Silkworm Genome Informatics Database

Gene

KWMTBOMO11645 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004001

Annotation

3-hydroxy-3-methylglutaryl-CoA_synthase_[Bombyx_mori]

Location

Bomo_Chr19(-):10453032-10454662 View in EpiBrowser

Full name

3-hydroxy-3-methylglutaryl coenzyme A synthase + More
Hydroxymethylglutaryl-CoA synthase 1

Alternative Name

3-hydroxy-3-methylglutaryl coenzyme A synthase 1

Location in the cell

Cytoplasmic Reliability : 1.84

CDS

ATGGGCGGAAAAGTTGAGAATGTAGGCATACTCGCCATGGAACTTTATTTCCCGTCGCAATACGTTGATCAGACTGAACTAGAAAAATTTGATGAGGTGTCTACTGGCAAGTACACTATTGGTTTGGGCCAGAGTAAAATGGGTTTCTGTTCTGATCGTGAAGACATCAATTCTATTTGTCTCACAGCCTTGCACAGACTAATTGACAAACAAAAGATCAACTTGCATGATATTGGACGCTTGGAGGTGGGCACAGAAACTATAATTGATAAAAGTAAGAGTGTTAAGACATTTTTGATGACATTGTTTGCTAAAGAAGGCGCTACTGACATAGAAGGAATAGATACAACTAATGCCTGTTATGGTGGCACTGCTGCTCTCTTTAATGCCATAAATTGGGTAGAATCTTCATCCTGGGATGGCAGGAAGGCCATAGTTGTTGCTGGTGACATTGCTGTCTATGGAAAGGGCCCTGCGAGACCTACAGGTGGTGCTGGTGCTGTTGCTATGTTGATAGGGCCTGATGCACCCCTTGTGTTTGATTGTGGAGTGCGGGCTTCATACATGACACATGCATATGACTTTTACAAGCCAGATTTATCATCAGAGTTTCCTTATGTAGATGGAAAACTATCCATACAGTGTTACCTCAATGCTTTAGATAATTGTTATAATTTATTTAGTAAAAAAATGAGAAAGACTGATCCTAACTTCAAAGGTTTGCTTAGTTTAGATGGTATGTTATTTCACTCTCCGTACTGTAAACTCGTTCAAAAATCATTAGCAAGAGTGTGCTTCAATGATTTTCTGAATATACCTGCTGAGGAACGTGAGAAACAATTTCCTGGGCTCTCCGAGTTTAGTAATCATAAATTAGAAGATACTTACTTTGATAGGGAAGTTGAAAAAGCATTTATGACATATAGCTTAAGTTTATTTGAGGAGAAAACAAAACCTTCTCTTCATATTGCACGTAATGTTGGTAATATGTACACACCATCATTATACGGAGGTCTTGTGTCTTATTTGATAAGCAAATCTCCAGATCAGTTAATTGGGAAGAAGTTTGCTTTGTTTTCATACGGTTCAGGATTGGCATCGACAATGTATTCCATAAATGTATGTCATGACATGAGTACTGGATCAAAGTTAGAAAAGCTTATCTCCTCATTACATGAAACAGTTGCTTTACTGGATAAAAGGCAGAGTGTGGAACCCAGTAAGTTTTCAGACATAATGGATGTTAGAACTAAAAATTATCATTCCGCACCATATGAGCCTACTGGTTCTTTAGATGTCCTGTTCCCAGGAACATATTACCTTGTGAAAATAGATGATCAGAGAAGGCGTACTTATGATAGGAAACATTAA

Protein

MGGKVENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAALFNAINWVESSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAPLVFDCGVRASYMTHAYDFYKPDLSSEFPYVDGKLSIQCYLNALDNCYNLFSKKMRKTDPNFKGLLSLDGMLFHSPYCKLVQKSLARVCFNDFLNIPAEEREKQFPGLSEFSNHKLEDTYFDREVEKAFMTYSLSLFEEKTKPSLHIARNVGNMYTPSLYGGLVSYLISKSPDQLIGKKFALFSYGSGLASTMYSINVCHDMSTGSKLEKLISSLHETVALLDKRQSVEPSKFSDIMDVRTKNYHSAPYEPTGSLDVLFPGTYYLVKIDDQRRRTYDRKH

