Gene

KWMTBOMO11413  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001876

Annotation

PREDICTED:_alpha-amylase_2-like_[Bombyx_mori]

Location

Bomo_Chr19(+):5004765-5016146      View in EpiBrowser

Full name

Alpha-amylase       + More
2-amino-3-ketobutyrate coenzyme A ligase      
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial      

Alternative Name

Glycine acetyltransferase
Aminoacetone synthase

Location in the cell

Mitochondrial   Reliability : 3.05

CDS

ATGGCTCTGCGCTCGCAGCTACTACGCAACGTACTGAATGGCACTCAAGTTCGTCATTTACACGAAGTGAAGAGGCAAGAAAGAGCTGGTGTAGCTAAGCTCCGAGATGTGTTAGAGGACCGCTTGCAAGAAATCAAGAGGGCTAAGACTTGGAAACATGAGAGGGTGCTCACATCGCCGCAAGACACTAAGGTGCGGGTCCAAGGTGCTCAAGGAGAATTCCTGAACTTCTGTGCCAACAACTATTTAGGCTTATCGAATCATCCTGAAGTCGTTGAAGCGGCTAGAGAGGGTTTGAAGAAATATGGCGCCGGCTTGAGCTCAGTGAGATTTATCTGCGGTACTCAAAGTATACACAAGGAGCTAGAGAACCGCCTGTCTCAGTTCCACGGCCGCGAAGACACAATCCTTTACGGGTCTTGTTTCGACGCCAACGCAGGCCTGTTCGAGTCCATGCTGACGCCTGAAGACGCGGTGTTCTCGGACGCTTTGAACCACGCGTCCATAATAGACGGGATCAGGCTATGCAAGGCGCAGAAATACCGATACCCTCACAGAGATTTGACCGAATTGGAGCACTTGTTAGCGCACAGCGAAGCAAGAATCAAGCTTATAGTAACAGACGGAGTATTCTCTATGGACGGGACTGTGGCTCCAATAAAAGGTCTGAGGGATCTGGCGGATAAATACAGAGCTTTATTAGTAGTTGATGACAGCCATGCGACCGGCTTCTTCGGGGAAACTGGCCGAGGCACTGAAGAGTATTGCGGTGTTATGGGGGCGGCGGATATCATCTGTTCGACCCTGGGCAAAGCAGTGAGTGGAGCGGCTGGCGGCTATACAACCGGACCGAAAGAGCTGGTCACATTACTTAGGAACGTGTCCAGGCCCTATCTCTTCTCGAACGCCCCTCCACCTCCCGTGGTGGCAGCCTCTTTAAAGTCTCTAGACTTGGTAGAACGTAGCGGTGAACTCCGTCAACGTCTACGCCAGAACACGACAGCTTTCCGTGAAGGACTGAAGGCGGCCGGCCTCACTGTGGCCGGAGACGACCATCCCATTTGTCCGGTAATGGTTGGAGAAGCATCACTGGCTGTGGACTTGGCTTCAGGAATGTTAGAGCGTGGTGTCTACGTGGTCGCCTTCAGCTACCCCGTGGTGCCGAAGGGCGCGGCGCGAGTGCGGGTGCAACTGAGCGCGGCGCACTCGTCCGGTGACGTCACCCGAGCGGTGCAAGCCTTCGCAGAGGTCGCTAAAAACGTAGGCATCGTTAAAAATTAA

Protein

MALRSQLLRNVLNGTQVRHLHEVKRQERAGVAKLRDVLEDRLQEIKRAKTWKHERVLTSPQDTKVRVQGAQGEFLNFCANNYLGLSNHPEVVEAAREGLKKYGAGLSSVRFICGTQSIHKELENRLSQFHGREDTILYGSCFDANAGLFESMLTPEDAVFSDALNHASIIDGIRLCKAQKYRYPHRDLTELEHLLAHSEARIKLIVTDGVFSMDGTVAPIKGLRDLADKYRALLVVDDSHATGFFGETGRGTEEYCGVMGAADIICSTLGKAVSGAAGGYTTGPKELVTLLRNVSRPYLFSNAPPPPVVAASLKSLDLVERSGELRQRLRQNTTAFREGLKAAGLTVAGDDHPICPVMVGEASLAVDLASGMLERGVYVVAFSYPVVPKGAARVRVQLSAAHSSGDVTRAVQAFAEVAKNVGIVKN

Description

Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.

