Gene

KWMTBOMO11581  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004096

Annotation

cAMP-dependent_protein_kinase_R2_[Bombyx_mori]

Location

Bomo_Chr19(+):9239758-9266561      View in EpiBrowser

Full name

cAMP-dependent protein kinase type II regulatory subunit      

Location in the cell

Cytoplasmic   Reliability : 3.268

CDS

ATGAGCAGGCCTCAGGGCGGACGCATTCAAGTCCCGGATGACCTTAGAGAGATCTTATTGGAGTTTACTATAAGTTATCTGCTGGAGCAGCCTGGGGACGTGATCAACTACGCGGTCGAGTTCTTCACAAGGTTACAAAACAACAGGACGACGACCATCGTACGGGGTCCTGTCGCCGGCACACCTGATGAGTCCATAATATCAGACGAAGAAGAGCCGCCAGTGGCGCGCTTTAACAATCGGCGCAAATCCGTTTTCGCCGAGACTTATGACCCCGAAGAGGATGATTCTGACGAAGGAGCCCCTGCCGTGTTCCCCAAGTCGGACGCACAGAGAGCCCGTCTCGCTGAGGCGGTCCGGGGCATACTGCTGTTCCGTTCTCTTGACGCGCAGCAAATGCAGCAGGTTCTGGATGCGATGTTCGAAAAGAGATCCGAGCCCGGCGAGTACGTAATCAGACAGGGCGATGACGGCGACAACTTCTACGTCATCGAGAACGGCGTTTTCGACGTCCTGGTCACCGGAGACGACCGCGTCGAAAAGGTGGTCCACACATACGAAGGTTCCGGTTCGTTTGGCGAACTGGCCCTGATGTACAACATGCCGCGGGCGGCATCTGTACGGGCCCAGACCGCCGGCGCTCTGTGGGCCATGGACCGCCACACGTTCCGTCGCATCCTGCTCAAGAGCGCATTCAAGAAACGCAAGCTGTACGAGGAGCTCCTCGACAAAGTGCCGATGCTGAAGGCGCTGCAGCCGTACGAGCGCGCTAATTTGGCCGATGCCCTGCTGCCCCGGACTCTGGTGGAAGGCGAGCTGATCATCCGTCAGGGGGACACGGCCGACGGCATGTATTTCGTCGAGGATGGCTCCGTCAGCATCCGGATCACGCGCGACGACGGCAACGAGCACGAAATCAAACGTCTCGGCAAAGGTGATTACTTCGGAGAGCTGGCCTTGGTCACCCACAAGCCGCGTGCCGCTTCTGTTTACGCTATTGGCGCTACCAAGGTGGCGTTCTTGGACGTCGAGACGTTTGAGCGCCTCCTCGGTCCGTGCATGGAGATCATGAAGCGCAACATCGACGACTACGAGGAGCAGCTCGTCAAGTTGTTTGGGGACAAGAGCAACCTCACCGACGTGCGATGA

Protein

MSRPQGGRIQVPDDLREILLEFTISYLLEQPGDVINYAVEFFTRLQNNRTTTIVRGPVAGTPDESIISDEEEPPVARFNNRRKSVFAETYDPEEDDSDEGAPAVFPKSDAQRARLAEAVRGILLFRSLDAQQMQQVLDAMFEKRSEPGEYVIRQGDDGDNFYVIENGVFDVLVTGDDRVEKVVHTYEGSGSFGELALMYNMPRAASVRAQTAGALWAMDRHTFRRILLKSAFKKRKLYEELLDKVPMLKALQPYERANLADALLPRTLVEGELIIRQGDTADGMYFVEDGSVSIRITRDDGNEHEIKRLGKGDYFGELALVTHKPRAASVYAIGATKVAFLDVETFERLLGPCMEIMKRNIDDYEEQLVKLFGDKSNLTDVR

Description

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells (PubMed:10781603, PubMed:9196067). Mediates membrane association by binding to anchoring proteins, such as Akap200 (PubMed:9196067, PubMed:12223401). Might play an essential role in the regulation of neuronal activity in the brain (PubMed:10781603, PubMed:9196067).

