGGCATCTCTTACGAAGATCATGGCCTGGTTTGGTGACAACCAGGACAGGCTTGCTCAGCACGCCGGGCCTGGACACTGGAACGACCCTGATATGTTACTAATTGGCAACTTCGGTCTATCGGTGGACCAAGCTAAAGTACAAATGGCTGTTTGGGCGATCCTAGCAGCACCGCTTCTGATCAGTACTGATTTGGCAACGATAAGGCCAGAATTCAAACAAATATTACTGAACAGAGACATTATAGCCGTCAACCAAGACAAATTGGGTAAACAAGGATTGCGTGTTTGGAAAAAAATGGGATCTGGATCCAGGTCCAAATTAGAGATATGGAAAAGAGAACTTTATGACGGTTCCTTTGCTATGGCATTTGTGAGTTATCGGGACGATGGAATACCTTACGCAGCCAAATTTACGTATTATGACATGCAATTACCTCAGTCGGAGTTTGAAGTACAGGACTTGTACAAAGAAGAAGAAGTTCGGTCATGGGATGGCACAAGCGACTTCGAAGTTCGGATTAACCCTTCTGGAGTTAAATTTTACAAATTCATTAGCAAAAAATCTATGTCGGAGATTTTGGATATAACAGTAAAAATGATTGTGAAGAATCAAGTGTGTAATTAG

Protein

MIRLILVFLTISHSYALNNGLAMTPPMGWLTWERFRCITDCEKYPNECISESLIKRTADLMVSEGYLDAGYEYLGIDDCWLEKTRDDKGRLVPDRKRFPNGMKAIADYIHSKGLKFGMYEDYGNLTCAGYPGVLGNEKIDINTFVEWEIDYLKLDGCYIDPIQMDKGYPDFGKLLNATGRSILYSCSWPAYQEEKKILPNYASIAEHCNLWRNYDDIEDSWASLTKIMAWFGDNQDRLAQHAGPGHWNDPDMLLIGNFGLSVDQAKVQMAVWAILAAPLLISTDLATIRPEFKQILLNRDIIAVNQDKLGKQGLRVWKKMGSGSRSKLEIWKRELYDGSFAMAFVSYRDDGIPYAAKFTYYDMQLPQSEFEVQDLYKEEEVRSWDGTSDFEVRINPSGVKFYKFISKKSMSEILDITVKMIVKNQVCN

Subunit

Homodimer.

Similarity

Belongs to the glycosyl hydrolase 27 family.

Feature

chain  Alpha-galactosidase

Uniprot

Q2F5Z9   A0A2H1VKD1   A0A2A4JM48   A0A212FA86   A0A194QIH9   A0A2A4JM49   + More
A0A2A4JKI6   A0A1I8N189   Q7K127   B4HSW9   B3NPJ7   B4QHX7   B4P682   A0A1I8PUH1   W8B716   A0A1W4UXD8   A0A034VJ62   A0A0L0C4I6   A0A0K8WDV6   A0A0A1X480   B3MFN5   Q291S9   D1ZZP5   A0A1B0AF32   B4MPF1   A0A0K8TAY4   B4MFP7   A0A3B0IZ83   A0A1B6FU31   A0A067RL82   A0A2J7Q6R5   Q17A03   A0A1L8DR08   A0A182Q255   A0A1L8DQP1   A0A2P8ZLY1   A0A182IPD0   B4J8F0   A0A1Q3G451   A0A1L8DQU5   A0A182MV14   A0A182VNL1   T1PFY5   A0A1L8DQP5   A0A1Q3G433   A0A182Y8D8   B4GAB8   A0A182L619   Q7Q1V0   A0A2S2QTQ5   A0A224XQS0   A0A182ICP7   A0A084VNI9   A0A2M4BML2   T1HM73   A0A2M4AC36   A0A2M3Z177   A0A2M4ACK0   A0A2M4DMQ3   A0A2M4DMN4   A0A1A9X4X6   A0A2M4DMS1   A0A1B6M6K3   A0A1A9XWH4   A0A1J1IRP1   B3MPM5   A0A151WST7   A0A195BWB5   A0A195CCG6   A0A026WYH3   J9K999   B4M8H2   A0A158NE94   A0A1W4UUS4   B4KRT1   B4NZ59   Q9VL27   J3JUA1   A0A336M9C7   Q8MYY3   A0A195FQA7   B3N935   J9JRF8   B4JP37   B4HWH1   B4Q8Q4   A0A1J1HJ44   F4WJD6   A0A1A9VU43   A0A1B0FRD5   A0A2S2ND41   A0A1A9UT81   A0A1A9ZVN6   T1HJA0   A0A151J0R5   A0A1Y1M843   A0A0L7QQI1   U4UPP5   B4G7B6   A0A1A9WLA3  

EC Number

3.2.1.-

Pubmed

22118469    26354079    25315136    10731132    12537568    12537572    + More
12537573    12537574    16110336    17569856    17569867    26109357    26109356    17994087    22936249    17550304    24495485    25348373    26108605    25830018    18057021    15632085    23185243    18362917    19820115    24845553    17510324    29403074    25244985    20966253    12364791    24438588    24508170    21347285    22516182    21719571    28004739    23537049   

EMBL

DQ311273    ABD36218.1    ODYU01003025    SOQ41275.1    NWSH01001127    PCG72472.1    + More
AGBW02009513    OWR50638.1    KQ459185    KPJ03256.1    PCG72470.1    PCG72471.1    AE013599    AY069427    AAF58008.2    AAL39572.1    CH480816    EDW48133.1    CH954179    EDV55764.1    CM000362    CM002911    EDX07348.1    KMY94252.1    CM000158    EDW91932.1    GAMC01009600    JAB96955.1    GAKP01016413    JAC42539.1    JRES01000930    KNC27200.1    GDHF01006436    GDHF01002966    JAI45878.1    JAI49348.1    GBXI01008395    JAD05897.1    CH902619    EDV37725.1    KPU77002.1    CM000071    EAL25033.2    KRT01803.1    KQ971338    EFA01818.1    CH963849    EDW73990.1    GBRD01003152    GBRD01003151    JAG62669.1    CH940667    EDW57218.1    KRF77681.1    OUUW01000001    SPP73435.1    GECZ01016138    GECZ01015544    JAS53631.1    JAS54225.1    KK852444    KDR23773.1    NEVH01017454    PNF24276.1    CH477342    EAT43068.1    GFDF01005314    JAV08770.1    AXCN02000647    GFDF01005311    JAV08773.1    PYGN01000019    PSN57511.1    CH916367    EDW02309.1    GFDL01000468    JAV34577.1    GFDF01005313    JAV08771.1    AXCM01001912    KA647732    AFP62361.1    GFDF01005312    JAV08772.1    GFDL01000485    JAV34560.1    CH479181    EDW31870.1    AAAB01008980    EAA14548.3    GGMS01011299    GGMS01014174    MBY80502.1    MBY83377.1    GFTR01006107    JAW10319.1    APCN01005736    ATLV01014759    KE524984    KFB39533.1    GGFJ01005176    MBW54317.1    ACPB03002860    GGFK01004999    MBW38320.1    GGFM01001531    MBW22282.1    GGFK01005007    MBW38328.1    GGFL01014654    MBW78832.1    GGFL01014652    MBW78830.1    GGFL01014653    MBW78831.1    GEBQ01008421    JAT31556.1    CVRI01000058    CRL02887.1    CH902620    EDV32273.1    KQ982769    KYQ50857.1    KQ976401    KYM92575.1    KQ978023    KYM97921.1    KK107079    EZA60164.1    ABLF02030053    CH940654    EDW57498.2    ADTU01013175    CH933808    EDW08351.1    CM000157    EDW88754.1    AE014134    BT044084    AAF52871.2    ACH92149.1    BT126814    AEE61776.1    UFQS01000272    UFQT01000272    SSX02272.1    SSX22648.1    AY113489    AAM29494.1    KQ981335    KYN42658.1    CH954177    EDV58470.2    ABLF02027051    ABLF02027053    CH916372    EDV99462.1    CH480818    EDW52366.1    CM000361    CM002910    EDX04469.1    KMY89418.1    CVRI01000001    CRK86297.1    GL888182    EGI65714.1    CCAG010015025    GGMR01002419    MBY15038.1    ACPB03006489    KQ980636    KYN14937.1    GEZM01037887    JAV81864.1    KQ414786    KOC60877.1    KB632308    ERL91995.1    CH479180    EDW28370.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000095301    UP000000803    UP000001292    + More
UP000008711    UP000000304    UP000002282    UP000095300    UP000192221    UP000037069    UP000007801    UP000001819    UP000007266    UP000092445    UP000007798    UP000008792    UP000268350    UP000027135    UP000235965    UP000008820    UP000075886    UP000245037    UP000075880    UP000001070    UP000075883    UP000075903    UP000076408    UP000008744    UP000075882    UP000007062    UP000075840    UP000030765    UP000015103    UP000091820    UP000092443    UP000183832    UP000075809    UP000078540    UP000078542    UP000053097    UP000007819    UP000005205    UP000009192    UP000078541    UP000007755    UP000078200    UP000092444    UP000078492    UP000053825    UP000030742   

