Gene

KWMTBOMO11407

Pre Gene Modal

BGIBMGA001875

Annotation

putative_lectin_C-type_domain_containing_protein_[Danaus_plexippus]

Location

Bomo_Chr19(+):4868456-4884292      View in EpiBrowser

Full name

Fanconi-associated nuclease      

Location in the cell

Nuclear   Reliability : 3.049

CDS

ATGTTGGGGAGAGCTCATCGAGTGACAGTAACGAATCAGCGAGCTGTTTTAAAAAAAAGAAGTCCAGTCAAAAAGAATTTAGCTCGAGATTCATTTGGATGCTTAGAAAACGATAACTCAATTGATCATGTTTTCAAAGCTGCAAGTGATGGAATGGATGATAAAACTATATTTCTATTGAACATCATCTATAATTTTTTGAATAATGAGAATTTGAAGAACCTACTAGATGAATGTTCTCAGACTCTTTTAAGTAGATGTCTTCATGTGAAAAAGCCTGGTGTCAGAGTTATATGTAGATTGTATTGGAGGCAGGCCACCATTTACCGCTGGGATGATCTTGAAAATATCAGCAATGATAGGTCTAATAAAATTCAAAAACAAATAGTACAAGAAATGATCAGTGATCTAGTGAAAAATGGTTTCCTTGAAAATGTTAATTCTGATGATACATGCAAATTAAATTTTCATGAGATAACTTCTAAATTGAAAGCTGATGAATTGAAACAAATATGCAAGGAATTAAATATAAAGGTTCAGTCCAAACAAAGTGCAATAAAATTATTAGAGAATTACAGCAACCAAAGTTCCATCAGCAAGTTCTTTATACAAGCGAAAGAAAACCCTACCAACAACAAGACCAGACTCTTGGAAATATTTAAAAAAAAATTAGGGTCGTGCTACAAGTTAACTGAAAAAGCAAGAAGTACACTGTATGAGCTGTATCTATTGACATACTTAGGAATGGGCTACTCAATTATAAGAGAGAAGAGGCTGGAACTTACATTACTGTATGAGAAGATTAATCGTGAGACATTTCCAATTATCGAAAACAGGGATATTGATGATGCGAGTGTTGTTTTCAAAAATCGAAAAGAGTTTGAGAAGTATCTAGACGCTCATTATATATACGAAAAGTATATAATCGAGACGGACGATAAAGTCAAATGTATTTTAGTAGAAACGGTGTATGAAATGTACAAGAAAATTGACAAGGAAGACATGATTAGATACACTTCACTACCAGAGTGGTTGCGTCGATATACGCCGCCATATATATTTGTGAAAATATTAGGCGAAGGGATCCAGTCGCTGAAGCGTAATAAAAGTGACGTGTCTTCGAACTTCGCCGTTGAAATACTCAGTGTGCTGATAGCGCAGGACTCGTTCAGGCAACACAAGAAAGCTGGCTGGTATACCGAAAAAGCTTTAATACTACAGAAATATCTTGGACGGCACGATGAAGCGGCCCAGTTATTATTGGAAGGACTTCAGTCCAACAAACTTTCAGACGACGCCAAAGACGCGATGCGACCTCAAGCTGTCAAAATATCGAAGCAGAAAACAAATGTAGGAAACAAACTAAGAATAATTCTCAACGAAATCGCCAATGAAAATATCAAATTGGAAAAGGATTTGAGCGCTGAGCATTTACACAAAAATCCTATGGATAACTGGTATAAAGGCAAATTGAAGTACGAGGTTTGCATAGATGGGATAAGGCAAGCCATTGAGGTTGAAGATTACTGTATCTGGCATTACATTAACAACGGAACGTACACCCACGGTGATCACTGGGAAGGCAGAATAATCACGACAATATTCTTTCTGCTGTTCTGGGATATCATATACTCGAAACCTGCTCACGCACCAGGTATATTCCTCAGTCGCTATCAGAGGTATCCATTGGACTTGTACTGCGATAGTTTCTACACGAATAGAAAGAGTGAGATCGACGAGCGATTGAGTAGTCTAGCGGCGGGCAGCGCAGAGGATATGTTGGAGGCCATGAGACGCGTGTGGGACTCGAGGCCCGAGGGTGAACTATCTGGACTAACGAGGAGCATAGAGTGGGACAGGATAGAGATGGTGGCGGGTTGCCTGGGGCCGCGGCGGGTGGGGGCGCTGTGCGAGCGACTCGCCACGAACTACGGGCACGCGCACAGCGGCTTCCCCGACCTCACGCTGTGGAACGCACACACGAAAACAATAACGTTCATGGAGGTGAAGTCTGACTCAGACCGTCCGTCCGTGAAGCAGCTGCAGTGGATGCACTATCTCCAGCAGCGCGGGCTCCGCACGGCCTTCTGCTACGTCGGCGGAGACTCCGGGCGCCGCGCCAGGCTCGACCGCCCCTGA

