Gene

KWMTBOMO11416  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001943

Annotation

PREDICTED:_ATPase_ASNA1_homolog_[Papilio_machaon]

Location

Bomo_Chr19(-):5050325-5054504      View in EpiBrowser

Full name

ATPase ASNA1 homolog       + More
Arsenical pump-driving ATPase      

Alternative Name

Arsenical pump-driving ATPase homolog
Arsenite-stimulated ATPase

Location in the cell

Cytoplasmic   Reliability : 3.117

CDS

ATGGAAGATACTAAAGATTTTGAACCACTAGAACCTTCGTTGAAAAATGTTATCGATCAAAAGTCGTTAAGGTGGATTTTCGTTGGAGGGAAAGGCGGAGTTGGGAAAACTACGTGCAGTTGCAGTCTCGCAGTTCAGCTGTCGAAAGTTCGCGAATCTGTGTTAATCATATCAACTGATCCTGCCCACAATATCTCTGATGCATTCGACCAGAAATTTTCTAAAGTACCAACAAAGGTTAAAGGGTTTGACAACCTATTCGCTATGGAGATTGATCCGAATGTTGGATTAACAGAGCTGCCTGAAGAATATTTTGAAGGAGAATCTGAGGCTATGAGATTGGACAAGGGTGTCATGCAAGAGATTGTTGGAGCTTTTCCTGGTATTGATGAGGCTATGAGCTATGCTGAGGTGATGAAACTAGTAAAAGGCATGAACTTTAGTGCTGTAGTGTTCGATACTGCACCGACTGGACATACTCTCAGACTTCTATCATTCCCGCAAGTTGTAGAACGAGGTCTCGGCAAGCTGATGCGTTTGAAGTCAAAGGTTGCCCCCTTCATCAATCAAATTGCGTCACTGTTTGGACTAGCAGATTTCAACTCGGACATGTTCAGCAACAAAATGGATGAGATGTTATCAGTTATCAGACAAGTGAATGCACAGTTCAAAGACCCGAATCAAACTACATTTGTGTGTGTTTGTATCGCAGAGTTCCTATCGCTTTACGAAACCGAACGTTTAGTTCAAGAATTAACGCGATGTGGAATCGATACACATAATATTATAGTTAATCAGTTGCTGCTTCGTTCATCTGCTCCTTGTGAACTATGTGCAGCCAGGCATAAGGTCCAAGAAAAATATCTGGAGCAAATTGCAGACTTGTATGAAGACTTCCATGTGACAAAGCTACCCTTGCTGGAAAAGGAAGTCCGAGGAGCTTCCGCTGTAAATGCATTTTCAGAACTTCTCTTGAAGCCTTACGATCCTCCTACATCCTCCACGTGA

Protein

MEDTKDFEPLEPSLKNVIDQKSLRWIFVGGKGGVGKTTCSCSLAVQLSKVRESVLIISTDPAHNISDAFDQKFSKVPTKVKGFDNLFAMEIDPNVGLTELPEEYFEGESEAMRLDKGVMQEIVGAFPGIDEAMSYAEVMKLVKGMNFSAVVFDTAPTGHTLRLLSFPQVVERGLGKLMRLKSKVAPFINQIASLFGLADFNSDMFSNKMDEMLSVIRQVNAQFKDPNQTTFVCVCIAEFLSLYETERLVQELTRCGIDTHNIIVNQLLLRSSAPCELCAARHKVQEKYLEQIADLYEDFHVTKLPLLEKEVRGASAVNAFSELLLKPYDPPTSST

Description

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.

Subunit

Homodimer.

Similarity

Belongs to the arsA ATPase family.

Keywords

ATP-binding   Complete proteome   Cytoplasm   Endoplasmic reticulum   Hydrolase   Metal-binding   Nucleotide-binding   Reference proteome   Transport   Zinc  