Catalytic Activity

acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA

Cofactor

pyridoxal 5'-phosphate

Subunit

Homodimer.

Similarity

Belongs to the glycosyl hydrolase 13 family.
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Keywords

Acetylation   Acyltransferase   Complete proteome   Direct protein sequencing   Mitochondrion   Nucleus   Pyridoxal phosphate   Reference proteome   Transferase   Transit peptide  

Feature

chain  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

Uniprot

H9IX93   A0A194QEK4   A0A2A4JLS4   I4DMI5   A0A212F9B5   A0A0N1IP47   + More
B4IZA2   B3M4C9   B4KUU4   A0A0N8P0T7   B3NH10   Q9VTN9   A0A0J9UJD7   A0A0M4EIU5   B4PFP7   B4HEZ3   A0A1W4W5Z6   Q29DY2   A0A0R3P6N8   A0A3B0J9V2   A0A3B0JVJ0   B4LCT0   B4N737   A0A1I8PBW2   T1PBL6   A0A1B0CI05   A0A0L0CA85   D3PI94   W8B641   E0VAW7   A0A0A1WYK0   A0A0K8VPJ6   A0A131Y2U8   A0A1L8DZZ8   A0A0L7LQZ1   A0A0K8RCE7   A0A3D1UV99   A0A1A9W149   A0A1B0AAT8   A0A182WLD2   A0A1B0AYM0   A0A1B0C4B6   A0A034VWG7   A0A1S3KFM1   A0A182PUZ4   Q16MH0   A0A1S3I7P8   B7QMM1   A0A067QVU5   A0A1G8V1G2   A0A1A9V0B0   A0A182VL50   Q7Q6L2   A0A1S4FVX9   D3TLC8   A0A182XMK6   A0A182I2D4   A0A143HKC0   B4H478   A0A0D2X191   A0A233RDP9   A0A182H1X5   A0A341CRF9   A0A182R4J6   H9H7A1   A0A340WYF9   A0A182JVQ7   F2UHA8   A0A2P7QXX5   A0A336LYI4   A0A1I1DG98   A0A383YSH4   A0A0X3U884   A0A1Q3FRY0   R7UR58   Q0P5L8   A0A231N199   A0A2Y9Q559   H2FY82   A0A084WED1   A0A0D8DER4   A0A2U3YBN6   A0A3Q1MNI2   A0A2M4A2Y3   A0A2U3UZX2   A0A2M4BP51   K7BBP9   A0A1A9Y7K5   W5JPZ7   A0A2Y9GZW6   A0A182FHD6   A0A2M3Z3H8   A0A2M3Z3E6   A0A182NJC4   W5PXR2   A0A2M4A560   A0A0K8WHJ8   M1ENL2   A0A2M4BP21  

EC Number

3.2.1.1
2.3.1.29

Pubmed

19121390    26354079    22651552    22118469    17994087    10731132    + More
12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    22936249    17550304    15632085    25315136    26108605    24495485    20566863    25830018    26227816    30148503    25348373    17510324    24845553    12364791    14747013    17210077    20353571    26483478    17495919    23254933    8307963    10712613    22461556    24438588    19393038    20920257    23761445    20809919    23236062   