Protein

MLGRAHRVTVTNQRAVLKKRSPVKKNLARDSFGCLENDNSIDHVFKAASDGMDDKTIFLLNIIYNFLNNENLKNLLDECSQTLLSRCLHVKKPGVRVICRLYWRQATIYRWDDLENISNDRSNKIQKQIVQEMISDLVKNGFLENVNSDDTCKLNFHEITSKLKADELKQICKELNIKVQSKQSAIKLLENYSNQSSISKFFIQAKENPTNNKTRLLEIFKKKLGSCYKLTEKARSTLYELYLLTYLGMGYSIIREKRLELTLLYEKINRETFPIIENRDIDDASVVFKNRKEFEKYLDAHYIYEKYIIETDDKVKCILVETVYEMYKKIDKEDMIRYTSLPEWLRRYTPPYIFVKILGEGIQSLKRNKSDVSSNFAVEILSVLIAQDSFRQHKKAGWYTEKALILQKYLGRHDEAAQLLLEGLQSNKLSDDAKDAMRPQAVKISKQKTNVGNKLRIILNEIANENIKLEKDLSAEHLHKNPMDNWYKGKLKYEVCIDGIRQAIEVEDYCIWHYINNGTYTHGDHWEGRIITTIFFLLFWDIIYSKPAHAPGIFLSRYQRYPLDLYCDSFYTNRKSEIDERLSSLAAGSAEDMLEAMRRVWDSRPEGELSGLTRSIEWDRIEMVAGCLGPRRVGALCERLATNYGHAHSGFPDLTLWNAHTKTITFMEVKSDSDRPSVKQLQWMHYLQQRGLRTAFCYVGGDSGRRARLDRP

Description

Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.

Catalytic Activity

Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.

Similarity

Belongs to the FAN1 family.

Uniprot

H9IX92   A0A2A4KAH8   A0A212FLR9   A0A1E1W4E8   A0A0N1INX1   A0A194QER5   + More
A0A2H1WEE6   A0A195EZY0   A0A195BPW9   A0A158P3D6   A0A151IIV5   F4X5G5   K1PPM8   A0A232EQZ2   A0A1B6E1X3   A0A1Y1MXD8   A0A3Q4GYP6   A0A3Q4H5E4   A0A3Q3BKM7   A0A026WUN0   A0A3L8DQN8   V4CF11   A0A3Q0SB63   A0A2J7PE50   A0A067RK85   A0A3P9DS61   A0A151MA71   W4ZGR0   I3JNQ4   A0A3Q2UAY9   A0A3P8UA54   A0A3Q1AVH2   A0A195DNH1   A0A3B4GZH6   A0A3B4ZPU5   A0A151WYM7   A0A3Q3RIZ4   A0A3B4Z8S4   A0A3B4VHW6   A0A1S3JTU7   A0A2H3IJE7   A0A3Q1IPR2   A0A3Q1EZD5   A0A1D1UQM7   A0A3Q3J254   A0A3P8W105   G3NS19   Q4S1C9   A0A1U8CXE0   H2TCT3   A0A3P8XKY7   A0A369SDZ5   K7GHJ6   A0A3P8P8U4   A0A3Q3FIG2   B3RR70   A0A293LFF3   B6QND3   A0A096M710   A0A225AJ22   A0A3B5MCV4   A0A0F8BYR9   A0A364L0F5   A0A3R7IJ89   E9ICP9   A0A315WGK5   A0A397I2X6   A0A3Q3X4D1   M3ZWL0   A0A3B3C8M0   A0A087XG46   H3D860   A0A093UR11   A0A3B3U8R5   A0A2R5LGX3   A0A3B3YTJ3   A0A3P9H6G9   A0A1Q5UHH2   I3JNQ3   A0A1S8BJ35   Q0CIM7   A0A1S3PDI8   A0A3B3HSW7   A0A1Y2ABU1   C5FT18   A0A3Q3BI08   C6HA30  

