Gene

KWMTBOMO11479  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001918

Annotation

phosphatidylinositol_glycan_precursor_[Bombyx_mori]

Location

Bomo_Chr19(-):6704652-6708416      View in EpiBrowser

Full name

GPI-anchor transamidase       + More
Putative GPI-anchor transamidase      

Alternative Name

Phosphatidylinositol glycan anchor biosynthesis protein class K

Location in the cell

PlasmaMembrane   Reliability : 2.45

CDS

ATGGCTTTTACAAATCTTATGCTAGTATTCATATTTAATTTATTATATTTATCATTATCATCAGGAATCGAGATACCAGAAGAATTTCAGAAGTCGAATCACACGAATAACTGGGCTGTGCTAGTGGACACTTCACGATTTTGGTTTAACTATCGTCACGTTGCGAATGTTTTATCGATTTATCGGAGTGTGAAACGATTAGGAATACCTGACAGTCAGATTATTCTAATGATTTCTGACGATATGGCATGTAACCCAAGGAATCCCCGACCAGCAACTATTTTTAATAGTGCCCATGAGCAGATCAACGTGTATGGAGATGATGTCGAAGTAGATTATAGAGGTTATGAGGTGTCAGTTGAAAATTTTATCCGTCTGCTAACTGGCAGAGTACCACCTGACACACCTCGCTCCAAGCAATTACTGACTGATGAAGGTAGTAACATACTAATCTACCTAACAGGCCATGGTGGTGACGGCTTCCTCAAGTTTCAGGACTCAGAAGAAGTGACCAGCCAAGAGCTTGCTGATGCTTTGGAACAAATGTGGCAGAAAAAAAGATATAATGAAATTTTTTTCATAATAGACACATGTCAAGCTTCATCAATGTATGAGAAGTTTTATTCACCAAATATATTAGCAACCGCAAGTAGTTTAGTCGGTGAAGATTCACTTTCTCATCATGTTGATTCAGCTATTGGTGTATACATCATTGATAGATACACATACTATGTGCTGGAGTTTTTGGAAAATGTTCACCCTAACAGCAAAAGGACTATGTCGGAATTTTTGGCTGTATGTCCGAAAAGTGCTTGCTTATCGACAGTGGGAGTACGAAAAGATTTATTCAATAGAGATCCTAGTAAAGTGCCTATCACCGACTTCTTTGGTTCAGTTAGACCAGTGATCCTGACAACAGATCCTATAAATATTGTAGAGACACCAAAAAGAAAGAAAAAGACTGAGAATAAAACCAAGATACAAGTGAAACGGGACTATGTGCCACAGTTTCCGATGCATCTAGTCCAAGTTACATAA

Protein

MAFTNLMLVFIFNLLYLSLSSGIEIPEEFQKSNHTNNWAVLVDTSRFWFNYRHVANVLSIYRSVKRLGIPDSQIILMISDDMACNPRNPRPATIFNSAHEQINVYGDDVEVDYRGYEVSVENFIRLLTGRVPPDTPRSKQLLTDEGSNILIYLTGHGGDGFLKFQDSEEVTSQELADALEQMWQKKRYNEIFFIIDTCQASSMYEKFYSPNILATASSLVGEDSLSHHVDSAIGVYIIDRYTYYVLEFLENVHPNSKRTMSEFLAVCPKSACLSTVGVRKDLFNRDPSKVPITDFFGSVRPVILTTDPINIVETPKRKKKTENKTKIQVKRDYVPQFPMHLVQVT

Description

Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.
Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity).

Similarity

Belongs to the peptidase C13 family.

Keywords

Complete proteome   GPI-anchor biosynthesis   Hydrolase   Protease   Reference proteome   Signal   Thiol protease  

Feature

chain  GPI-anchor transamidase

Uniprot

Q1HPH2   A0A2A4JZD3   A0A212FGH5   A0A2H1V6N2   S4PY80   A0A067R5W0   + More
A0A2P8Y022   A0A088AL45   A0A2J7PSN3   E0VQW5   A0A2A3ERR2   A0A232FIJ4   K7J1G0   A0A0M9A411   A0A1B6MNQ7   H9IXD5   A0A1B6G6C9   A0A0L7QTX1   A0A026VU67   A0A1B6DM73   E2B817   E9J1B2   N6TWV0   A0A0T6ATT9   F4X801   A0A151JAM5   A0A1Y1LJ05   A0A158NVQ9   A0A195FXD0   A0A139WFR6   A0A1Y1LK07   A0A1S3DII2   A0A3Q0JID1   A0A151IDU5   A0A154P611   A0A151XEM8   A0A023F9E8   A0A2R7WAE1   A0A310SKF9   A0A336MQ12   A0A0P4VWX2   R4FLF6   A0A1B0DHL5   A0A0V0GE85   A0A0K8WK85   A0A0A9WQL0   A0A226F1Z0   A0A1J1I510   A0A034WP24   J9JPI1   A0A1W7R826   A0A182G8X8   A0A0L0BVR9   A0A2K8JMF4   A0A1I8N9K8   A0A0P4VZ99   A0A0A1WMN4   A0A1I8NZ40   A0A023EPP1   Q16SV5   A0A0K8TTB9   A0A1L8DU17   A0A1L8DTW9   A0A1W4WJ50   W8C4T3   A0A1L8DU23   A0A182QDG2   A0A182PAI3   A0A1Q3G392   A0A182VY47   A0A1Q3G334   A0A182L6W0   Q7QAC9   A0A182R5M8   A0A151I1X5   A0A182XWR1   E2A5G5   A0A1A9W1Y3   A0A182X8U5   A0A182ID27   A0A1B0BM95   A0A1A9YM54   A0A1A9UGJ1   A0A1B0FAS4   A0A1B0A1V9   A0A2M4DMQ1   A0A2M4ASZ8   B4JK59   B4Q1J6   A0A182F9K1   B3P8U4   A0A2M4ATK0   A0A2M3ZA43   B4I9M5   A0A2M4DMK7   Q8T4E1   A0A2M4BT04   B3MYQ4   B4MES3   A0A3R7SVD3  

EC Number

3.-.-.-

Pubmed

22118469    23622113    24845553    29403074    20566863    28648823    + More
20075255    19121390    24508170    30249741    20798317    21282665    23537049    21719571    28004739    21347285    18362917    19820115    25474469    27129103    25401762    26823975    25348373    26483478    26108605    25315136    25830018    24945155    17510324    26369729    24495485    20966253    12364791    14747013    17210077    25244985    17994087    17550304    10731132    12537572    10731137    12537569    18057021   

EMBL

DQ443430    ABF51519.1    NWSH01000386    PCG76770.1    AGBW02008683    OWR52803.1    + More
ODYU01000957    SOQ36498.1    GAIX01003753    JAA88807.1    KK852722    KDR17719.1    PYGN01001100    PSN37596.1    NEVH01021925    PNF19345.1    DS235442    EEB15771.1    KZ288191    PBC34455.1    NNAY01000193    OXU30117.1    KQ435741    KOX76767.1    GEBQ01002434    JAT37543.1    BABH01017977    GECZ01011773    JAS57996.1    KQ414740    KOC62070.1    KK107899    QOIP01000006    EZA47277.1    RLU21554.1    GEDC01010550    JAS26748.1    GL446273    EFN88159.1    GL767601    EFZ13391.1    APGK01057802    KB741282    KB631802    ENN70787.1    ERL86239.1    LJIG01022832    KRT78488.1    GL888900    EGI57418.1    KQ979294    KYN22003.1    GEZM01058070    JAV71925.1    ADTU01027401    KQ981193    KYN45093.1    KQ971352    KYB26647.1    GEZM01058069    JAV71926.1    KQ977907    KYM98840.1    KQ434809    KZC06638.1    KQ982249    KYQ58829.1    GBBI01001088    JAC17624.1    KK854536    PTY16654.1    KQ761917    OAD56436.1    UFQS01001999    UFQT01001999    SSX12914.1    SSX32356.1    GDKW01002511    JAI54084.1    ACPB03008305    GAHY01002129    JAA75381.1    AJVK01061283    GECL01000514    JAP05610.1    GDHF01032811    GDHF01002800    GDHF01000812    JAI19503.1    JAI49514.1    JAI51502.1    GBHO01036513    GBHO01036509    GBHO01036508    GBRD01014348    GBRD01004175    GDHC01020969    GDHC01013854    JAG07091.1    JAG07095.1    JAG07096.1    JAG51478.1    JAP97659.1    JAQ04775.1    LNIX01000001    OXA63799.1    CVRI01000037    CRK93465.1    GAKP01002557    GAKP01002555    GAKP01002553    GAKP01002551    JAC56399.1    ABLF02037822    GEHC01000382    JAV47263.1    JXUM01048525    JXUM01048526    JXUM01048527    KQ561566    KXJ78150.1    JRES01001264    KNC24093.1    KY031103    ATU82854.1    GDRN01101436    JAI58377.1    GBXI01014371    JAC99920.1    GAPW01002116    JAC11482.1    CH477664    EAT37564.1    GDAI01000428    JAI17175.1    GFDF01004194    JAV09890.1    GFDF01004193    JAV09891.1    GAMC01005294    JAC01262.1    GFDF01004180    JAV09904.1    AXCN02001189    GFDL01000836    JAV34209.1    GFDL01000835    JAV34210.1    AAAB01008898    EAA09153.5    KQ976554    KYM80804.1    GL436931    EFN71330.1    APCN01004978    JXJN01016746    CCAG010005731    GGFL01014627    MBW78805.1    GGFK01010588    MBW43909.1    CH916370    EDV99961.1    CM000162    EDX01437.1    CH954183    EDV45549.1    GGFK01010587    MBW43908.1    GGFM01004621    MBW25372.1    CH480825    EDW43906.1    GGFL01014628    MBW78806.1    AE014298    AL009192    AY089234    AAF45703.2    AAL89972.1    CAA15687.1    GGFJ01007001    MBW56142.1    CH902632    EDV32748.1    CH940664    EDW63048.1    KRF80881.1    QCYY01001598    ROT76880.1   

