Gene

KWMTBOMO11424

Pre Gene Modal

BGIBMGA001882

Annotation

PREDICTED:_potassium/sodium_hyperpolarization-activated_cyclic_nucleotide-gated_channel_2_isoform_X12_[Bombyx_mori]

Location

Bomo_Chr19(+):5364524-5373571      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 4.756

CDS

ATGGGAGGCTACCTAAAATTCTTGCCGGAACACGACAGATTTTACTGGGACTTATGCATGCTGCTACTTCTTGTGGCGAATTTAATCATCCTACCAGTTGCCATCTCCTTCTTCAACGATGACCTTAGCACGCGCTGGATTGCCTTCAATTGTCTGTCCGATACCATATTTCTAATAGATATCGTTGTTAATTTTAGAACAGGAATAATGCAACAAGATAATGCAGAGCAAGTAATACTAGATCCAAAGTTAATAGCGAAACACTATTTGAGGACTTGGTTCTTCCTGGACCTCATCTCTAGTATACCACTAGATTATATATTTTTGATCTTCAATCAGGTAAACGATTTCAGTGAAAACTTTCAAATACTACATGCGGGTCGCGCGCTGAGGATACTCCGATTAGCAAAGCTGCTATCATTGGTTCGACTGCTCCGTCTCTCCAGGCTCGTCCGATATGTCTCACAATGGGAGGAAGTATATTTTCTCAACATGGCTTCCGTGTTCATGCGGATATTCAACTTAATATGTATGATGCTGTTGATCGGCCATTGGTCCGGATGTCTACAGTTCCTGGTTCCTATGCTGCAAGGATTTCCACCAAACTCGTGGGTTGCTATAAACGAGTTACAGGAGGCTTTTTGGTTAGAACAATATTCATGGGCGCTGTTCAAGGCAATGTCACATATGTTGTGCATCGGTTACGGACGGTTCCCTCCTCAATCACTCACCGACATGTGGCTCACGATGCTCTCGATGATATCAGGAGCCACTTGCTACGCGCTCTTCCTAGGTCACGCAACCAATCTCATCCAGAGTCTCGACTCTTCACGCAGGCAATACCGTGAAAAGGTGAAACAAGTAGAAGAGTACATGGCGTATCGCAAATTACCACGTGAAATGCGTCAACGTATCACCGAGTACTTCGAACACAGATACCAAGGGAAATTCTTCGATGAGGAAGTAATTTTGGGCGAGCTGAGCGAAAAACTGCGCGAAGATGTCATCAACTACAACTGTCGCTCACTTGTGGCCTCTGTACCTTTCTTTGCAAACGCCGACTCCAACTTTGTGTCAGATGTCGTCACCAAACTACGCTATGAAGTGTTTCAGCCTGGTGACATTATCATAAAGGAAGGAACAATAGGAAATAAAATGTATTTCATCCAAGAAGGCATCGTAGATATAGTCATGGCCAACGGTGAAGTTGCCACCAGTCTATCCGACGGTTCGTACTTCGGAGAAATCTGCTTGCTAACAAACGCTCGCAGAGTAGCATCCGTCCGCGCCGAGACGTACTGCAATCTGTTCTCTTTGTCGGTGGATCATTTCAACGCCGTGCTAGACCAGTATCCGTTGATGCGACGCACGATGGAAAGTGTCGCAGCCGAACGACTGAACAAGATCGGCAAAAACCCGAATCTGGTGGCGCACCGCGAAGACGACACGACATCCGAAGGGAACACGATCAACGCAGTGGTTAACGCTCTCGCGGCAGAAGCAGAGCACGTGAGTCTGTCAGACGACAGTGTGGCACGACTGTCGGAGAGGTCGCTGGGGCTAGCACTGCAACCGCTGCAGGCGGCATCGTGTCGCATGGCAGGTGTGGCCCTACCGGGGCTGGGCGTAGCGGCTGCGCTGCCGCGTCCCAAGTCGGAGCACGACTTCAGTTCGACGCAGGCTCAGCCGCCGTCGTTGTCGTCGGTCGGAGCCGCCTTCCACAAATCGGACGCGGGCATCGCACCCTGA

Protein

MGGYLKFLPEHDRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQVNDFSENFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPPNSWVAINELQEAFWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPREMRQRITEYFEHRYQGKFFDEEVILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLRYEVFQPGDIIIKEGTIGNKMYFIQEGIVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVRAETYCNLFSLSVDHFNAVLDQYPLMRRTMESVAAERLNKIGKNPNLVAHREDDTTSEGNTINAVVNALAAEAEHVSLSDDSVARLSERSLGLALQPLQAASCRMAGVALPGLGVAAALPRPKSEHDFSSTQAQPPSLSSVGAAFHKSDAGIAP