EC Number

3.1.4.1

Pubmed

19121390    22118469    26354079    21347285    21719571    22992520    + More
28648823    28004739    25186727    24508170    30249741    23254933    24845553    22293439    28951729    27649274    24487278    15496914    21551351    25069045    30042472    17381049    18719581    25676766    25835551    28649280    21282665    29703783    23542700    29451363    25330172    17554307    22951933   

EMBL

BABH01018115    BABH01018116    BABH01018117    NWSH01000016    PCG80793.1    AGBW02007717    + More
OWR54676.1    GDQN01009245    GDQN01001405    JAT81809.1    JAT89649.1    KQ460772    KPJ12470.1    KQ459053    KPJ03972.1    ODYU01008094    SOQ51397.1    KQ981905    KYN33467.1    KQ976432    KYM87539.1    ADTU01007654    KQ977459    KYN02574.1    GL888716    EGI58321.1    JH815782    EKC26127.1    NNAY01002706    OXU20737.1    GEDC01005365    JAS31933.1    GEZM01024050    JAV88027.1    KK107099    EZA59668.1    QOIP01000005    RLU22755.1    KB200701    ESP00585.1    NEVH01026109    PNF14614.1    KK852461    KDR23438.1    AKHW03006295    KYO21391.1    AAGJ04163082    AERX01010884    KQ980713    KYN14377.1    KQ982649    KYQ52988.1    NPFK01000054    PCH04433.1    BDGG01000002    GAU91751.1    CAAE01014769    CAG05553.1    NOWV01000018    RDD45148.1    AGCU01176510    AGCU01176511    AGCU01176512    DS985243    EDV26826.1    GFWV01002752    MAA27482.1    DS995903    EEA21421.1    AYCK01018417    LFMY01000007    OKL59343.1    KQ041939    KKF20760.1    MIKG01000009    RAO69293.1    NIDN02000090    RLL97047.1    GL762354    EFZ21646.1    NHOQ01000384    PWA30476.1    NKHV02000033    RHZ69895.1    JPOX01000045    KFX42365.1    GGLE01004640    MBY08766.1    MNBE01000259    OKP11903.1    MSZU01000076    OMP87486.1    CH476602    EAU33001.1    MCFA01000002    ORY19485.1    DS995705    EEQ33021.1    GG692421    EER43163.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000078541    + More
UP000078540    UP000005205    UP000078542    UP000007755    UP000005408    UP000215335    UP000261580    UP000264840    UP000053097    UP000279307    UP000030746    UP000261340    UP000235965    UP000027135    UP000265160    UP000050525    UP000007110    UP000005207    UP000265000    UP000265080    UP000257160    UP000078492    UP000261460    UP000261400    UP000075809    UP000261640    UP000261420    UP000085678    UP000218381    UP000265040    UP000257200    UP000186922    UP000261600    UP000265120    UP000007635    UP000189705    UP000005226    UP000265140    UP000253843    UP000007267    UP000265100    UP000261660    UP000009022    UP000001294    UP000028760    UP000214365    UP000261380    UP000249363    UP000215289    UP000215394    UP000261620    UP000002852    UP000261560    UP000007303    UP000029285    UP000261500    UP000261480    UP000265200    UP000186955    UP000190776    UP000007963    UP000087266    UP000001038    UP000193144    UP000002035    UP000264800    UP000002624   

