Gene

KWMTBOMO11490  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001906

Annotation

PREDICTED:_thrombospondin_type-1_domain-containing_protein_4-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr19(+):6876657-6894325      View in EpiBrowser

Full name

ADAMTS-like protein 4      

Alternative Name

Thrombospondin repeat-containing protein 1

Location in the cell

Extracellular   Reliability : 3.74

CDS

ATGGCGTCCGCATCCGTTCTACTTTATATCGTCTTGTTTTTCGTAATCGGACGGGAGTCTGTATTAGCAGGCAGCAATTCTCGGGAGCTGAGATGTGGAAGAAGGCTCGTTTCAGGATTGTTCTCGAAACCTCGACTGCCACTGGGCTACACTTTTGTAGCGACCGTCCCAAGGGGAGCATGCCGGATTAATGTGACAGAATTAGCTTCAAGCGAAAATTATATCGCCCTGAGGCTGTCGAATAGCTCGTATATATTAAATGGAGAGTTTGCCGTGAGTGCTCCAGGAATGTATGAGGCGGCTGGAGCCAGATTTCTTTATACCCGTACCGCTGGACTGGACAATGTGCATGCAAATGGACCCATATATCATCCTATTGATATTATGATTCTTTATACTCAACCAAAACCGAACATTAAATATGAATACTTTACGGACTCTCCGATTGATGAAGGTGATGAAGCTAGGCCAGAAATACCAGATGTCGTACCAGCTATTATTACTAAACATACAAGGAGACATCACAGTTTTGATGCTTATCCCAGGGCAACAGGGAATATACCTAGACATTTAGATCATCCGAGCACTTCCAATGAACAGACGAGTGTTGAAACTGGCATCGATGCAAATGTAATTGGCAACAGAAAATTCATGTGGAGAATTTTGTCATTCACCCAATGCACAAGAAGCTGTGGTGGCGGAATTCAGTTAGGAAAGTATAGGTGTGTAGAATCAACAAGCTCTGGAGATCGAGAGGTATCATCGGTCCATTGTACTGGTTCACCTCCGATCGGGCGGAGACGACGATGTGGTAATGTGCCCTGTCCACCAAGATGGAGGGCAGCCTCCTGGTCTCCTTGTCCCCGATGTGGACCTGCTACTCGGACAAGGATAGTAGGATGTGTACAGGATCACTCTAAAGGAATTACCAAGATAAGTGACCACAAATGTCCACCTCCAAAGCCACCCACAACAGAAATGTGTAACATCCCGAACTGCGATGACCTAAGTTTGGGCCCGGTAAGACGCATTGAATCAAAGAGAACTCGAAACAAGGAACTCACCGACACATTCCGCGAAGGCCCCGTTTATACCGTATCCATCAATACTACTGAATCCGAAATCGGCCCAGAATATAGTTTTAATGCGGCAGCTGGCTGGCTTTACACCGAATGGTCGGAGTGTATCGGGTGGTGTGTCGGTGGTGGCGTGCAAACAAGAGGTGTGCGTTGTACTGATCCTTCAGGATGTGCTCCAAGAAAGGAACCTCAAACAAGCAGAAGCTGCTCGCCTGCCCTGTCATGCGAGTCTTCGGAGGGGCAATGGTTTACTGGTGACTGGTCGCGTTGCACTTCAAAGTGCAAAGGACGACAGATTCGCGGTGTTCTGTGCATCGGTGGCACCGGTAGGCATCTTCGTGATTCGGCATGCAAGGACCCTAAGCCTGATCACGTAAGGGAATGCGGCGCCGACTGCCCTCCCACTTGGTACTTCAGCGATTGGGGCAAGTGCACAGGGAACTGTACATCTGAAGTAGGTTTACAAACGAGATCAGTAATCTGTGCTCACCCTGAAACCAACGGCACGGGCGGTGAAGCTGATTGCAAGACTGCGAGACCTCATGAGCAGAAATCTTGCGAAATGCGCTGTCCTACCATTTCTACTCTACCGCCAGATTTGACTATCGAATCTCAAAAAGTCGTTACTTCGAGTAATCGGCCTCCCATTATTAGAGAAACCGGACCTAGAGAATGCGAAGATAAACTGAACAACTGTTTCCTGGCGGTTCAAGCTCGCCTTTGTCATTATAACTTCTACGTGCAGAACTGCTGTAATTCCTGCAAAGGACTGTGA

