Gene

KWMTBOMO11631

Pre Gene Modal

BGIBMGA004120

Annotation

PREDICTED:_inhibitor_of_Bruton_tyrosine_kinase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr19(+):10337553-10358756      View in EpiBrowser

Full name

Inhibitor of Bruton tyrosine kinase      

Location in the cell

Nuclear   Reliability : 3.7

CDS

ATGAGTAAACAGAAAGCAGAAGTTGATTGCACATCAAAGTGCAAATCTCGCAACCACGGCCAGGTACTCACAAGTGCAATTACAAAGCGATCAATTAGCGATGAAGCCCTTGCTAGTTTTATCAAGGCCACATGCTCGAATTTTGTCAAGGCTTTTGATAAAGAGGGGCGAACGCCTCTTCACGTAGCAGCCTCTCGAGGCAGGGTTGCACTAATGGAATGGCTGATCAAGCATTCCTCGGAAGCTTTTGCAAATGCCCGAGATCGCGAGTCAGGCTACACGCCTCTCCATAGAAGTATATTTTATGGTCAAATACATGCGGCTGTATCCTTAATGAAAATTGGCTTAAACACCGATATAGTCGACAAGGATGACTACAAGGCGTTAGAGCACGCCATGCTAGACCGGCACTACATGTACGAACACGAAGGCGGTCAGCCCAGCGAGGTGTACGTGTGGGGAAGCAATTCGAACTACACCCTCGGAACGGGTACGCAACAGCAACGCAACACCCCGGAATTGCTCACGTATTTCAGCCGCAATAATTTATCTGTTAAACAGGTCTGCCTCGGTAAGTTTCACAGTGTGTGGCTAACGTCGGGCCCAAATGGGAATGAAGTCTGGTGCTGTGGACAGTGCGGAAGGGCGGGCGGGCCTCACTATACTGCTCTTAGACCCACGCCTTTGAAATTAGCGGAGCCGTGCGTCAGTGTTGCCATAACATTGAACTCAACTGTGCTTCTACTCGAGAGCGGGGCTGTAATTCAGTATACTTTGGACGGCACGGAAAACGTCAGTCAATCGAATACGAAGACGCCATCTTGTATTAAACTGCCTGCGGTGAGGCCCCTCATGAAGCTGTCGGCGCCCCTCGGGGTCCGCGCCGGCCGGACCCACGCCGTGGTCTGGAACAGCCGGGCCGTGTACACGTGGGGCACGAACCTGGGCCAGCTGGGACACCCGCAACAGGACGGAGACATACCAGCGCCTAAACGAGTAATGATATCAATGAACAATAGAGACGAACCCGGACTGGAGTTAGTGGAGACAGGAGACGCGGCCACCGTGTTGACGACGAGTCGAGGCGACGTTTACTTACTGCACAAGTTTATATGCAAAAAAATCGCAATTAAACAAATAAACCTGCGTCAGGTGTGCGTGGAAGCGCGGGTGAGCAACCAAACCGGCTTCACGCGAGTCACCGTGCTGCTACTGACCAACGTCGGACAATTACTGCTCTGGCAAGACACCACTAACCAACTCACAAGATGCGTATTTGGTCTCCAGCATCAAACCATCATAACTCAAGCCGTTCTCACGCACGAAGCTCTGTATTTCACGACTAAGCACGGCGAAGCGTTCGTCGGCTACATATCGCGTAAGACCTCGCCCATAGCTCTATCTCAGCCAATCAGGAAAGAGAAGGAAAGAGACAACAAGAGCACCCTTGTGAAGTTCTTAGAAAAAGGCGACTGTACTTCTGTCAGGATAATGAAAATACCGAATATATATCGTGCCGTCTCTATTGCAGTCGATGGCGAGGGATTAAACTTTGCCTGTCTACAGATCAAACCCACATGCGGCTTGAGGTCTGTGCCGGAACTATCCCCGACGAGTTTGTCGAAGCACATGGAGTCTCTACGCGAAACTGCCGCTGTAGACGACTTACTGCACGACGTTTTGTTTAAAGTAGGCACGAAACTGTATCCCGCCCACATCTACATTATAGCAACGAGCAGTGAATACTTATATAAAATGTATCAAGAGAACCTAACGGACAACAACGAGAAACCAATAATTGCATTAAACAATATCCATCCCGACGTTTTCGATAGAATATTAAAATACACTTACACAGGGACATGCGATGTTGCGGAACTGGGCCCTTGCAGTTTGAAGATTAAAAAGGAAGATGTCATTGGAAAGAAAGATTTGGATGATATTGATATTGAAGTAGATGTTATCGAGAACTCGTCCGAAATATCAGCGTACGAAGTCTACAGCAAACAAAACGAGAAATCGACCAGGAAATCACGTAATCGCCGCAGTACTGACACTCCGACCAGACAAAACTTGTACTGTGACCCCGTAAGGATGGTGCAGGCCGCGGCTAAAAGGCTCCACGTTAAGGGACTACAAAAACTTCTTGATAAGTTCTATTACAGAGATGGCGCTGTGCTTCTCAGAGAAAATGCGACGTCCACAAAAAATGCCCCACTGCATTGGGACCGTGATGCATTCCCAGAACTGGTCGACACTAATGTCTGTTCCAAGGATGGAATGCTAATCTCTGCTCACAAATGTGTTCTAGCAGCCCGTTTGGAATACTTCAATGGGATGTTTATGCATTCTTGGACCGAGAGCAAGCTGCTATCGAAAGTGTCCCTTCCAATCAACCACAGTATTCTATTGCCGGTCATCAATTTTCTATACACCGACGTTTGTCCAGAAGTCGAAAACTGTGACAGTATCGATTTTATTTGCAACTTATTGATTGTCGCCGATCAACTATTCATAACAAGGTTGCGCGAGATGTGCGAAATTGCTTTAGCAAATTTGATTACGCTCAAAAACTGCGCTGAATTGTGTCAATTTGCTCACACGTACAACTCGACCCAACTAAAACAGTGCTGCATGGAATTCATATCACTCAACTTATGCAGCATCTTGGAGAACAGATGTCTCGATCTATTGGAAGAATCATTACTTGACGATATCACGAATTACTATTGTAAATTTAACCCGATCATGTCTTCAAGAGTTATAACGCCATTCTTTAATGCTCCTTCGGACGAAGTTATAGATGAATTCGCTAAAAATTTCCCAGTCGATTTAAATTACGTAGATGAAGATGTCAAAAGGCAAGACACTGCAGAGTTAACGAAGAAGAAAAAGCCTTCAAAAAAGATAGAGTACACAGATAGAGAAAAGGAAAGAATGAGATATGAATCGGTGAACTCAGTATCTTCACTTGACCTTTCAAATGAGACTGGTGATATTACATTATCTCTCAGCAATATTGAGAAGGACGAGAAAGGCTCTAAAGAAAAGCAAGAGAAATGGATCGAGGTACCGTCATCACAAACAAAACAAAGCAAAGTAGTCCAAGCTCGATTGAAAGCCATAAGTAATGCCAAAGAAATTCTCGATGAGATTCCCACAGAATCATTCACAAAGCTGACTAAAAGTAGCTCCTCCAGCGCTATGATTGTTGTAGAACCATCCACATCACGCATGTCGGTCTCTCCAAAAGATTCTCCTATTGCAGAAATGGCTAGAAGCCCTCAAAACAATATTTTTATAAGTCATGTTGGACCAAAACTATCCCAAAAGCAAAGGAAAAAATTAGCAATGCAAGGCAATGAACCAAACACAAGTTTGAATGATTATCTGTCTGATAAATTGAACATAGGCAGTCCTACAAGCAAACCAAAAAATCCTTGGAAACTATGTGAAACTCCAATAGCATGTAACAGTCCAAACTTCAAACCTGTGGAATTTGATAAAATATTGACTGATCAAAAGAAGCAAAAGGAGAACTCTTCAAGAATTATGACGAAATCTTTGACATTAACACAGCTTGAAGATAAAGCAATAGAGCAACTGGAGAGGTTTTACAATGTACATGAGATTGATGATGAACTCATCACTGTTCGTCGCATTGAGCTTCTGGTGTCTGCACCTCAATGGATCCACACTGCCCCAAAATGA