Uniprot

A0A2A4K4K4   A0A2A4K4L7   O96777   S4PAD1   K7INL3   A0A158NZ19   + More
A0A2A3EAG6   Q6WL04   A0A1Y1L055   A0A1Y1KXP8   K7INL2   A0A139WF05   A0A154P706   Q5XQT6   A0A151WKF2   A0A088A929   A0A232EZ95   A0A139WF98   A0A026W9G0   F4W9U9   A0A084WS95   A0A034V7Z9   A0A182F6Z2   A0A0K8VQZ6   B7YZE7   A1Z9N8   A0A1J1HRM1   A0A0Q5VWH7   A0A1W4VZ70   A0A0R3NQ18   A0A0R3NXD6   A0A0P9C033   A0A0Q9X0V2   A0A0Q5VMJ9   B4QFF5   A0A0R3NW28   Q56JI0   A0A0R1DQM2   A0A0N8P0E5   Q16ZU7   A0A1I8MGZ7   A0A0R1DQJ9   A0A0Q9WXF4   A0A1W4WBE4   A0A1I8MH01   A0A0R3NVR5   A0A3B0J0U5   A0A3B0J4W2   N6VFV5   A0A0R3NQ48   A0A1I8PZB0   A0A034V5W6   A0A034V5W1   A0A1I8PZ82   Q9Y1J9   W5J915   A0A0A1XB94   W8BX37   E0W2H0   F7VJU3   A0A1J1HRQ0   A1Z9P0   A0A0Q9WYQ8   Q56JH8   A0A0Q5VNV9   A0A0P8ZR17   Q56JH9   A0A0R1DXL0   A0A1J1HW14   A0A034V8L7   B4HRA8   F5HIW0   B4KSK8   A1Z9N7   A0A0Q9WNN2   A0A0Q5VNM9   A0A3B0J1B4   A0A0R3NPR9   Q28X53   A0A0R3NPY8   Q56JH7   B7YZE8   A0A0R3NWD5   A0A0R3NUU7   B4P738   A0A0P8XQQ5   B4MJM3   A0A1W4WA06   A0A0J9RCI0   A0A1I8MGZ4   A0A1B6HCW2   A0A1W4WAY6   A0A0R1DQU9   B3MDZ1   B3NR62   A0A1I8MGY4   A0A1I8MGZ2   A0A0R3NPS5   A0A1I8MGZ6   A0A1I8PZ81  

Pubmed

10319439    23622113    20075255    21347285    14563363    28004739    + More
18362917    19820115    15388341    28648823    24508170    21719571    24438588    25348373    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17994087    15632085    15804582    17550304    17510324    25315136    12491074    20920257    23761445    25830018    24495485    20566863    18057021    26109357    26109356    12364791    22936249   

EMBL

NWSH01000136    PCG79185.1    PCG79187.1    AJ012664    CAA10110.1    GAIX01005081    + More
JAA87479.1    ADTU01000847    ADTU01000848    ADTU01000849    ADTU01000850    ADTU01000851    ADTU01000852    ADTU01000853    ADTU01000854    ADTU01000855    ADTU01000856    KZ288318    PBC28282.1    AY280848    AAQ16312.1    GEZM01070976    JAV66151.1    GEZM01070975    JAV66152.1    KQ971354    KYB26550.1    KQ434829    KZC07726.1    AY739658    AAU85297.1    KQ983012    KYQ48353.1    NNAY01001523    OXU23701.1    KYB26549.1    KK107321    EZA52675.1    GL888033    EGI69085.1    ATLV01026403    KE525413    KFB53089.1    GAKP01021057    JAC37895.1    GDHF01011008    JAI41306.1    AE013599    ACL83121.1    ABC66058.1    CVRI01000020    CRK90703.1    CH954179    KQS62633.1    CM000071    KRT03122.1    KRT03126.1    CH902619    KPU76898.1    CH963846    KRF97533.1    KQS62631.1    CM000362    EDX07065.1    KRT03120.1    AY928069    AAX78393.1    CM000158    KRJ99559.1    KPU76900.1    CH477484    EAT40174.1    KRJ99557.1    KRF97534.1    KRT03125.1    OUUW01000001    SPP74654.1    SPP74653.1    ENO01935.1    KRT03124.1    GAKP01021053    JAC37899.1    GAKP01021058    JAC37894.1    AF124300    AAD42059.1    ADMH02001843    ETN60932.1    GBXI01005648    JAD08644.1    GAMC01008724    JAB97831.1    DS235878    EEB19826.1    BT128743    AEH59646.1    CRK90701.1    ABC66060.2    KRF97532.1    AY928071    AAX78395.1    KQS62632.1    KQS62634.1    KQS62636.1    KPU76895.1    KPU76899.1    AY928070    AAX78394.1    ABC66059.1    AFH08072.1    AFH08073.1    AFH08074.1    KRJ99558.1    KRJ99561.1    KRJ99562.1    CRK90702.1    GAKP01021054    JAC37898.1    CH480816    EDW47837.1    AAAB01008799    EGK96221.1    CH933808    EDW09513.2    ABC66057.1    KRF97530.1    KQS62628.1    SPP74655.1    KRT03121.1    EAL26463.3    KRT03127.1    AY928072    AAX78396.1    ACL83122.1    KRT03123.1    KRT03119.1    EDW91003.2    KPU76893.1    EDW72312.2    CM002911    KMY93738.1    GECU01035169    JAS72537.1    KRJ99560.1    EDV37536.2    EDV56051.1    KRT03118.1   