Protein

MASASVLLYIVLFFVIGRESVLAGSNSRELRCGRRLVSGLFSKPRLPLGYTFVATVPRGACRINVTELASSENYIALRLSNSSYILNGEFAVSAPGMYEAAGARFLYTRTAGLDNVHANGPIYHPIDIMILYTQPKPNIKYEYFTDSPIDEGDEARPEIPDVVPAIITKHTRRHHSFDAYPRATGNIPRHLDHPSTSNEQTSVETGIDANVIGNRKFMWRILSFTQCTRSCGGGIQLGKYRCVESTSSGDREVSSVHCTGSPPIGRRRRCGNVPCPPRWRAASWSPCPRCGPATRTRIVGCVQDHSKGITKISDHKCPPPKPPTTEMCNIPNCDDLSLGPVRRIESKRTRNKELTDTFREGPVYTVSINTTESEIGPEYSFNAAAGWLYTEWSECIGWCVGGGVQTRGVRCTDPSGCAPRKEPQTSRSCSPALSCESSEGQWFTGDWSRCTSKCKGRQIRGVLCIGGTGRHLRDSACKDPKPDHVRECGADCPPTWYFSDWGKCTGNCTSEVGLQTRSVICAHPETNGTGGEADCKTARPHEQKSCEMRCPTISTLPPDLTIESQKVVTSSNRPPIIRETGPRECEDKLNNCFLAVQARLCHYNFYVQNCCNSCKGL

Description

Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (By similarity).

Subunit

Interacts with CTSB. Interacts with FBN1 (By similarity).

Keywords

Apoptosis   Complete proteome   Extracellular matrix   Glycoprotein   Reference proteome   Repeat   Secreted   Signal  

Feature

chain  ADAMTS-like protein 4

Uniprot

H9IXC3   A0A2H1W4A6   A0A2A4K7Z3   A0A194QQC1   A0A212FNT5   A0A194R1I0   + More
A0A2A4K683   A0A2H1VLJ6   A0A194QJH5   A0A212FNU8   A0A194QW54   A0A0L7KRF4   H2E289   A0A0L7KXP3   A0A2A3E938   A0A088AE44   A0A0L7QRQ3   A0A026WNZ3   A0A3L8DVJ3   F4X3W6   A0A151WJC8   E2BVZ1   A0A154PAW7   A0A1B6CQ79   E9FVK8   A0A1Y1L1E5   A0A336LKH9   A0A139WEM4   A0A067RBW0   A0A0L7RBC8   R7V680   A0A1J1I0V6   X1WYM5   A0A087ZTP2   A0A336LGM6   Q7Q127   A0A0C9S2T5   A0A026W198   A0A3L8DX48   A0A195FPF2   A0A0Q9XDB3   A0A151X6G6   B4KHR2   A0A195EKD7   F4X2C1   A0A158NJN3   A0A151I0E7   A0A3B3Q9M2   A0A195D6Q8   A0A0K8T7F9   B4MUB3   A0A3B3Q7Y2   A0A146KYS9   E2ARR9   A0A182K0D3   A0A1W4UUQ5   B4JQ02   A0A3P8XRH5   A0A0P9A639   A0A3Q7PE72   A0A3N0Y7G8   A0A1U7R9Y4   A0A1W4UG20   V4AH23   W5QI32   A0A2D0QRT2   A0A146WD30   A0A2K6TV35   G1L3V9   A0A0Q5WJU2   A0A2U3W7Q5   A0A3P8QDY9   A0A3Q7VX73   A0A2K5QME0   A0A3P9BCI1   A0A3Q0R8X4   A6QLD8   A0A3Q7U2I6   A0A2K5QMD0   F1PAP2   A0A3Q2P929   A0A3P8VQL4   A0A2Y9MLE1   A0A0D9RZP8   A0A2U4A3U1   F7BLA5   A0A1A6HL34   I2CX85   Q4FZU4   A0A1S3A9U1   A0A2K5W6U2   G8F5X8   G7MDH8   Q80T21   A0A287ANN1   A0A2K5W6U7   G1RFS9   A0A2I3H401  

