Gene

KWMTBOMO11486  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001915

Annotation

proteasome_subunit_alpha_type-4_[Papilio_xuthus]

Location

Bomo_Chr19(-):6754884-6758026      View in EpiBrowser

Full name

Proteasome subunit alpha type       + More
Proteasome endopeptidase complex      
Proteasome subunit beta      

Location in the cell

Cytoplasmic   Reliability : 1.964

CDS

ATGGCACGACGTTATGATACCCGTACAACCATATTCTCGCCGGAAGGTCGTCTGTATCAAGTCGAATATGCTATGGAAGCTATAAGTCATGCGGGAACATCGCTGGGTATTTTAGCAACGGATGGTATTCTTTTGGCTGCAGAACGCAGGAACACCAATAAACTTCTAGATGAAGTTTTCTTTTCTGAAAAAATCTACAAGCTCAATGATGACATGGTCTGTTCAGTCGCTGGTATAACATCGGATGCTAACGTTTTGACAAACGAATTAAGACTGATCGCTCAAAGATACCTGCTGCAATATGGCGAATCTATCCCTTGTGAGCAATTAGTCTCCTGGCTTTGTGATGTGAAACAAGCTTACACACAATATGGAGGTAAAAGGCCCTTTGGAGTCTCAATTCTGTATATGGGCTGGGATAAGCACTATGGTTATCAGCTCTACCAGTCTGATCCCAGTGGAAACTATGGGGGGTGGAAAGCAACATGCATCGGTAACAATAGTGCTGCAGCAGTTTCAAGTTTAAAACAGGAGTACAAGGAAAATGAGACAACTCTGGCAGAAGCACAGGCCCTGGCAATCAAAGTACTTAGCAAGACTCTGGATATGACTAAACTGACTCCAGAAAAAGTCGAAATGGCAACATTAACTCGTAAGGACAACAAGACTATCATCAGGATTCTAACGAATACAGAAGTTGAGAAACTCATTGCCGAATTCGAAAAGACCGAAGCTGAAGCTGAAGCTGCCAAGAAACAGCCTGCTAAATCTTAA

Protein

MARRYDTRTTIFSPEGRLYQVEYAMEAISHAGTSLGILATDGILLAAERRNTNKLLDEVFFSEKIYKLNDDMVCSVAGITSDANVLTNELRLIAQRYLLQYGESIPCEQLVSWLCDVKQAYTQYGGKRPFGVSILYMGWDKHYGYQLYQSDPSGNYGGWKATCIGNNSAAAVSSLKQEYKENETTLAEAQALAIKVLSKTLDMTKLTPEKVEMATLTRKDNKTIIRILTNTEVEKLIAEFEKTEAEAEAAKKQPAKS

Description

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.

Catalytic Activity

Cleavage of peptide bonds with very broad specificity.

Subunit

The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

Similarity

Belongs to the peptidase T1A family.
Belongs to the peptidase T1B family.

Uniprot

I4DK20   A0A3G1T1M6   A0A3S2NIA4   A0A2A4K7Z4   A0A212F5Q4   A0A2H1WB52   + More
Q60FS3   A0A1Y1MKT5   A0A0C9QWS6   A0A2J7Q0B4   A0A1W4WBV2   D6WSJ0   V5GN54   A0A1B6DW66   A0A026WIN6   K7J976   A0A1B6JBP7   A0A1B6GUW9   A0A023GH28   G3MLT2   E9IBT3   A0A194QXM5   A0A2P6LEC0   A0A087SWI0   A0A023FY32   E0VLL3   A0A1E1X2Z1   S4PTA8   E2A3M2   F4W8N1   J3JYC7   B0WVH1   A0A023FGZ7   Q16TY4   A0A0K8RM20   A0A195EHJ1   A0A131XL10   A0A224YS45   A0A131Z3Y6   L7M2B5   V9IIY5   T1DGS8   A0A1Q3FFJ4   A0A023ENX8   A0A194QK15   A0A2M4ANC0   A0A2M4BX52   A0A2M4AAR7   A0A2M3ZHB4   A0A2A3E1A3   E9HJU6   A0A182YR47   A0A2C9H4D1   A0A182FB12   A0A2K6VB16   A0A1L8DSU3   A0A240SY42   A0A1Q3FFJ7   A0A1Z5KXF2   A0A182KFM1   A0A182PTW1   A0A158NKS7   A0A182WM26   A0A182XEH6   A0A182VKR5   A0A182KNN7   A0A182HQL9   A0A182ULJ9   Q7PPI7   A0A182LS11   A0A182RE57   A0A2M4CTT7   A0A182J2X4   A0A336KJN3   A0A2M4AAK3   A0A182N1Y2   A0A2R5LIV4   A0A182QKR3   A0A0J7KT49   A0A3G5APG7   A0A0N8CTG7   A0A0N8DRX8   A0A0P6HIT7   A0A0K8TSN2   A0A0P5PBU4   A0A0P5ASC4   U5EWD4   A0A293LMM4   A0A088A859   A0A3G5AP11   T1K2I7   A0A1V9XRM7   A0A2G8LMW8   A0A0P6I7G1   H3CW10   A0A3Q3M748   A0A3P9H0Q5   H2L7M2   A0A3P9JWC0   A0A3S2Q941  