Feature

chain  ATPase ASNA1 homolog

Uniprot

H9IXG0   A0A2A4JMB3   A0A2H1W6L0   A0A212F9C0   S4PCC6   A0A0L7KW95   + More
A0A0N1PHK1   A0A194QEW7   A0A0C9R9J4   A0A0J7KJI2   A0A154P793   E0VDM0   A0A026WTN5   A0A023EQ71   A0A2A3E513   V9IHT7   B0WEV5   A0A087ZY48   A0A067RLC5   A0A1B6G8W3   A0A1B6I1K2   A0A1B6DK67   A0A1Q3FCF8   A0A0M8ZVY9   K7IME4   A0A1B6MRI1   A0A0K8TNT1   Q16MG9   U5EIV3   A0A151WEM8   A0A0L7RCC5   A0A310SCD1   A0A182GNT7   W8BCD5   A0A1Y1NJ49   A0A0A1X261   A0A034VJ18   A0A195FGS3   E2BL31   A0A158NPA9   A0A195BEQ3   F4X362   A0A0C9RNL2   A0A151IVP1   A0A0K8U1B7   A0A232FDB4   A0A1W4UZX5   A0A151IL13   A0A0J9TVE2   B4QEC4   B4P1R6   A0A1I8MPI4   A0A1A9VQH0   A0A336LP49   D3TN99   A0A1I8P9Y2   A0A1L8DFI2   B3N9X2   Q7JWD3   A0A1L8DFB0   A0A1A9Z569   A0A1A9YJE2   A0A1B0C0I7   Q28YJ2   B4H8J5   B3MHB7   A0A1B0CAG5   A0A2M4AFJ3   A0A2J7QQB0   A0A182JGD8   A0A084WED0   B4J4F6   A0A3B0JXA3   E2AIS3   B4KTG7   B4LN33   W5JQD0   A0A2M4BSP7   A0A2M4BSM7   A0A2M4BSP8   A0A0M4EVN8   A0A2M3Z582   B4N645   A0A2M3ZH77   A0A1A9WQH6   A0A182T3X5   A0A023EP66   T1DGA5   A0A182I2D3   A0A182FHD5   A0A182XMK5   A0A182JVQ8   A0A182UVV4   A0A182KQ73   Q5TRE7   D2A135   A0A182NJC5   A0A182R4J5   A0A182PUZ3   A0A0P5RW25  

EC Number

3.6.-.-

Pubmed

19121390    22118469    23622113    26227816    26354079    20566863    + More
24508170    30249741    24945155    24845553    20075255    26369729    17510324    26483478    24495485    28004739    25830018    25348373    20798317    21347285    21719571    28648823    22936249    17994087    25315136    20353571    10731132    12537572    12537569    15632085    24438588    20920257    23761445    20966253    12364791    18362917    19820115   

EMBL

BABH01018100    NWSH01001047    PCG72926.1    ODYU01006642    SOQ48667.1    AGBW02009615    + More
OWR50317.1    GAIX01005502    JAA87058.1    JTDY01005079    KOB67390.1    KQ460772    KPJ12479.1    KQ459053    KPJ03964.1    GBYB01013084    JAG82851.1    LBMM01006692    KMQ90391.1    KQ434829    KZC07747.1    DS235082    EEB11476.1    KK107106    QOIP01000002    EZA59425.1    RLU25731.1    GAPW01002393    JAC11205.1    KZ288369    PBC26778.1    JR046608    AEY60222.1    DS231911    KK852607    KDR20350.1    GECZ01010892    JAS58877.1    GECU01026898    JAS80808.1    GEDC01011231    JAS26067.1    GFDL01009853    JAV25192.1    KQ435847    KOX71146.1    GEBQ01001482    JAT38495.1    GDAI01001579    JAI16024.1    CH477862    CH477728    GANO01002482    JAB57389.1    KQ983238    KYQ46245.1    KQ414616    KOC68450.1    KQ769179    OAD52923.1    JXUM01077077    JXUM01080023    KQ563159    KQ562985    KXJ74379.1    KXJ74707.1    GAMC01011888    GAMC01011887    JAB94668.1    GEZM01001382    GEZM01001381    GEZM01001380    GEZM01001379    GEZM01001378    GEZM01001377    JAV97901.1    GBXI01008868    JAD05424.1    GAKP01015696    JAC43256.1    KQ981606    KYN39576.1    GL448906    EFN83600.1    ADTU01000325    KQ976509    KYM82689.1    GL888609    EGI59043.1    GBYB01009995    JAG79762.1    KQ980895    KYN11741.1    GDHF01032184    JAI20130.1    NNAY01000431    OXU28439.1    KQ977151    KYN05294.1    CM002911    KMY92015.1    CM000362    CM000157    UFQT01000091    UFQT01000704    SSX19565.1    SSX26667.1    EZ422901    ADD19177.1    GFDF01008947    JAV05137.1    CH954177    AE013599    AY070974    AY113636    BT044579    GFDF01008948    JAV05136.1    JXJN01023642    CM000071    CH479223    CH902619    AJWK01003749    GGFK01006212    MBW39533.1    NEVH01012087    PNF30769.1    ATLV01023201    KE525341    KFB48574.1    CH916367    OUUW01000001    SPP75718.1    GL439874    EFN66662.1    CH933808    CH940648    ADMH02000830    ETN64944.1    GGFJ01006964    MBW56105.1    GGFJ01006944    MBW56085.1    GGFJ01006949    MBW56090.1    CP012524    ALC41720.1    GGFM01002926    MBW23677.1    CH964154    GGFM01007100    MBW27851.1    GAPW01002822    JAC10776.1    GAMD01002836    JAA98754.1    APCN01000146    AAAB01008960    KQ971338    EFA01588.1    GDIQ01104703    JAL47023.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000037510    UP000053240    UP000053268    + More
UP000036403    UP000076502    UP000009046    UP000053097    UP000279307    UP000242457    UP000002320    UP000005203    UP000027135    UP000053105    UP000002358    UP000008820    UP000075809    UP000053825    UP000069940    UP000249989    UP000078541    UP000008237    UP000005205    UP000078540    UP000007755    UP000078492    UP000215335    UP000192221    UP000078542    UP000000304    UP000002282    UP000095301    UP000078200    UP000095300    UP000008711    UP000000803    UP000092445    UP000092443    UP000092460    UP000001819    UP000008744    UP000007801    UP000092461    UP000235965    UP000075880    UP000030765    UP000001070    UP000268350    UP000000311    UP000009192    UP000008792    UP000000673    UP000092553    UP000007798    UP000091820    UP000075901    UP000075840    UP000069272    UP000076407    UP000075881    UP000075903    UP000075882    UP000007062    UP000007266    UP000075884    UP000075900    UP000075885   

