Gene

KWMTBOMO11445

Pre Gene Modal

BGIBMGA001893

Annotation

PREDICTED:_uncharacterized_protein_LOC106132669_[Amyelois_transitella]

Location

Bomo_Chr19(+):5994764-5997059      View in EpiBrowser

Full name

RecQ-mediated genome instability protein 2      

Location in the cell

Cytoplasmic   Reliability : 1.305 Mitochondrial   Reliability : 1.126

CDS

ATGTCAATATGTCCAAGGAAATACTTTATTAAAGACCTCATAAACAAACCGACTCCCATCGATGTATGGCTGCAAGGAACAATCGAACAGACTGTAGGCCGCGATATTTTAATAATTTCCGATACGTTTGGACGAGCAAAAATCACGAAATGTGAAACGGCTGACGGGGTTATTGATAAAAATTCCATAAAAAAAGGAACATACTGCTGTATAATTGGGACAGCTGTCAAAACAAAAGGTGTACCTGAAGTTCAAGCTTATAAATTCATTGATTTGAGTTCACAACCTGAGATGAAAAGTTCATGGGAGATCGAAGTGAATGAAGCTAATCTATTTTTAGAAGGGAAGTTAATACCTAACATTGAGGATTGTCATAAATTATAA

Protein

MSICPRKYFIKDLINKPTPIDVWLQGTIEQTVGRDILIISDTFGRAKITKCETADGVIDKNSIKKGTYCCIIGTAVKTKGVPEVQAYKFIDLSSQPEMKSSWEIEVNEANLFLEGKLIPNIEDCHKL

Description

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.

Subunit

Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM (By similarity).

Similarity

Belongs to the RMI2 family.

Keywords

Alternative splicing   Complete proteome   DNA replication   DNA-binding   Nucleus   Phosphoprotein   Reference proteome  

Feature

chain  RecQ-mediated genome instability protein 2
splice variant  In isoform 2.

Uniprot

H9IXB0   A0A2A4K1F3   A0A2H1WRL2   S4PFD6   A0A194QJD7   A0A194QL73   + More
A0A194RFM3   A0A212F5B0   A0A0L7L1C4   A0A067R4M9   A0A2Z5TRJ8   A0A2J7PZP7   A0A2P8YV89   A0A210PEN9   V4L8H2   A0A1S3ESK0   A0A072UJT6   F2DXH0   A0A0E0KHI5   A0A2K1IBW2   A0A1J3DR99   A0A0L8GBY1   A0A1D2N2B2   A0A3B6IKV3   A0A3B6JCV0   F1RL13   A0A2Y9KGM3   A0A199UN74   A0A2P6QGH8   Q3UPE3   A0A0S3NU51   K4AGB2   A0A287MZI4   A0A340XU69   A0A2Y9LRI9   A0A059BVM6   A0A3Q7XN23   M7YY14   A0A2G2YHD3   A0A1U8EW11   A0A2G3BBE7   A0A2U4ATZ8   A0A0D9VXJ0   A0A2U3W064   A0A0A0LVL5   A0A1U7QRM7   A0A0Q3KRU6   A0A3B6HWV1   A0A314L4K8   A0A2K6V8N1   A0A2Y9SRI4   A0A3Q7MTU0   A0A176VUP0   A0A2R6XGA7   A0A2H3Y6K0   A0A067KH80   A0A1A6GU82   M0TZ97   F1PLC5   A0A2R6P7S9   A0A3B5YRB0   R0I4J1   A0A2Y9DF28   A0A2R8MAW4   A0A3N6R900   A0A3P6EWI5   A0A341BBQ8   A0A1S4C6Y9   A0A2P5VQM3   A0A2G2VQ53   A0A287MZF7   A0A1R3H5D2   A0A0D3FMI8   A0A0E0GRY5   A0A0E0NZN8   I1NVX4   Q10F22   A0A0D9ZBQ2  

Pubmed

19121390    23622113    26354079    22118469    26227816    24845553    + More
26760975    29403074    28812685    23518688    22089132    24767513    30397259    21415278    18079367    29237241    27289101    30723633    27374615    16141072    26514418    22580951    23075845    24919147    23535596    24591624    29089032    19881527    19495411    20565788    22047402    20148030    23917264    24837971    22801500    16341006    29661190    23749190    24807620    22408737    16109971    16100779    15685292    16381971    23299411    24280374   