Subunit

Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits (PubMed:9196067). In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer (By similarity). Interacts with Akap200 (PubMed:10480936).

Similarity

Belongs to the cAMP-dependent kinase regulatory chain family.

Keywords

Alternative splicing   Biological rhythms   cAMP   cAMP-binding   Cell membrane   Complete proteome   Cytoplasm   Direct protein sequencing   Membrane   Nucleotide-binding   Phosphoprotein   Reference proteome   Repeat  

Feature

chain  cAMP-dependent protein kinase type II regulatory subunit
splice variant  In isoform D.

Uniprot

A8WFD8   A0A212EIE9   A0A194R197   A0A2H1V1E6   A0A2A4JHD4   A0A194QCW5   + More
D6WSE3   A0A2J7R5H9   A0A139WF94   T1E240   V5GYF5   A0A067QJK5   A0A3F2Z223   A0A2C9GPU6   A0A084WCY9   U5EXY6   A0A2M4CTE0   A0A1B6ENV6   A0A182FLA2   A0A2M4AAP7   A0A2M3Z186   A0A2M4BRY2   A0A1Q3FUR1   A0A1Y1LC62   Q7PPI8   A0A0C9QXQ1   A0A1W4WTD5   A0A195DXQ7   A0A1B6D046   A0A1L8DMJ6   A0A158NGT3   E2ACB7   A0A3L8DRM1   A0A2A3ECZ8   V9IE81   T1PBD6   A0A1I8PGG5   Q6ZXJ1   A0A088ARJ5   A0A0V0GB10   A0A023FA94   A0A069DTE6   A0A0K8VD26   A0A195B7M4   A0A034VE34   A0A0K8V830   U4UMJ4   A0A034VEP7   K7J478   A0A0K8UZF9   W8BTG5   T1HVU8   E2BQT5   W8C3P2   A0A232FK92   Q290U0   B4J5A3   A0A0L7R4D3   A0A3B0JK61   A0A3B0IZR1   A0A1J1IBD5   B4LM12   A0A026WYU0   B4KLK0   B4NX29   A0A0J9R972   P81900   B3N6S4   A0A1W4UZ64   A0A2M4ABX9   B3MHI6   A0A151XCX4   A0A0K8TLJ7   A0A224YJ47   A0A131YV19   A0A195FEK8   A0A0M4EUL5   A0A1E1X8B1   L7LYQ1   F4WZN8   A0A131XTD4   B4QHU9   B4HMB0   A0A023FTL3   A0A1E1XT36   A0A2R5LHM2   A0A034VD37   A0A034V9R4   A0A023GJI4   A0A1L8DLW3   A0A1I8PG80   R4WTF6   A0A0A9ZB68   J9K8S6   A0A2H8TYM5   T1E8H8   A0A2S2PNX4   A0A0R3NS26   B4GB88   A0A0A1XJ99  

Pubmed

19121390    22118469    26354079    18362917    19820115    24330624    + More
24845553    24438588    28004739    12364791    14747013    17210077    21347285    20798317    30249741    25315136    25474469    26334808    25348373    23537049    20075255    24495485    28648823    15632085    17994087    18057021    24508170    17550304    22936249    10781603    10731132    12537572    12537569    9196067    10480936    12223401    18327897    29444420    26369729    28797301    26830274    28503490    25576852    21719571    29209593    23691247    25401762    26823975    25830018   

EMBL

BABH01021562    BABH01021563    EU263340    ABW97443.1    AGBW02014665    OWR41254.1    + More
KQ461073    KPJ09616.1    ODYU01000201    SOQ34586.1    NWSH01001566    PCG70843.1    KQ459185    KPJ03307.1    KQ971352    EFA06381.2    NEVH01006994    PNF36087.1    KYB26602.1    GALA01001084    JAA93768.1    GALX01003043    JAB65423.1    KK853284    KDR08982.1    APCN01004628    ATLV01022901    ATLV01022902    KE525337    KFB48083.1    GANO01000675    JAB59196.1    GGFL01004415    MBW68593.1    GECZ01030148    GECZ01014703    JAS39621.1    JAS55066.1    GGFK01004533    MBW37854.1    GGFM01001539    MBW22290.1    GGFJ01006407    MBW55548.1    GFDL01003853    JAV31192.1    GEZM01060169    JAV71224.1    AAAB01008948    EAA10349.4    GBYB01000464    GBYB01000465    JAG70231.1    JAG70232.1    KQ980107    KYN17685.1    GEDC01018250    JAS19048.1    GFDF01006500    JAV07584.1    ADTU01015202    ADTU01015203    ADTU01015204    GL438491    EFN68907.1    QOIP01000005    RLU23067.1    KZ288282    PBC29607.1    JR040086    AEY58972.1    KA645450    AFP60079.1    AJ698737    CAG27571.1    GECL01000952    JAP05172.1    GBBI01000315    JAC18397.1    GBGD01001858    JAC87031.1    GDHF01029840    GDHF01015582    JAI22474.1    JAI36732.1    KQ976574    KYM80247.1    GAKP01018907    JAC40045.1    GDHF01017217    JAI35097.1    KB632281    ERL91356.1    GAKP01018916    GAKP01018913    GAKP01018910    GAKP01018909    GAKP01018905    GAKP01018903    JAC40043.1    AAZX01003267    AAZX01010390    AAZX01016184    GDHF01020328    GDHF01012258    JAI31986.1    JAI40056.1    GAMC01010029    JAB96526.1    ACPB03001685    GL449799    EFN81960.1    GAMC01010031    JAB96524.1    NNAY01000080    OXU31166.1    CM000071    EAL25272.1    CH916367    EDW01745.1    KQ414657    KOC65684.1    OUUW01000001    SPP73636.1    SPP73637.1    CVRI01000047    CRK97544.1    CH940648    EDW59932.1    KRF79161.1    KRF79162.1    KRF79163.1    KRF79164.1    KK107063    EZA61182.1    CH933808    EDW08636.1    KRG04209.1    CM000157    EDW89590.2    CM002911    KMY92637.1    KMY92638.1    KMY92639.1    AF274008    AE013599    AY069669    BT029569    BT029610    BT029637    BT029963    CH954177    EDV58173.2    GGFK01004970    MBW38291.1    CH902619    EDV37986.1    KQ982294    KYQ58203.1    GDAI01002808    JAI14795.1    GFPF01006532    MAA17678.1    GEDV01006099    JAP82458.1    KQ981625    KYN39115.1    CP012524    ALC41145.1    GFAC01003740    JAT95448.1    GACK01008109    JAA56925.1    GL888480    EGI60313.1    GEFM01005889    JAP69907.1    CM000362    EDX06433.1    CH480816    EDW47187.1    GBBL01002526    JAC24794.1    GFAA01001313    JAU02122.1    GGLE01004904    MBY09030.1    GAKP01018915    GAKP01018902    JAC40037.1    GAKP01018901    JAC40051.1    GBBM01001377    JAC34041.1    GFDF01006638    JAV07446.1    AK418002    BAN21217.1    GBHO01002488    GBRD01014057    GDHC01010493    JAG41116.1    JAG51769.1    JAQ08136.1    ABLF02021385    ABLF02021388    GFXV01007579    MBW19384.1    GAMD01002167    JAA99423.1    GGMR01018455    MBY31074.1    KRT02031.1    CH479181    EDW32190.1    GBXI01003216    JAD11076.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000218220    UP000053268    UP000007266    + More
UP000235965    UP000027135    UP000076407    UP000075840    UP000030765    UP000069272    UP000007062    UP000192223    UP000078492    UP000005205    UP000000311    UP000279307    UP000242457    UP000095301    UP000095300    UP000005203    UP000078540    UP000030742    UP000002358    UP000015103    UP000008237    UP000215335    UP000001819    UP000001070    UP000053825    UP000268350    UP000183832    UP000008792    UP000053097    UP000009192    UP000002282    UP000000803    UP000008711    UP000192221    UP000007801    UP000075809    UP000078541    UP000092553    UP000007755    UP000000304    UP000001292    UP000007819    UP000008744   

PRIDE

A8WFD8    A0A088ARJ5    P81900   

Pfam

PF00027   cNMP_binding        + More
PF02197   RIIa

Interpro

IPR018488   cNMP-bd_CS        + More
IPR014710   RmlC-like_jellyroll       
IPR000595   cNMP-bd_dom       
IPR018490   cNMP-bd-like       
IPR012198   cAMP_dep_PK_reg_su       
IPR003117   cAMP_dep_PK_reg_su_I/II_a/b       

SUPFAM

SSF51206   SSF51206       

Gene 3D

2.60.120.10    

CDD

cd00038  CAP_ED

ProteinModelPortal

A8WFD8   A0A212EIE9   A0A194R197   A0A2H1V1E6   A0A2A4JHD4   A0A194QCW5   + More
D6WSE3   A0A2J7R5H9   A0A139WF94   T1E240   V5GYF5   A0A067QJK5   A0A3F2Z223   A0A2C9GPU6   A0A084WCY9   U5EXY6   A0A2M4CTE0   A0A1B6ENV6   A0A182FLA2   A0A2M4AAP7   A0A2M3Z186   A0A2M4BRY2   A0A1Q3FUR1   A0A1Y1LC62   Q7PPI8   A0A0C9QXQ1   A0A1W4WTD5   A0A195DXQ7   A0A1B6D046   A0A1L8DMJ6   A0A158NGT3   E2ACB7   A0A3L8DRM1   A0A2A3ECZ8   V9IE81   T1PBD6   A0A1I8PGG5   Q6ZXJ1   A0A088ARJ5   A0A0V0GB10   A0A023FA94   A0A069DTE6   A0A0K8VD26   A0A195B7M4   A0A034VE34   A0A0K8V830   U4UMJ4   A0A034VEP7   K7J478   A0A0K8UZF9   W8BTG5   T1HVU8   E2BQT5   W8C3P2   A0A232FK92   Q290U0   B4J5A3   A0A0L7R4D3   A0A3B0JK61   A0A3B0IZR1   A0A1J1IBD5   B4LM12   A0A026WYU0   B4KLK0   B4NX29   A0A0J9R972   P81900   B3N6S4   A0A1W4UZ64   A0A2M4ABX9   B3MHI6   A0A151XCX4   A0A0K8TLJ7   A0A224YJ47   A0A131YV19   A0A195FEK8   A0A0M4EUL5   A0A1E1X8B1   L7LYQ1   F4WZN8   A0A131XTD4   B4QHU9   B4HMB0   A0A023FTL3   A0A1E1XT36   A0A2R5LHM2   A0A034VD37   A0A034V9R4   A0A023GJI4   A0A1L8DLW3   A0A1I8PG80   R4WTF6   A0A0A9ZB68   J9K8S6   A0A2H8TYM5   T1E8H8   A0A2S2PNX4   A0A0R3NS26   B4GB88   A0A0A1XJ99  

PDB

3J4R     E-value=2.72811e-96,     Score=898

KEGG

100126870    K04739 cAMP-dependent protein kinase regulator | (RefSeq) Pka-r2; cAMP-dependent protein kinase R2

GO

GO:0005952   GO:0030552   GO:0008603   GO:0016301   GO:0005829   GO:0019934   GO:0047555   GO:0045475   GO:0007411   GO:0048148   GO:0071361   GO:0005737   GO:0048149   GO:0004691   GO:0007623   GO:0005886   GO:0007622   GO:0001932   GO:0005524   GO:0004713   GO:0004888   GO:0007166   GO:0003707   GO:0006418   GO:0003824  

Subcellular location

Cytoplasm   Localization to the membrane depends on Akap200.   With evidence from 5 publications.
Cell membrane   Localization to the membrane depends on Akap200.   With evidence from 5 publications.

Length:

382

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00832

Exp number, first 60 AAs:

0.00065

Total prob of N-in:

0.01516

outside

1  -  382

 

 

Pi

186.501451

Theta

179.078727

Tajima's D

-0.70849

CLR

1.257124

CSRT

0.19794010299485

Interpretation

Uncertain