Gene

KWMTBOMO11601

Annotation

PREDICTED:_high_affinity_cAMP-specific_and_IBMX-insensitive_3'?5'-cyclic_phosphodiesterase_8A_[Bombyx_mori]

Location

Bomo_Chr19(+):9758849-9810188      View in EpiBrowser

Full name

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8       + More
Phosphodiesterase      

Alternative Name

Phosphodiesterase 8

Location in the cell

Nuclear   Reliability : 2.627

CDS

ATGATCGTTCTGTTGTCAACAGGCAGTTCAAGTGGGTCGCCAGGAGCTCGTGCCGGCCGACGTTCCTCCCTTGCTCTAACACCAGAGGATGAACCTTTAGTTGATGTCACTAACAGATCACCGCCGCCAGCAAACATCCCAACCGCATTAATCTACTCACCGCCGGAACCTTTAGAGTTGCTATGCGTGTTCCCCGAGCGCACGTCACGCGTGTGCGCCGCGGCGTGCTCGGCGGTGGAGCGGGCAGGCGGCGAGGCGCGGTCCCTGCGGTGCGCCAGGGAAACACTCGACGCGCTACGTCGCGACAACGACACGCGCGTGCCCCACGTCATCGTTGTCGACGCGCGACAACCGCAGCAACTCGATGCATTGCTGCTCGCTAGAGCTATACGAGGAACGAAGAACACTCAGCACGTATACCTGATTGCCATCGTGAAGAAAAGGTACGTTAGATTATATTATTGA

Protein

MIVLLSTGSSSGSPGARAGRRSSLALTPEDEPLVDVTNRSPPPANIPTALIYSPPEPLELLCVFPERTSRVCAAACSAVERAGGEARSLRCARETLDALRRDNDTRVPHVIVVDARQPQQLDALLLARAIRGTKNTQHVYLIAIVKKRYVRLYY

Description

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Involved in the positive regulation of MAP kinase signaling and in inhibiting oxidative stress-induced cell death (PubMed:23509299).

Catalytic Activity

3',5'-cyclic AMP + H2O = AMP + H(+)

Cofactor

a divalent metal cation

Similarity

Belongs to the cyclic nucleotide phosphodiesterase family.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.

Keywords

Alternative splicing   cAMP   Complete proteome   Hydrolase   Metal-binding   Reference proteome  

Feature

chain  High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8
splice variant  In isoform C.

Uniprot

A0A2A4JLK6   A0A3S2NP76   A0A212EGZ0   A0A2A4JM00   A0A194QWB3   A0A194QCM1   + More
A0A3B0JHX1   Q8MLR1   A0A1W4U9K6   A0A1W4UA72   Q28ZF2   A0A1W4UNC3   A0A1W4UA69   A0A1W4U9K2   Q6NNF2-2   Q6NNF2   E1JGU6   B3NPQ1   A0A0J9U9F1   B4P9Q8   Q6NNF2-4   B4NMM0   B4I8R1   Q8IGT9   B3MFI3   A0A0K8ULH7   A0A0A1XDN2   Q7QJ01   A0A034VBY3   A0A0K8U7D3   A0A0A1XQ71   A0A084VQY3   A0A182UG75   B4LLX8   A0A1Q3FX90   A0A1Q3FUP7   A0A182LS27   A0A2M4A7Z6   A0A2M4CS56   A0A0A1XJC2   A0A0K8TN27   B4KS04   W8ARC4   B4J7C7   W8BBA4   A0A139WF42   A0A2U3VSX9   A0A3Q7S5X7   A0A3Q7R3E8   A0A2U3VSP7   A0A182IU06   A0A3Q7XTB9   A0A3Q7WMI8   A0A337SMY2   M3WJ55   A0A182FGD7   A0A2Y9K5C9   A0A2Y9GE73   A0A2Y9K0N7   A0A336LSU9   A0A336LT50  

EC Number

3.1.4.53
3.1.4.-

Pubmed

22118469    26354079    10731132    12537568    12537572    12537573    + More
12537574    16110336    17569856    17569867    15632085    17994087    12537569    15673286    23509299    22936249    17550304    25830018    12364791    14747013    17210077    25348373    24438588    26369729    24495485    18362917    19820115    17975172   

