Gene

KWMTBOMO11430  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001886

Annotation

PREDICTED:_gamma-tubulin_complex_component_4_[Bombyx_mori]

Location

Bomo_Chr19(+):5416514-5428715      View in EpiBrowser

Full name

Gamma-tubulin complex component       + More
Guanylate cyclase      
Gamma-tubulin complex component 4      

Alternative Name

Gamma-ring complex protein 76 kDa

Location in the cell

Nuclear   Reliability : 2.356

CDS

ATGATTCATGACGTACTATTAATTCTTTGGGATTCATCTGAAAATGCTATCGAAAAAAAAGAGAACCTTGCTTATGCGAATGAGGGTGATGTTGAAATCTATGGTAGATTAAGTGAGATAGCAAAGAGCCATCATAGAATCCAATCCTTTGTAGAAGAGACTGGATTCCAATCCCGAAAAGCTTTATCAGCAACAACACACAGTCACAGATATGGACTCTATACCCAAGCACTAAGTGAAGGCATCACTGAAGTCCTACTATCATATAAGAAAACACTTGTAGAAGTTGAATCTCTAGTAATAGGGAATCACAACTACACTTTATCATATGTCTATAGTTACATTGAGAAATATCAAGGTCTGTTCAATACATTGAACAGAATTATAACAACTATTAAAGAAAGGAGATTAATGGGCTGTCAGATATTGAGTTTAATTCATCAATATATTTTAAGTGGCAACAAGTCGATTCATGATGCCGTTTTGAAAATATTTACAAGTGTGAACAAAGTATTCATACATCAACTATGTACTTGGCTTCTTTATGGGGAATTAAAGGATGTGTATCAAGAGTTCTTCATATCAAAAAGAAAAGATGACTCGTCAGAAACTTTATTGTCAACACCATCTTCTTCTAATGTCTGTGACAAAACTCTTGTTTCTACATTGCAGGAGACATTAGGTTGTGGTTACACACTCAATCCAACACTGATACCACATTTCATGCCATTGTCATTAGCACAAGAAATTTTGTTTATCGGAAAAACTGTAATACTTTTCGATTTAGATCCAAAAAAAGTAAAAAAACACAGTGGCTTCGCTTCAAGCAGACCGATGTTGCCTTTGAAAAAGTATGGAATTGAGTCTAGAAGGTTTACAATTTGGGAGGACAAAGAATCTGAATTTCATGAGAAACTACAAAAACTTAAAGATCCAGATAATTTTGAAGTTCATAATCTGAGAAGTGTTATAAGGGAGATTAAAGAATGTGTAACTAAGCATTTGTGGACAGTGGCAGTCGAAGAAGCCCAATTGATACATGAGTTGAAGCTAATGAAAGATTTCTATCTACTTGGCCGGGGCGAATTGTTTCTGGAATTATTAAGACTCACAGCACATATGCTGGACAAACCGACGATTCGCACGTCAAGTAGAGACATGAACCAGGCTTTTCAAATGGCGGCACGCTCCGTTTTCCTAAGTAATAATACTGATATAGAAAAGTTTAGTTTCGAGCTGCCTTATGTTAAGCCGAACATATCAGGGAATTCGTCGATTGACGAAGACTACAGTACCGTTGCAGATGGATGGTCGAGTATAATCTTGAAATATGATTTCAAATGGCCGTTACATTTATTATTTACACCGGAAGTACTTGCCCGTTATAATGATATGTTTCGACTATTGCTCCGGCTAAAGAAAACCCAACACGATCTGCATTCGCTTTGGAAAACGTACAAACAGTCGGCGAGTTTCGCGATGTCCCAACTACACAACAAACTGATGTTTCTAATGGACAACCTCCAACACTACATGCAAGCAGACGTATTAGAAACCAATTTCTCTCGTCTGATGGACGCTGTCAACAAGACAAACGACTTTGAGAAACTCAAGAAGGCTCACGCCACGTTCCTGGCTGATATATTGAGTCAGTCATTTTTGACTGTGACTTTGTCGTCAGATAGCGATTGTTCTGGAGATCCCGCCGATACATTAAATAACCCAGTGTTCTGTAACATTATGGAACTATTGAAATTGTGTCATTCATTCTGCAGTATGAGTGAGATAGCAAACGATAGGGAAGCTGAAGATTATTACATAAAAGGATATTCTGAAAGGTTCAACAAATTAGTGAAGCAACTAATGCAACTTCTAGTTTCGCTACGAGATCGTCCGTGCGGCGTTTACTTAGCGAGACTTCTGATGAGACTCGACTACAACCGGTGGCTCAGTAGAGAGGCGCAGTTAACGCAATCTGTAACGAACATGTTAAGATACTGA