PRIDE

H9IXG0    Q7JWD3    Q28YJ2    B3MHB7    B4N645    Q5TRE7    + More

Pfam

PF02374   ArsA_ATPase

Interpro

IPR027417   P-loop_NTPase        + More
IPR027542   ATPase_ArsA/GET3_euk       
IPR016300   ATPase_ArsA/GET3       
IPR025723   Anion-transp_ATPase-like_dom       

SUPFAM

SSF52540   SSF52540       

CDD

cd02035  ArsA

ProteinModelPortal

H9IXG0   A0A2A4JMB3   A0A2H1W6L0   A0A212F9C0   S4PCC6   A0A0L7KW95   + More
A0A0N1PHK1   A0A194QEW7   A0A0C9R9J4   A0A0J7KJI2   A0A154P793   E0VDM0   A0A026WTN5   A0A023EQ71   A0A2A3E513   V9IHT7   B0WEV5   A0A087ZY48   A0A067RLC5   A0A1B6G8W3   A0A1B6I1K2   A0A1B6DK67   A0A1Q3FCF8   A0A0M8ZVY9   K7IME4   A0A1B6MRI1   A0A0K8TNT1   Q16MG9   U5EIV3   A0A151WEM8   A0A0L7RCC5   A0A310SCD1   A0A182GNT7   W8BCD5   A0A1Y1NJ49   A0A0A1X261   A0A034VJ18   A0A195FGS3   E2BL31   A0A158NPA9   A0A195BEQ3   F4X362   A0A0C9RNL2   A0A151IVP1   A0A0K8U1B7   A0A232FDB4   A0A1W4UZX5   A0A151IL13   A0A0J9TVE2   B4QEC4   B4P1R6   A0A1I8MPI4   A0A1A9VQH0   A0A336LP49   D3TN99   A0A1I8P9Y2   A0A1L8DFI2   B3N9X2   Q7JWD3   A0A1L8DFB0   A0A1A9Z569   A0A1A9YJE2   A0A1B0C0I7   Q28YJ2   B4H8J5   B3MHB7   A0A1B0CAG5   A0A2M4AFJ3   A0A2J7QQB0   A0A182JGD8   A0A084WED0   B4J4F6   A0A3B0JXA3   E2AIS3   B4KTG7   B4LN33   W5JQD0   A0A2M4BSP7   A0A2M4BSM7   A0A2M4BSP8   A0A0M4EVN8   A0A2M3Z582   B4N645   A0A2M3ZH77   A0A1A9WQH6   A0A182T3X5   A0A023EP66   T1DGA5   A0A182I2D3   A0A182FHD5   A0A182XMK5   A0A182JVQ8   A0A182UVV4   A0A182KQ73   Q5TRE7   D2A135   A0A182NJC5   A0A182R4J5   A0A182PUZ3   A0A0P5RW25  

PDB

2WOO     E-value=5.47894e-98,     Score=912

KEGG

101735717    K01551 arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-] | (RefSeq) ATPase ASN

GO

GO:0005524   GO:0045048   GO:0005783   GO:0016887   GO:0046872   GO:0006620   GO:0043529   GO:0071816   GO:0030170   GO:0006567   GO:0008890   GO:0008152   GO:0016740   GO:0003707   GO:0006418   GO:0003824  

PANTHER

PTHR10803:SF3   PTHR10803  

Subcellular location

Cytoplasm  
Endoplasmic reticulum  

Length:

335

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0359

Exp number, first 60 AAs:

0.01393

Total prob of N-in:

0.00814

outside

1  -  335

 

 

Pi

223.851998

Theta

188.620741

Tajima's D

0.572294

CLR

0.003999

CSRT

0.534073296335183

Interpretation

Possibly Positive selection