EMBL

BABH01018031    NWSH01000239    PCG78095.1    PCG78096.1    ODYU01010534    SOQ55710.1    + More
GAIX01004062    JAA88498.1    KQ458575    KPJ05683.1    KPJ05685.1    KQ460436    KPJ14731.1    AGBW02010207    OWR48928.1    JTDY01003736    KOB69074.1    KK852981    KDR12928.1    FX985832    BBA93719.1    NEVH01020333    PNF21800.1    PYGN01000340    PSN48163.1    NEDP02076747    OWF34921.1    KI517683    ESQ36048.1    CM001220    PSQE01000004    KEH29927.1    RHN60599.1    AK368588    BAJ99791.1    ABEU02000026    PNR26759.1    GEVI01010657    JAU21663.1    KQ422679    KOF74428.1    LJIJ01000286    ODM99361.1    AEMK02000018    DQIR01223990    HDB79467.1    LSRQ01006332    OAY66292.1    PDCK01000043    PRQ33286.1    AK080331    AK143588    AB984725    BAT46589.1    AGNK02005432    CM003536    RCV41465.1    KK198758    KCW70024.1    KD206609    EMS52522.1    AYRZ02000011    PHT69130.1    MCIT02000011    PHU03762.1    CM002922    KGN64872.1    CM000880    KQK13761.1    MJEQ01000486    OIT36009.1    LVLJ01002763    OAE23855.1    KZ772688    PTQ45142.1    KK914534    KDP34348.1    LZPO01075857    OBS68897.1    AAEX03004534    AAEX03004535    NKQK01000028    PSR86525.1    KB870805    EOA37194.1    QGKV01235161    RQL93654.1    LR031877    VDD41866.1    KZ671486    PPR81123.1    MLFT02000011    PHT35083.1    AWUE01020826    OMO65547.1    AC087851    DP000009    AK102497    AP008209    AP014959    CM000140    AAK14410.1    ABF98243.1    BAG95584.1    BAH92315.1    BAS85789.1    EAZ28164.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000037510    + More
UP000027135    UP000235965    UP000245037    UP000242188    UP000030689    UP000081671    UP000002051    UP000265566    UP000026962    UP000006727    UP000053454    UP000094527    UP000019116    UP000008227    UP000248482    UP000092600    UP000238479    UP000000589    UP000004995    UP000011116    UP000265300    UP000248483    UP000030711    UP000286642    UP000015106    UP000189700    UP000222542    UP000224522    UP000245320    UP000032180    UP000245340    UP000029981    UP000189706    UP000008810    UP000187609    UP000233220    UP000248484    UP000286641    UP000228380    UP000027138    UP000092124    UP000012960    UP000002254    UP000241394    UP000029121    UP000248480    UP000008225    UP000252040    UP000084051    UP000239757    UP000224567    UP000187203    UP000026960    UP000006591    UP000008022    UP000007306    UP000059680    UP000026961   

PRIDE

H9IXB0    Q3UPE3   

Pfam

PF16100   RMI2        + More
PF04718   ATP-synt_G

Interpro

IPR032245   RMI2        + More
IPR012340   NA-bd_OB-fold       
IPR006808   ATP_synth_F0_gsu_mt       

SUPFAM

SSF50249   SSF50249       

ProteinModelPortal

H9IXB0   A0A2A4K1F3   A0A2H1WRL2   S4PFD6   A0A194QJD7   A0A194QL73   + More
A0A194RFM3   A0A212F5B0   A0A0L7L1C4   A0A067R4M9   A0A2Z5TRJ8   A0A2J7PZP7   A0A2P8YV89   A0A210PEN9   V4L8H2   A0A1S3ESK0   A0A072UJT6   F2DXH0   A0A0E0KHI5   A0A2K1IBW2   A0A1J3DR99   A0A0L8GBY1   A0A1D2N2B2   A0A3B6IKV3   A0A3B6JCV0   F1RL13   A0A2Y9KGM3   A0A199UN74   A0A2P6QGH8   Q3UPE3   A0A0S3NU51   K4AGB2   A0A287MZI4   A0A340XU69   A0A2Y9LRI9   A0A059BVM6   A0A3Q7XN23   M7YY14   A0A2G2YHD3   A0A1U8EW11   A0A2G3BBE7   A0A2U4ATZ8   A0A0D9VXJ0   A0A2U3W064   A0A0A0LVL5   A0A1U7QRM7   A0A0Q3KRU6   A0A3B6HWV1   A0A314L4K8   A0A2K6V8N1   A0A2Y9SRI4   A0A3Q7MTU0   A0A176VUP0   A0A2R6XGA7   A0A2H3Y6K0   A0A067KH80   A0A1A6GU82   M0TZ97   F1PLC5   A0A2R6P7S9   A0A3B5YRB0   R0I4J1   A0A2Y9DF28   A0A2R8MAW4   A0A3N6R900   A0A3P6EWI5   A0A341BBQ8   A0A1S4C6Y9   A0A2P5VQM3   A0A2G2VQ53   A0A287MZF7   A0A1R3H5D2   A0A0D3FMI8   A0A0E0GRY5   A0A0E0NZN8   I1NVX4   Q10F22   A0A0D9ZBQ2  

PDB

4DAY     E-value=0.00577875,     Score=86

KEGG

101745354    K15365 RecQ-mediated genome instability protein 2 | (RefSeq) recQ-mediated genome instability protei

PATHWAY

03460    Fanconi anemia pathway - Bombyx mori (domestic silkworm)

GO

GO:0016607   GO:0033045   GO:0005829   GO:0043007   GO:0009555   GO:2000042   GO:0006281   GO:0015078   GO:0015986   GO:0000276   GO:0003677   GO:0006260  

PANTHER

PTHR33962   PTHR12386  

Subcellular location

Nucleus   Colocalizes with BLM at nuclear DNA repair foci.   With evidence from 1 publications.

Length:

127

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00101

Exp number, first 60 AAs:

0.00019

Total prob of N-in:

0.22591

outside

1  -  127

 

 

Pi

233.919529

Theta

185.957765

Tajima's D

0.761448

CLR

0.016102

CSRT

0.591720413979301

Interpretation

Uncertain