Gene

KWMTBOMO11492  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001913

Annotation

thrombospondin_type-1_domain-containing_protein_4-like_precursor_[Bombyx_mori]

Location

Bomo_Chr19(-):6908588-6927056      View in EpiBrowser

Full name

ADAMTS-like protein 4      

Alternative Name

Thrombospondin repeat-containing protein 1

Location in the cell

Extracellular   Reliability : 3.424

CDS

ATGGTAGTTGGCCGCGAAGGTGTTCTAGCCTCGTCTTCTGAGAGAGAACTAAGATGTGGAAGTCGTCTTGTGTCAGGACTATTCTCGAAGCCACGACTCCCGCTCGGATACTCTTACGTAACGACAGTGCCTCGTGGAGCATGCCGACTCAATGTAACTGAAGTAGTTCCTAGCGAAAACTACATTGCATTAAAAGAATCCAATGGCACGTACATTATAAATGGGGAGTTTGCTGTGAGTGCGCCTGGAACTTACGATGTTGCTGGAGCCCGATTTTTATACACCCGAACGGCCAGTCTTGACGGCATTTTTGCTGTGGGTCCGATACATAAACCCATTGACATAATGATATTATACACACAACCAAACCCGAATATTAGGTACGAATATTTAACTGACACGGAAGATGAAACCAGTAACGACATTCCGACTTCAATGCCTCCCGCCCATCACCAGATGCAGAGGCATCACCGTCACCACCCACCACCCCATAGCTTGCCCAGAACAGATTCTTCTATATCGAAGGAATCAAATTTCTATAGCCTTGAAAGCCAATCACAAGCGGAAAGTAACGTGATCGGAGATAGGAAATTTATGTGGAAAATTATGTCTTTCACCCCGTGCTCTCGTACCTGTGGCGGAGGACTACAAATCGGAAAGTTCAAGTGTGTAGAAGTTGGTTTAAAAGAAGACAAAGAGGTATCTCCAGTGCATTGTACTGGTGCGGCACCACCTTCCCGCCGACGGAGGTGTTCTGGGGCTCCATGTCCTCCCCGTTGGAGGGCTGCAGCGTGGGGTCCTTGTCCGGTCTGCGGACCAGCCCACAGAACTCGAATTGTGGGATGTGTTCAGGATCATGCTCGAGGAATTATCAAGATAAGCGATCAAAAGTGCCCATTGCCAATGCCACCAAGCAGTGAGCGCTGTAATGTTCCAAACTGCGATGGCTCAGTAACTACCACAGCTTTGCCACGTCTCGATTCACGACGCCAAGTACGACCAAAAGATCGAACGGATCATTTCCGAGAAGGCCCTGTTATAACTCTTGCAACAAATTTAACAGACAATGAGATTACTTCCACTCCGCCCACTTCGTATAGTTTCAGTGCTGGTGGAGGCTGGTTATATACGGAATGGTCCGAGTGTGTTGGTTGGTGTGTGGGCGGCGGTGTACAATCTAGAGGAGTAAGATGCGCCGATCCTTCTGGATGTTCATCGCACCGTGCACCATTGCCTACTCAAGCTTGTAGCGTGCGAAGCCAATGCGATTCTCAATGGTTCACAAGCGAATGGTCAAAGTGCTCCGCTGGATGCGGTGGCCGACAGGTTCGAGGCGTGATATGTATTGGAGGGAACGGCAGGAGATTAAGAGATTCGGCATGTAGAGGAACCAAACCTGAAACTGAAAGGGACTGTGGTGGGGACTGCTCTCCCTCTTGGTACTTGAGTGACTGGAGCGAGTGCAAAGGTCCCTGTGAAGCTGGAGTCCAGTCCCGAACTGTCTGGTGTGCCCGTGGCGGAATCGAAGGAGCAAACGGTGCCGCTCGAGACGGAGAATGTCCAGGAGTGAGGCCTCCAGCAAAGAAAATGTGTGTACCAGCACGATGTACCAGCAAACCAGTTATCAATCCAAACGTTATCAGTCCTCCAGCAGTTTCAGATCCTCAGCAGCGCGTTACGAGACATCAAATCAATACCCCTCCACATATCAGGGATAGGTCATATGCTGACGGAGCATGTGTAGACAAATTGAATACATGTGCATTAGCGGTACAGGCACGTCTGTGCCACTACCCTTACTACGCAGACAATTGTTGCGACTCTTGCCATGGACGGTAG