Protein

MIHDVLLILWDSSENAIEKKENLAYANEGDVEIYGRLSEIAKSHHRIQSFVEETGFQSRKALSATTHSHRYGLYTQALSEGITEVLLSYKKTLVEVESLVIGNHNYTLSYVYSYIEKYQGLFNTLNRIITTIKERRLMGCQILSLIHQYILSGNKSIHDAVLKIFTSVNKVFIHQLCTWLLYGELKDVYQEFFISKRKDDSSETLLSTPSSSNVCDKTLVSTLQETLGCGYTLNPTLIPHFMPLSLAQEILFIGKTVILFDLDPKKVKKHSGFASSRPMLPLKKYGIESRRFTIWEDKESEFHEKLQKLKDPDNFEVHNLRSVIREIKECVTKHLWTVAVEEAQLIHELKLMKDFYLLGRGELFLELLRLTAHMLDKPTIRTSSRDMNQAFQMAARSVFLSNNTDIEKFSFELPYVKPNISGNSSIDEDYSTVADGWSSIILKYDFKWPLHLLFTPEVLARYNDMFRLLLRLKKTQHDLHSLWKTYKQSASFAMSQLHNKLMFLMDNLQHYMQADVLETNFSRLMDAVNKTNDFEKLKKAHATFLADILSQSFLTVTLSSDSDCSGDPADTLNNPVFCNIMELLKLCHSFCSMSEIANDREAEDYYIKGYSERFNKLVKQLMQLLVSLRDRPCGVYLARLLMRLDYNRWLSREAQLTQSVTNMLRY

Description

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Catalytic Activity

GTP = 3',5'-cyclic GMP + diphosphate

Subunit

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with NINL. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome (PubMed:26213385).

Similarity

Belongs to the TUBGCP family.
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

3D-structure   Alternative splicing   Complete proteome   Cytoplasm   Cytoskeleton   Direct protein sequencing   Mental retardation   Microtubule   Primary microcephaly   Reference proteome  

Feature

chain  Gamma-tubulin complex component
splice variant  In isoform 2.

Uniprot

A0A2A4K4L0   A0A2H1V5U6   A0A212FGZ7   A0A194QEP6   H9IXA3   A0A194RA79   + More
A0A2Z5U7B5   A0A154P4F8   E2AHZ6   K7J485   A0A1Q3F4W2   A0A1Q3F4S0   A0A2A3EMN2   A0A088AL65   B0WU20   A0A310SEX1   A0A026WTB7   A0A2J7QYH5   A0A158NL53   A0A0M8ZUL3   A0A0C9R8R5   A0A067RAM5   Q0IG23   E2B6I6   A0A195C034   A0A0L7R764   A0A182K390   A0A151JSQ1   A0A195F1M9   F4WFW3   A0A151XBJ8   A0A182IW86   A0A084VYH1   A0A182VFJ6   W5JU71   A0A182NUP1   A0A182Y971   Q7PWU6   A0A2C9GRZ4   A0A182KNH6   A0A336L0T3   A0A336MBV4   A0A182R499   A0A1J1I5S3   A0A182MP26   A0A182XDI7   A0A182F1Z3   A0A1S4F4Z4   A0A0C9QLV5   A0A182VU61   A0A0J7L5U5   A0A1B0FCW2   A0A182P9Q0   A0A182H916   A0A182TPB3   A0A195BH14   A0A1A9VI50   A0A1A9YH42   A0A1A9ZEY2   A0A3Q3X7X3   A0A3P8VJ44   A0A3Q0S2N5   A0A3Q2PPM5   A0A146V2N1   B4KHQ7   A0A3P9PUZ3   A0A3B4CXV7   A0A087XQL3   A0A3B3TMV5   A0A3B3WMY5   A0A3B4YQQ2   A0A3B4V6S8   I3JIZ7   H2UBS6   A0A3Q1J2N3   A0A1A8HAU1   A0A232F3N5   A0A3Q2WKJ7   I3JIZ6   A0A1V4JDX7   A0A3Q4H2K7   A0A1A8K099   A0A1A8QIU2   W5NA20   A0A1W5B1M1   M4AUZ7   E1BQM2   A0A1A8DHC5   A0A1A7YDD3   A0A2I4CA55   A0A3P9CG09   Q9UGJ1-2   K7C990   A0A2I2Y2W4   A0A3Q3FQ69  

