SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO11579
Pre Gene Modal
BGIBMGA004093
Annotation
PREDICTED:_semaphorin-1A_isoform_X4_[Bombyx_mori]
Full name
Semaphorin-1A      
Alternative Name
Semaphorin-I
Fasciclin IV
Fasciclin-4
Location in the cell
Extracellular   Reliability : 1.893
 

Sequence

CDS
ATGATATATACAAATAATAGAGTTGACGACACGCACAAGTTCTTAGGAAACGAAACCCACACAGACTTCTTCAGATTATTGCTAAGAGATGGAAATTACTTACTCGTAGGCGGCAGGAACGTGGTGTACAACCTAAGTCTCACGGACCTGACGGAGCAGCGGAGGCTGATCTGGTACTCACCCGAGAATGACGTCAAGATGTGCGTCGTTAAAGGAAAAGATGAGGAGAGCTGTCAGAACTACATTCGCGTCCTGGTCTCGCTGGGCCCAGGACGGCTATTGGTATGCGGTACGAATAGCTTCAAGCCTTTCTGCAGAGAGTACGGAGTCCAGCGAGACTCGTACCACATGGAGAGGGAGAAGTCTGGACAGGCAGTCTGCCCTTATGACCCTGAACATAATTCTACTGCTGTTTATGCTGATGGCGAATTATATTCGGGGACAGTTGCGGATTTCAGTGGAATAGAACCAATAATATACCGAGAACCGTTGCAGACCGAACCCTACGACTCGATGACATTGAACGCTCCGGATTTCGTGAATTCACTGGTGCACGGAAATTTCGTTTATTTCTTCTTCAGAGAAACAGCAGTGGAATACATTAACTGCGGCAAGTCCGTCTTTTCTAGAGTTGCTAGAGTCTGTCGTGATGATCGAGGAGGTCCGCATAGGTTCAAGCAGCGCTGGACGTCGTTCCTGAAATCAAGACTGAACTGTTCAGTCGCCGGAGACTTCCCATTTTACTTTAACGAGATTCAATCGACGACCGAACTAATTGAGGGCGTTTACGGAGGCTTAAACGCTCAACTAATCTACGGTACATTCACGACTCCGCCTAACAGTATATCCGGGAGTGCGGTCTGTGCGTTCAGCATGCAGGACATAGCCGACACGTTCGAAGGAACTTTCAAGGAACAAAGCGCTTTTAATTCAAATTGGCTGCCTGTCAACAATGCTAAAGTACCTGAACCACGCCCGGGAACCTGTCATAACGACTCGAGACAACTGCCGGATAAAACATTGAATTTCATAAAAACCCACGCGTTAATGGACGAGTCTGTGCCCGCGTTCTTTGGAGAACCTATCGTTATTAGGACTAGCTTTCACTACAGATTTACGCAAATCGCAGTAGATCCACAAGTGAAGACTCCGGGCGGGAAAGCGTATGACGTACTGTTTATTGGCACAGACAATGGTAAAATAATAAAAGCGGTCAACGCGATTTCGTATGATTCAAACAAACGCGCCGTGCCGATCGTCATTGAGGAGCTACAAGCATTCGCCGCTGGCTCGCCTGTGCGCGCGCTGCGGGTCGCCCGCGCCGGCCGGGACGCCGCCAGACTCATTGCCGTCTCCGATAGAGAAGTACTCAGCTTGAGGCTCCATAGGTGCTCCAGTGATAAGATCAGCTCGTGCTCCGAATGTGTTGCTCTACAAGATCCGTACTGTGCGTGGGACAAACAAGCCGGACGGTGTCGAGCGTACTCGCACGGCGTCAGTCGCTGGCTGGACGAAAACTCCTTCTACCAGAGTGTCAGCACGGGAAGCCATACTGCCTGCCCTCACAGTAAAGACGCAGGTGCAGTGGGTGGTTTAAGTTCGGGTCTTTACGATGACGCAAGAGGAGAAAATAAAGGCGAGGTTATCAATATTGTCCAAGATAAGGATGGGAAGGGAAATAGCAACAACAATGAAGGACCTGAAGTCCTGGCCGCTGATCCACCACCAGCAGCATACTCCGTTGAAACACTTGCATTAGCTGTAGCCGCCGGCGCTCTGGCAGCCCTGGGCGCAGGATTCGCGGCCGGATACATTTGCGGAAGAAGATGCAAGAAGGACGAAGACGACAACATGCCCTATCCCGATACTGAATACGAATATTTCGAACAGCGACAGAACATCAATAGCAGAATCCAAGCCGAACCGAAGCTGCTGCAGCAGGTCGAGGAGGTGACGTACGCCGAGCCCGTGCTGGCGCCGCAGCCGAAGCCGGCGTCCCCCCGCGCTACCTTGCGGAAGCATCCTCCCTACCACCCTCACCACGAGACGCTGTTCCAGTTCCAGCCGGACGCGTACCGCCGCGACAACTTCGGCACCCTCCGCTCTCACCAGGGCGATGGGTACCGGCGCGGCAACGACAACGGCTTCTCGACGACGCGTTCCGTGAAGAAAGTGTATCTCTGA
Protein
MIYTNNRVDDTHKFLGNETHTDFFRLLLRDGNYLLVGGRNVVYNLSLTDLTEQRRLIWYSPENDVKMCVVKGKDEESCQNYIRVLVSLGPGRLLVCGTNSFKPFCREYGVQRDSYHMEREKSGQAVCPYDPEHNSTAVYADGELYSGTVADFSGIEPIIYREPLQTEPYDSMTLNAPDFVNSLVHGNFVYFFFRETAVEYINCGKSVFSRVARVCRDDRGGPHRFKQRWTSFLKSRLNCSVAGDFPFYFNEIQSTTELIEGVYGGLNAQLIYGTFTTPPNSISGSAVCAFSMQDIADTFEGTFKEQSAFNSNWLPVNNAKVPEPRPGTCHNDSRQLPDKTLNFIKTHALMDESVPAFFGEPIVIRTSFHYRFTQIAVDPQVKTPGGKAYDVLFIGTDNGKIIKAVNAISYDSNKRAVPIVIEELQAFAAGSPVRALRVARAGRDAARLIAVSDREVLSLRLHRCSSDKISSCSECVALQDPYCAWDKQAGRCRAYSHGVSRWLDENSFYQSVSTGSHTACPHSKDAGAVGGLSSGLYDDARGENKGEVINIVQDKDGKGNSNNNEGPEVLAADPPPAAYSVETLALAVAAGALAALGAGFAAGYICGRRCKKDEDDNMPYPDTEYEYFEQRQNINSRIQAEPKLLQQVEEVTYAEPVLAPQPKPASPRATLRKHPPYHPHHETLFQFQPDAYRRDNFGTLRSHQGDGYRRGNDNGFSTTRSVKKVYL

Summary

Description
Involved in growth cone guidance through its role in axonal repulsion.
Similarity
Belongs to the semaphorin family.
Keywords
Cell membrane   Complete proteome   Developmental protein   Differentiation   Disulfide bond   Glycoprotein   Membrane   Neurogenesis   Reference proteome   Transmembrane   Transmembrane helix   Direct protein sequencing   Signal  
Feature
chain  Semaphorin-1A
EMBL
RSAL01000096    RVE47715.1    NWSH01000111    PCG79442.1    KQ459185    KPJ03310.1    + More
KQ461073    KPJ09619.1    ODYU01001295    SOQ37312.1    KQ971354    EFA07551.2    GEZM01073256    JAV65223.1    GEZM01073258    JAV65221.1    GL451363    EFN79430.1    KQ982254    KYQ58752.1    KYB26553.1    KQ981820    KYN35175.1    AAZX01003470    AAZX01003475    KQ976424    KYM88279.1    GEZM01073257    JAV65222.1    KQ434899    KZC11021.1    GEZM01073259    JAV65220.1    MF817714    AXC32911.1    KQ414617    KOC68114.1    KQ435793    KOX74250.1    GANO01002767    JAB57104.1    GL887596    EGI70735.1    KQ981082    KYN09676.1    GEDC01000668    JAS36630.1    ADTU01012667    GBXI01011042    JAD03250.1    GBXI01011783    JAD02509.1    GDHF01027673    GDHF01001886    JAI24641.1    JAI50428.1    GDHF01009527    JAI42787.1    GBHO01014082    JAG29522.1    CH940649    EDW63760.2    CH379062    KRT05030.1    AE014134    ADV36982.1    CH933807    EDW13147.2    CH902620    EDV31809.2    GDHF01028577    GDHF01005530    JAI23737.1    JAI46784.1    CH964214    EDW80411.2    CH954177    EDV58281.2    CM000157    EDW88554.2    KRT05029.1    AGB92801.1    GDHF01003140    GDHF01000015    JAI49174.1    JAI52299.1    AAN10677.3    ADV36981.1    CM002910    KMY89129.1    GFTR01007930    JAW08496.1    AGB92802.1    OUUW01000006    SPP81482.1    EAL32877.3    AGB92803.1    CM000361    EDX04274.1    CH480818    EDW52176.1    L26082    AY113455    AAM29460.1    DS235099    EEB11913.1    CAQQ02129896    CAQQ02129897    CAQQ02129898    CAQQ02129899    CAQQ02129900    CAQQ02129901    AAAB01008944    EAA10136.5    GFDL01004100    JAV30945.1    JRES01000130    KNC33913.1    CH479184    EDW37380.1    KK107696    EZA48040.1    ACPB03022318    ACPB03022319    GGFL01001313    MBW65491.1    CVRI01000037    CRK93680.1    KQ977600    KYN01459.1    QOIP01000002    RLU25323.1    KK852461    KDR23443.1    GL441804    EFN64251.1    APCN01000697    GL765847    EFZ15870.1    AXCN02002203    GGMS01011334    MBY80537.1    ABLF02034510    ABLF02034514    ABLF02034515    ABLF02034517    ABLF02034518    GFXV01006592    MBW18397.1    GEBQ01013725    JAT26252.1    GAKP01005032    JAC53920.1    CH477247    EAT46138.1    UFQS01003204    UFQT01003204    SSX15357.1    SSX34729.1    CH916368    EDW03507.1    BT125079    ADL32751.1    GDRN01075290    JAI63080.1    CP012523    ALC38983.1    L00709    ALC38992.1    GDIP01175510    JAJ47892.1   
Pfam
PF01403   Sema        + More
PF01437   PSI
PF04516   CP2
Interpro
IPR001627   Semap_dom        + More
IPR042068   SEM1A_sema_dom       
IPR002165   Plexin_repeat       
IPR027231   Semaphorin       
IPR036352   Semap_dom_sf       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR016201   PSI       
IPR007604   CP2       
SUPFAM
SSF101912   SSF101912       
Gene 3D
PDB
6FKN     E-value=1.51456e-134,     Score=1231

Ontologies

Topology

Subcellular location
Cell membrane  
Membrane  
Length:
727
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
21.09796
Exp number, first 60 AAs:
0.01349
Total prob of N-in:
0.00284
outside
1  -  584
TMhelix
585  -  607
inside
608  -  727
 
 

Population Genetic Test Statistics

Pi
167.509492
Theta
161.17827
Tajima's D
-1.175011
CLR
0.873815
CSRT
0.110994450277486
Interpretation
Uncertain
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