Protein

MVVGREGVLASSSERELRCGSRLVSGLFSKPRLPLGYSYVTTVPRGACRLNVTEVVPSENYIALKESNGTYIINGEFAVSAPGTYDVAGARFLYTRTASLDGIFAVGPIHKPIDIMILYTQPNPNIRYEYLTDTEDETSNDIPTSMPPAHHQMQRHHRHHPPPHSLPRTDSSISKESNFYSLESQSQAESNVIGDRKFMWKIMSFTPCSRTCGGGLQIGKFKCVEVGLKEDKEVSPVHCTGAAPPSRRRRCSGAPCPPRWRAAAWGPCPVCGPAHRTRIVGCVQDHARGIIKISDQKCPLPMPPSSERCNVPNCDGSVTTTALPRLDSRRQVRPKDRTDHFREGPVITLATNLTDNEITSTPPTSYSFSAGGGWLYTEWSECVGWCVGGGVQSRGVRCADPSGCSSHRAPLPTQACSVRSQCDSQWFTSEWSKCSAGCGGRQVRGVICIGGNGRRLRDSACRGTKPETERDCGGDCSPSWYLSDWSECKGPCEAGVQSRTVWCARGGIEGANGAARDGECPGVRPPAKKMCVPARCTSKPVINPNVISPPAVSDPQQRVTRHQINTPPHIRDRSYADGACVDKLNTCALAVQARLCHYPYYADNCCDSCHGR

Description

Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (By similarity).

Subunit

Interacts with CTSB. Interacts with FBN1 (By similarity).

Keywords

Apoptosis   Complete proteome   Extracellular matrix   Glycoprotein   Reference proteome   Repeat   Secreted   Signal  

Feature

chain  ADAMTS-like protein 4

Uniprot

H2E289   A0A2A4K683   A0A2H1VLJ6   A0A194R1I0   A0A194QJH5   A0A212FNU8   + More
A0A0L7KRF4   A0A2H1W4A6   A0A194QQC1   A0A2A4K7Z3   A0A212FNT5   A0A194QW54   H9IXC3   A0A0L7KXP3   A0A088AE44   A0A2A3E938   A0A310SGC1   A0A1B6CQ79   A0A0L7QRQ3   A0A1Y1L1E5   A0A026WNZ3   A0A0T6B5M0   A0A3L8DVJ3   F4X3W6   A0A151WJC8   A0A195F1L2   A0A1B6DYX2   A0A195BFM3   A0A1B6CXW5   A0A139WEM4   E2BVZ1   A0A195CA76   A0A195EJN0   A0A067RBW0   E9FVK8   A0A1B6E6Q0   X1WYM5   A0A1J1I0V6   A0A2S2NPY5   A0A336LKH9   A0A336LGM6   A0A026W198   A0A3L8DX48   A0A182GLJ4   A0A087ZTP2   A0A182F545   A0A0L7RBC8   A0A3Q0R8X4   A0A1B0CLI7   V4AH23   A0A182Q0E7   F4X2C1   A0A3Q1B771   A0A1L8E3F1   A0A182F544   A0A3P8SH39   A0A3P9NQJ4   A0A3Q1H0Q9   A0A1I8PDB6   A0A1I8PDJ4   Q4FZU4   A0A3N0Y7G8   A0A3P9LDV2   A0A1I8PD91   A0A1B0CX07   W8C0H5   W8B1W2   A0A182IQK8   A0A3Q7PE72   A0A287ANN1   F1SS80   A0A2U3W7Q5   A0A0K8T7F9   A0A3Q7R9U3   A0A2B4T034   Q80T21   A0A2Y9GWW7   A0A146KYS9   G3WAQ2   B4JQ02   A0A2Y9MDI7   A0A3P4MU24   K9J078   A0A2K6TV35   A0A383ZSE7   A0A287A826   A0A383ZSI2   A0A2Y9EVZ8   A0A2U4A3U1   G5BH41   A0A2Y9MLE1   A0A2K5QMD0   A0A1A6HL34   A0A2Y9S3J9   A0A2K5QME0   A0A2Y9S804   A0A2Y9MFT0   A0A341D3I6  

