Gene

KWMTBOMO11626

Pre Gene Modal

BGIBMGA004117

Annotation

PREDICTED:_sodium_channel_protein_60E-like_[Papilio_xuthus]

Location

Bomo_Chr19(+):10253893-10256159      View in EpiBrowser

Full name

Sodium channel protein       + More
Multifunctional fusion protein      
Sodium channel protein 60E      

Alternative Name

Drosophila ion channel 60
Drosophila sodium channel 1
Protein smell-impaired 60E
Sodium channel 2

Location in the cell

PlasmaMembrane   Reliability : 1.949

CDS

ATGTTCAAGCTAAAAGGTTTCAAGCATATAGAGACATTCTGCGTGGTGTCAAAAAGATTCCGTAAGAACTACATACATCGGTTCACCGCTACGAGATCTCTGTTCTGGTGGTCACCCTGGTCTCCGGTCCGAAGAGCCTGCGTCTATCTCTCCACTAATCAGTACTTCGACTACTTCGTCATGGCGACAATCCTTCTCAACTGTGTCTTCCTCGCCATGTCGGAGACTATCGAAGAAGCTGAATCTCTTAGTACAATGATTTTTAAACTTATGTAA

Protein

MFKLKGFKHIETFCVVSKRFRKNYIHRFTATRSLFWWSPWSPVRRACVYLSTNQYFDYFVMATILLNCVFLAMSETIEEAESLSTMIFKLM

Description

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Plays a role in processing of olfactory information during the olfactory avoidance response.

Similarity

Belongs to the sodium channel (TC 1.A.1.10) family.
Belongs to the NAC-beta family.
Belongs to the sodium channel (TC 1.A.1.10) family. NaCP60E subfamily.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Disulfide bond   Glycoprotein   Ion channel   Ion transport   Membrane   Olfaction   Reference proteome   Repeat   RNA editing   Sensory transduction   Sodium   Sodium channel   Sodium transport   Transmembrane   Transmembrane helix   Transport   Voltage-gated channel  

Feature

chain  Sodium channel protein 60E
splice variant  In isoform P.

Uniprot

H9J3N0   A0A2H1V7R2   A0A212EJX6   H9N1C7   A0A2A4K344   A0A194R3U4   + More
A0A182R4L4   Q7QIV0   A0A182YEH3   A0A1B0CQM7   A0A182WWV2   A0A182VP92   A0A182I2E9   A0A182FHE9   A0A182PBH0   A0A182M232   A0A182NJB1   A0A182WLE5   A0A182J5X3   A0A182K599   E9IH13   A0A3L8DAV4   B0WD52   A0A151IGP2   A0A182TY85   A0A336LX80   A0A336LX33   A0A1B6K885   A0A1B6KWD9   A0A0N0BCK8   A0A088A777   A0A2A3E6C3   U5JD83   A0A0B4KG05   D6W4K7   A8E6M2   A0A154PD88   A0A026X1Y7   A0A0R3NKX8   A0A0R3NRX8   A0A3R7M3W0   A0A0R3NT58   A0A0R3NRD6   A0A0R3NLI0   A0A1J1IA68   A0A0R3NL11   A0A0R3NL53   A0A158NPP2   A0A2P8XI60   A0A195ESK3   A0A195AT64   B5DZ24   A0A0R3NL32   A0A0R1DUK3   B4GD21   A0A0R1DZ54   A0A0B4KGE9   A0A1W4UYY8   A0A0J9RM20   A0A0J9RKH3   A0A0Q5VPJ6   A0A0R1DZ68   A0A0R1DXI6   A0A0B4KFH8   Q9W0Y8   A0A0J9RM15   A0A0B4K814   A0A3B0J127   A0A0Q5VQI5   A0A0Q5VP39   A0A0J9RL22   A0A0J9RM24   A0A0J9UAV6   A0A0Q5W231   A0A0B4K887   B4PBX0   Q9W0Y8-3   A0A1W4ULH8   B3NR09   A0A0R1DVT7   A0A0J9RKT8   A0A0R1DTU2   A0A0Q5W3A6   A0A0B4K7I8   B4IHA4   A0A1W4V0J5   A0A1W4UM09   A0A0J9RL18   A0A0J9RKH8   B4QCM1   A0A0J7KM21   E0VGC3   Q9BMQ4   A0A0M5IZE8   B4J8W8   F4W7K3   A0A151X8G0   A0A195ELG0   A0A1I8MS87   H9N1C8  

