Gene

KWMTBOMO11595

Pre Gene Modal

BGIBMGA004017

Annotation

PREDICTED:_GPI_ethanolamine_phosphate_transferase_2_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr19(-):9369737-9388437      View in EpiBrowser

Full name

GPI ethanolamine phosphate transferase 2      

Alternative Name

GPI7 homolog
Phosphatidylinositol-glycan biosynthesis class G protein

Location in the cell

PlasmaMembrane   Reliability : 4.787

CDS

ATGATCACATTATTGCAATACCGATGGACAGGGCTCTTCCTTCTAATCACGGCCTTAGGAGCATTAACCCTTTTCCTGTATGGATTTTTTCCACTAAAATATCATTCAGGAAAATTTGCCCACATGAGTGACCTTCCTAACTTCATAGATGGTGTAAGTATTGACGGACAGCAAGTATATAACTCTGGGGAGAATAGTGTGATTCTAATGGTTATTGATGGATTACGCTATGATTTTGTAACAGAAGAATATATGGCATATACAGGCCAACTCTTGAAGAACAAATCAGCTTGCATTTATGTTACTGTTGCTGAGCCTCCTACTGTGACTATGCCCAGAATAAAATCACCAGAACGGAAAAAGGAAAAAGCACAGTGGAGACGCACAATAAACTTCTGGAGGGACATATTCGCCATGATGACTGGGAGTGTATCGACGTTTGCCGATGTAGCGTTAAACTTCGGAGCGCCTGCTGTTCGAGGGGACAGCGTACTACGCGTCGCCGCTTCTAGAGGTCGACGCACCGTCATGTACGGGGACGACACCTGGATCAGACTATTCCCAGGCCTGTGGTCCGAATACGACGGAACCACTTCGTTCTTCGTGACCGATTATACAGAGGTGGACAACAATGTCACCAGGCATTTAGACAAAGTGTTGGCGCCTGATGAAAAGAAACAACCGAAATTCGACCTTTTAGTACTGCACTATTTAGGCTTAGATCACATTGGTCACTTGGAAGGCGCCCGCAGTACAAAAATCAAACCGAAGCTAGTGGAAATGGATGAGATAGTGAAGAAGATTTATGTGGCCATGCAAAAATGGGATCGTAACGGAATCCTAATAGTTTGCGGAGACCACGGCATGCGGGACGCGGGGGGCCACGGGGGCTCCACTCCCGCAGAGGTTCTAGTTCCTCTGGTGGTCATAAAAAGTCAAGATTTCGAATGCCCACATCCATTAGGGCCAGGACCTACGGTGGCTCAGGTCGACGTTGCGCCCACGATATCCTGGTTGCTAAACGCCCCGCCCCCCGGGGATAGCACGGGCCGGATACTGCCGTCCCTGCTCCCCGCCGACACGAGACAGCATCTCTACTTACTTCACATCATAGCTGAAAGAATGGCAAAACAAAACGACTTGCCCACAGATAAAGAGTTTTACAAGCAATTCGAGAGGGCCGAAAATCAATTTGCCCACTATTTGGCGACCGGTCAGCAAAGCGCCGCGAAAATATCAAAAGAGTTCTACGAACAGTCGCTGGCGGAGATGACCGAGTACCTCAACGGAACCACGGTCGACTTCGACATGTTCTCTATAGTAGTTGCTATAATACTGCTTTATTTTATTGTCGCGTCGCTTCTGTGCGTAACTCTATACTCACTCCAGCCGGACCACAGCAGGAAACACAGTACGACGAAGCGAGGCTACCAAAGCTCTAACGCCGGTAGAATAGTGGCGTTTCTATTCATGCTCTGCTTGTCCGGTAGCGGCTTGATCGTCGCCTGTTTCATAACCGAAACCAAAAGTCAGCTGTGCTCGTTCAACGGGCTCTGGCTACCGGTCCTTTTAGTCGTCGCGGCAGCGTTCACAATAACATACTTCATCATGAAAACCGGCATCGAGAGAATAAAAAATCTGTCGTCGCTAAACGAGCTGAACGCGATCGATTTTCTACTGATCGGCGGGACAGTTTTCCATGCGTGGTCTTTCTTCGGCACGAGTTTCATCGAGGAAGAGCACATGACGTGGTATTTCTTCTGGAACACATTCATGTTTTTCGTTTTGATACGGAGCATCGTGGTTGTCGTTATGTATTGGAGTAAGAAGATGACCGGCGCGACTGAAGTACAAGAGAAACCTGGCTTAGATGAGAAAATGAGCGCCGTCGGTATCAGTATTGTCCCGAAATGGGTCCTACTCATAGCCTTACATAGATATTTGCGCACCATGAACCAGACCGGGGACCGCTGGTTGTTCCTGCCGGACACAGCGGACTGGCTCAACGAACCTGAGAACTCGCTATACTTAGAACTCCACGTGATCATTGGAACTATAATGACAGTATTAATATGTGTCCACAATCTCGTTTACACGAATAACTTGATGTACATCCACACGGCGCTGACGGCCGCGGCCGCGACCTGCACCTTCTGCTACAGGGTTGCCACGCACGCCGTGCACGCACCCTTCGAGGACATGAAGACCTGGGACCCCATTATAATCGTCAGCGTTTTCTGGGGAATCCTAATGGCCCAGTTCATATACGAGATCATCACTTACGTTGGATTCTTCAAAAGCTGCGGCGTCCATCCCGCCGAGCACGCAATGAACAGCAAAAAGTTCGATTACGTGAAACCTAAGACAAAAACTGAAGATTATATCTACGATCCGACAATTGAGGAGCCGTGGAACGTCGAGGAAGTCAAACTGAATCTCGCTCGTTCGCTTTCGCATCTGATGCTCAATAATATGATGCTAGTAATACTGTTGCTGATGAGACCGCACAACGTGGTAATGGTGCCCAGTGTATACATTACGTGTGTCGTGAGTTCGAAATGTGTGGACCATAAACTGCTGGATCGGAGGTCCGCTAGGAACACGGACGTCGCGGACGTTCTGAGCAGGACGCTGGTGCACATGTGGATCGGGATACTGTTCTTCTTCTATCAGGGTAATTCGAACAGTCTGGCGTCTGTGGACCTGGGGTCGGGGTATGTTGGTCTGCGCGAGTACAGCCCTGTGAGGGTGGCGACGCGCATGGGGCTCCACGCGTACGCCGGACCCGCGCTGGCTGGCGCCGTGCTGTTCTGCACCCTCGCTGCGGAGGCCCGCGATTGGCAACAGTACTTAAAATCAATATGGCGGGCTACAAACATATTGGCGCTCCACAGAGTATACGCTGTCGTCTTATATACAGTGATAGCGACAATATTTCGACACCATTTATTTGTGTGGTCTGTCTTCTCTCCTAAACTATTATACGATTTCGTTGCAACAGTCTTTGGTGTACAGGCGTTAGCTACCATAGGTTATATTATTTTTTTAACGCATGTTACGAGTTGGCTGGCTAGAGTACTAATCACTAGATCAGGACTGAGGTAA

Protein

MITLLQYRWTGLFLLITALGALTLFLYGFFPLKYHSGKFAHMSDLPNFIDGVSIDGQQVYNSGENSVILMVIDGLRYDFVTEEYMAYTGQLLKNKSACIYVTVAEPPTVTMPRIKSPERKKEKAQWRRTINFWRDIFAMMTGSVSTFADVALNFGAPAVRGDSVLRVAASRGRRTVMYGDDTWIRLFPGLWSEYDGTTSFFVTDYTEVDNNVTRHLDKVLAPDEKKQPKFDLLVLHYLGLDHIGHLEGARSTKIKPKLVEMDEIVKKIYVAMQKWDRNGILIVCGDHGMRDAGGHGGSTPAEVLVPLVVIKSQDFECPHPLGPGPTVAQVDVAPTISWLLNAPPPGDSTGRILPSLLPADTRQHLYLLHIIAERMAKQNDLPTDKEFYKQFERAENQFAHYLATGQQSAAKISKEFYEQSLAEMTEYLNGTTVDFDMFSIVVAIILLYFIVASLLCVTLYSLQPDHSRKHSTTKRGYQSSNAGRIVAFLFMLCLSGSGLIVACFITETKSQLCSFNGLWLPVLLVVAAAFTITYFIMKTGIERIKNLSSLNELNAIDFLLIGGTVFHAWSFFGTSFIEEEHMTWYFFWNTFMFFVLIRSIVVVVMYWSKKMTGATEVQEKPGLDEKMSAVGISIVPKWVLLIALHRYLRTMNQTGDRWLFLPDTADWLNEPENSLYLELHVIIGTIMTVLICVHNLVYTNNLMYIHTALTAAAATCTFCYRVATHAVHAPFEDMKTWDPIIIVSVFWGILMAQFIYEIITYVGFFKSCGVHPAEHAMNSKKFDYVKPKTKTEDYIYDPTIEEPWNVEEVKLNLARSLSHLMLNNMMLVILLLMRPHNVVMVPSVYITCVVSSKCVDHKLLDRRSARNTDVADVLSRTLVHMWIGILFFFYQGNSNSLASVDLGSGYVGLREYSPVRVATRMGLHAYAGPALAGAVLFCTLAAEARDWQQYLKSIWRATNILALHRVYAVVLYTVIATIFRHHLFVWSVFSPKLLYDFVATVFGVQALATIGYIIFLTHVTSWLARVLITRSGLR