Pubmed

19121390    26354079    22118469    26227816    28004739    24508170    + More
30249741    21719571    18362917    19820115    20798317    24845553    21292972    26483478    23254933    15489334    17554307    24495485    26823975    12706885    21709235    17994087    30723633    21993625   

EMBL

BABH01017965    BABH01017966    JN701183    AEY78648.1    NWSH01000085    PCG79775.1    + More
ODYU01003223    SOQ41695.1    KQ461073    KPJ09706.1    KQ458575    KPJ05723.1    AGBW02004790    OWR55370.1    JTDY01006868    KOB65631.1    ODYU01006251    SOQ47921.1    KPJ05721.1    PCG79780.1    OWR55369.1    KPJ09707.1    BABH01017967    JTDY01004531    KOB68038.1    KZ288321    PBC28238.1    KQ772519    OAD52442.1    GEDC01021748    JAS15550.1    KQ414782    KOC61181.1    GEZM01071486    JAV65765.1    KK107139    EZA57658.1    LJIG01009642    KRT82671.1    QOIP01000003    RLU24431.1    GL888624    EGI58913.1    KQ983045    KYQ47910.1    KQ981856    KYN34465.1    GEDC01006443    JAS30855.1    KQ976490    KYM83398.1    GEDC01018976    JAS18322.1    KQ971354    KYB26305.1    GL451079    EFN80139.1    KQ978081    KYM97096.1    KQ978782    KYN28460.1    KK852607    KDR20349.1    GL732525    EFX88574.1    GEDC01003744    JAS33554.1    ABLF02030672    ABLF02030674    CVRI01000038    CRK93983.1    GGMR01006578    MBY19197.1    UFQT01000002    SSX17113.1    SSX17112.1    KK107499    EZA49788.1    RLU24509.1    JXUM01013697    JXUM01013698    JXUM01013699    JXUM01013700    JXUM01013701    JXUM01013702    JXUM01013703    KQ560383    KXJ82683.1    KQ414617    KOC68227.1    AJWK01017317    KB200049    ESP03329.1    AXCN02001960    AXCN02001961    GL888575    EGI59403.1    GFDF01000898    JAV13186.1    BC099119    AAH99119.1    RJVU01050255    ROL42153.1    AJWK01033098    GAMC01011436    JAB95119.1    GAMC01011435    GAMC01011434    JAB95120.1    AEMK02000022    GBRD01004470    GBRD01004469    GDHC01004985    JAG61351.1    JAQ13644.1    LSMT01000002    PFX34779.1    AY158701    BC117925    AAI17926.1    AAO17738.1    GDHC01017670    JAQ00959.1    AEFK01176859    AEFK01176860    CH916372    EDV98982.1    CYRY02013529    VCW84113.1    GABZ01003954    JAA49571.1    DQIR01259078    HDC14556.1    JH170305    EHB08602.1    LZPO01027203    OBS79198.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000037510    + More
UP000005203    UP000242457    UP000053825    UP000053097    UP000279307    UP000007755    UP000075809    UP000078541    UP000078540    UP000007266    UP000008237    UP000078542    UP000078492    UP000027135    UP000000305    UP000007819    UP000183832    UP000069940    UP000249989    UP000069272    UP000261340    UP000092461    UP000030746    UP000075886    UP000257160    UP000265080    UP000242638    UP000257200    UP000095300    UP000002494    UP000265180    UP000075880    UP000286641    UP000008227    UP000245340    UP000286640    UP000225706    UP000000589    UP000248481    UP000007648    UP000001070    UP000248483    UP000233220    UP000261681    UP000245320    UP000006813    UP000233040    UP000092124    UP000248484    UP000252040   