EC Number

4.6.1.2

Pubmed

22118469    26354079    19121390    20798317    20075255    24508170    + More
30249741    21347285    24845553    17510324    21719571    24438588    20920257    23761445    25244985    12364791    14747013    17210077    20966253    26483478    24487278    17994087    25186727    21551351    28648823    23542700    15592404    10562286    14702039    16572171    15489334    12852856    21269460    25817018    26213385    22398555   

EMBL

NWSH01000136    PCG79191.1    ODYU01000592    SOQ35644.1    AGBW02008579    OWR53004.1    + More
KQ459053    KPJ03952.1    BABH01018072    BABH01018073    BABH01018074    BABH01018075    KQ460436    KPJ14748.1    AP017509    BBB06823.1    KQ434809    KZC06733.1    GL439621    EFN66904.1    AAZX01003261    GFDL01012482    JAV22563.1    GFDL01012480    JAV22565.1    KZ288209    PBC32988.1    DS232099    EDS34736.1    KQ765447    OAD53938.1    KK107111    QOIP01000011    EZA58911.1    RLU16553.1    NEVH01009089    PNF33641.1    ADTU01019255    ADTU01019256    KQ435843    KOX71287.1    GBYB01004531    GBYB01004532    GBYB01004533    GBYB01004535    JAG74298.1    JAG74299.1    JAG74300.1    JAG74302.1    KK852779    KDR16711.1    CH477274    EAT45190.1    GL445975    EFN88678.1    KQ978501    KYM93518.1    KQ414642    KOC66715.1    KQ978530    KYN30314.1    KQ981866    KYN34077.1    GL888128    EGI66730.1    KQ982320    KYQ57727.1    ATLV01018366    KE525231    KFB43015.1    ADMH02000358    ETN66843.1    AAAB01008984    EAA14809.4    APCN01003350    UFQS01001202    UFQT01001202    SSX09724.1    SSX29491.1    UFQT01000665    SSX26293.1    CVRI01000040    CRK94932.1    AXCM01000043    GBYB01004534    JAG74301.1    LBMM01000598    KMQ97986.1    CCAG010017495    JXUM01030305    KQ560880    KXJ80500.1    KQ976488    KYM83518.1    GCES01074661    JAR11662.1    CH933807    EDW13344.1    AYCK01027203    AERX01043080    AERX01043081    AERX01043082    HAEB01007560    HAEC01012386    SBQ80603.1    NNAY01001043    OXU25374.1    LSYS01007908    OPJ70225.1    HAED01009278    HAEE01005622    SBR25642.1    HAEF01007349    HAEG01012832    SBR93362.1    AHAT01024787    AADN05000047    HAEA01005260    SBQ33740.1    HADX01006041    SBP28273.1    AJ249677    AK001639    AK027703    AC018924    CH471125    BC009870    BC012801    GABC01008888    GABF01002251    GABD01010221    NBAG03000046    JAA02450.1    JAA19894.1    JAA22879.1    PNI94641.1    CABD030095860    CABD030095861   

Proteomes

UP000218220    UP000007151    UP000053268    UP000005204    UP000053240    UP000076502    + More
UP000000311    UP000002358    UP000242457    UP000005203    UP000002320    UP000053097    UP000279307    UP000235965    UP000005205    UP000053105    UP000027135    UP000008820    UP000008237    UP000078542    UP000053825    UP000075881    UP000078492    UP000078541    UP000007755    UP000075809    UP000075880    UP000030765    UP000075903    UP000000673    UP000075884    UP000076408    UP000007062    UP000075840    UP000075882    UP000075900    UP000183832    UP000075883    UP000076407    UP000069272    UP000075920    UP000036403    UP000092444    UP000075885    UP000069940    UP000249989    UP000075902    UP000078540    UP000078200    UP000092443    UP000092445    UP000261620    UP000265120    UP000261340    UP000265000    UP000009192    UP000242638    UP000261440    UP000028760    UP000261500    UP000261480    UP000261360    UP000261420    UP000005207    UP000005226    UP000265040    UP000215335    UP000264840    UP000190648    UP000261580    UP000018468    UP000192224    UP000002852    UP000000539    UP000192220    UP000265160    UP000005640    UP000001519    UP000261660   

PRIDE

H9IXA3    Q9UGJ1   

Pfam

PF17681   GCP_N_terminal        + More
PF04130   GCP_C_terminal
PF00211   Guanylate_cyc
PF07714   Pkinase_Tyr
PF01094   ANF_receptor
PF02826   2-Hacid_dh_C
PF00389   2-Hacid_dh
PF02949   7tm_6