EMBL

NWSH01001129    PCG72464.1    RSAL01000182    RVE44887.1    AGBW02014996    OWR40748.1    + More
PCG72463.1    KQ461073    KPJ09594.1    KQ459185    KPJ03288.1    OUUW01000001    SPP72989.1    AE013599    AAM68264.1    CM000071    EAL25661.4    AY060327    BT021326    BT011336    BT133111    AAL25366.1    AAR96128.1    AAX33474.1    AEX98031.1    ACZ94550.2    CH954179    EDV56842.2    CM002911    KMY96080.1    CM000158    EDW92366.2    CH964282    EDW85609.2    CH480824    EDW56986.1    BT001607    AAN71362.1    CH902619    EDV36668.2    GDHF01025104    JAI27210.1    GBXI01005719    JAD08573.1    AAAB01008807    EAA04173.4    GAKP01019336    GAKP01019335    JAC39617.1    GDHF01029828    JAI22486.1    GBXI01001272    JAD13020.1    ATLV01015348    ATLV01015349    ATLV01015350    KE525007    KFB40377.1    CH940648    EDW62001.2    GFDL01002870    JAV32175.1    GFDL01003738    JAV31307.1    AXCM01000307    GGFK01003602    MBW36923.1    GGFL01003965    MBW68143.1    GBXI01003302    JAD10990.1    GDAI01002067    JAI15536.1    CH933808    EDW09445.2    GAMC01019432    JAB87123.1    CH916367    EDW01051.1    GAMC01019431    JAB87124.1    KQ971354    KYB26564.1    AANG04002993    UFQT01000164    SSX21064.1    SSX21065.1   

Proteomes

UP000218220    UP000283053    UP000007151    UP000053240    UP000053268    UP000268350    + More
UP000000803    UP000192221    UP000001819    UP000008711    UP000002282    UP000007798    UP000001292    UP000007801    UP000007062    UP000030765    UP000075902    UP000008792    UP000075883    UP000009192    UP000001070    UP000007266    UP000245340    UP000286641    UP000075880    UP000286642    UP000011712    UP000069272    UP000248482    UP000248481   

PRIDE

Q8MLR1    Q6NNF2    E1JGU6    Q8IGT9   

Pfam

PF00233   PDEase_I        + More
PF13426   PAS_9
PF00989   PAS
PF08629   PDE8

Interpro

IPR023088   PDEase        + More
IPR003607   HD/PDEase_dom       
IPR036971   PDEase_catalytic_dom_sf       
IPR002073   PDEase_catalytic_dom       
IPR000014   PAS       
IPR035965   PAS-like_dom_sf       
IPR013767   PAS_fold       
IPR011006   CheY-like_superfamily       
IPR023174   PDEase_CS       
IPR013938   PDEase_PDE8       

SUPFAM

SSF55785   SSF55785        + More
SSF52172   SSF52172       

Gene 3D

1.10.1300.10    

CDD

cd00077  HDc
cd00130  PAS

ProteinModelPortal

A0A2A4JLK6   A0A3S2NP76   A0A212EGZ0   A0A2A4JM00   A0A194QWB3   A0A194QCM1   + More
A0A3B0JHX1   Q8MLR1   A0A1W4U9K6   A0A1W4UA72   Q28ZF2   A0A1W4UNC3   A0A1W4UA69   A0A1W4U9K2   Q6NNF2-2   Q6NNF2   E1JGU6   B3NPQ1   A0A0J9U9F1   B4P9Q8   Q6NNF2-4   B4NMM0   B4I8R1   Q8IGT9   B3MFI3   A0A0K8ULH7   A0A0A1XDN2   Q7QJ01   A0A034VBY3   A0A0K8U7D3   A0A0A1XQ71   A0A084VQY3   A0A182UG75   B4LLX8   A0A1Q3FX90   A0A1Q3FUP7   A0A182LS27   A0A2M4A7Z6   A0A2M4CS56   A0A0A1XJC2   A0A0K8TN27   B4KS04   W8ARC4   B4J7C7   W8BBA4   A0A139WF42   A0A2U3VSX9   A0A3Q7S5X7   A0A3Q7R3E8   A0A2U3VSP7   A0A182IU06   A0A3Q7XTB9   A0A3Q7WMI8   A0A337SMY2   M3WJ55   A0A182FGD7   A0A2Y9K5C9   A0A2Y9GE73   A0A2Y9K0N7   A0A336LSU9   A0A336LT50  

KEGG

101737283    K18437 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:3.1.4.5

GO

GO:0016787   GO:0046872   GO:0004114   GO:0007165   GO:0007498   GO:0046058   GO:0006198   GO:0070374   GO:1903206   GO:0004115   GO:0006355   GO:0019900   GO:0071364   GO:0047555  

Length:

154

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00274

Exp number, first 60 AAs:

0.00068

Total prob of N-in:

0.07287

outside

1  -  154

 

 

Pi

203.425058

Theta

166.311839

Tajima's D

0.71204

CLR

0.359687

CSRT

0.574571271436428

Interpretation

Uncertain