Description

Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.

Subunit

Forms a complex with PIGF. PIGF is required to stabilize it. Competes with PIGO for the binding of PIGF.

Similarity

Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.

Keywords

Alternative splicing   Complete proteome   Disease mutation   Endoplasmic reticulum   Glycoprotein   GPI-anchor biosynthesis   Membrane   Mental retardation   Polymorphism   Reference proteome   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  GPI ethanolamine phosphate transferase 2
splice variant  In isoform 6.
sequence variant  In dbSNP:rs34120878.

Uniprot

A0A2H1V5Z2   A0A3S2LZI0   A0A2A4JCS8   A0A194QIL6   A0A194QWC4   H9J3D0   + More
A0A2H1WSG9   A0A212EW94   A0A0L7KZ77   A0A067R4Q3   A0A3B4UI57   A0A3B4YN70   A0A3Q3A5T0   A0A3P9AF43   A0A1B6DRI5   A0A3B4ZZD4   H2T4E8   A0A3P8SH69   A0A3Q3MNI8   A0A2I0M6D2   A0A3Q1J506   H0YPF6   A0A3P8YU47   A0A2C9GPL6   K7GFI5   A0A218UMB5   H9FW81   A0A182RE55   G7NWQ8   A0A2K5V853   A0A182KNN6   A0A182JVZ3   A0A2K5K6S7   A0A3P8WCD6   G7MG66   A0A2K6PID3   A0A2K5LDA7   U3JS33   A0A3P8W6Y7   H9ZAH6   K7D9U0   J3SEG9   A0A182N1Y4   A0A182UV55   A0A091IJP4   A0A1S3WVZ1   A0A099YYZ5   A0A182YR49   U3D705   A0A091VIB7   U3F0M8   Q5H8A4-2   T1DMX4   K7BYG4   A0A2J8SSF0   A0A093PJP2   H9G5I3   A0A182J5P2   A0A091FDR4   K7GFH3   A0A091VDW9   A0A0Q3PVM7   Q5H8A4   F6SKB9   V9KC18   G1QJB2   A0A2I0UNF3   A0A2K6BI25   A0A0A0ABJ5   A0A091J0Z8   A0A182QI15   A0A2J8SSG2   W4Y790   F7HKG0   A0A2K6JU75   A0A1S3WWB8   A0A2K6PIM3   A0A0D9RRK0   A0A2K5E4N3   A0A2K5QQ78   A0A1U7QN93   M0RDM7   M3W965   A0A3Q7QB77   A0A1L8HN52   A0A2R9A5W5   H2QP26   A0A2Y9G5I0   E7EWV1   A0A2K6ETQ2   H0WI69   L8IWH2   A0A182TYI6   Q8NCI4   A0A3Q0DM45   F6VAS9   A0A3Q7VV01   A0A3Q0G8V4   A0A3Q0G5C2  

EC Number

2.-.-.-

Pubmed

26354079    19121390    22118469    26227816    24845553    25069045    + More
21551351    23371554    20360741    17381049    25319552    22002653    20966253    24487278    25362486    23025625    25244985    25243066    15632136    12975309    16303743    14702039    15815621    15489334    26996948    23758969    25727380    21881562    17495919    24402279    17431167    15057822    17975172    27762356    22722832    16136131    22751099    20431018   

EMBL

ODYU01000850    SOQ36237.1    RSAL01000096    RVE47703.1    NWSH01001992    PCG69498.1    + More
KQ459185    KPJ03296.1    KQ461073    KPJ09604.1    BABH01021572    BABH01021573    BABH01021574    BABH01021575    ODYU01010708    SOQ55988.1    AGBW02012080    OWR45714.1    JTDY01004149    KOB68527.1    KK852981    KDR12958.1    GEDC01009000    JAS28298.1    AKCR02000034    PKK25239.1    ABQF01041685    ABQF01041686    ABQF01041687    ABQF01041688    ABQF01041689    ABQF01041690    ABQF01041691    ABQF01041692    APCN01004657    AGCU01006575    AGCU01006576    AGCU01006577    AGCU01006578    AGCU01006579    AGCU01006580    AGCU01006581    MUZQ01000235    OWK54570.1    JU335137    JV047461    AFE78890.1    AFI37532.1    CM001276    EHH49448.1    AQIA01053376    AQIA01053377    AQIA01053378    AQIA01053379    AQIA01053380    AQIA01053381    CM001253    EHH14205.1    AGTO01011095    JU476138    AFH32942.1    GABC01005165    GABF01003032    GABD01008606    GABE01001696    NBAG03000389    JAA06173.1    JAA19113.1    JAA24494.1    JAA43043.1    PNI30843.1    JU174700    GBEX01001430    AFJ50226.1    JAI13130.1    KL218793    KFP08492.1    KL887216    KGL74656.1    GAMR01006010    JAB27922.1    KL411079    KFR03147.1    GAMT01003635    GAMS01009608    GAMP01001953    JAB08226.1    JAB13528.1    JAB50802.1    AB162713    AY358538    AK074815    AK000272    AK027465    AK097244    AK296507    AC092574    AC116565    BC000937    BC001249    BC110878    GAAZ01001017    GBKC01001510    JAA96926.1    JAG44560.1    GABC01005166    GABF01003031    GABD01008607    GABE01001697    JAA06172.1    JAA19114.1    JAA24493.1    JAA43042.1    PNI30842.1    NDHI03003552    PNJ23708.1    KL225457    KFW72402.1    AAWZ02013353    AAWZ02013354    KK718913    KFO59800.1    KK733874    KFR00935.1    LMAW01002545    KQK80180.1    JW862803    AFO95320.1    ADFV01125059    ADFV01125060    ADFV01125061    KZ505675    PKU47557.1    KL871357    KGL91909.1    KK501335    KFP14282.1    AXCN02000977    PNJ23707.1    AAGJ04096092    JSUE03032701    JSUE03032702    JSUE03032703    AQIB01147730    AQIB01147731    AQIB01147732    AABR07014132    AC103314    AANG04001605    CM004467    OCT97514.1    AJFE02035480    AACZ04061257    PNI30844.1    AAQR03169398    AAQR03169399    AAQR03169400    AAQR03169401    JH880544    ELR60801.1    AK074715    BAC11157.1    AAMC01111117    AAMC01111118    AAMC01111119    AAMC01111120   

Proteomes

UP000283053    UP000218220    UP000053268    UP000053240    UP000005204    UP000007151    + More
UP000037510    UP000027135    UP000261420    UP000261360    UP000264800    UP000265140    UP000261400    UP000005226    UP000265080    UP000261640    UP000053872    UP000265040    UP000007754    UP000075840    UP000007267    UP000197619    UP000075900    UP000009130    UP000233100    UP000075882    UP000075881    UP000233080    UP000265120    UP000233200    UP000233060    UP000016665    UP000075884    UP000075903    UP000054308    UP000079721    UP000053641    UP000076408    UP000053283    UP000008225    UP000005640    UP000054081    UP000001646    UP000075880    UP000052976    UP000053605    UP000051836    UP000002280    UP000001073    UP000233120    UP000053858    UP000053119    UP000075886    UP000007110    UP000006718    UP000233180    UP000029965    UP000233020    UP000233040    UP000189706    UP000002494    UP000011712    UP000286641    UP000186698    UP000240080    UP000002277    UP000248481    UP000233160    UP000005225    UP000075902    UP000189704    UP000008143    UP000286642    UP000189705   

PRIDE

H9J3D0    Q5H8A4    E7EWV1   

Pfam

PF01663   Phosphodiest

Interpro

IPR037674   PIG-G_N        + More
IPR002591   Phosphodiest/P_Trfase       
IPR039527   PIGG/GPI7       
IPR017850   Alkaline_phosphatase_core_sf       

SUPFAM

SSF53649   SSF53649       

Gene 3D

3.40.720.10    

CDD

cd16024  GPI_EPT_2

ProteinModelPortal

A0A2H1V5Z2   A0A3S2LZI0   A0A2A4JCS8   A0A194QIL6   A0A194QWC4   H9J3D0   + More
A0A2H1WSG9   A0A212EW94   A0A0L7KZ77   A0A067R4Q3   A0A3B4UI57   A0A3B4YN70   A0A3Q3A5T0   A0A3P9AF43   A0A1B6DRI5   A0A3B4ZZD4   H2T4E8   A0A3P8SH69   A0A3Q3MNI8   A0A2I0M6D2   A0A3Q1J506   H0YPF6   A0A3P8YU47   A0A2C9GPL6   K7GFI5   A0A218UMB5   H9FW81   A0A182RE55   G7NWQ8   A0A2K5V853   A0A182KNN6   A0A182JVZ3   A0A2K5K6S7   A0A3P8WCD6   G7MG66   A0A2K6PID3   A0A2K5LDA7   U3JS33   A0A3P8W6Y7   H9ZAH6   K7D9U0   J3SEG9   A0A182N1Y4   A0A182UV55   A0A091IJP4   A0A1S3WVZ1   A0A099YYZ5   A0A182YR49   U3D705   A0A091VIB7   U3F0M8   Q5H8A4-2   T1DMX4   K7BYG4   A0A2J8SSF0   A0A093PJP2   H9G5I3   A0A182J5P2   A0A091FDR4   K7GFH3   A0A091VDW9   A0A0Q3PVM7   Q5H8A4   F6SKB9   V9KC18   G1QJB2   A0A2I0UNF3   A0A2K6BI25   A0A0A0ABJ5   A0A091J0Z8   A0A182QI15   A0A2J8SSG2   W4Y790   F7HKG0   A0A2K6JU75   A0A1S3WWB8   A0A2K6PIM3   A0A0D9RRK0   A0A2K5E4N3   A0A2K5QQ78   A0A1U7QN93   M0RDM7   M3W965   A0A3Q7QB77   A0A1L8HN52   A0A2R9A5W5   H2QP26   A0A2Y9G5I0   E7EWV1   A0A2K6ETQ2   H0WI69   L8IWH2   A0A182TYI6   Q8NCI4   A0A3Q0DM45   F6VAS9   A0A3Q7VV01   A0A3Q0G8V4   A0A3Q0G5C2  

PDB

1O99     E-value=0.00113378,     Score=104

KEGG

101736874    K05310 ethanolamine phosphate transferase 2 subunit G [EC:2.7.-.-] | (RefSeq) GPI ethanolamine phosp

PATHWAY

00563    Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0051377   GO:0006506   GO:0016021   GO:0051267   GO:0005783   GO:0016780   GO:0030176   GO:0005789   GO:0016254   GO:0016020   GO:0016740   GO:0003824   GO:0008152   GO:0005524   GO:0000723   GO:0003684   GO:0005634   GO:0042162   GO:0043564   GO:0006418  

PANTHER

PTHR23072  

Subcellular location

Endoplasmic reticulum membrane  

Length:

1034

Number of predicted TMHs:

14

Exp number of AAs in TMHs:

312.12575

Exp number, first 60 AAs:

21.83914

Total prob of N-in:

0.80374

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  29

outside

30  -  439

TMhelix

440  -  462

inside

463  -  482

TMhelix

483  -  505

outside

506  -  514

TMhelix

515  -  537

inside

538  -  549

TMhelix

550  -  569

outside

570  -  583

TMhelix

584  -  606

inside

607  -  626

TMhelix

627  -  649

outside

650  -  674

TMhelix

675  -  697

inside

698  -  701

TMhelix

702  -  724

outside

725  -  738

TMhelix

739  -  761

inside

762  -  872

TMhelix

873  -  892

outside

893  -  921

TMhelix

922  -  944

inside

945  -  956

TMhelix

957  -  979

outside

980  -  993

TMhelix

994  -  1016

inside

1017  -  1034

 

 

Pi

195.327648

Theta

137.763776

Tajima's D

0.434444

CLR

1.422444

CSRT

0.489725513724314

Interpretation

Uncertain