Protein

MSKQKAEVDCTSKCKSRNHGQVLTSAITKRSISDEALASFIKATCSNFVKAFDKEGRTPLHVAASRGRVALMEWLIKHSSEAFANARDRESGYTPLHRSIFYGQIHAAVSLMKIGLNTDIVDKDDYKALEHAMLDRHYMYEHEGGQPSEVYVWGSNSNYTLGTGTQQQRNTPELLTYFSRNNLSVKQVCLGKFHSVWLTSGPNGNEVWCCGQCGRAGGPHYTALRPTPLKLAEPCVSVAITLNSTVLLLESGAVIQYTLDGTENVSQSNTKTPSCIKLPAVRPLMKLSAPLGVRAGRTHAVVWNSRAVYTWGTNLGQLGHPQQDGDIPAPKRVMISMNNRDEPGLELVETGDAATVLTTSRGDVYLLHKFICKKIAIKQINLRQVCVEARVSNQTGFTRVTVLLLTNVGQLLLWQDTTNQLTRCVFGLQHQTIITQAVLTHEALYFTTKHGEAFVGYISRKTSPIALSQPIRKEKERDNKSTLVKFLEKGDCTSVRIMKIPNIYRAVSIAVDGEGLNFACLQIKPTCGLRSVPELSPTSLSKHMESLRETAAVDDLLHDVLFKVGTKLYPAHIYIIATSSEYLYKMYQENLTDNNEKPIIALNNIHPDVFDRILKYTYTGTCDVAELGPCSLKIKKEDVIGKKDLDDIDIEVDVIENSSEISAYEVYSKQNEKSTRKSRNRRSTDTPTRQNLYCDPVRMVQAAAKRLHVKGLQKLLDKFYYRDGAVLLRENATSTKNAPLHWDRDAFPELVDTNVCSKDGMLISAHKCVLAARLEYFNGMFMHSWTESKLLSKVSLPINHSILLPVINFLYTDVCPEVENCDSIDFICNLLIVADQLFITRLREMCEIALANLITLKNCAELCQFAHTYNSTQLKQCCMEFISLNLCSILENRCLDLLEESLLDDITNYYCKFNPIMSSRVITPFFNAPSDEVIDEFAKNFPVDLNYVDEDVKRQDTAELTKKKKPSKKIEYTDREKERMRYESVNSVSSLDLSNETGDITLSLSNIEKDEKGSKEKQEKWIEVPSSQTKQSKVVQARLKAISNAKEILDEIPTESFTKLTKSSSSSAMIVVEPSTSRMSVSPKDSPIAEMARSPQNNIFISHVGPKLSQKQRKKLAMQGNEPNTSLNDYLSDKLNIGSPTSKPKNPWKLCETPIACNSPNFKPVEFDKILTDQKKQKENSSRIMTKSLTLTQLEDKAIEQLERFYNVHEIDDELITVRRIELLVSAPQWIHTAPK

Description

Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development.
Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.

Subunit

Interacts with the PH domain of BTK. Isoform 2 does not interact with BTK.

Similarity

Belongs to the tetraspanin (TM4SF) family.

Keywords

ANK repeat   Cytoplasm   Membrane   Repeat   Alternative splicing   Complete proteome   Nucleus   Phosphoprotein   Polymorphism   Reference proteome  

Feature

chain  Inhibitor of Bruton tyrosine kinase
splice variant  In isoform 3.
sequence variant  In dbSNP:rs12662902.

Uniprot

H9J3N3   A0A194QII9   A0A2A4K341   A0A212EJT7   A0A1E1W571   A0A2H1VSE9   + More
A0A1B6DIQ9   A0A1B6DWT5   D6WTD6   U4U0B8   N6TLV7   T1J4N7   A0A087TJY7   A0A0T6BB52   A0A1S3J007   A0A1S3H675   W5NKD3   R0JG07   A0A091W1P8   U3I654   A0A091KIF5   A0A293N4D8   A0A091TWX2   A0A099ZER1   A0A3B4F911   Q6NRS1   A0A1S3GHN6   I3ITY9   A0A3Q2WWA5   A0A091KL51   H2L964   A0A1S3GFT8   A0A091JLP6   G5BYI1   A0A3P8R2Z9   A0A3P8TR40   A0A3P9BZZ9   A0A093F0I6   A0A091GVV8   A0A3Q4MH95   A0A091RM64   A0A091PJ14   A0A091MSC1   A0A218VBI3   A0A091LHJ6   A0A3M0KJ78   A0A0A0AMZ6   A0A1D5PBT6   A0A093C5I0   A0A3P9PLU3   F1RQL8   A0A093P9F0   A0A091W9J9   U3JJ40   W5NKD2   A0A1S3P8M3   U3FCC3   M3X7Y0   A0A3Q3AWN9   A0A1S3WKQ8   A0A091MEJ4   A0A093PME1   A0A2U3YJ31   A0A0B8RSE3   A0A087R8M6   G1NLW2   A0A059TDI6   A0A2K6V6K9   A0A337STV9   A0A0F7ZAC4   A0A3Q2U7Z3   A0A2I0MV67   Q9P2D0-2   A0A2Y9RWW6   A0A2J8V2J7   A0A2Y9RR54   A0A087VQN3   A0A059TEM0   A0A2J8V2J8   H2PJN8   I3M348   A0A2K6A7D3   A0A1V4JMD3   A0A2I0MV59   A0A2Y9E471   W5PBG5   A0A3L8T073   F1MMV0   A0A2K5QNY7   B7ZLE0   A0A2Y9HBT1   A0A096N160   G3SCX5   A0A059TDI8   Q9P2D0  

Pubmed

19121390    26354079    22118469    18362917    19820115    23537049    + More
26383154    23749191    25186727    17554307    21993625    15592404    23915248    17975172    25476704    20838655    24725956    23371554    18596081    10718198    12168954    14574404    15489334    17974005    11577348    18669648    19690332    20068231    21406692    23186163    24275569    20809919    30282656    19393038    22398555   

EMBL

BABH01021660    BABH01021661    BABH01021662    BABH01021663    KQ459185    KPJ03266.1    + More
NWSH01000182    PCG78675.1    AGBW02014399    OWR41746.1    GDQN01008928    JAT82126.1    ODYU01004187    SOQ43781.1    GEDC01011761    JAS25537.1    GEDC01007167    JAS30131.1    KQ971352    EFA06701.1    KB631817    ERL86522.1    APGK01059364    KB741293    ENN70225.1    JH431846    KK115564    KFM65426.1    LJIG01002372    KRT84568.1    AHAT01026690    KB744050    EOA96200.1    KL411541    KFR09364.1    ADON01119654    KK529473    KFP27579.1    GFWV01023225    MAA47952.1    KK466685    KFQ82262.1    KL892027    KGL79335.1    BC070653    AERX01031264    KK747655    KFP40767.1    KK502275    KFP21904.1    JH172450    EHB14342.1    KL474764    KFV20191.1    KL515091    KFO87731.1    KK821633    KFQ40327.1    KK673878    KFQ07218.1    KK834679    KFP79153.1    MUZQ01000012    OWK63414.1    KL326565    KFP56511.1    QRBI01000106    RMC13312.1    KL872360    KGL95307.1    AADN05000003    KL233878    KFV07532.1    AEMK02000001    KL225531    KFW73548.1    KK734920    KFR11508.1    AGTO01000664    GAEP01000812    JAB54009.1    AANG04003966    KK528521    KFP69014.1    KL670077    KFW77998.1    GBSH01000439    JAG68585.1    KL226213    KFM09830.1    KJ531799    AHY35257.1    GBEX01001628    JAI12932.1    AKCR02000002    PKK33571.1    DQ005633    DQ005634    DQ005635    AB037838    AL050333    BC027490    BC038244    BC042171    BC113696    BC113698    AL050018    AF235049    NDHI03003436    PNJ51726.1    KL502039    KFO14925.1    KJ531808    AHY35266.1    PNJ51725.1    ABGA01075920    ABGA01075921    ABGA01075922    ABGA01075923    ABGA01075924    ABGA01075925    ABGA01075926    ABGA01075927    AGTP01036146    AGTP01036147    LSYS01006902    OPJ73351.1    PKK33572.1    AMGL01105737    AMGL01105738    AMGL01105739    AMGL01105740    AMGL01105741    QUSF01000002    RLW12181.1    BC143745    AAI43746.1    AHZZ02025139    CABD030046305    CABD030046306    CABD030046307    CABD030046308    KJ531804    AHY35262.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000007151    UP000007266    UP000030742    + More
UP000019118    UP000054359    UP000085678    UP000018468    UP000053283    UP000016666    UP000053641    UP000261460    UP000081671    UP000005207    UP000264840    UP000001038    UP000053119    UP000006813    UP000265100    UP000265080    UP000265160    UP000261580    UP000197619    UP000269221    UP000053858    UP000000539    UP000242638    UP000008227    UP000054081    UP000053605    UP000016665    UP000087266    UP000011712    UP000079721    UP000053258    UP000245341    UP000053286    UP000001645    UP000233220    UP000053872    UP000005640    UP000248480    UP000001595    UP000005215    UP000233140    UP000190648    UP000002356    UP000276834    UP000009136    UP000233040    UP000248481    UP000028761    UP000001519   

PRIDE

H9J3N3    Q6NRS1    F1RQL8    Q9P2D0    B7ZLE0   

Pfam

PF00651   BTB        + More
PF00335   Tetraspanin
PF00415   RCC1
PF12796   Ank_2

Interpro

IPR011333   SKP1/BTB/POZ_sf        + More
IPR000210   BTB/POZ_dom       
IPR018499   Tetraspanin/Peripherin       
IPR009091   RCC1/BLIP-II       
IPR002110   Ankyrin_rpt       
IPR020683   Ankyrin_rpt-contain_dom       
IPR008952   Tetraspanin_EC2_sf       
IPR036770   Ankyrin_rpt-contain_sf       
IPR000408   Reg_chr_condens       

SUPFAM

SSF50985   SSF50985        + More
SSF54695   SSF54695       
SSF48652   SSF48652       
SSF48403   SSF48403       

Gene 3D

2.130.10.30     1.25.40.20    

CDD

cd00204  ANK

ProteinModelPortal

H9J3N3   A0A194QII9   A0A2A4K341   A0A212EJT7   A0A1E1W571   A0A2H1VSE9   + More
A0A1B6DIQ9   A0A1B6DWT5   D6WTD6   U4U0B8   N6TLV7   T1J4N7   A0A087TJY7   A0A0T6BB52   A0A1S3J007   A0A1S3H675   W5NKD3   R0JG07   A0A091W1P8   U3I654   A0A091KIF5   A0A293N4D8   A0A091TWX2   A0A099ZER1   A0A3B4F911   Q6NRS1   A0A1S3GHN6   I3ITY9   A0A3Q2WWA5   A0A091KL51   H2L964   A0A1S3GFT8   A0A091JLP6   G5BYI1   A0A3P8R2Z9   A0A3P8TR40   A0A3P9BZZ9   A0A093F0I6   A0A091GVV8   A0A3Q4MH95   A0A091RM64   A0A091PJ14   A0A091MSC1   A0A218VBI3   A0A091LHJ6   A0A3M0KJ78   A0A0A0AMZ6   A0A1D5PBT6   A0A093C5I0   A0A3P9PLU3   F1RQL8   A0A093P9F0   A0A091W9J9   U3JJ40   W5NKD2   A0A1S3P8M3   U3FCC3   M3X7Y0   A0A3Q3AWN9   A0A1S3WKQ8   A0A091MEJ4   A0A093PME1   A0A2U3YJ31   A0A0B8RSE3   A0A087R8M6   G1NLW2   A0A059TDI6   A0A2K6V6K9   A0A337STV9   A0A0F7ZAC4   A0A3Q2U7Z3   A0A2I0MV67   Q9P2D0-2   A0A2Y9RWW6   A0A2J8V2J7   A0A2Y9RR54   A0A087VQN3   A0A059TEM0   A0A2J8V2J8   H2PJN8   I3M348   A0A2K6A7D3   A0A1V4JMD3   A0A2I0MV59   A0A2Y9E471   W5PBG5   A0A3L8T073   F1MMV0   A0A2K5QNY7   B7ZLE0   A0A2Y9HBT1   A0A096N160   G3SCX5   A0A059TDI8   Q9P2D0  

PDB

3HTM     E-value=2.06076e-10,     Score=163

KEGG

101739290    no KO assigned | (RefSeq) inhibitor of Bruton tyrosine kinase

GO

GO:0016021   GO:0016301   GO:0005654   GO:0005737   GO:0019901   GO:0051209   GO:0030292   GO:0016020   GO:0001933   GO:0005515   GO:0001518   GO:0005248   GO:0006814   GO:0005216   GO:0006811   GO:0043564   GO:0006418   GO:0003824  

Subcellular location

Cytoplasm  
Membrane  
Nucleus  

Length:

1236

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03048

Exp number, first 60 AAs:

0.00022

Total prob of N-in:

0.00146

outside

1  -  1236

 

 

Pi

36.082174

Theta

56.000349

Tajima's D

0.221201

CLR

1.572814

CSRT

0.429828508574571

Interpretation

Uncertain