Description

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

Catalytic Activity

acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)

Similarity

Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

Keywords

Lipid biosynthesis Lipid metabolism Steroid biosynthesis Steroid metabolism Sterol biosynthesis Sterol metabolism Transferase

Feature

chain Hydroxymethylglutaryl-CoA synthase 1

Uniprot

A5A798 S4PXF1 A0A194QYF5 A0A194QCR2 A0A2H4UZK8 A0A2A4JK71 + More
A0A212FA99 A0A0L7L7C1 A0A1Z2RRK3 A0A3R7QP60 A0A182MTP9 B4KRT0 T1PFL3 A0A0L0C4L8 A0A1B0D5Z8 A0A182K882 A0A182UVP9 A0A182WLA7 B3MFN4 A0A1B1UZE6 A0A2J7PJ15 A0A0P4WH43 A0A182KPZ4 A0A182P2V5 Q7K4Q9 A0A1I8NV17 A0A182XMD4 Q7Q6H2 A0A182SSX9 A0A182U419 A0A182I268 A0A182RZ09 A0A182FHK8 A0A0M4EJP1 B4HSW8 D6WTE1 W5J493 A0A336M0B0 A0A182YJ82 A0A0A1XAN4 A0A2M3Z663 B4GAB9 A0A0H4J592 A0A0J9U3K7 Q291S8 A0A084WE91 A0A182INR2 A0A0K8U0N4 A0A182QPL2 Q3YMU3 A0A2M4ADM2 A0A2M4BMI2 A0A2M4ADR9 B4MFP6 B4P683 A0A1W4UXD3 D3TNU7 A0A1A9VU47 B4MPF2 B0W3P9 A0A1B0FZZ3 A0A182NJE8 A0A2M3Z619 B3NPJ8 A0A034W9T2 A0A1Q3FHG2 P54961 A0A1A9XWH6 A0A2J7Q3C5 A0A2P8YLN7 A0A1A9X4X4 A0A3B0J2Q9 W8B3Y5 Q17AU0 A0A182H7D3 A0A232F701 K7J490 A0A067QWL5 B4J8F1 A0A1B6EG97 A0A1L8DYU3 A0A1L8DYU1 A0A023ETR7 A0A3B4CVB9 A0A3B4CV79 A0A3B4CX05 A0A2D0SSG9 W5UBM5 A0A3B4EBA1 A0A067QZJ3 A0A3B4Z3T1 Q7ZWE2 A0A2D4NMQ5 A0A2C9JHT6 A0A0B8RYL6 V8PGS5 A0A3B1K1Z9 A0A3B1IPM8 A0A3B4VIK7 A0A0R4IQG1

EC Number

2.3.3.10

Pubmed

17628279 19121390 23622113 26354079 29185447 22118469 + More
26227816 28605547 17994087 18057021 25315136 26108605 20966253 10731132 12537568 12537572 12537573 12537574 15917496 16110336 17569856 17569867 26109357 26109356 12364791 14747013 17210077 18362917 19820115 20920257 23761445 25244985 25830018 26899871 22936249 15632085 23185243 24438588 17550304 20353571 25348373 7901012 29403074 24495485 17510324 26483478 28648823 20075255 24845553 24945155 23127152 15562597 25476704 24297900 25329095 23594743

