Gene

KWMTBOMO11586  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004021

Annotation

G_protein_alpha_subunit_Go_isoform_2_[Bombyx_mori]

Location

Bomo_Chr19(-):9295831-9317597      View in EpiBrowser

Full name

Guanine nucleotide-binding protein G(o) subunit alpha       + More
G protein alpha o subunit      

Alternative Name

Guanine nucleotide-binding protein G(o) subunit alpha 47A

Location in the cell

Cytoplasmic   Reliability : 1.221 Nuclear   Reliability : 1.432

CDS

ATGGGCTGCGCTTCATCCGCTGAGGAACGTGCTGCCCTTGCGCGCAGCAAGCAGATCGAGAAGAACCTCAAGGAGGATGGCATCCAGGCTGCCAAGGACATCAAACTTCTGCTCCTTGGTGCTGGCGAATCGGGCAAGAGTACTATAGTCAAACAGATGAAAATTATCCATGAAAGTGGATTCACAAATGAAGACTTCAAACAGTACCGGCCCGTGGTCTACAGCAATACGATCCAGTCGCTCGTCGCCATCTTGCGTGCCATGCCCAACTTGGGCATCATCTATGGCAATAGAGACCGAGAAAGCGATGGTAAGATGGTGTTCGACGTGATTCAACGGATGGAGGACACGGAACCGTTCAGTGAGGAGCTTCTCGCCGCGATGAAAAGGCTCTGGGCCGACTCTGGCGTTCAGGAGTGCTTTGGTCGTTCCAACGAGTACCAACTCAACGACTCCGCTAAATATGAAACCCAGCGCAACAACTATCCCATTTAA

Protein

MGCASSAEERAALARSKQIEKNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTNEDFKQYRPVVYSNTIQSLVAILRAMPNLGIIYGNRDRESDGKMVFDVIQRMEDTEPFSEELLAAMKRLWADSGVQECFGRSNEYQLNDSAKYETQRNNYPI

Description

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Plays a role in glial cell differentiation during embryogenesis; loco, Galphai and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord.

Subunit

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Similarity

Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Keywords

GTP-binding   Lipoprotein   Magnesium   Metal-binding   Myristate   Nucleotide-binding   Palmitate   Transducer   Alternative splicing   Complete proteome   Reference proteome  

Feature

chain  Guanine nucleotide-binding protein G(o) subunit alpha
splice variant  In isoform B.

Uniprot

D2XZ05   A0A2A4JG95   H9J3D4   A0A212EW37   Q5R250   A0A194QVW2   + More
A0A194QCN6   D2XZ04   A0A1B6CFF5   A0A1E1W4B8   A0A1Y1JVD3   A0A1B6I097   A0A1B6KYF7   A0A1B6GKT7   P38404   A0A067R1D8   C7G307   A0A226F1B7   P53359   A0A3L8DKF4   A0A0K2TAL5   A0A1L8DL24   A0A224YUE4   V5HEV5   A0A1E1XNB3   A0A131Z3G0   E2AK59   A0A195BWQ7   E0VQK9   T1K203   T1JHQ3   A0A2R5L5D8   A0A0N7ZCH2   Q28XI2   B4GG59   A0A1W4VQ13   A0A0Q9X0Z5   A0A0P8XRN2   B4KN42   B4LKE6   A0A0C9RDS9   W8C0A1   A0A023FAP1   V9IM78   A0A0A9WN03   A0A1W7R6W8   A0A1Q3G4I3   L7M2P1   A0A131XDQ0   A0A1E1X375   A0A336LHE6   A0A3B0JSM1   P16378-2   A0A2M4CK32   B4QID9   B3N6D7   B4NXN6   W5J5Q9   A0A182JA14   A0A2M4CKF9   A0A2M4AJ07   A0A2M4BT69   B4HMQ2   A0A1Q3FUA8   E9H7Z0   D6WMD3   A0A162SZC2   A0A1Y1JSB5   A0A182XML4   A0A182Q989   A0A182Y249   A0A182L362   A0A182PLU8   A0A182TGW5   A0A182SP29   A0A195CG05   A0A0F7VK34   F2VP16   A0A026W7B7   A0A0F7VKH2   A0A0P6AJP4   A0A1I8NGD7   A0A1I8NT71   A0A0A1WW36   A0A034VX55   A0A2S2NVV3   A0A1A9YET9   A0A1A9VGL3   A0A1A9ZGA7   A0A151X688   A0A2S2NNX1   V5GS00   A0A195ELZ1   A0A195F926   Q6J2K4   J9K924   A0A2S2Q8T0   A0A0R3NPG2   B3MI39   B4N661  

Pubmed

19121390    22118469    15776452    26354079    28004739    2119206    + More
24845553    8612978    30249741    28797301    25765539    29209593    26830274    20798317    20566863    15632085    17994087    18057021    24495485    25474469    25401762    26823975    25576852    28049606    28503490    2519611    2509462    2509463    2509464    10731132    12537572    12537569    10079238    22936249    17550304    20920257    23761445    21292972    18362917    19820115    25244985    20966253    21125564    24508170    25315136    25830018    25348373   

EMBL

GU266214    ADB25317.1    NWSH01001566    PCG70839.1    BABH01021565    BABH01021566    + More
BABH01021567    BABH01021568    AGBW02012080    OWR45706.1    AB167957    BAD74000.1    KQ461073    KPJ09612.1    KQ459185    KPJ03303.1    GU266213    ADB25316.1    GEDC01025198    JAS12100.1    GDQN01009250    JAT81804.1    GEZM01101985    JAV52128.1    GECU01027357    JAS80349.1    GEBQ01023498    JAT16479.1    GECZ01028525    GECZ01006856    JAS41244.1    JAS62913.1    KK852779    KDR16702.1    AB488393    BAH98114.1    LNIX01000001    OXA63573.1    Z49080    QOIP01000007    RLU20924.1    HACA01005145    CDW22506.1    GFDF01007019    JAV07065.1    GFPF01008223    MAA19369.1    GANP01010716    JAB73752.1    GFAA01002666    JAU00769.1    GEDV01003272    JAP85285.1    GL440194    EFN66163.1    KQ976396    KYM93017.1    DS235430    EEB15665.1    CAEY01001358    JH431841    GGLE01000585    MBY04711.1    GDRN01067017    JAI64440.1    CM000071    EAL26334.1    CH479183    EDW35479.1    CH964154    KRF99171.1    CH902619    KPU77232.1    KPU77233.1    CH933808    EDW08869.1    CH940648    EDW61737.1    KRF80195.1    KRF80197.1    GBYB01014719    JAG84486.1    GAMC01007499    JAB99056.1    GBBI01000170    JAC18542.1    JR051451    AEY61499.1    KM610204    GBHO01035721    GDHC01014612    AJQ81035.1    JAG07883.1    JAQ04017.1    GEHC01000747    JAV46898.1    GFDL01000334    JAV34711.1    GACK01006709    JAA58325.1    GEFH01002877    JAP65704.1    GFAC01005469    JAT93719.1    UFQT01000004    SSX17266.1    OUUW01000001    SPP74108.1    M86660    M29602    M31203    M29601    M31198    M31199    M31200    M31201    M31202    M30151    M30152    M31129    M29731    M29732    AE013599    AY121631    BT001768    BT046134    GGFL01001485    MBW65663.1    CM000362    CM002911    EDX06499.1    KMY92789.1    CH954177    EDV58106.1    KQS70246.1    CM000157    EDW89661.1    KRJ98648.1    ADMH02002165    ETN58109.1    GGFL01001483    MBW65661.1    GGFK01007401    MBW40722.1    GGFJ01006827    MBW55968.1    CH480816    EDW47264.1    GFDL01003861    JAV31184.1    GL732602    EFX72162.1    KQ971343    EFA04253.1    LRGB01000024    KZS21762.1    GEZM01101984    JAV52129.1    AXCN02000515    KQ977791    KYM99695.1    LN830656    CFW94165.1    GU564592    ADK94869.1    KK107364    EZA51950.1    LN830713    CFW94222.1    GDIP01028355    JAM75360.1    GBXI01011210    JAD03082.1    GAKP01012514    GAKP01012512    JAC46440.1    GGMR01008658    MBY21277.1    KQ982490    KYQ55819.1    GGMR01006262    MBY18881.1    GALX01005458    JAB63008.1    KQ978691    KYN29233.1    KQ981727    KYN36943.1    AY603976    AAT34978.1    ABLF02021378    ABLF02021382    ABLF02021383    ABLF02021386    ABLF02021387    GGMS01004936    MBY74139.1    KRT03006.1    EDV38049.1    EDW79850.1   

Proteomes

UP000218220    UP000005204    UP000007151    UP000053240    UP000053268    UP000027135    + More
UP000198287    UP000279307    UP000000311    UP000078540    UP000009046    UP000015104    UP000001819    UP000008744    UP000192221    UP000007798    UP000007801    UP000009192    UP000008792    UP000268350    UP000000803    UP000000304    UP000008711    UP000002282    UP000000673    UP000075880    UP000001292    UP000000305    UP000007266    UP000076858    UP000076407    UP000075886    UP000076408    UP000075882    UP000075885    UP000075902    UP000075901    UP000078542    UP000053097    UP000095301    UP000095300    UP000092443    UP000078200    UP000092445    UP000075809    UP000078492    UP000078541    UP000007819   

PRIDE

D2XZ05    H9J3D4    Q5R250    D2XZ04    P38404    P53359    + More
V5HEV5    L7M2P1    P16378   

Pfam

PF00503   G-alpha

Interpro

IPR011025   GproteinA_insert        + More
IPR027417   P-loop_NTPase       
IPR001019   Gprotein_alpha_su       
IPR001408   Gprotein_alpha_I       

SUPFAM

SSF47895   SSF47895        + More
SSF52540   SSF52540       

Gene 3D

1.10.400.10    

CDD

cd00066  G-alpha

ProteinModelPortal

D2XZ05   A0A2A4JG95   H9J3D4   A0A212EW37   Q5R250   A0A194QVW2   + More
A0A194QCN6   D2XZ04   A0A1B6CFF5   A0A1E1W4B8   A0A1Y1JVD3   A0A1B6I097   A0A1B6KYF7   A0A1B6GKT7   P38404   A0A067R1D8   C7G307   A0A226F1B7   P53359   A0A3L8DKF4   A0A0K2TAL5   A0A1L8DL24   A0A224YUE4   V5HEV5   A0A1E1XNB3   A0A131Z3G0   E2AK59   A0A195BWQ7   E0VQK9   T1K203   T1JHQ3   A0A2R5L5D8   A0A0N7ZCH2   Q28XI2   B4GG59   A0A1W4VQ13   A0A0Q9X0Z5   A0A0P8XRN2   B4KN42   B4LKE6   A0A0C9RDS9   W8C0A1   A0A023FAP1   V9IM78   A0A0A9WN03   A0A1W7R6W8   A0A1Q3G4I3   L7M2P1   A0A131XDQ0   A0A1E1X375   A0A336LHE6   A0A3B0JSM1   P16378-2   A0A2M4CK32   B4QID9   B3N6D7   B4NXN6   W5J5Q9   A0A182JA14   A0A2M4CKF9   A0A2M4AJ07   A0A2M4BT69   B4HMQ2   A0A1Q3FUA8   E9H7Z0   D6WMD3   A0A162SZC2   A0A1Y1JSB5   A0A182XML4   A0A182Q989   A0A182Y249   A0A182L362   A0A182PLU8   A0A182TGW5   A0A182SP29   A0A195CG05   A0A0F7VK34   F2VP16   A0A026W7B7   A0A0F7VKH2   A0A0P6AJP4   A0A1I8NGD7   A0A1I8NT71   A0A0A1WW36   A0A034VX55   A0A2S2NVV3   A0A1A9YET9   A0A1A9VGL3   A0A1A9ZGA7   A0A151X688   A0A2S2NNX1   V5GS00   A0A195ELZ1   A0A195F926   Q6J2K4   J9K924   A0A2S2Q8T0   A0A0R3NPG2   B3MI39   B4N661  

PDB

6OIK     E-value=2.46825e-61,     Score=592

KEGG

692460    K04534 guanine nucleotide-binding protein G(o) subunit alpha | (RefSeq) Go, GaO1, GaO2; G protein al

GO

GO:0031683   GO:0046872   GO:0003924   GO:0005525   GO:0007188   GO:0007186   GO:0007165   GO:0050916   GO:0005834   GO:0045886   GO:0030866   GO:0008356   GO:0042595   GO:0007419   GO:0060857   GO:0019991   GO:0061343   GO:0019722   GO:0001737   GO:0032291   GO:0035567   GO:0007507   GO:0005886   GO:0001664   GO:0016021   GO:0004871   GO:0019001   GO:0006418   GO:0003824  

PANTHER

PTHR10218  

Length:

164

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.37461

Exp number, first 60 AAs:

0.00015

Total prob of N-in:

0.17806

outside

1  -  164

 

 

Pi

164.833556

Theta

160.933013

Tajima's D

-0.666535

CLR

1.038581

CSRT

0.203989800509975

Interpretation

Uncertain