Gene

KWMTBOMO11613  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004112

Annotation

leukotriene_A-4_hydrolase_[Bombyx_mori]

Location

Bomo_Chr19(+):10009709-10025736      View in EpiBrowser

Full name

Leukotriene A(4) hydrolase      

Location in the cell

Cytoplasmic   Reliability : 2.788

CDS

ATGGGTGCTTTCAGTCCTCTGGATCCGTCTTCCTTTTCGCGGCCTGAACAAGCTGTAATAAAACACGTGACTTTATCGTTGAACGTGGATTTTGAAAACAAAGTCTTAAACGGATCCGCCACTCTCGACGTTGACGTGCTCCAAGATATCGGAGACGTGGTCCTTGATTCGAGTGAACTGACAATAGAATCAATAGAACTAGACGGTGCTCAATTGACGTACAAATTAGATGACCCAGTGCCGAACTATGGCTCCAAATTGACTATACAATTGCCGAAACGAGCCTCAAGTGGCGATAAGTTAAAAATTAAAATTAAGTACACAACGTCCCCGTCCGCGACTGCGTTACAATGGTTACAGCCAGCTCAAACTTCGGGGAAGAAACACCCTTATCTATTCAGCCAGTGTCAGCCGATTCATGCCCGTTCGATTCTTCCGTGTCAAGACACTCCATTTGTAAAGTTCACTTATGACGCTGAGGTCACGGCGCCCGAGGAGTTCACAGTACTGATGAGCGCGCTCAGAGGCGAGAGTCGCAGCACTAAGACGACCTTCAATCAGCCGATGCCTTTGCCGTCGTATCTTTTGGCCATTGCGGTCGGCGTGTTGGAGCACAGGACTCTAGGACCCAGGTCTAAAGTTTGGTCCGAGAAAGAGGAGATCGAACGTAGCGCTTGGGAGTTCGCTGAGGCCGAGAAATATCTGCAAGCCGCCGAAAGACTCTGCGGCGCTTACGAATGGAAACAGTACGACTTGCTGGTGCTGCCACCTTCCTTCCCTTACGGGGGGATGGAGAACCCGTGCCTTACTTTTGTAACGCCCACTTTGTTGGCTGGTGATAGAAGTCAAGCAGACGTGTTGATCCACGAGATCATGCACAGTTGGACCGGTAACCTCGTCACGAATAGAAATTTTGAACATTTCTGGCTAAACGAGGGCTTCACTGTATTCCTGGAGAGAAAAGTCAAAGCTTCTTTGATAGAAGATCCAATTGAAGCCAAGAAAAGCAGAGACTTTCATAGTATACTCGGACTGGAGGAGTTAAGTGAAGCGGTGGTAAGTCAGTTAGGCGTTGACAATCCTCTGACCCGGTTGGTACCCGACCTCCATGACGTGCATCCTGACGATGCATTCTCCACGGTTCCCTACGAAAAGGGCTCGCTGTTTTTGCGATACCTTGAGGACTTAATAGGAGGACCAGAAGTATTCGATGATTTCCTACGATCGTACCTGAAGAACTTCAGTCGGAAATCTCTTGACACGGACGAGTTCAAGGCCTATCTGTTTAACTATTTCCAAGACAATGAAAAATTGAAGAGCGTTGATTGGGAAACATGGTTGTACAAGAGCGGTATGCCCCCCGTCATACCAGACTACGACACTTCAATGACGAAACCGATAACGGCTCTCGTTGCGAAGATCAACCAGCGCAACGCGTCGCTGATATCGTATCAAGACGTGCAAACGTTTACTCCTCATCAAATAATGATATTCCTGCAAGAACTGATAAAACATCCTCCACTGCCGCTAGACATTCTCCACACTCTTGGCGCAGAGTATAAAATCGATAGTAGCAAGAATACCGAGATTTTGTATAGATGGTTGCGGCTGTGCCTTAGAAGCAAAGATCAATCGATCTTGGGCGAAGTGTTCGATTTTGTGAACCACATAGGACGGATGCGGTACGTCCGTCCACTGTATAGAGACCTCTACGATTGGGAAGACGTTAGAAATCAAGCAATAGAAAACTTCCTCAAAAACGAACAATACATGATGCACGTGTGTGCTCATACTGTGAAAAAAGATTTACATTTAATTGACTAG

Protein

MGAFSPLDPSSFSRPEQAVIKHVTLSLNVDFENKVLNGSATLDVDVLQDIGDVVLDSSELTIESIELDGAQLTYKLDDPVPNYGSKLTIQLPKRASSGDKLKIKIKYTTSPSATALQWLQPAQTSGKKHPYLFSQCQPIHARSILPCQDTPFVKFTYDAEVTAPEEFTVLMSALRGESRSTKTTFNQPMPLPSYLLAIAVGVLEHRTLGPRSKVWSEKEEIERSAWEFAEAEKYLQAAERLCGAYEWKQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDRSQADVLIHEIMHSWTGNLVTNRNFEHFWLNEGFTVFLERKVKASLIEDPIEAKKSRDFHSILGLEELSEAVVSQLGVDNPLTRLVPDLHDVHPDDAFSTVPYEKGSLFLRYLEDLIGGPEVFDDFLRSYLKNFSRKSLDTDEFKAYLFNYFQDNEKLKSVDWETWLYKSGMPPVIPDYDTSMTKPITALVAKINQRNASLISYQDVQTFTPHQIMIFLQELIKHPPLPLDILHTLGAEYKIDSSKNTEILYRWLRLCLRSKDQSILGEVFDFVNHIGRMRYVRPLYRDLYDWEDVRNQAIENFLKNEQYMMHVCAHTVKKDLHLID

Catalytic Activity

H2O + leukotriene A4 = leukotriene B4

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M1 family.

Feature

chain  Leukotriene A(4) hydrolase

Uniprot

H9J3M5   Q1HPZ6   A0A2A4J1R9   A0A2A4J028   A0A2A4IZL0   A0A2A4J1U2   + More
A0A2A4J0U5   A0A212EGY7   A0A194QEA7   S4PDP9   A0A0N1INX3   I4DMU9   E2AJV4   A0A3L8DEW0   A0A026WSW2   A0A067R2V8   D6WQA3   N6TK18   A0A0J7NQV8   A0A2J7RI89   K7IPJ4   A0A232F4W0   A0A087SXZ5   A0A1S3HTK7   A0A0P4WA18   A0A1B6EZ69   A0A0P5HVT5   A0A0P5HTE4   A0A0P6I2V5   A0A162P439   A0A0P6D086   A0A1W4WJA4   A0A034VLU1   A0A0L0BZJ4   A0A2H8TMS3   A0A0K8V4Y7   A0A0P6F148   A0A1I8MPT4   A0A1I8MPT3   A0A0K8WE97   A0A1Y1MLJ2   T1PAM3   A0A0A1XDU2   A0A0K8V3D7   W8BRL6   Q17EU2   A0A1S4F5A1   A0A293MVW2   A0A1Q3FAS5   U5EZH8   E9G305   A0A336KHS5   A0A210PJC8   A0A0P6EKM3   A0A2M4AIT2   A0A2M4BHC6   A0A2M4BHM9   A0A1Q3FB79   A0A182F3W0   A0A084W8N2   W5JVF8   B4JB55   B4KHC6   A0A182ILY2   E2BTZ7   A0A1L8EA25   T1JM78   A0A0Q9XER5   A0A3B0J9M7   A0A2J7RI85   A0A1Z5L5Q1   A0A182RR80   J9JSZ2   B4LU93   A0A0P5I5C9   A0A1L8EA35   A0A182JTT2   A0A1L8EAE0   A0A1L8E9Y8   A0A182TNS2   B0WVS1   A0A3B0JE93   B5DI51   A0A1I8Q2R3   A0A0Q9WLT2   A0A0R3NXG4   A0A182HRI1   A0A182XJK3   U4UFC5   A0A1I8Q2N7   A0A182VM67   B4G8I9   Q7Q192   A0A1S4H3A8   A0A182KTJ7   A0A0K2SWE2   B4MTS5   A0A023EVM8   A0A0M4EGR4   G3MF29  

EC Number

3.3.2.6

Pubmed

19121390    22118469    26354079    23622113    22651552    20798317    + More
30249741    24508170    24845553    18362917    19820115    23537049    20075255    28648823    25348373    26108605    25315136    28004739    25830018    24495485    17510324    21292972    28812685    24438588    20920257    23761445    17994087    28528879    18057021    15632085    12364791    20966253    24945155    22216098   

EMBL

BABH01021632    BABH01021633    BABH01021634    BABH01021635    DQ443256    ABF51345.1    + More
NWSH01004210    PCG65352.1    PCG65351.1    PCG65357.1    PCG65353.1    PCG65356.1    AGBW02014995    OWR40757.1    KQ459185    KPJ03280.1    GAIX01003576    JAA88984.1    KQ460772    KPJ12486.1    AK402617    BAM19239.1    GL440100    EFN66270.1    QOIP01000009    RLU18861.1    KK107119    EZA58766.1    KK852949    KDR13370.1    KQ971354    EFA07524.1    APGK01035291    APGK01035292    KB740923    ENN78248.1    LBMM01002417    KMQ94850.1    NEVH01003504    PNF40549.1    NNAY01001008    OXU25510.1    KK112471    KFM57734.1    GDRN01079561    JAI62381.1    GECZ01026423    JAS43346.1    GDIQ01224453    JAK27272.1    GDIQ01223199    JAK28526.1    GDIQ01026659    JAN68078.1    LRGB01000512    KZS18502.1    GDIP01007387    JAM96328.1    GAKP01016434    GAKP01016433    JAC42518.1    JRES01001109    KNC25502.1    GFXV01003669    MBW15474.1    GDHF01018312    JAI34002.1    GDIQ01063011    JAN31726.1    GDHF01033565    GDHF01016049    GDHF01006128    GDHF01002826    JAI18749.1    JAI36265.1    JAI46186.1    JAI49488.1    GEZM01033892    JAV84067.1    KA645821    AFP60450.1    GBXI01015035    GBXI01005659    JAC99256.1    JAD08633.1    GDHF01018877    JAI33437.1    GAMC01007042    JAB99513.1    CH477279    EAT45009.1    GFWV01019521    MAA44249.1    GFDL01010361    JAV24684.1    GANO01000771    JAB59100.1    GL732530    EFX86132.1    UFQS01000439    UFQT01000439    SSX03967.1    SSX24332.1    NEDP02076559    OWF36589.1    GDIQ01061218    JAN33519.1    GGFK01007321    MBW40642.1    GGFJ01003319    MBW52460.1    GGFJ01003320    MBW52461.1    GFDL01010238    JAV24807.1    ATLV01021496    KE525319    KFB46576.1    ADMH02000223    ETN67323.1    CH916368    EDW03947.1    CH933807    EDW11190.1    GL450531    EFN80896.1    GFDG01003212    JAV15587.1    JH431873    KRG02567.1    OUUW01000004    SPP78974.1    PNF40547.1    GFJQ02004586    JAW02384.1    ABLF02033844    CH940649    EDW64080.1    KRF81412.1    GDIQ01224454    JAK27271.1    GFDG01003211    JAV15588.1    GFDG01003210    JAV15589.1    GFDG01003209    JAV15590.1    DS232131    EDS35678.1    SPP78973.1    CH379060    EDY69989.1    KRF81413.1    KRT03949.1    APCN01001706    KB632333    ERL92679.1    CH479180    EDW28669.1    AAAB01008980    EAA14067.4    HACA01000708    CDW18069.1    CH963852    EDW75514.2    GAPW01000492    JAC13106.1    CP012523    ALC39980.1    JO840480    AEO32097.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000000311    + More
UP000279307    UP000053097    UP000027135    UP000007266    UP000019118    UP000036403    UP000235965    UP000002358    UP000215335    UP000054359    UP000085678    UP000076858    UP000192223    UP000037069    UP000095301    UP000008820    UP000000305    UP000242188    UP000069272    UP000030765    UP000000673    UP000001070    UP000009192    UP000075880    UP000008237    UP000268350    UP000075900    UP000007819    UP000008792    UP000075881    UP000075902    UP000002320    UP000001819    UP000095300    UP000075840    UP000076407    UP000030742    UP000075903    UP000008744    UP000007062    UP000075882    UP000007798    UP000092553   

PRIDE

H9J3M5    Q1HPZ6   

Pfam

PF01433   Peptidase_M1        + More
PF09127   Leuk-A4-hydro_C
PF00572   Ribosomal_L13

Interpro

IPR034015   M1_LTA4H        + More
IPR001930   Peptidase_M1       
IPR036899   Ribosomal_L13_sf       
IPR015211   Peptidase_M1_C       
IPR027268   Peptidase_M4/M1_CTD_sf       
IPR038502   M1_LTA-4_hydro/amino_C_sf       
IPR016024   ARM-type_fold       
IPR014782   Peptidase_M1_dom       
IPR042097   Aminopeptidase_N-like_N       
IPR005822   Ribosomal_L13       
IPR012777   LTA4H       

SUPFAM

SSF52161   SSF52161        + More
SSF48371   SSF48371       

Gene 3D

1.10.390.10     1.25.40.320     2.60.40.1730     3.90.1180.10    

CDD

cd09599  M1_LTA4H
cd00392  Ribosomal_L13

ProteinModelPortal

H9J3M5   Q1HPZ6   A0A2A4J1R9   A0A2A4J028   A0A2A4IZL0   A0A2A4J1U2   + More
A0A2A4J0U5   A0A212EGY7   A0A194QEA7   S4PDP9   A0A0N1INX3   I4DMU9   E2AJV4   A0A3L8DEW0   A0A026WSW2   A0A067R2V8   D6WQA3   N6TK18   A0A0J7NQV8   A0A2J7RI89   K7IPJ4   A0A232F4W0   A0A087SXZ5   A0A1S3HTK7   A0A0P4WA18   A0A1B6EZ69   A0A0P5HVT5   A0A0P5HTE4   A0A0P6I2V5   A0A162P439   A0A0P6D086   A0A1W4WJA4   A0A034VLU1   A0A0L0BZJ4   A0A2H8TMS3   A0A0K8V4Y7   A0A0P6F148   A0A1I8MPT4   A0A1I8MPT3   A0A0K8WE97   A0A1Y1MLJ2   T1PAM3   A0A0A1XDU2   A0A0K8V3D7   W8BRL6   Q17EU2   A0A1S4F5A1   A0A293MVW2   A0A1Q3FAS5   U5EZH8   E9G305   A0A336KHS5   A0A210PJC8   A0A0P6EKM3   A0A2M4AIT2   A0A2M4BHC6   A0A2M4BHM9   A0A1Q3FB79   A0A182F3W0   A0A084W8N2   W5JVF8   B4JB55   B4KHC6   A0A182ILY2   E2BTZ7   A0A1L8EA25   T1JM78   A0A0Q9XER5   A0A3B0J9M7   A0A2J7RI85   A0A1Z5L5Q1   A0A182RR80   J9JSZ2   B4LU93   A0A0P5I5C9   A0A1L8EA35   A0A182JTT2   A0A1L8EAE0   A0A1L8E9Y8   A0A182TNS2   B0WVS1   A0A3B0JE93   B5DI51   A0A1I8Q2R3   A0A0Q9WLT2   A0A0R3NXG4   A0A182HRI1   A0A182XJK3   U4UFC5   A0A1I8Q2N7   A0A182VM67   B4G8I9   Q7Q192   A0A1S4H3A8   A0A182KTJ7   A0A0K2SWE2   B4MTS5   A0A023EVM8   A0A0M4EGR4   G3MF29  

PDB

4GAA     E-value=3.07906e-163,     Score=1478

KEGG

732953    K01254 leukotriene-A4 hydrolase [EC:3.3.2.6] | (RefSeq) leukotriene A4 hydrolase

PATHWAY

00590    Arachidonic acid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006412   GO:0003735   GO:0008237   GO:0005840   GO:0008270   GO:0004463   GO:0019370   GO:0005737   GO:0046872   GO:0044255   GO:0004177   GO:0004301   GO:0016021   GO:0005488   GO:0003684   GO:0005634   GO:0042162   GO:0043564   GO:0006418   GO:0003824   GO:0006508  

Subcellular location

Cytoplasm  

Length:

607

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00175

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00011

outside

1  -  607

 

 

Pi

221.79814

Theta

161.314134

Tajima's D

1.194034

CLR

0.021136

CSRT

0.713814309284536

Interpretation

Uncertain