Pubmed

19121390    26354079    22118469    26227816    24508170    30249741    + More
21719571    20798317    21292972    28004739    18362917    19820115    24845553    23254933    12364791    17994087    21347285    29240929    26823975    25069045    20809919    20010809    25186727    16341006    24487278    17431167    25319552    15489334    22002653    12706885   

EMBL

BABH01017967    ODYU01006251    SOQ47921.1    NWSH01000085    PCG79780.1    KQ458575    + More
KPJ05721.1    AGBW02004790    OWR55369.1    KQ461073    KPJ09706.1    PCG79775.1    ODYU01003223    SOQ41695.1    KPJ05723.1    OWR55370.1    KPJ09707.1    JTDY01006868    KOB65631.1    BABH01017965    BABH01017966    JN701183    AEY78648.1    JTDY01004531    KOB68038.1    KZ288321    PBC28238.1    KQ414782    KOC61181.1    KK107139    EZA57658.1    QOIP01000003    RLU24431.1    GL888624    EGI58913.1    KQ983045    KYQ47910.1    GL451079    EFN80139.1    KQ434849    KZC08524.1    GEDC01021748    JAS15550.1    GL732525    EFX88574.1    GEZM01071486    JAV65765.1    UFQT01000002    SSX17113.1    KQ971354    KYB26305.1    KK852607    KDR20349.1    KQ414617    KOC68227.1    AMQN01004858    KB294550    ELU14368.1    CVRI01000038    CRK93983.1    ABLF02030672    ABLF02030674    SSX17112.1    AAAB01008980    EAA13911.4    GBYB01014270    GBYB01015211    JAG84037.1    JAG84978.1    KK107499    EZA49788.1    RLU24509.1    KQ981424    KYN41824.1    CH933807    KRG03706.1    KQ982482    KYQ55942.1    EDW13349.2    KQ978782    KYN28387.1    GL888575    EGI59403.1    ADTU01018081    ADTU01018082    ADTU01018083    ADTU01018084    KQ976666    KYM78288.1    KQ976818    KYN08109.1    GBRD01004470    GBRD01004469    GDHC01004985    JAG61351.1    JAQ13644.1    CH963857    EDW76039.2    GDHC01017670    JAQ00959.1    GL442166    EFN63877.1    CH916372    EDV98982.1    CH902620    KPU73913.1    RJVU01050255    ROL42153.1    KB200049    ESP03329.1    AMGL01004601    GCES01058343    JAR27980.1    ACTA01024204    CH954177    KQS70603.1    BC147928    AAI47929.1    AAEX03011048    JSUE03002373    LZPO01027203    OBS79198.1    JV636230    AFJ71570.1    BC099119    AAH99119.1    AQIA01002516    AQIA01002517    JH332400    EHH62692.1    CM001253    EHH15175.1    AY158701    BC117925    AAI17926.1    AAO17738.1    AEMK02000022    ADFV01183079   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000053240    UP000037510    + More
UP000242457    UP000005203    UP000053825    UP000053097    UP000279307    UP000007755    UP000075809    UP000008237    UP000076502    UP000000305    UP000007266    UP000027135    UP000014760    UP000183832    UP000007819    UP000007062    UP000078541    UP000009192    UP000078492    UP000005205    UP000078540    UP000261540    UP000078542    UP000007798    UP000000311    UP000075881    UP000192221    UP000001070    UP000265140    UP000007801    UP000286641    UP000189706    UP000030746    UP000002356    UP000221080    UP000233220    UP000008912    UP000008711    UP000245340    UP000265100    UP000286642    UP000233040    UP000265160    UP000261340    UP000002254    UP000265000    UP000265120    UP000248483    UP000029965    UP000245320    UP000006718    UP000092124    UP000002494    UP000079721    UP000233100    UP000009130    UP000000589    UP000008227    UP000001073   

