Gene

KWMTBOMO11604

Pre Gene Modal

BGIBMGA004107

Annotation

PREDICTED:_high_affinity_cAMP-specific_and_IBMX-insensitive_3'?5'-cyclic_phosphodiesterase_8A_[Bombyx_mori]

Location

Bomo_Chr19(+):9866179-9888362      View in EpiBrowser

Full name

Phosphodiesterase       + More
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8      

Alternative Name

Phosphodiesterase 8

Location in the cell

Cytoplasmic   Reliability : 1.136 Mitochondrial   Reliability : 1.595

CDS

ATGACACTAATGCAAACTGAAACAAAGGATATATGTTTTATGAAAACAGCAAGCCGCCGTCACGTTATAGACGACACGCTCTCTGACGCTTCGACTGCATATCTCAAAGATGAATTCGGTGTGCTGGCATATTTAGAGGCAGGATTCAACAGGGTAATGGTGGAAACAGTAAACACGACAGCTTGGTGCGCTGAAGTACTACAGGCGCGTTCCTCAGCCGCGTGCTCCCGGGCACAGATCGCAGCCACAGCCGCCTTGGCCGCTGCCGCCGACCGTTGCAGAGATTTGGTTGCTATCACTGACGACCAGCAGAGGATCCTCCTCACTAATAAATCCTGGTGCCGTATGCTGGGGTGGCGTTTGGAGGAAGGTCCGAGGCCAATCCACGAAGCGGCTGGAGGAGAAGCTCTACGACTGGCAACAACCGGAGCCAGGGACTGGGAGGCGCCAGTTACTCTCCGTCGCAGGGCTGCTCCAGATCCAATCATGCTGCCATGCAGGGGTGCCACTATAGGGCTCACTAAGACAACTTCTCACATAGTATTCGTCTGTGAGCCGAGCGCAGGAGAGGGCGACCGTGGTAGGGGCTCGCTGCACTCGATCAGACGCGGCTCGCTTGACGTGCGCTCAGTGGCCTCGGACGGACTGCGTCGAACCTCACTGGCCAAACTACAGGGACTACCTCTCGAAGCACCCATCACTAAGGTGATATCTCTACTATCGGCGGCTACGGAGGGTGCTCCGCCTTCCACCGTGGCCTGTATAGAGCGAGCCGTCGACATGCTCAGGACTTCAGAGCTGTACTCACCACAGATGAGAGACGAAACCAAACTCAGAGTCGAGGACCCCATAGCCACCGATCTCATTGGCGCACTGCTATCGGGAAATGCTAACGTCTTATCGTCGCGTCGAAGCAGCAATGACTCCACCGTCGTGCGTTCACAAACTAACCGAACCAACATCAAACACAAGACGACTGGTCAACTTCGGGAGCTTCTGGACACGGCTCTGAGCTGGGACTTCGAGATCTTCCGCCTGGAGGATCTGACCCGCGGACGGCCCCTCGCGCACCTCGGGCTCGCGCTCATGGGGGGCAGGTTCGACGTGTGCGCCGCCCTGGAGTGCGACGAGAGAACGCTCCTGCACTGGCTCACCGTCATCGAGACCAACTACCACGCCGTCAACACCTACCACAATTCCACGCATGCGGCAGATGTACTACAGGCAGTGGCGTACTTCCTGGAGAAGGATCGGCTGAAGAACCTTCTGGAGCCAGTGGAGGCGGCCGCGGCTCTGATCTCGGCGGCGGCGCACGACATCGACCACCCGGGCACCTCGTCCGCCTTCCTCTGCAACGCGCGACACCCGCTCGCGATCCTCTACAATGACGTCAGCGTGCTCGAGTCGCATCACGCCGCGCTCACATTCAAACTCACGCTCAACGACGACCGCGTGAACATATTCAAGAATCTCGACCGCGACACGTACAAGACGGTGCGGCACCACGTCATCGACATGATCCTCGCGACGGAGATGACGAAACACTTCGAGCATCTCGCCAAGTTCGTCAACGTGTTCTACGCTAAGTCCTCCGGTAGCAAGGAGGACGGCATGCACACTGATGAGCCATTATCACTAGACACCACAGCACTTTCTCAACCAGAGAATGTCTTGTTGGTGAAAAGAATGATGATCAAATGCGCTGATGTCTCGAACGCGTCACGACCTCAAAAGTTCGCTATGGAGTGGGCTAGACGGATTGCTGAGGAATATTTCCTACAGACGGATGAAGAAAAGGCGAAAGACTTGCCTGTCGTGATGCCAATGTTCGATCGAGCCACCTGCTCTATCCCGCGCTCACAAATCGGCTTCATCGACTACATCATCATAGACATGATGGAGGCCTGGGCTGCCTTCATCGACATGCCAGAACTAGTGAACCACGCCAGAAGCAACAACCAACACTGGCGGGAACTGGACGAGGCGGGAGTGACCACGCTCGCCGACGTCAAACGTGTTCAACGACAAAACGCTATACAAGCCCCTCCCACCACTACCGCCGAACCGACAACTGAAGAATAA

Protein

MTLMQTETKDICFMKTASRRHVIDDTLSDASTAYLKDEFGVLAYLEAGFNRVMVETVNTTAWCAEVLQARSSAACSRAQIAATAALAAAADRCRDLVAITDDQQRILLTNKSWCRMLGWRLEEGPRPIHEAAGGEALRLATTGARDWEAPVTLRRRAAPDPIMLPCRGATIGLTKTTSHIVFVCEPSAGEGDRGRGSLHSIRRGSLDVRSVASDGLRRTSLAKLQGLPLEAPITKVISLLSAATEGAPPSTVACIERAVDMLRTSELYSPQMRDETKLRVEDPIATDLIGALLSGNANVLSSRRSSNDSTVVRSQTNRTNIKHKTTGQLRELLDTALSWDFEIFRLEDLTRGRPLAHLGLALMGGRFDVCAALECDERTLLHWLTVIETNYHAVNTYHNSTHAADVLQAVAYFLEKDRLKNLLEPVEAAAALISAAAHDIDHPGTSSAFLCNARHPLAILYNDVSVLESHHAALTFKLTLNDDRVNIFKNLDRDTYKTVRHHVIDMILATEMTKHFEHLAKFVNVFYAKSSGSKEDGMHTDEPLSLDTTALSQPENVLLVKRMMIKCADVSNASRPQKFAMEWARRIAEEYFLQTDEEKAKDLPVVMPMFDRATCSIPRSQIGFIDYIIIDMMEAWAAFIDMPELVNHARSNNQHWRELDEAGVTTLADVKRVQRQNAIQAPPTTTAEPTTEE

Description

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Involved in the positive regulation of MAP kinase signaling and in inhibiting oxidative stress-induced cell death (PubMed:23509299).

Catalytic Activity

3',5'-cyclic AMP + H2O = AMP + H(+)

Cofactor

a divalent metal cation

Similarity

Belongs to the cyclic nucleotide phosphodiesterase family.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.

Keywords

Alternative splicing   cAMP   Complete proteome   Hydrolase   Metal-binding   Reference proteome  

Feature

chain  High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8
splice variant  In isoform C.

Uniprot

A0A194QCM1   A0A3S2NP76   A0A194QWB3   A0A212EGX9   A0A1Y1LB63   A0A1Y1LB55   + More
A0A1Y1LGH2   A0A1B6C1Q8   A0A139WFF3   A0A139WF42   A0A1B6D166   N6TN97   A0A2H8TXF4   A0A2S2NVJ8   J9JTW7   A0A2S2QE64   A0A1B6GW39   A0A336LT50   A0A336LSU9   E0VRW3   E2C088   A0A1J1HIG6   A0A182WX29   A0A182LS27   A7URN7   A0A182UG75   A0A2J7QT83   A0A067RHJ8   A0A0K8TN27   Q7QJ01   A0A182PDQ2   Q16JF3   A0A182WJV1   A0A182RCM5   A0A158P0G0   A0A182GBB1   A0A182NJW4   A0A182R086   A0A151I4C0   A0A1S4FYS0   A0A0K8U7D3   A0A034VBY3   A0A0A1XJC2   E9IKR3   A0A0A1WUU5   W8BBA4   A0A1I8PV34   A0A0L0C916   A0A0A1XQ71   W8ARC4   A0A084VQY3   A0A182I2M1   B4NMM0   A0A182Y2P7   A0A195D1Y8   T1PKA6   A0A1I8MIV0   A0A1Q3FX90   A0A195E195   A0A195F2E0   A0A2M4A8P1   A0A182IU06   A0A2M4A7Z6   A0A151WXN6   Q28ZF2   A0A2M4CS56   A0A3B0JHX1   A0A1B6LW76   A0A1Q3FUP7   W5J8B3   A0A232FCU7   B3MFI3   T1PMT6   B4LLX8   A0A182FGD7   Q8MLR1   Q6NNF2-2   B3NPQ1   A0A026W1V4   A0A3L8D7R8   E1JGU6   K7IY17   B4P9Q8   F4WRM3   B4I8R1   Q6NNF2   A0A0J9U9F1   Q6NNF2-5   B4J7C7   A0A1W4UA72   A0A1W4UA69   A0A182KQI6   A0A182VP90   A0A1W4U9K6   A0A1W4U9K2   B4KS04   A0A0P6HD91  

EC Number

3.1.4.-
3.1.4.53

Pubmed

26354079    22118469    28004739    18362917    19820115    23537049    + More
20566863    20798317    12364791    14747013    17210077    24845553    26369729    17510324    21347285    26483478    25348373    25830018    21282665    24495485    26108605    24438588    17994087    25244985    25315136    15632085    20920257    23761445    28648823    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    15673286    23509299    24508170    30249741    20075255    17550304    21719571    22936249    20966253   

EMBL

KQ459185    KPJ03288.1    RSAL01000182    RVE44887.1    KQ461073    KPJ09594.1    + More
AGBW02014996    OWR40747.1    GEZM01062028    JAV70111.1    GEZM01062023    JAV70118.1    GEZM01062027    GEZM01062024    JAV70117.1    GEDC01029994    JAS07304.1    KQ971354    KYB26565.1    KYB26564.1    GEDC01017839    JAS19459.1    APGK01058439    APGK01058440    APGK01058441    APGK01058442    APGK01058443    KB741288    ENN70710.1    GFXV01007170    MBW18975.1    GGMR01008463    MBY21082.1    ABLF02028341    GGMS01006816    MBY76019.1    GECZ01003152    JAS66617.1    UFQT01000164    SSX21065.1    SSX21064.1    DS235562    EEB16119.1    GL451753    EFN78640.1    CVRI01000001    CRK86262.1    AXCM01000307    AAAB01008807    EDO64678.1    NEVH01011198    PNF31799.1    KK852504    KDR22513.1    GDAI01002067    JAI15536.1    EAA04173.4    CH478011    EAT34419.1    ADTU01004819    ADTU01004820    ADTU01004821    ADTU01004822    JXUM01008983    JXUM01008984    JXUM01008985    JXUM01008986    JXUM01008987    JXUM01008988    KQ560273    KXJ83391.1    AXCN02000526    KQ976463    KYM84601.1    GDHF01029828    JAI22486.1    GAKP01019336    GAKP01019335    JAC39617.1    GBXI01003302    JAD10990.1    GL764026    EFZ18745.1    GBXI01011650    JAD02642.1    GAMC01019431    JAB87124.1    JRES01000729    KNC28923.1    GBXI01001272    JAD13020.1    GAMC01019432    JAB87123.1    ATLV01015348    ATLV01015349    ATLV01015350    KE525007    KFB40377.1    APCN01000169    CH964282    EDW85609.2    KQ976948    KYN06887.1    KA648495    AFP63124.1    GFDL01002870    JAV32175.1    KQ979824    KYN18908.1    KQ981856    KYN34745.1    GGFK01003853    MBW37174.1    GGFK01003602    MBW36923.1    KQ982656    KYQ52699.1    CM000071    EAL25661.4    GGFL01003965    MBW68143.1    OUUW01000001    SPP72989.1    GEBQ01012040    JAT27937.1    GFDL01003738    JAV31307.1    ADMH02002070    ETN59633.1    NNAY01000405    OXU28624.1    CH902619    EDV36668.2    KA650004    AFP64633.1    CH940648    EDW62001.2    AE013599    AAM68264.1    AY060327    BT021326    BT011336    BT133111    AAL25366.1    AAR96128.1    AAX33474.1    AEX98031.1    CH954179    EDV56842.2    KK107488    EZA50013.1    QOIP01000012    RLU15938.1    ACZ94550.2    CM000158    EDW92366.2    GL888291    EGI63168.1    CH480824    EDW56986.1    CM002911    KMY96080.1    CH916367    EDW01051.1    CH933808    EDW09445.2    GDIQ01021167    JAN73570.1   

Proteomes

UP000053268    UP000283053    UP000053240    UP000007151    UP000007266    UP000019118    + More
UP000007819    UP000009046    UP000008237    UP000183832    UP000076407    UP000075883    UP000007062    UP000075902    UP000235965    UP000027135    UP000075885    UP000008820    UP000075920    UP000075900    UP000005205    UP000069940    UP000249989    UP000075884    UP000075886    UP000078540    UP000095300    UP000037069    UP000030765    UP000075840    UP000007798    UP000076408    UP000078542    UP000095301    UP000078492    UP000078541    UP000075880    UP000075809    UP000001819    UP000268350    UP000000673    UP000215335    UP000007801    UP000008792    UP000069272    UP000000803    UP000008711    UP000053097    UP000279307    UP000002358    UP000002282    UP000007755    UP000001292    UP000001070    UP000192221    UP000075882    UP000009192   

PRIDE

Q8MLR1    Q6NNF2    E1JGU6   

Pfam

PF00233   PDEase_I        + More
PF13426   PAS_9
PF00989   PAS

Interpro

IPR023088   PDEase        + More
IPR003607   HD/PDEase_dom       
IPR036971   PDEase_catalytic_dom_sf       
IPR002073   PDEase_catalytic_dom       
IPR035965   PAS-like_dom_sf       
IPR011006   CheY-like_superfamily       
IPR000014   PAS       
IPR013767   PAS_fold       
IPR023174   PDEase_CS       
IPR001789   Sig_transdc_resp-reg_receiver       

SUPFAM

SSF55785   SSF55785        + More
SSF52172   SSF52172       

Gene 3D

1.10.1300.10    

CDD

cd00077  HDc
cd00130  PAS
cd00156  REC

ProteinModelPortal

A0A194QCM1   A0A3S2NP76   A0A194QWB3   A0A212EGX9   A0A1Y1LB63   A0A1Y1LB55   + More
A0A1Y1LGH2   A0A1B6C1Q8   A0A139WFF3   A0A139WF42   A0A1B6D166   N6TN97   A0A2H8TXF4   A0A2S2NVJ8   J9JTW7   A0A2S2QE64   A0A1B6GW39   A0A336LT50   A0A336LSU9   E0VRW3   E2C088   A0A1J1HIG6   A0A182WX29   A0A182LS27   A7URN7   A0A182UG75   A0A2J7QT83   A0A067RHJ8   A0A0K8TN27   Q7QJ01   A0A182PDQ2   Q16JF3   A0A182WJV1   A0A182RCM5   A0A158P0G0   A0A182GBB1   A0A182NJW4   A0A182R086   A0A151I4C0   A0A1S4FYS0   A0A0K8U7D3   A0A034VBY3   A0A0A1XJC2   E9IKR3   A0A0A1WUU5   W8BBA4   A0A1I8PV34   A0A0L0C916   A0A0A1XQ71   W8ARC4   A0A084VQY3   A0A182I2M1   B4NMM0   A0A182Y2P7   A0A195D1Y8   T1PKA6   A0A1I8MIV0   A0A1Q3FX90   A0A195E195   A0A195F2E0   A0A2M4A8P1   A0A182IU06   A0A2M4A7Z6   A0A151WXN6   Q28ZF2   A0A2M4CS56   A0A3B0JHX1   A0A1B6LW76   A0A1Q3FUP7   W5J8B3   A0A232FCU7   B3MFI3   T1PMT6   B4LLX8   A0A182FGD7   Q8MLR1   Q6NNF2-2   B3NPQ1   A0A026W1V4   A0A3L8D7R8   E1JGU6   K7IY17   B4P9Q8   F4WRM3   B4I8R1   Q6NNF2   A0A0J9U9F1   Q6NNF2-5   B4J7C7   A0A1W4UA72   A0A1W4UA69   A0A182KQI6   A0A182VP90   A0A1W4U9K6   A0A1W4U9K2   B4KS04   A0A0P6HD91  

PDB

3ECN     E-value=1.62042e-109,     Score=1015

KEGG

101737283    K18437 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:3.1.4.5

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004114   GO:0007165   GO:0046872   GO:0016787   GO:0070374   GO:0006355   GO:0000160   GO:0007498   GO:0046058   GO:0006198   GO:1903206   GO:0004115   GO:0016021   GO:0008081   GO:0015074   GO:0003684   GO:0005634   GO:0042162   GO:0043564   GO:0006418   GO:0003824  

Length:

693

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0287

Exp number, first 60 AAs:

0.00112

Total prob of N-in:

0.00081

outside

1  -  693

 

 

Pi

245.481875

Theta

167.966071

Tajima's D

1.381901

CLR

0.250323

CSRT

0.757562121893905

Interpretation

Uncertain