Pubmed

19121390    22118469    22321571    26354079    12364791    25244985    + More
21282665    30249741    24155671    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    24508170    15632085    17994087    23185243    21347285    29403074    17550304    22936249    2444928    12537569    8083728    12196396    12907802    18057021    20566863    11267908    21719571    25315136   

EMBL

BABH01021650    ODYU01001099    SOQ36851.1    AGBW02014399    OWR41748.1    JN619366    + More
AFC61133.1    NWSH01000182    PCG78667.1    KQ460949    KPJ10511.1    AAAB01008807    EAA04706.4    AJWK01023773    APCN01000153    APCN01000154    AXCM01000980    GL763122    EFZ20141.1    QOIP01000011    RLU16999.1    DS231893    EDS44187.1    KQ977674    KYN00608.1    UFQT01000259    SSX22525.1    SSX22524.1    GECU01000039    JAT07668.1    GEBQ01024242    JAT15735.1    KQ435916    KOX68791.1    KZ288353    PBC27313.1    KC699920    AGL91670.1    AE013599    AGB93704.1    BT124907    ADH29875.1    BT030814    ABV82196.1    KQ434869    KZC09354.1    KK107021    EZA62325.1    CM000071    KRT01608.1    KRT01603.1    QCYY01002924    ROT66505.1    KRT01606.1    KRT01613.1    KRT01612.1    CVRI01000043    CRK95854.1    KRT01610.1    KRT01611.1    ADTU01022675    ADTU01022676    ADTU01022677    ADTU01022678    ADTU01022679    ADTU01022680    ADTU01022681    ADTU01022682    ADTU01022683    ADTU01022684    PYGN01002049    PSN31689.1    KQ981986    KYN31225.1    KQ976745    KYM75413.1    EDY68760.2    KRT01607.1    CM000158    KRK00607.1    CH479181    EDW31559.1    KRK00609.1    AGB93703.1    CM002911    KMY96464.1    KMY96463.1    CH954179    KQS63155.1    KRK00610.1    KRK00611.1    AGB93702.1    DQ466888    X14394    X14395    X14396    X14397    X14398    X84409    AY060357    AAL25396.1    CAA32567.1    CAA59129.1    KMY96459.1    AFH08261.1    OUUW01000001    SPP74497.1    KQS63156.1    KQS63152.1    KMY96467.1    KMY96469.1    KMY96460.1    KQS63154.1    AFH08262.1    EDW92624.2    EDV57092.2    KRK00606.1    KMY96461.1    KRK00608.1    KQS63151.1    AFH08263.1    CH480838    EDW49280.1    KMY96462.1    KMY96468.1    CM000362    EDX08637.1    LBMM01005702    KMQ91281.1    AAZO01002065    AAZO01002066    AAZO01002067    DS235135    EEB12429.1    AF312365    AAK01090.1    CP012524    ALC41436.1    CH916367    EDW02408.1    GL887844    EGI69876.1    KQ982409    KYQ56665.1    KQ978730    KYN28966.1    JN619367    AFC61134.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000053240    UP000075900    UP000007062    + More
UP000076408    UP000092461    UP000076407    UP000075903    UP000075840    UP000069272    UP000075885    UP000075883    UP000075884    UP000075920    UP000075880    UP000075881    UP000279307    UP000002320    UP000078542    UP000075902    UP000053105    UP000005203    UP000242457    UP000000803    UP000076502    UP000053097    UP000001819    UP000283509    UP000183832    UP000005205    UP000245037    UP000078541    UP000078540    UP000002282    UP000008744    UP000192221    UP000008711    UP000268350    UP000001292    UP000000304    UP000036403    UP000009046    UP000092553    UP000001070    UP000007755    UP000075809    UP000078492    UP000095301   

PRIDE

H9J3N0    H9N1C7    D6W4K7    A8E6M2    Q9W0Y8   

Pfam

PF00520   Ion_trans        + More
PF16905   GPHH
PF01849   NAC

Interpro

IPR000048   IQ_motif_EF-hand-BS        + More
IPR005821   Ion_trans_dom       
IPR031649   GPHH_dom       
IPR001696   Na_channel_asu       
IPR027359   Volt_channel_dom_sf       
IPR038187   NAC_A/B_dom_sf       
IPR002715   Nas_poly-pep-assoc_cplx_dom       

Gene 3D

1.20.120.350     2.20.70.30    

ProteinModelPortal

H9J3N0   A0A2H1V7R2   A0A212EJX6   H9N1C7   A0A2A4K344   A0A194R3U4   + More
A0A182R4L4   Q7QIV0   A0A182YEH3   A0A1B0CQM7   A0A182WWV2   A0A182VP92   A0A182I2E9   A0A182FHE9   A0A182PBH0   A0A182M232   A0A182NJB1   A0A182WLE5   A0A182J5X3   A0A182K599   E9IH13   A0A3L8DAV4   B0WD52   A0A151IGP2   A0A182TY85   A0A336LX80   A0A336LX33   A0A1B6K885   A0A1B6KWD9   A0A0N0BCK8   A0A088A777   A0A2A3E6C3   U5JD83   A0A0B4KG05   D6W4K7   A8E6M2   A0A154PD88   A0A026X1Y7   A0A0R3NKX8   A0A0R3NRX8   A0A3R7M3W0   A0A0R3NT58   A0A0R3NRD6   A0A0R3NLI0   A0A1J1IA68   A0A0R3NL11   A0A0R3NL53   A0A158NPP2   A0A2P8XI60   A0A195ESK3   A0A195AT64   B5DZ24   A0A0R3NL32   A0A0R1DUK3   B4GD21   A0A0R1DZ54   A0A0B4KGE9   A0A1W4UYY8   A0A0J9RM20   A0A0J9RKH3   A0A0Q5VPJ6   A0A0R1DZ68   A0A0R1DXI6   A0A0B4KFH8   Q9W0Y8   A0A0J9RM15   A0A0B4K814   A0A3B0J127   A0A0Q5VQI5   A0A0Q5VP39   A0A0J9RL22   A0A0J9RM24   A0A0J9UAV6   A0A0Q5W231   A0A0B4K887   B4PBX0   Q9W0Y8-3   A0A1W4ULH8   B3NR09   A0A0R1DVT7   A0A0J9RKT8   A0A0R1DTU2   A0A0Q5W3A6   A0A0B4K7I8   B4IHA4   A0A1W4V0J5   A0A1W4UM09   A0A0J9RL18   A0A0J9RKH8   B4QCM1   A0A0J7KM21   E0VGC3   Q9BMQ4   A0A0M5IZE8   B4J8W8   F4W7K3   A0A151X8G0   A0A195ELG0   A0A1I8MS87   H9N1C8  

PDB

5XSY     E-value=6.20343e-10,     Score=147

KEGG

100884165    K21862 voltage-gated cation channel | (RefSeq) SC1; voltage-dependent cation channel SC1

GO

GO:0016021   GO:0001518   GO:0005248   GO:0005244   GO:0034765   GO:0005216   GO:0019228   GO:0005886   GO:0035725   GO:0086010   GO:0005272   GO:0042048   GO:0006814   GO:0007608   GO:0022843  

Subcellular location

Cell membrane  

Length:

91

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

16.84154

Exp number, first 60 AAs:

4.5524

Total prob of N-in:

0.74386

inside

1  -  54

TMhelix

55  -  77

outside

78  -  91

 

 

Pi

306.940398

Theta

184.457744

Tajima's D

2.520892

CLR

0.042782

CSRT

0.947202639868007

Interpretation

Uncertain