PRIDE

H2E289    H9IXC3    Q4FZU4    F1SS80    Q80T21   

Pfam

PF05986   ADAM_spacer1        + More
PF08686   PLAC
PF00090   TSP_1

Interpro

IPR036383   TSP1_rpt_sf        + More
IPR000884   TSP1_rpt       
IPR010294   ADAM_spacer1       
IPR010909   PLAC       
IPR011257   DNA_glycosylase       
IPR013273   ADAMTS/ADAMTS-like       
IPR003582   ShKT_dom       
IPR017985   MeTrfase_CN4_CS       
IPR013087   Znf_C2H2_type       

SUPFAM

SSF82895   SSF82895        + More
SSF48150   SSF48150       

Gene 3D

2.20.100.10    

ProteinModelPortal

H2E289   A0A2A4K683   A0A2H1VLJ6   A0A194R1I0   A0A194QJH5   A0A212FNU8   + More
A0A0L7KRF4   A0A2H1W4A6   A0A194QQC1   A0A2A4K7Z3   A0A212FNT5   A0A194QW54   H9IXC3   A0A0L7KXP3   A0A088AE44   A0A2A3E938   A0A310SGC1   A0A1B6CQ79   A0A0L7QRQ3   A0A1Y1L1E5   A0A026WNZ3   A0A0T6B5M0   A0A3L8DVJ3   F4X3W6   A0A151WJC8   A0A195F1L2   A0A1B6DYX2   A0A195BFM3   A0A1B6CXW5   A0A139WEM4   E2BVZ1   A0A195CA76   A0A195EJN0   A0A067RBW0   E9FVK8   A0A1B6E6Q0   X1WYM5   A0A1J1I0V6   A0A2S2NPY5   A0A336LKH9   A0A336LGM6   A0A026W198   A0A3L8DX48   A0A182GLJ4   A0A087ZTP2   A0A182F545   A0A0L7RBC8   A0A3Q0R8X4   A0A1B0CLI7   V4AH23   A0A182Q0E7   F4X2C1   A0A3Q1B771   A0A1L8E3F1   A0A182F544   A0A3P8SH39   A0A3P9NQJ4   A0A3Q1H0Q9   A0A1I8PDB6   A0A1I8PDJ4   Q4FZU4   A0A3N0Y7G8   A0A3P9LDV2   A0A1I8PD91   A0A1B0CX07   W8C0H5   W8B1W2   A0A182IQK8   A0A3Q7PE72   A0A287ANN1   F1SS80   A0A2U3W7Q5   A0A0K8T7F9   A0A3Q7R9U3   A0A2B4T034   Q80T21   A0A2Y9GWW7   A0A146KYS9   G3WAQ2   B4JQ02   A0A2Y9MDI7   A0A3P4MU24   K9J078   A0A2K6TV35   A0A383ZSE7   A0A287A826   A0A383ZSI2   A0A2Y9EVZ8   A0A2U4A3U1   G5BH41   A0A2Y9MLE1   A0A2K5QMD0   A0A1A6HL34   A0A2Y9S3J9   A0A2K5QME0   A0A2Y9S804   A0A2Y9MFT0   A0A341D3I6  

KEGG

100861590    K23377 thrombospondin type-1 domain-containing protein 4 | (RefSeq) thrombospondin type-1 domain-con

PATHWAY

04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0008233   GO:0003824   GO:0006281   GO:0003677   GO:0015667   GO:0016021   GO:0005614   GO:0030198   GO:0002064   GO:0002020   GO:0043065   GO:0006915   GO:0031012   GO:0005615   GO:0004222   GO:0004298   GO:0005839   GO:0051603   GO:0016740   GO:0003707   GO:0006418  

Subcellular location

   Colocalizes with FMN1 microfibrils in the eye ECM.   With evidence from 1 publications.

Length:

612

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01401

Exp number, first 60 AAs:

0.00058

Total prob of N-in:

0.00093

outside

1  -  612

 

 

Pi

27.552449

Theta

161.024526

Tajima's D

-1.386394

CLR

2792.046968

CSRT

0.0786960651967402

Interpretation

Uncertain