PRIDE

H9IXC3    H2E289    Q4FZU4    Q80T21   

Pfam

PF05986   ADAM_spacer1        + More
PF08686   PLAC
PF00090   TSP_1

Interpro

IPR010294   ADAM_spacer1        + More
IPR010909   PLAC       
IPR000884   TSP1_rpt       
IPR036383   TSP1_rpt_sf       
IPR013273   ADAMTS/ADAMTS-like       
IPR003582   ShKT_dom       
IPR011257   DNA_glycosylase       
IPR013087   Znf_C2H2_type       
IPR000048   IQ_motif_EF-hand-BS       

SUPFAM

SSF82895   SSF82895        + More
SSF48150   SSF48150       

Gene 3D

2.20.100.10    

ProteinModelPortal

H9IXC3   A0A2H1W4A6   A0A2A4K7Z3   A0A194QQC1   A0A212FNT5   A0A194R1I0   + More
A0A2A4K683   A0A2H1VLJ6   A0A194QJH5   A0A212FNU8   A0A194QW54   A0A0L7KRF4   H2E289   A0A0L7KXP3   A0A2A3E938   A0A088AE44   A0A0L7QRQ3   A0A026WNZ3   A0A3L8DVJ3   F4X3W6   A0A151WJC8   E2BVZ1   A0A154PAW7   A0A1B6CQ79   E9FVK8   A0A1Y1L1E5   A0A336LKH9   A0A139WEM4   A0A067RBW0   A0A0L7RBC8   R7V680   A0A1J1I0V6   X1WYM5   A0A087ZTP2   A0A336LGM6   Q7Q127   A0A0C9S2T5   A0A026W198   A0A3L8DX48   A0A195FPF2   A0A0Q9XDB3   A0A151X6G6   B4KHR2   A0A195EKD7   F4X2C1   A0A158NJN3   A0A151I0E7   A0A3B3Q9M2   A0A195D6Q8   A0A0K8T7F9   B4MUB3   A0A3B3Q7Y2   A0A146KYS9   E2ARR9   A0A182K0D3   A0A1W4UUQ5   B4JQ02   A0A3P8XRH5   A0A0P9A639   A0A3Q7PE72   A0A3N0Y7G8   A0A1U7R9Y4   A0A1W4UG20   V4AH23   W5QI32   A0A2D0QRT2   A0A146WD30   A0A2K6TV35   G1L3V9   A0A0Q5WJU2   A0A2U3W7Q5   A0A3P8QDY9   A0A3Q7VX73   A0A2K5QME0   A0A3P9BCI1   A0A3Q0R8X4   A6QLD8   A0A3Q7U2I6   A0A2K5QMD0   F1PAP2   A0A3Q2P929   A0A3P8VQL4   A0A2Y9MLE1   A0A0D9RZP8   A0A2U4A3U1   F7BLA5   A0A1A6HL34   I2CX85   Q4FZU4   A0A1S3A9U1   A0A2K5W6U2   G8F5X8   G7MDH8   Q80T21   A0A287ANN1   A0A2K5W6U7   G1RFS9   A0A2I3H401  

PDB

2RJQ     E-value=0.00385596,     Score=97

KEGG

101742424    K23377 thrombospondin type-1 domain-containing protein 4 | (RefSeq) thrombospondin type-1 domain-con

GO

GO:0008233   GO:0003824   GO:0006281   GO:0016021   GO:0007508   GO:1901203   GO:0062023   GO:0030198   GO:0002064   GO:0002020   GO:0005614   GO:0043065   GO:0003676   GO:0006915   GO:0031012   GO:0005615   GO:0004222   GO:0004298   GO:0005839   GO:0051603   GO:0016740   GO:0003707   GO:0006418  

Subcellular location

   Colocalizes with FMN1 microfibrils in the eye ECM.   With evidence from 1 publications.

SignalP

Position:   1 - 23,         Likelihood:  0.887813

 

 

Length:

617

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

6.51195999999998

Exp number, first 60 AAs:

6.42169

Total prob of N-in:

0.31744

outside

1  -  617

 

 

Pi

36.508784

Theta

150.459103

Tajima's D

-1.405474

CLR

1739.534352

CSRT

0.0747462626868657

Interpretation

Uncertain