PRIDE

H9IX92   

Pfam

PF08774   VRR_NUC

Interpro

IPR033315   Fan1-like        + More
IPR014883   VRR_NUC       
IPR011856   tRNA_endonuc-like_dom_sf       
IPR003034   SAP_dom       
IPR006642   Znf_Rad18_put       
IPR011990   TPR-like_helical_dom_sf       

SUPFAM

SSF48452   SSF48452       

Gene 3D

3.40.1350.10     1.25.40.10    

ProteinModelPortal

H9IX92   A0A2A4KAH8   A0A212FLR9   A0A1E1W4E8   A0A0N1INX1   A0A194QER5   + More
A0A2H1WEE6   A0A195EZY0   A0A195BPW9   A0A158P3D6   A0A151IIV5   F4X5G5   K1PPM8   A0A232EQZ2   A0A1B6E1X3   A0A1Y1MXD8   A0A3Q4GYP6   A0A3Q4H5E4   A0A3Q3BKM7   A0A026WUN0   A0A3L8DQN8   V4CF11   A0A3Q0SB63   A0A2J7PE50   A0A067RK85   A0A3P9DS61   A0A151MA71   W4ZGR0   I3JNQ4   A0A3Q2UAY9   A0A3P8UA54   A0A3Q1AVH2   A0A195DNH1   A0A3B4GZH6   A0A3B4ZPU5   A0A151WYM7   A0A3Q3RIZ4   A0A3B4Z8S4   A0A3B4VHW6   A0A1S3JTU7   A0A2H3IJE7   A0A3Q1IPR2   A0A3Q1EZD5   A0A1D1UQM7   A0A3Q3J254   A0A3P8W105   G3NS19   Q4S1C9   A0A1U8CXE0   H2TCT3   A0A3P8XKY7   A0A369SDZ5   K7GHJ6   A0A3P8P8U4   A0A3Q3FIG2   B3RR70   A0A293LFF3   B6QND3   A0A096M710   A0A225AJ22   A0A3B5MCV4   A0A0F8BYR9   A0A364L0F5   A0A3R7IJ89   E9ICP9   A0A315WGK5   A0A397I2X6   A0A3Q3X4D1   M3ZWL0   A0A3B3C8M0   A0A087XG46   H3D860   A0A093UR11   A0A3B3U8R5   A0A2R5LGX3   A0A3B3YTJ3   A0A3P9H6G9   A0A1Q5UHH2   I3JNQ3   A0A1S8BJ35   Q0CIM7   A0A1S3PDI8   A0A3B3HSW7   A0A1Y2ABU1   C5FT18   A0A3Q3BI08   C6HA30  

PDB

4RIC     E-value=1.51057e-31,     Score=343

KEGG

101745448    K15363 fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1] | (RefSeq) fanconi-associated nuclease 1-

PATHWAY

03460    Fanconi anemia pathway - Bombyx mori (domestic silkworm)

GO

GO:0004528   GO:0003676   GO:0036297   GO:0005634   GO:0046872   GO:0006281   GO:0017108   GO:0008409   GO:0070336   GO:0003677   GO:0000724   GO:0033683   GO:0045171   GO:0005654   GO:0005829   GO:0140036   GO:0016021   GO:0016788   GO:0016491   GO:0006313   GO:0007018   GO:0030286   GO:0046034   GO:0032559   GO:0004812   GO:0006418   GO:0003824   GO:0004518  

PANTHER

PTHR15749  

Subcellular location

Nucleus  

Length:

712

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.996589999999999

Exp number, first 60 AAs:

0.00011

Total prob of N-in:

0.05067

outside

1  -  712

 

 

Pi

230.106268

Theta

175.028345

Tajima's D

0

CLR

0.618895

CSRT

0.369531523423829

Interpretation

Possibly Positive selection