EMBL

BABH01021673 AB274989 BAF62107.1 GAIX01005148 JAA87412.1 KQ460949 + More
KPJ10497.1 KQ459185 KPJ03257.1 KY971767 AUA18034.1 NWSH01001127 PCG72475.1 AGBW02009513 OWR50639.1 JTDY01002454 KOB71378.1 KY938837 ASA46478.1 QCYY01002017 ROT73592.1 AXCM01007911 CH933808 EDW08350.1 KA647592 AFP62221.1 JRES01000930 KNC27202.1 AJVK01011892 AJVK01011893 AJVK01011894 CH902619 EDV37724.1 KPU77000.1 KX428478 ANW09589.1 NEVH01024952 PNF16335.1 GDRN01061875 JAI65151.1 AE013599 AY051743 DQ062782 AAF58009.1 AAK93167.1 AAY56655.1 AAAB01008960 EAA11950.3 APCN01000126 CP012524 ALC41505.1 CH480816 EDW48132.1 KQ971352 EFA06304.1 ADMH02002096 ETN59247.1 UFQS01000243 UFQS01000465 UFQT01000243 UFQT01000465 SSX01906.1 SSX04229.1 SSX22283.1 GBXI01016889 GBXI01005963 GBXI01005496 JAC97402.1 JAD08329.1 JAD08796.1 GGFM01003187 MBW23938.1 CH479181 EDW31871.1 KP689335 AKO63317.1 CM002911 KMY94250.1 CM000071 EAL25034.1 KRT01804.1 ATLV01023195 KE525341 KFB48535.1 GDHF01032035 GDHF01029515 GDHF01011154 GDHF01010481 GDHF01008926 GDHF01007390 JAI20279.1 JAI22799.1 JAI41160.1 JAI41833.1 JAI43388.1 JAI44924.1 AXCN02000446 DQ062783 AAY56656.1 GGFK01005565 MBW38886.1 GGFJ01005010 MBW54151.1 GGFK01005569 MBW38890.1 CH940667 EDW57217.1 KRF77678.1 CM000158 EDW91933.1 EZ423099 ADD19375.1 CH963849 EDW73991.1 DS231833 EDS32196.1 CCAG010015025 GGFM01003215 MBW23966.1 CH954179 EDV55765.1 GAKP01008065 GAKP01008064 GAKP01008063 GAKP01008062 GAKP01008061 GAKP01008060 JAC50890.1 GFDL01008076 JAV26969.1 X73679 NEVH01019068 PNF23083.1 PYGN01000508 PSN45160.1 OUUW01000001 SPP73432.1 GAMC01014773 GAMC01014772 JAB91783.1 CH477330 EAT43368.1 JXUM01028207 KQ560814 KXJ80783.1 NNAY01000847 OXU26219.1 AAZX01003268 KK852930 KDR13644.1 CH916367 EDW02310.1 GEDC01000341 JAS36957.1 GFDF01002444 JAV11640.1 GFDF01002443 JAV11641.1 GAPW01001322 JAC12276.1 JT410966 AHH39250.1 KK852812 KDR15853.1 BC049456 AAH49456.1 IACN01015026 LAB47007.1 GBSH01001307 JAG67718.1 AZIM01000079 ETE73530.1 BX322605

Proteomes

UP000005204 UP000053240 UP000053268 UP000218220 UP000007151 UP000037510 + More
UP000283509 UP000075883 UP000009192 UP000095301 UP000037069 UP000092462 UP000075881 UP000075903 UP000075920 UP000007801 UP000235965 UP000075882 UP000075885 UP000000803 UP000095300 UP000076407 UP000007062 UP000075901 UP000075902 UP000075840 UP000075900 UP000069272 UP000092553 UP000001292 UP000007266 UP000000673 UP000076408 UP000008744 UP000001819 UP000030765 UP000075880 UP000075886 UP000008792 UP000002282 UP000192221 UP000078200 UP000007798 UP000002320 UP000092444 UP000075884 UP000008711 UP000092443 UP000245037 UP000091820 UP000268350 UP000008820 UP000069940 UP000249989 UP000215335 UP000002358 UP000027135 UP000001070 UP000261440 UP000221080 UP000261360 UP000076420 UP000018467 UP000261420 UP000000437