PRIDE

Q2F5Z9    Q7K127    Q8MYY3   

Pfam

PF16499   Melibiase_2        + More
PF17450   Melibiase_2_C
PF00307   CH
PF00402   Calponin

Interpro

IPR017853   Glycoside_hydrolase_SF        + More
IPR035373   Melibiase/NAGA_C       
IPR013780   Glyco_hydro_b       
IPR000111   Glyco_hydro_27/36_CS       
IPR002241   Glyco_hydro_27       
IPR013785   Aldolase_TIM       
IPR001715   CH-domain       
IPR036872   CH_dom_sf       
IPR000557   Calponin_repeat       

SUPFAM

SSF51445   SSF51445        + More
SSF47576   SSF47576       

Gene 3D

2.60.40.1180     3.20.20.70     1.10.418.10    

CDD

cd14792  GH27
cd00014  CH

ProteinModelPortal

Q2F5Z9   A0A2H1VKD1   A0A2A4JM48   A0A212FA86   A0A194QIH9   A0A2A4JM49   + More
A0A2A4JKI6   A0A1I8N189   Q7K127   B4HSW9   B3NPJ7   B4QHX7   B4P682   A0A1I8PUH1   W8B716   A0A1W4UXD8   A0A034VJ62   A0A0L0C4I6   A0A0K8WDV6   A0A0A1X480   B3MFN5   Q291S9   D1ZZP5   A0A1B0AF32   B4MPF1   A0A0K8TAY4   B4MFP7   A0A3B0IZ83   A0A1B6FU31   A0A067RL82   A0A2J7Q6R5   Q17A03   A0A1L8DR08   A0A182Q255   A0A1L8DQP1   A0A2P8ZLY1   A0A182IPD0   B4J8F0   A0A1Q3G451   A0A1L8DQU5   A0A182MV14   A0A182VNL1   T1PFY5   A0A1L8DQP5   A0A1Q3G433   A0A182Y8D8   B4GAB8   A0A182L619   Q7Q1V0   A0A2S2QTQ5   A0A224XQS0   A0A182ICP7   A0A084VNI9   A0A2M4BML2   T1HM73   A0A2M4AC36   A0A2M3Z177   A0A2M4ACK0   A0A2M4DMQ3   A0A2M4DMN4   A0A1A9X4X6   A0A2M4DMS1   A0A1B6M6K3   A0A1A9XWH4   A0A1J1IRP1   B3MPM5   A0A151WST7   A0A195BWB5   A0A195CCG6   A0A026WYH3   J9K999   B4M8H2   A0A158NE94   A0A1W4UUS4   B4KRT1   B4NZ59   Q9VL27   J3JUA1   A0A336M9C7   Q8MYY3   A0A195FQA7   B3N935   J9JRF8   B4JP37   B4HWH1   B4Q8Q4   A0A1J1HJ44   F4WJD6   A0A1A9VU43   A0A1B0FRD5   A0A2S2ND41   A0A1A9UT81   A0A1A9ZVN6   T1HJA0   A0A151J0R5   A0A1Y1M843   A0A0L7QQI1   U4UPP5   B4G7B6   A0A1A9WLA3  

PDB

1KTC     E-value=6.06757e-116,     Score=1068

KEGG

692881    K01189 alpha-galactosidase [EC:3.2.1.22] | (RefSeq) alpha-N-acetylgalactosaminidase

PATHWAY

00052    Galactose metabolism - Bombyx mori (domestic silkworm)
00561    Glycerolipid metabolism - Bombyx mori (domestic silkworm)
00600    Sphingolipid metabolism - Bombyx mori (domestic silkworm)
00603    Glycosphingolipid biosynthesis - globo and isoglobo series - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0005975   GO:0004553   GO:0016021   GO:0005737   GO:0009311   GO:0016139   GO:0004557   GO:0046477   GO:0003824   GO:0008152   GO:0005216   GO:0006811   GO:0016020   GO:0043564   GO:0006418  

PANTHER

PTHR11452  

SignalP

Position:   1 - 16,         Likelihood:  0.989151

 

 

Length:

428

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.24901

Exp number, first 60 AAs:

1.04202

Total prob of N-in:

0.04998

outside

1  -  428

 

 

Pi

27.92622

Theta

22.541395

Tajima's D

-0.642981

CLR

0.720347

CSRT

0.207389630518474

Interpretation

Uncertain