Proteomes

UP000218220    UP000002358    UP000005205    UP000242457    UP000007266    UP000076502    + More
UP000075809    UP000005203    UP000215335    UP000053097    UP000007755    UP000030765    UP000069272    UP000000803    UP000183832    UP000008711    UP000192221    UP000001819    UP000007801    UP000007798    UP000000304    UP000002282    UP000008820    UP000095301    UP000268350    UP000095300    UP000000673    UP000009046    UP000001292    UP000007062    UP000009192   

PRIDE

A1Z9N8    Q56JI0    Q9Y1J9    F7VJU3    A1Z9P0    Q56JH8    + More
Q56JH9    A1Z9N7    Q56JH7   

Pfam

PF00520   Ion_trans        + More
PF00027   cNMP_binding
PF08412   Ion_trans_N
PF10545   MADF_DNA_bdg

Interpro

IPR013621   Ion_trans_N        + More
IPR018488   cNMP-bd_CS       
IPR000595   cNMP-bd_dom       
IPR003938   K_chnl_volt-dep_EAG/ELK/ERG       
IPR005821   Ion_trans_dom       
IPR018490   cNMP-bd-like       
IPR014710   RmlC-like_jellyroll       
IPR006578   MADF-dom       

SUPFAM

SSF51206   SSF51206       

Gene 3D

2.60.120.10    

CDD

cd00038  CAP_ED

ProteinModelPortal

A0A2A4K4K4   A0A2A4K4L7   O96777   S4PAD1   K7INL3   A0A158NZ19   + More
A0A2A3EAG6   Q6WL04   A0A1Y1L055   A0A1Y1KXP8   K7INL2   A0A139WF05   A0A154P706   Q5XQT6   A0A151WKF2   A0A088A929   A0A232EZ95   A0A139WF98   A0A026W9G0   F4W9U9   A0A084WS95   A0A034V7Z9   A0A182F6Z2   A0A0K8VQZ6   B7YZE7   A1Z9N8   A0A1J1HRM1   A0A0Q5VWH7   A0A1W4VZ70   A0A0R3NQ18   A0A0R3NXD6   A0A0P9C033   A0A0Q9X0V2   A0A0Q5VMJ9   B4QFF5   A0A0R3NW28   Q56JI0   A0A0R1DQM2   A0A0N8P0E5   Q16ZU7   A0A1I8MGZ7   A0A0R1DQJ9   A0A0Q9WXF4   A0A1W4WBE4   A0A1I8MH01   A0A0R3NVR5   A0A3B0J0U5   A0A3B0J4W2   N6VFV5   A0A0R3NQ48   A0A1I8PZB0   A0A034V5W6   A0A034V5W1   A0A1I8PZ82   Q9Y1J9   W5J915   A0A0A1XB94   W8BX37   E0W2H0   F7VJU3   A0A1J1HRQ0   A1Z9P0   A0A0Q9WYQ8   Q56JH8   A0A0Q5VNV9   A0A0P8ZR17   Q56JH9   A0A0R1DXL0   A0A1J1HW14   A0A034V8L7   B4HRA8   F5HIW0   B4KSK8   A1Z9N7   A0A0Q9WNN2   A0A0Q5VNM9   A0A3B0J1B4   A0A0R3NPR9   Q28X53   A0A0R3NPY8   Q56JH7   B7YZE8   A0A0R3NWD5   A0A0R3NUU7   B4P738   A0A0P8XQQ5   B4MJM3   A0A1W4WA06   A0A0J9RCI0   A0A1I8MGZ4   A0A1B6HCW2   A0A1W4WAY6   A0A0R1DQU9   B3MDZ1   B3NR62   A0A1I8MGY4   A0A1I8MGZ2   A0A0R3NPS5   A0A1I8MGZ6   A0A1I8PZ81  

PDB

6GYO     E-value=5.51558e-160,     Score=1449

KEGG

101745162    K04955 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 | (RefSeq) potassium/

GO

GO:0016021   GO:0005249   GO:0034765   GO:0005216   GO:0007637   GO:0045475   GO:0045938   GO:0071484   GO:1903294   GO:0016057   GO:0014059   GO:0008340   GO:0071632   GO:0050802   GO:0006813   GO:0016020   GO:0006811   GO:0008152   GO:0016740   GO:0003707   GO:0006418   GO:0003824   GO:0055085  

Length:

582

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

99.6878700000001

Exp number, first 60 AAs:

32.53492

Total prob of N-in:

0.20918

POSSIBLE N-term signal

sequence

outside

1  -  14

TMhelix

15  -  37

inside

38  -  171

TMhelix

172  -  194

outside

195  -  582

 

 

Pi

223.711563

Theta

203.856119

Tajima's D

0.180881

CLR

0.055047

CSRT

0.423978801059947

Interpretation

Uncertain