Proteomes

UP000218220    UP000007151    UP000027135    UP000245037    UP000005203    UP000235965    + More
UP000009046    UP000242457    UP000215335    UP000002358    UP000053105    UP000005204    UP000053825    UP000053097    UP000279307    UP000008237    UP000019118    UP000030742    UP000007755    UP000078492    UP000005205    UP000078541    UP000007266    UP000079169    UP000078542    UP000076502    UP000075809    UP000015103    UP000092462    UP000198287    UP000183832    UP000007819    UP000069940    UP000249989    UP000037069    UP000095301    UP000095300    UP000008820    UP000192223    UP000075886    UP000075885    UP000075920    UP000075882    UP000007062    UP000075900    UP000078540    UP000076408    UP000000311    UP000091820    UP000076407    UP000075840    UP000092460    UP000092443    UP000078200    UP000092444    UP000092445    UP000001070    UP000002282    UP000069272    UP000008711    UP000001292    UP000000803    UP000007801    UP000008792    UP000283509   

PRIDE

Q1HPH2    H9IXD5    Q8T4E1   

Pfam

PF01650   Peptidase_C13        + More
PF01607   CBM_14
PF07648   Kazal_2

Interpro

IPR028361   GPI_transamidase        + More
IPR001096   Peptidase_C13       
IPR002557   Chitin-bd_dom       
IPR036508   Chitin-bd_dom_sf       
IPR036773   TB_dom_sf       
IPR003645   Fol_N       
IPR036058   Kazal_dom_sf       
IPR017878   TB_dom       
IPR002350   Kazal_dom       

SUPFAM

SSF57625   SSF57625        + More
SSF100895   SSF100895       

Gene 3D

3.90.290.10    

ProteinModelPortal

Q1HPH2   A0A2A4JZD3   A0A212FGH5   A0A2H1V6N2   S4PY80   A0A067R5W0   + More
A0A2P8Y022   A0A088AL45   A0A2J7PSN3   E0VQW5   A0A2A3ERR2   A0A232FIJ4   K7J1G0   A0A0M9A411   A0A1B6MNQ7   H9IXD5   A0A1B6G6C9   A0A0L7QTX1   A0A026VU67   A0A1B6DM73   E2B817   E9J1B2   N6TWV0   A0A0T6ATT9   F4X801   A0A151JAM5   A0A1Y1LJ05   A0A158NVQ9   A0A195FXD0   A0A139WFR6   A0A1Y1LK07   A0A1S3DII2   A0A3Q0JID1   A0A151IDU5   A0A154P611   A0A151XEM8   A0A023F9E8   A0A2R7WAE1   A0A310SKF9   A0A336MQ12   A0A0P4VWX2   R4FLF6   A0A1B0DHL5   A0A0V0GE85   A0A0K8WK85   A0A0A9WQL0   A0A226F1Z0   A0A1J1I510   A0A034WP24   J9JPI1   A0A1W7R826   A0A182G8X8   A0A0L0BVR9   A0A2K8JMF4   A0A1I8N9K8   A0A0P4VZ99   A0A0A1WMN4   A0A1I8NZ40   A0A023EPP1   Q16SV5   A0A0K8TTB9   A0A1L8DU17   A0A1L8DTW9   A0A1W4WJ50   W8C4T3   A0A1L8DU23   A0A182QDG2   A0A182PAI3   A0A1Q3G392   A0A182VY47   A0A1Q3G334   A0A182L6W0   Q7QAC9   A0A182R5M8   A0A151I1X5   A0A182XWR1   E2A5G5   A0A1A9W1Y3   A0A182X8U5   A0A182ID27   A0A1B0BM95   A0A1A9YM54   A0A1A9UGJ1   A0A1B0FAS4   A0A1B0A1V9   A0A2M4DMQ1   A0A2M4ASZ8   B4JK59   B4Q1J6   A0A182F9K1   B3P8U4   A0A2M4ATK0   A0A2M3ZA43   B4I9M5   A0A2M4DMK7   Q8T4E1   A0A2M4BT04   B3MYQ4   B4MES3   A0A3R7SVD3  

PDB

4NOM     E-value=2.05938e-25,     Score=286

KEGG

733045    K05290 GPI-anchor transamidase subunit K | (RefSeq) phosphatidylinositol glycan

PATHWAY

00563    Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0008234   GO:0042765   GO:0016255   GO:0003923   GO:0034394   GO:0006030   GO:0005576   GO:0008061   GO:0008233   GO:0006508   GO:0016010   GO:0016740   GO:0003707   GO:0006418   GO:0003824  

PANTHER

PTHR12000   PTHR12000:SF1  

SignalP

Position:   1 - 22,         Likelihood:  0.978711

 

 

Length:

345

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.16720000000001

Exp number, first 60 AAs:

2.16273

Total prob of N-in:

0.10697

outside

1  -  345

 

 

Pi

152.577554

Theta

162.037086

Tajima's D

-0.470052

CLR

0.598643

CSRT

0.248037598120094

Interpretation

Uncertain