EC Number

3.4.25.1

Pubmed

22651552    22118469    28004739    18362917    19820115    24508170    + More
30249741    20075255    22216098    21282665    26354079    20566863    28503490    23622113    20798317    21719571    22516182    23537049    17510324    28049606    28797301    26830274    25576852    24330624    24945155    26483478    21292972    25244985    20920257    28528879    21347285    20966253    12364791    14747013    17210077    26369729    28327890    29023486    15496914    17554307   

EMBL

AK401638    BAM18260.1    MG992425    AXY94863.1    RSAL01000086    RVE48288.1    + More
NWSH01000085    PCG79782.1    AGBW02010153    OWR49066.1    ODYU01007425    SOQ50186.1    AB189026    BAD52258.1    GEZM01028378    JAV86333.1    GBYB01005127    JAG74894.1    NEVH01019983    PNF22021.1    KQ971354    EFA05912.1    GALX01005474    JAB62992.1    GEDC01007419    JAS29879.1    KK107183    QOIP01000011    EZA55885.1    RLU17216.1    AAZX01011560    GECU01011253    JAS96453.1    GECZ01003562    JAS66207.1    GBBM01002141    JAC33277.1    JO842833    AEO34450.1    GL762137    EFZ21978.1    KQ461073    KPJ09710.1    MWRG01000153    PRD36921.1    KK112265    KFM57219.1    GBBL01001682    JAC25638.1    DS235274    EEB14269.1    GFAC01005782    JAT93406.1    GAIX01012363    JAA80197.1    GL436457    EFN71914.1    GL887908    EGI69522.1    APGK01028660    BT128253    KB740694    KB632194    AEE63213.1    ENN79476.1    ERL89890.1    DS232126    EDS35577.1    GBBK01003311    JAC21171.1    CH477637    EAT37982.1    GADI01002219    JAA71589.1    KQ978881    KYN27738.1    GEFH01002215    JAP66366.1    GFPF01005496    MAA16642.1    GEDV01002438    JAP86119.1    GACK01007027    JAA58007.1    JR047620    AEY60461.1    GALA01000077    JAA94775.1    GFDL01008731    JAV26314.1    JXUM01024338    GAPW01003439    KQ560687    JAC10159.1    KXJ81276.1    KQ458575    KPJ05719.1    GGFK01008962    MBW42283.1    GGFJ01008519    MBW57660.1    GGFK01004519    MBW37840.1    GGFM01007195    MBW27946.1    KZ288473    PBC25304.1    GL732664    EFX68008.1    GGFL01004417    MBW68595.1    GFDF01004637    JAV09447.1    AJWK01030742    GFDL01008730    JAV26315.1    GFJQ02007147    JAV99822.1    ADTU01018781    APCN01004657    AAAB01008948    EAA10351.5    AXCM01003001    GGFL01004413    MBW68591.1    UFQS01000509    UFQT01000509    SSX04491.1    SSX24855.1    GGFK01004449    MBW37770.1    GGLE01005131    MBY09257.1    AXCN02000977    LBMM01003526    KMQ93419.1    MH979785    AYV89240.1    GDIP01100511    LRGB01000930    JAM03204.1    KZS15037.1    GDIP01006823    JAM96892.1    GDIQ01042133    JAN52604.1    GDAI01000470    JAI17133.1    GDIQ01152492    JAK99233.1    GDIP01194751    JAJ28651.1    GANO01001465    JAB58406.1    GFWV01003225    MAA27955.1    MH990543    AYV89090.1    CAEY01001363    MNPL01005442    OQR76018.1    MRZV01000028    PIK61603.1    GDIQ01008583    JAN86154.1    CM012439    RVE74211.1   