EMBL

BABH01018101    BABH01018102    BABH01018103    BABH01018104    KQ459053    KPJ03968.1    + More
NWSH01001047    PCG72931.1    AK402503    BAM19125.1    AGBW02009615    OWR50321.1    KQ460772    KPJ12475.1    CH916366    EDV96657.1    CH902618    EDV39399.2    CH933809    EDW19350.2    KPU78036.1    CH954178    EDV51467.1    AE014296    BT044491    AAF50007.2    ACH95265.1    CM002912    KMY99075.1    CP012525    ALC43851.1    CM000159    EDW94196.1    CH480815    EDW41162.1    CH379070    EAL30281.2    KRT08788.1    OUUW01000002    SPP76752.1    SPP76751.1    CH940647    EDW70972.2    CH964168    EDW80176.1    KA646064    AFP60693.1    AJWK01012952    JRES01000678    KNC29338.1    BT121350    ADD38280.1    GAMC01009940    JAB96615.1    DS235018    EEB10523.1    GBXI01010809    JAD03483.1    GDHF01011510    JAI40804.1    GEFM01002991    JAP72805.1    GFDF01002212    JAV11872.1    JTDY01000282    KOB77918.1    GADI01004966    JAA68842.1    DPDG01000076    HCG26536.1    JXJN01005872    JXJN01025375    GAKP01011286    GAKP01011285    JAC47666.1    CH477862    EAT35518.1    ABJB011012451    DS972266    EEC20093.1    KK852954    KDR13310.1    FNFH01000001    SDJ59205.1    AAAB01008960    EAA11897.4    EZ422230    ADD18506.1    APCN01000146    CP014864    AMX02184.1    CH479208    EDW31193.1    KE346361    KJE90399.1    NBIM01000003    OXY81519.1    JXUM01104076    KQ564857    KXJ71651.1    GL832974    EGD76507.1    PXYH01000010    PSJ42799.1    UFQT01000228    SSX22071.1    FOKT01000001    SFB73864.1    LQBR01000001    KUJ84283.1    GFDL01004711    JAV30334.1    AMQN01006652    KB298871    ELU08660.1    BC119870    AF195767    CP012621    NMUO01000013    ATG72560.1    OXS16263.1    CP003171    AEY00404.1    ATLV01023201    KE525341    KFB48575.1    JYNJ01000030    KJE47045.1    GGFK01001677    MBW34998.1    GGFJ01005612    MBW54753.1    GABC01010407    GABF01010591    GABD01005927    NBAG03000283    JAA00931.1    JAA11554.1    JAA27173.1    PNI49010.1    ADMH02000830    ETN64945.1    GGFM01002330    MBW23081.1    GGFM01002293    MBW23044.1    AMGL01083895    GGFK01002560    MBW35881.1    GDHF01001683    JAI50631.1    JP010368    AER98965.1    GGFJ01005613    MBW54754.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000007151    UP000053240    UP000001070    + More
UP000007801    UP000009192    UP000008711    UP000000803    UP000092553    UP000002282    UP000001292    UP000192221    UP000001819    UP000268350    UP000008792    UP000007798    UP000095300    UP000095301    UP000092461    UP000037069    UP000009046    UP000037510    UP000262492    UP000091820    UP000092445    UP000075920    UP000092460    UP000085678    UP000075885    UP000008820    UP000001555    UP000027135    UP000199305    UP000078200    UP000075903    UP000007062    UP000076407    UP000075840    UP000076077    UP000008744    UP000008743    UP000242757    UP000069940    UP000249989    UP000252040    UP000075900    UP000002280    UP000265300    UP000075881    UP000007799    UP000242181    UP000181967    UP000261681    UP000054457    UP000014760    UP000009136    UP000215233    UP000217763    UP000248483    UP000007742    UP000030765    UP000032352    UP000245341    UP000245320    UP000092443    UP000000673    UP000248481    UP000069272    UP000075884    UP000002356   

PRIDE

H9IX93    Q9VTN9    B7QMM1    Q0P5L8   

Pfam

PF02806   Alpha-amylase_C        + More
PF00155   Aminotran_1_2
PF00128   Alpha-amylase