Interpro

IPR040457   GCP_C        + More
IPR007259   GCP       
IPR042241   GCP_C_sf       
IPR041470   GCP_N       
IPR011009   Kinase-like_dom_sf       
IPR018297   A/G_cyclase_CS       
IPR000719   Prot_kinase_dom       
IPR029787   Nucleotide_cyclase       
IPR001828   ANF_lig-bd_rcpt       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR001054   A/G_cyclase       
IPR028082   Peripla_BP_I       
IPR029752   D-isomer_DH_CS1       
IPR029753   D-isomer_DH_CS       
IPR006139   D-isomer_2_OHA_DH_cat_dom       
IPR006140   D-isomer_DH_NAD-bd       
IPR036291   NAD(P)-bd_dom_sf       
IPR004117   7tm6_olfct_rcpt       
IPR018247   EF_Hand_1_Ca_BS       

SUPFAM

SSF55073   SSF55073        + More
SSF53822   SSF53822       
SSF56112   SSF56112       
SSF51735   SSF51735       

Gene 3D

1.20.120.1900     3.30.70.1230    

ProteinModelPortal

A0A2A4K4L0   A0A2H1V5U6   A0A212FGZ7   A0A194QEP6   H9IXA3   A0A194RA79   + More
A0A2Z5U7B5   A0A154P4F8   E2AHZ6   K7J485   A0A1Q3F4W2   A0A1Q3F4S0   A0A2A3EMN2   A0A088AL65   B0WU20   A0A310SEX1   A0A026WTB7   A0A2J7QYH5   A0A158NL53   A0A0M8ZUL3   A0A0C9R8R5   A0A067RAM5   Q0IG23   E2B6I6   A0A195C034   A0A0L7R764   A0A182K390   A0A151JSQ1   A0A195F1M9   F4WFW3   A0A151XBJ8   A0A182IW86   A0A084VYH1   A0A182VFJ6   W5JU71   A0A182NUP1   A0A182Y971   Q7PWU6   A0A2C9GRZ4   A0A182KNH6   A0A336L0T3   A0A336MBV4   A0A182R499   A0A1J1I5S3   A0A182MP26   A0A182XDI7   A0A182F1Z3   A0A1S4F4Z4   A0A0C9QLV5   A0A182VU61   A0A0J7L5U5   A0A1B0FCW2   A0A182P9Q0   A0A182H916   A0A182TPB3   A0A195BH14   A0A1A9VI50   A0A1A9YH42   A0A1A9ZEY2   A0A3Q3X7X3   A0A3P8VJ44   A0A3Q0S2N5   A0A3Q2PPM5   A0A146V2N1   B4KHQ7   A0A3P9PUZ3   A0A3B4CXV7   A0A087XQL3   A0A3B3TMV5   A0A3B3WMY5   A0A3B4YQQ2   A0A3B4V6S8   I3JIZ7   H2UBS6   A0A3Q1J2N3   A0A1A8HAU1   A0A232F3N5   A0A3Q2WKJ7   I3JIZ6   A0A1V4JDX7   A0A3Q4H2K7   A0A1A8K099   A0A1A8QIU2   W5NA20   A0A1W5B1M1   M4AUZ7   E1BQM2   A0A1A8DHC5   A0A1A7YDD3   A0A2I4CA55   A0A3P9CG09   Q9UGJ1-2   K7C990   A0A2I2Y2W4   A0A3Q3FQ69  

PDB

3RIP     E-value=1.49585e-76,     Score=730

KEGG

101746824    K16571 gamma-tubulin complex component 4 | (RefSeq) gamma-tubulin complex component 4

GO

GO:0000922   GO:0007020   GO:0005815   GO:0005737   GO:0043015   GO:0005874   GO:0051225   GO:0005813   GO:0000923   GO:0000930   GO:0031122   GO:0000278   GO:0051321   GO:0051415   GO:0004383   GO:0035556   GO:0005524   GO:0004672   GO:0016021   GO:0016616   GO:0051287   GO:0004984   GO:0005549   GO:0007112   GO:0007058   GO:0045450   GO:0060221   GO:0042670   GO:0055037   GO:0008274   GO:0005200   GO:0005829   GO:0015630   GO:0016020   GO:0065003   GO:0000226   GO:0008152   GO:0016740   GO:0003707   GO:0006418   GO:0003824  

PANTHER

PTHR19302  

Subcellular location

  

Length:

666

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00975999999999998

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00029

outside

1  -  666

 

 

Pi

182.768581

Theta

170.598505

Tajima's D

0.348446

CLR

0.031048

CSRT

0.476126193690316

Interpretation

Uncertain