Proteomes

UP000283053    UP000218220    UP000007151    UP000235965    UP000192223    UP000007266    + More
UP000053097    UP000279307    UP000002358    UP000053240    UP000054359    UP000009046    UP000000311    UP000007755    UP000019118    UP000030742    UP000002320    UP000008820    UP000078492    UP000069940    UP000249989    UP000053268    UP000242457    UP000000305    UP000076408    UP000075901    UP000069272    UP000092461    UP000075881    UP000075885    UP000005205    UP000075920    UP000076407    UP000075903    UP000075882    UP000075840    UP000075902    UP000007062    UP000075883    UP000075900    UP000075880    UP000075884    UP000075886    UP000036403    UP000076858    UP000005203    UP000015104    UP000192247    UP000230750    UP000007303    UP000261640    UP000265200    UP000001038    UP000265180   

PRIDE

G3MLT2    L7M2B5    A0A088A859   

Pfam

PF10584   Proteasome_A_N        + More
PF00227   Proteasome
PF03188   Cytochrom_B561
PF05253   zf-U11-48K

Interpro

IPR023332   Proteasome_alpha-type        + More
IPR016050   Proteasome_bsu_CS       
IPR000426   Proteasome_asu_N       
IPR029055   Ntn_hydrolases_N       
IPR001353   Proteasome_sua/b       
IPR006593   Cyt_b561/ferric_Rdtase_TM       
IPR022776   TRM13/UPF0224_CHHC_Znf_dom       
IPR036236   Znf_C2H2_sf       

SUPFAM

SSF56235   SSF56235        + More
SSF57667   SSF57667       

Gene 3D

3.60.20.10    

ProteinModelPortal

I4DK20   A0A3G1T1M6   A0A3S2NIA4   A0A2A4K7Z4   A0A212F5Q4   A0A2H1WB52   + More
Q60FS3   A0A1Y1MKT5   A0A0C9QWS6   A0A2J7Q0B4   A0A1W4WBV2   D6WSJ0   V5GN54   A0A1B6DW66   A0A026WIN6   K7J976   A0A1B6JBP7   A0A1B6GUW9   A0A023GH28   G3MLT2   E9IBT3   A0A194QXM5   A0A2P6LEC0   A0A087SWI0   A0A023FY32   E0VLL3   A0A1E1X2Z1   S4PTA8   E2A3M2   F4W8N1   J3JYC7   B0WVH1   A0A023FGZ7   Q16TY4   A0A0K8RM20   A0A195EHJ1   A0A131XL10   A0A224YS45   A0A131Z3Y6   L7M2B5   V9IIY5   T1DGS8   A0A1Q3FFJ4   A0A023ENX8   A0A194QK15   A0A2M4ANC0   A0A2M4BX52   A0A2M4AAR7   A0A2M3ZHB4   A0A2A3E1A3   E9HJU6   A0A182YR47   A0A2C9H4D1   A0A182FB12   A0A2K6VB16   A0A1L8DSU3   A0A240SY42   A0A1Q3FFJ7   A0A1Z5KXF2   A0A182KFM1   A0A182PTW1   A0A158NKS7   A0A182WM26   A0A182XEH6   A0A182VKR5   A0A182KNN7   A0A182HQL9   A0A182ULJ9   Q7PPI7   A0A182LS11   A0A182RE57   A0A2M4CTT7   A0A182J2X4   A0A336KJN3   A0A2M4AAK3   A0A182N1Y2   A0A2R5LIV4   A0A182QKR3   A0A0J7KT49   A0A3G5APG7   A0A0N8CTG7   A0A0N8DRX8   A0A0P6HIT7   A0A0K8TSN2   A0A0P5PBU4   A0A0P5ASC4   U5EWD4   A0A293LMM4   A0A088A859   A0A3G5AP11   T1K2I7   A0A1V9XRM7   A0A2G8LMW8   A0A0P6I7G1   H3CW10   A0A3Q3M748   A0A3P9H0Q5   H2L7M2   A0A3P9JWC0   A0A3S2Q941  

PDB

6AVO     E-value=2.33316e-112,     Score=1035

KEGG

105842587    K02728 20S proteasome subunit alpha 3 [EC:3.4.25.1] | (RefSeq) proteasome subunit alpha type-4-like

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0005737   GO:0005634   GO:0004298   GO:0006511   GO:0019773   GO:0055114   GO:0016021   GO:0004175   GO:0010499   GO:0005839   GO:0010498   GO:0043161   GO:0051603   GO:0016740   GO:0003707   GO:0006418   GO:0003824  

Subcellular location

Cytoplasm  
Nucleus  

Length:

257

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.66481

Exp number, first 60 AAs:

1.65302

Total prob of N-in:

0.52558

outside

1  -  257

 

 

Pi

202.446583

Theta

187.216036

Tajima's D

0.262753

CLR

0.419223

CSRT

0.445077746112694

Interpretation

Uncertain