Interpro

IPR006047   Glyco_hydro_13_cat_dom        + More
IPR015421   PyrdxlP-dep_Trfase_major       
IPR015424   PyrdxlP-dep_Trfase       
IPR006048   A-amylase/branching_C       
IPR004839   Aminotransferase_I/II       
IPR031319   A-amylase_C       
IPR006046   Alpha_amylase       
IPR001917   Aminotrans_II_pyridoxalP_BS       
IPR013780   Glyco_hydro_b       
IPR015422   PyrdxlP-dep_Trfase_dom1       
IPR017853   Glycoside_hydrolase_SF       
IPR011282   2am3keto_CoA_ligase       

SUPFAM

SSF51445   SSF51445        + More
SSF53383   SSF53383       

Gene 3D

2.60.40.1180     3.40.640.10     3.90.1150.10    

ProteinModelPortal

H9IX93   A0A194QEK4   A0A2A4JLS4   I4DMI5   A0A212F9B5   A0A0N1IP47   + More
B4IZA2   B3M4C9   B4KUU4   A0A0N8P0T7   B3NH10   Q9VTN9   A0A0J9UJD7   A0A0M4EIU5   B4PFP7   B4HEZ3   A0A1W4W5Z6   Q29DY2   A0A0R3P6N8   A0A3B0J9V2   A0A3B0JVJ0   B4LCT0   B4N737   A0A1I8PBW2   T1PBL6   A0A1B0CI05   A0A0L0CA85   D3PI94   W8B641   E0VAW7   A0A0A1WYK0   A0A0K8VPJ6   A0A131Y2U8   A0A1L8DZZ8   A0A0L7LQZ1   A0A0K8RCE7   A0A3D1UV99   A0A1A9W149   A0A1B0AAT8   A0A182WLD2   A0A1B0AYM0   A0A1B0C4B6   A0A034VWG7   A0A1S3KFM1   A0A182PUZ4   Q16MH0   A0A1S3I7P8   B7QMM1   A0A067QVU5   A0A1G8V1G2   A0A1A9V0B0   A0A182VL50   Q7Q6L2   A0A1S4FVX9   D3TLC8   A0A182XMK6   A0A182I2D4   A0A143HKC0   B4H478   A0A0D2X191   A0A233RDP9   A0A182H1X5   A0A341CRF9   A0A182R4J6   H9H7A1   A0A340WYF9   A0A182JVQ7   F2UHA8   A0A2P7QXX5   A0A336LYI4   A0A1I1DG98   A0A383YSH4   A0A0X3U884   A0A1Q3FRY0   R7UR58   Q0P5L8   A0A231N199   A0A2Y9Q559   H2FY82   A0A084WED1   A0A0D8DER4   A0A2U3YBN6   A0A3Q1MNI2   A0A2M4A2Y3   A0A2U3UZX2   A0A2M4BP51   K7BBP9   A0A1A9Y7K5   W5JPZ7   A0A2Y9GZW6   A0A182FHD6   A0A2M3Z3H8   A0A2M3Z3E6   A0A182NJC4   W5PXR2   A0A2M4A560   A0A0K8WHJ8   M1ENL2   A0A2M4BP21  

PDB

3TQX     E-value=1.62593e-118,     Score=1090

KEGG

101736114    K01176 alpha-amylase [EC:3.2.1.1] | (RefSeq) alpha-amylase 2-like

PATHWAY

00500    Starch and sucrose metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0103025   GO:0009058   GO:0043169   GO:0016740   GO:0005975   GO:0030170   GO:0004556   GO:0008890   GO:0016874   GO:0006567   GO:0006520   GO:0005739   GO:0008483   GO:0019518   GO:0016607   GO:0005634   GO:0003824   GO:0008152   GO:0003707   GO:0006418  

Subcellular location

Mitochondrion   Translocates to the nucleus upon cold and osmotic stress.   With evidence from 1 publications.
Nucleus   Translocates to the nucleus upon cold and osmotic stress.   With evidence from 1 publications.

Length:

426

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01954

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00606

outside

1  -  426

 

 

Pi

184.061042

Theta

170.331824

Tajima's D

0.301812

CLR

0.045102

CSRT

0.455477226138693

Interpretation

Uncertain