PRIDE

A5A798 Q7K4Q9 P54961

Pfam

PF01154 HMG_CoA_synt_N + More
PF08540 HMG_CoA_synt_C

Interpro

IPR010122   HMG_CoA_synthase_euk        + More
IPR013746   HMG_CoA_synt_C_dom
IPR013528   HMG_CoA_synth_N
IPR016039   Thiolase-like
IPR000590   HMG_CoA_synt_AS

SUPFAM

SSF53901 SSF53901

Gene 3D

3.40.47.10

ProteinModelPortal

A5A798 S4PXF1 A0A194QYF5 A0A194QCR2 A0A2H4UZK8 A0A2A4JK71 + More
A0A212FA99 A0A0L7L7C1 A0A1Z2RRK3 A0A3R7QP60 A0A182MTP9 B4KRT0 T1PFL3 A0A0L0C4L8 A0A1B0D5Z8 A0A182K882 A0A182UVP9 A0A182WLA7 B3MFN4 A0A1B1UZE6 A0A2J7PJ15 A0A0P4WH43 A0A182KPZ4 A0A182P2V5 Q7K4Q9 A0A1I8NV17 A0A182XMD4 Q7Q6H2 A0A182SSX9 A0A182U419 A0A182I268 A0A182RZ09 A0A182FHK8 A0A0M4EJP1 B4HSW8 D6WTE1 W5J493 A0A336M0B0 A0A182YJ82 A0A0A1XAN4 A0A2M3Z663 B4GAB9 A0A0H4J592 A0A0J9U3K7 Q291S8 A0A084WE91 A0A182INR2 A0A0K8U0N4 A0A182QPL2 Q3YMU3 A0A2M4ADM2 A0A2M4BMI2 A0A2M4ADR9 B4MFP6 B4P683 A0A1W4UXD3 D3TNU7 A0A1A9VU47 B4MPF2 B0W3P9 A0A1B0FZZ3 A0A182NJE8 A0A2M3Z619 B3NPJ8 A0A034W9T2 A0A1Q3FHG2 P54961 A0A1A9XWH6 A0A2J7Q3C5 A0A2P8YLN7 A0A1A9X4X4 A0A3B0J2Q9 W8B3Y5 Q17AU0 A0A182H7D3 A0A232F701 K7J490 A0A067QWL5 B4J8F1 A0A1B6EG97 A0A1L8DYU3 A0A1L8DYU1 A0A023ETR7 A0A3B4CVB9 A0A3B4CV79 A0A3B4CX05 A0A2D0SSG9 W5UBM5 A0A3B4EBA1 A0A067QZJ3 A0A3B4Z3T1 Q7ZWE2 A0A2D4NMQ5 A0A2C9JHT6 A0A0B8RYL6 V8PGS5 A0A3B1K1Z9 A0A3B1IPM8 A0A3B4VIK7 A0A0R4IQG1

PDB

2P8U E-value=9.7903e-162, Score=1463

KEGG

100101203 K01641 hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] | (RefSeq) Hmg-s, Hmg-s_bm; 3-hydroxy-3-meth

PATHWAY

00072    Synthesis and degradation of ketone bodies - Bombyx mori (domestic silkworm)
00280    Valine, leucine and isoleucine degradation - Bombyx mori (domestic silkworm)
00650    Butanoate metabolism - Bombyx mori (domestic silkworm)
00900    Terpenoid backbone biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016126 GO:0008299 GO:0004421 GO:0006084 GO:0010142 GO:0014033 GO:0048703 GO:0014003 GO:0003824 GO:0008152 GO:0005216 GO:0006811 GO:0016020 GO:0043564 GO:0006418

Length:

456

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.74298

Exp number, first 60 AAs:

0.00283

Total prob of N-in:

0.00979

outside

1 - 456

Pi

29.686378

Theta

80.641767

Tajima's D

-1.864429

CLR

461.048469

CSRT

0.0233988300584971

Interpretation

Possibly Positive selection

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics