Silkworm Genome Informatics Database

Gene

KWMTBOMO11629

Pre Gene Modal

BGIBMGA004118

Annotation

voltage-dependent_cation_channel_SC1_[Bombyx_mori]

Location

Bomo_Chr19(+):10277133-10323521 View in EpiBrowser

Full name

Sodium channel protein

Location in the cell

PlasmaMembrane Reliability : 4.063

CDS

ATGGATATATACATATTCCTGGCGATCTACACGGCGGAGATGATAATCAAATGCATAGCCAAGGGCTTTATCCTGAACAAGTACACTTACCTTAGGAACCCGTGGAACTGGCTGGACTTCGTCGTGATCACATCAGGGTACGCCACAATCGGTATGGAAGTGGGAAATTTGGCCGGCCTTAGGACCTTCAGAGTGTTGAGAGCACTAAAGACTGTCTCTATTATGCCAGGATTGAAAACCATCATCAACGCGCTTCTGCATTCGTTCAAGCAGCTAGCAGAGGTAATGACCCTGACAATATTCTGCCTCATGGTGTTCGCCTTGTTCGCGCTCCAGGTATACATGGGCGAACTTAGAAACAAATGCGTCAAGAACTTGGTTATGCAGCCGGGAGAGAACTTTACTGACGAAATCTGGTCGGCGTGGATCAAAGAACCTACAAACTGGATGGTAGATGAAGAACTAGTTCCAATTATTTGCGGGAACTTGACAGGGGCCAGGCATTGTCCGTTACATTACACCTGCCTTTGCGTGGGCCCAAATCCCAACCATGGGTACACTAATTTCGACAATTTCCTCTGGTCAATGTTGACCACCTTCCAGTTGATCACGCTTGACTACTGGGAGAATGTTTATAACATGGTACTGTCTTCGTGTGGTCCAATGTCCGTATCATTTTTCACGGTGGTGGTTTTTTTTGGCTCGTTTTACCTCATCAACCTGATGCTGGCCGTAGTCGCACTGAGCTATGAAGAGGAATCACAGATCACACAAGAAGAGAGAAAGAAGGATCTGAACGAGCACAGAGATGATTCTACATTCAGCTTTGATCCCTCATCGCTGGCTGTGAGGACCCTCGCTAAGGACTCGAAGAAACGAATCGACGCTAGGAAAGGACTATTATTAGCCTCTTACTCACGCAAAAGAACAAGAAGACGCAAAAGAGGCAGGAGTGCTATACATCATGCTGCTGCGGTTGCCGCCGTGGCTGAACGGTCGAGATCCAGGTCGGTGACCCCGAGCGCGTCACCGCCACCTTTGCCGCCGCCGCCGCCTCCACCGCCGCCCCCTCACACCCTCCACCCCGACAATGCATTAGGTCGTGGCATCCTGAGTGCAGCTGGTCGTCAACTGAGCGATCACAGTAACAACAGGGAATCATCGCTCGACGACTCCGGCGTGGTCGATGACCACGACGACGGAGAACACACGTCTGATGACCAGGCCCCTCACCCTCACCCGAGGCGGGTACTGCTAATGCCGCCACCATTGCCTGCTTTGCAGCAATCAACACCAATGCCACCTTTACAACAAACACAGGAGAGTCACACAGAAGAACCAAAACAGAAAGCCAAACTGAGAATCCGAGAAGAGAAACCAATAGAGAAAGTAAAGAAAGGCGATAAGCAGAAAGAAACCGTGTACGAAAGATATCCATTGAATCCGGACTACCTCAATCAGATCGTCGTTTTAGGGGCGGACTGGCCATACGAGCGTGCGCCCGCCCTCCCGCAAGCGGAAACGACGAAAATTAATGAGATCGGTTTATTGGCAGCAAAGCACAAAACTCATATGGGCAATTACGAGCAAAATTGCACTTACTTCACAGATGAGCTCGTGGATAGAAACTGCGAGTGTTGCGTGTCTTGCTGCATAGACTACGAAGGTTGGCTTCAATTCCAAAACTGTCTTTACGGGATCGTGAAGGATCCTCTATTCGAGTTGTTCATTACGACTTGTATCGTTTTAAACACACTGTTTTTGGCTCTAGAGCATCACGGCATGAGCGAGAACGTTAGAAGGGTCTTAGATATAGGAAATAAGGTTTTCACTTCTATATTTACTTTAGAGTGTATAATGAAAGTGATGGCGATGAGTAAAGACTTTTTTGCTTGCGGATGGAATATATTCGATCTAATCATAGTTTCGGCTAGCTTACTCGATCTCATATTTGAATTAGTGGACGGCTTGTCTGTGCTACGTGGCCTGCGTTTGTTGAGAGTGTTAAAGTTAGCCCAGTCGTGGACTACGATGAAAGTGTTGTTGAGTATTATAATATCGACTATAGGTGCTCTTGGTAATTTGACGTTCGTATTAGTGATAGTTATATACATATTTGCGGTAATCGGTATGCAGCTGTTTTCTAAATCGTACACCCCTGATAAGTTCGATCCAGATCCAGTACCCAGATGGAACTTTAATGATTTCTTCCATTCGTTCATGATGATATTTCGGATACTGTGCGGTGAATGGATCGAGCCCCTGTGGGACTGTATGAGAGCCGAGCAAGCCAGTGGCGCAGAGAGCTGTTTCTTCATATTCTTACCGGCTCTCGTAATGGGAAATTTCATGGTGCTCAATCTCTTCCTTGCCTTGCTGCTCAACAGCTTTAACAGTGAAGAACTTAAAAATAAAAAAGAGGAAGTGGGCGAAGATTCAAAATTAGCTAAAAGCTTCGATAGAATACGTTCTATAGTAAGGAAGAAAGGTTTTCTTATATCTAGAAGTAAAGAGACTGAAAAAAAATCGAAATTAGAGGAGCTAGTTAACGAATTCATGTCACAGCAACGAGCTATTAAAGAGAAGAAAGCGTCAATACCGACCGAGCAGCGTTACTCCGCCTCAATACAGGAGACCATACTCTTTCCGCATGACAATATCTATAGCCATAGCTACCAAGAGGCCGTAAACAGGCCAATTTCTGTTGGTTCAGAATTCGCATACCCGCAACTGTATCAGAGCTGCAGCAACATTAACCACGGCAGTCAAGAGACGTTGAAAGACGTACGAGACTTGGCAACCGAACATAAGATAACAAGCATTAGGGAAGATTCCAAAGAAAATCTAGAAGATACGTCGCCGTTCGAACAAAAATCAGCGCAAAAACTACTAAATCAAATATCTTCTGGATATTACACACAGCCATCGGATTCGAGAGACGAAGAGAACGAACATTATGAAATGGCACAGTTCTCTTGTAAAACAACACCGGAGAAAACTAAGAAGCAAGGTAGAGACCCGCCAAACACGTTATCTAAAGATCCGAATAAAAAGCCCGACGAGGACGACATGAAACATCCGTGGCAAACATTAGTTTCTTATGTGGATGAATTGACCGTAGGGGGGCGGAAGAACTCTAAAGGCCAGTACATCGATGCGATGGGAAATTTTCCGGGATTCGGGAAACAGAAGGAACCAAAAGTGCCCCAGGATTGCTTCCCGAGTCAATGTTACGATATAAGCTCGTGTTGGGACACGTGTATAGACACAAAAATTGGCCAACGTTGGATGTTGGTTCGAACATTTGTTTTACGTTATGTCGACACGCCCGCATTCGAATGGTTCGTTCTGGTCCTGATATTTGCTTCGAGCATCACGCTGTGCTTCGAAGACATTCACCTAGAAAAGAACAAACCATTAAAGAAGATATTGTACTGGACCAATTTGGGATTCTGTATGATATTCATAATAGAAATGTTTCTCAAATGGATAGCTTTAGGATTCTTCAGATACTTCACTAGCTTTTGGACGTTGTTAGATTTTACTATAGTATTCGTTTCTGTATTTAGTTTGTTGATAGAAGAGAATGAAAATTTGAAAGTTTTGAGGTCGTTACGGACTTTACGCGCTTTGAGGCCGCTTCGGGCGATCTCGAGGTGGCAGGGTATGCGTATAGTCGTGAACGCCCTGATGTACGCGATACCCAGCATTTTCAACGTTCTGCTAGTTTGTTTAGTGTTTTGGTTGATATTCTCTATAATGGGAGTACAGTTTTTCGGAGGAAAATTCTTCAAGTGCGTTAATGAAGAAGGAGAATTATTACCTTTAGACATAGTAAACGATAAATGGGAATGTTACTATAATAATTTCTCTTGGGTGAATTCCAAGATATCTTTTGACCATGTCGGTATAGCGTATTTAGCGTTATTTCAAGTAGCCACGTTTGAGGGGTGGATGGAAGTAATGGCCGACGCAGTTGACGCACGAGGAGTCGACTTGCAACCAGCGAGAGAGGCAAATCTATATGCGTACATATATTTTGTTATATTTATCGTCTGCGGCTCTTTCTTCACCCTCAATCTATTTATAGGAGTAATAATAGATAATTTTAATATGCTCAAGAAGAAGTATGAAGGAGGAGTATTAGAAATGTTCCTTACAGAAAGCCAAAAACATTATTACACTGCTATGAAGAAACTTGGCAGGAAAAAGCCCCAGAAAGTAATAAAGAGGCCAAGAAATCAATTTCTAGCAATGTTCTATGATTTATCGAATTCGCGTCGTTTCGAAATAGCTATATTCGTTCTAATTTTTTTAAACATGCTCACCATGGGTATAGAGCATTACGATCAGCCTCATTCCGTATTCTTCATTCTTGAAGTTAGTAATGCGTTTTTTACTACAGTATTCGGCTTAGAAGCAATAGTTAAGATCGTCGGTCTAAGGTATCATTACTTTACGGTGCCTTGGAACGTCTTTGATTTCCTTTTAGTTTTAGCGTCAATTTTAGGCATAGTTATGGAAGATATAATGATAGATCTGCCCATATCGCCCACTCTACTGAGAGTGGTGAGAGTATTTCGTATAGGAAGAATCTTAAGACTGATTAAAGCTGCTAAGGGCATAAGGAAACTTCTATTCGCATTAGTGGTATCGTTACCGGCTCTATTCAATATAGGAGCTCTGTTAGCGTTGATTACATTCATATACGCAATAATCGGTATGTCGGTCTTCGGTCACGTCAAAGAACAAGGTGCCTTAGACGATATAGTCAACTTTCAAACGTTCGGACGGAGTATGCAGTTGCTTTTTCGTCTGATGACGTCGGCGGGTTGGAACGATGTATTAGAGTCACTCATGATCCAACCGCCGGACTGTGAACAAGGCGACCATGGTCACTCGAACGGCAACTGTGGAAGTCCACTTCTAGCGATCACCTACTTCACTTCCTTCATCATAATAAGCTACATGATCGTTATCAACATGTACATAGCTATTATCCTCGAGAATTTCAACCAAGCCCACCAGGAAGAAGAAATTGGTATCGTTGAAGATGACCTTGAAATGTTTTACATTAGATGGTCCAAATACGACCCACATGCGACTCAGTTCATCAGTTTTGCTCAGCTATCCGAGTTCATAGCCTCCTTAGACCCACCTTTGGGCATCTCAAAGCCCAACACCGTGGCTTTAGTCAGTTTTAATCTCCCTATAGCTAGAGGGAATAAGATACATTGTTTAGATATCTTGCATGCACTGGTGAAACACGTTTTGGGTCACGTTGAAGAAACTGAAACCTTCAGGCAATTGCAAGAGCAGATGGATATCAAATTCAAGAAGCAATTTCCGACGAGAAAGGAACTGGAAATTGTCTCTTCGACTAGGATATGGAAGAGAGAAGATAAGGCTGCGAGGACTATACAGCGTGCTTGGAGAGAATACGTCAAGCGTAAAAACCGCAGTCCGTCTGTTGAAGAGGAAAGCACGAAATGGTCTCCGGGAGGAGGCTGGGGCGGTCGCCTCAGTGCTTTGCTGCACGTGAGAAGAGGATCGCATGCGTCAAGTCGGAAATCTTCAAGGGCTTCCGAAGCATCAGACATAAGCGAATTGGGAGGGGCCTGGTTAAATTTACCACTCCTCTTGTTGCCTGGTGCCACGCCGGCTGAACAGATGGCAGCCTGTTCAGAATCAGCACCAACCAGACGTAGGTCGGCATACGGTTTGCCTATTTTCCTTCGTCACCAAGACGCAATGGATGAAGATGTCGGCCCCAAACGCGCAGGTTCCCTTCGTCTGAGCTCAAGAAGAAACTCAGCTCGGCGACCAACGCCTCCCGCCCGCGCCCGCACTCCTTCCCCGCACGCAAATAACAGCGAAGTTAGCATCCTCGTTACTGAAGCATCACCGGACGCAGCCCCGGTTCCGACAGCGCCGCCAACCGTAGTACGAGTCCTCGTGCACAGAGAGAGTGACGAGCAACCCAGCTGA

Protein

MDIYIFLAIYTAEMIIKCIAKGFILNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFKQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVKNLVMQPGENFTDEIWSAWIKEPTNWMVDEELVPIICGNLTGARHCPLHYTCLCVGPNPNHGYTNFDNFLWSMLTTFQLITLDYWENVYNMVLSSCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEESQITQEERKKDLNEHRDDSTFSFDPSSLAVRTLAKDSKKRIDARKGLLLASYSRKRTRRRKRGRSAIHHAAAVAAVAERSRSRSVTPSASPPPLPPPPPPPPPPHTLHPDNALGRGILSAAGRQLSDHSNNRESSLDDSGVVDDHDDGEHTSDDQAPHPHPRRVLLMPPPLPALQQSTPMPPLQQTQESHTEEPKQKAKLRIREEKPIEKVKKGDKQKETVYERYPLNPDYLNQIVVLGADWPYERAPALPQAETTKINEIGLLAAKHKTHMGNYEQNCTYFTDELVDRNCECCVSCCIDYEGWLQFQNCLYGIVKDPLFELFITTCIVLNTLFLALEHHGMSENVRRVLDIGNKVFTSIFTLECIMKVMAMSKDFFACGWNIFDLIIVSASLLDLIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTFVLVIVIYIFAVIGMQLFSKSYTPDKFDPDPVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEQASGAESCFFIFLPALVMGNFMVLNLFLALLLNSFNSEELKNKKEEVGEDSKLAKSFDRIRSIVRKKGFLISRSKETEKKSKLEELVNEFMSQQRAIKEKKASIPTEQRYSASIQETILFPHDNIYSHSYQEAVNRPISVGSEFAYPQLYQSCSNINHGSQETLKDVRDLATEHKITSIREDSKENLEDTSPFEQKSAQKLLNQISSGYYTQPSDSRDEENEHYEMAQFSCKTTPEKTKKQGRDPPNTLSKDPNKKPDEDDMKHPWQTLVSYVDELTVGGRKNSKGQYIDAMGNFPGFGKQKEPKVPQDCFPSQCYDISSCWDTCIDTKIGQRWMLVRTFVLRYVDTPAFEWFVLVLIFASSITLCFEDIHLEKNKPLKKILYWTNLGFCMIFIIEMFLKWIALGFFRYFTSFWTLLDFTIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEEGELLPLDIVNDKWECYYNNFSWVNSKISFDHVGIAYLALFQVATFEGWMEVMADAVDARGVDLQPAREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPRNQFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHSVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASILGIVMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLALITFIYAIIGMSVFGHVKEQGALDDIVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCEQGDHGHSNGNCGSPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFISFAQLSEFIASLDPPLGISKPNTVALVSFNLPIARGNKIHCLDILHALVKHVLGHVEETETFRQLQEQMDIKFKKQFPTRKELEIVSSTRIWKREDKAARTIQRAWREYVKRKNRSPSVEEESTKWSPGGGWGGRLSALLHVRRGSHASSRKSSRASEASDISELGGAWLNLPLLLLPGATPAEQMAACSESAPTRRRSAYGLPIFLRHQDAMDEDVGPKRAGSLRLSSRRNSARRPTPPARARTPSPHANNSEVSILVTEASPDAAPVPTAPPTVVRVLVHRESDEQPS

Description

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.

Similarity

Belongs to the sodium channel (TC 1.A.1.10) family.

Feature

chain Sodium channel protein

Uniprot

H9N1C7 A0A212EJX6 H9J3N1 A0A0L7KS34 A0A2H1W2G9 A0A2A4K4S9 + More
D6WRS1 E2B5I1 F4W7K3 A0A151X8G0

Pubmed

22321571 22118469 19121390 26227816 18362917 19820115 + More
20798317 21719571

EMBL

JN619366 AFC61133.1 AGBW02014399 OWR41748.1 BABH01021655 BABH01021656 + More
JTDY01006349 KOB66083.1 ODYU01005906 SOQ47279.1 NWSH01000182 PCG78672.1 KQ971354 EFA05958.2 GL445827 EFN89067.1 GL887844 EGI69876.1 KQ982409 KYQ56665.1

Proteomes

UP000007151 UP000005204 UP000037510 UP000218220 UP000007266 UP000008237 + More
UP000007755 UP000075809

PRIDE

H9N1C7 H9J3N1

Pfam

PF00520 Ion_trans + More
PF16905 GPHH

Interpro

IPR005821   Ion_trans_dom        + More
IPR000048   IQ_motif_EF-hand-BS
IPR001696   Na_channel_asu
IPR031649   GPHH_dom
IPR027359   Volt_channel_dom_sf

Gene 3D

1.20.120.350

ProteinModelPortal

H9N1C7 A0A212EJX6 H9J3N1 A0A0L7KS34 A0A2H1W2G9 A0A2A4K4S9 + More
D6WRS1 E2B5I1 F4W7K3 A0A151X8G0

PDB

6J8E E-value=0, Score=1900

KEGG

100884165 K21862 voltage-gated cation channel | (RefSeq) SC1; voltage-dependent cation channel SC1

GO

GO:0001518 GO:0005244 GO:0034765 GO:0005248 GO:0005886 GO:0019228 GO:0035725 GO:0086010 GO:0005515 GO:0006814 GO:0005216 GO:0006811 GO:0016020 GO:0043564 GO:0006418 GO:0003824 GO:0055085

Subcellular location

Cell membrane

Length:

1995

Number of predicted TMHs:

17

Exp number of AAs in TMHs:

415.10857

Exp number, first 60 AAs:

39.9077

Total prob of N-in:

0.41557

POSSIBLE N-term signal

sequence

inside

1 - 2

TMhelix

3 - 25

outside

26 - 39

TMhelix

40 - 60

inside

61 - 91

TMhelix

92 - 114

outside

115 - 225

TMhelix

226 - 248

inside

249 - 628

TMhelix

629 - 651

outside

652 - 683

TMhelix

684 - 706

inside

707 - 770

TMhelix

771 - 793

outside

794 - 1109

TMhelix

1110 - 1132

inside

1133 - 1143

TMhelix

1144 - 1166

outside

1167 - 1170

TMhelix

1171 - 1193

inside

1194 - 1228

TMhelix

1229 - 1251

outside

1252 - 1344

TMhelix

1345 - 1367

inside

1368 - 1428

TMhelix

1429 - 1446

outside

1447 - 1455

TMhelix

1456 - 1478

inside

1479 - 1484

TMhelix

1485 - 1507

outside

1508 - 1549

TMhelix

1550 - 1572

inside

1573 - 1642

TMhelix

1643 - 1665

outside

1666 - 1995

Pi

233.286398

Theta

159.034529

Tajima's D

1.533415

CLR

0.198693

CSRT

0.797910104494775

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics