Gene

KWMTBOMO11403

Pre Gene Modal

BGIBMGA001949

Annotation

PREDICTED:_retinoblastoma-like_protein_1_isoform_X2_[Papilio_xuthus]

Location

Bomo_Chr19(-):4773212-4784665      View in EpiBrowser

Full name

Retinoblastoma-like protein 1      

Alternative Name

107 kDa retinoblastoma-associated protein
pRb1

Location in the cell

Nuclear   Reliability : 3.886

CDS

ATGCCCAAATCAGACGAAAACGAAGATTGGATTGAGAAGATGGAGGATCTTTGTTCTAATTTAAACGTCGATTCATCAGCTGCGAAGAAATCGAAAGATTCTTTTTCAGAAATAAAACGAAATTATATACTAGATGGTGATGAATTACATTGGATGGCATGCGCATTGTATGTGGCTTGTAGGACATCGGTCACTCCTACAGTGCAAACAGGAAAAGTGGTGGAAGGGAACTGTGTCAGCCTGACAAAACTTTTGAGATTATGTAATCTAAGCTTAATTCAGTTCTTCATCAAAATAAAAAACTGGATGGAGATGGCCTCAATGTCTACAGATTTTAAAGAAAGGATATCTCGTTTGGAACACAAGTTTGCAGTCTCTTCAGTACTCTTCAGGAAGTTCCAACCGATTTTCATGGAACTGTTTGTTGGGTTAACAAATGAGCCTGTAAAACAAGTCTCGAAGAGAAGACCAAAACTGCAACCATGTTCAACAAATGCCTTGTTTGAGTTTACATGGTGTTTGTACATTTGTGTGAAAGGAGAATTCCACAATTCTGCTAATGACTTAGTAGATATGTATCACATATTACTATCATGTTTGGATTATATATTTGCCAATGCATTTATGGCCCGAAGGGTAGACATTATTAATCCTGAATTTAAAGGATTACCTACAGATTGGACTAAAAATGATTTCAAAATGCCAAAAACTCCTCCATGTGTAATTTCTACTTTATGTGAGATCAAGGATGGCTTATCGAAAGAGGCAACCACTATGAAAGAATATAGCTGGAAACCTGTTATTGATTCTTTTTTTGAAAAAGGGATACTGAAAGGCAATAGTGAGCCTACGCTTGGAATTCTAGATTTGGGAGTGTTTGATGTAAATCTTAAATCACTGAACAACTTGTATGAAACATATGTTCTCAGTGTAGGAGAATTTGATGAAAGGATTTTTTTAGGCGAACAAGCAAATGAACAAATTGGAATGAAGAACAAAGTGTCCGGTGATGAGATCTCAGAAGTAATAGCTAATTTCGGTCCTAGCGGTCGTGCGTGCCCGGACACGCCGCTGACGGGGCGGCGCTACCTGTCGCGCCGCAGCGAGGAGCTGACGCCCGTGTCGGAGGCCAAGAACAGCCTGGCGCGCCTCGCCGCCACGCTGCGACACGCGCGCCCCCAACCCTCGCCCACGCTGCTCAGGCTCTTCACGGAATGCGGCGTAACTGATGAAATGATAAATGCAAAACTAATAAAACCCTGCAATGGTTGGATGGAACAATTTGGGGCCAGCTTGAAGGAAGCACACAATACCCCGCATAGTGAGACAATTTCTATACGCTGTAATATGGTCACATGTTTATATTATAAGGTGTTTGAACATATCATCAAAGAGGAACATAGGAAAAAGCCACAGGTTTCATTGCAGATGCTTCTTTCACAAGAAACATACCAGCTAACTGTATATGCGTGCTGTACGGAGATTGTCCTACATGCCTATGGAGTGAATTCATTCAAGTTTCCCAGAGTGCTGCAGATATTCAAGCTGAGCGCATTTCATTTCTATAAGATTATTGAACTAGTTGTACAGGCCGTGGTCGATAAGCTTAGTCGAGACGTCATCAAACATTTGAATGCAGTCGAAGAAGAAGTACTAGAGTCTCTGGTGTGGACTTCTGACAGTCCTCTGTGGGACCAACTCAGTAAAACGCCAGTGCCAGCCTCTGCCGACGTCTCCGTACAAGATTCACCTTTTCGAAGAACTAATGGTCTACAATCACCTGTCTCTACAATAGACCGCTTCATGTCACCTATGGCTGAACAAGCCAAGAAGCAATTATTCAAAGACCCTATTAAACCCGGCCAGTCACTTTTAGTACAAGCAAACACAACACCAGTGAAAGAGCCAGCAGTGTCTGCTAATACATCACAACCATCACAAAGTACTTCAAGTTGTGAGACCACGCCTACATCGACACCCAAAAAAAACAATTCATTAATATTGTTTTTTAGGAAGTTTTACAGTTTAGCGGTAGTACGTATGAACGATCTGTGCACGAGATTGCGACTGACTGACGACGAATTAAAACGCAAAATTTGGACTTGTCTTGAGTACTCAATAATGCATCAAACACATCTAATGAAAGACAGACATCTAGATCAGATACTTATGTGCTCTGTTTATGTTATATGTAAGGTTTCAAATAATCCGTCTAGTAATCAAGTGGAGAAAACATTTGCAGAAATCATGCGATGTTACAGACAACGCCCTTTAGCGGATAATCATGTTTATAGATCTGTTTTAATCAAACAAAGCACAGACGAGAGTTCACCAGAAAGAGGAGATTTGATTAACTTTTATAATAAAGTTTATGTGCAATGTATGCAGAATTTTGCACTTAGATTTTCTGGACGACACAGGGATGAGTGCAGCCTGTCTCCGCTGCCGACGGGGCGGTGTGAGGCGCGCTCCCCGGCCGGCACGCGCGTGTCCGAGCGACATCAGCTCTACGTCAAGCCGCTCACCGACCCGCCGCCGCAACACCACCACCTCACCTACAGATTCAGCCGCAGCCCCGCCAAGGACCTACAGGCGATCAACAGTTTGGTCTGGTGCGACACAGGACTGGGGTCGGGCGTAGGCCTGAAGCGTGCGCTGGAAGGAGCGTTGGACAGCGACCCGAATAAGCGAAACAGAGCCGCACCCGCCGTAGCCAGAAAGCTGCATCATCTACTATCTGACAGGCAGGCTGTCTAG

Protein

MPKSDENEDWIEKMEDLCSNLNVDSSAAKKSKDSFSEIKRNYILDGDELHWMACALYVACRTSVTPTVQTGKVVEGNCVSLTKLLRLCNLSLIQFFIKIKNWMEMASMSTDFKERISRLEHKFAVSSVLFRKFQPIFMELFVGLTNEPVKQVSKRRPKLQPCSTNALFEFTWCLYICVKGEFHNSANDLVDMYHILLSCLDYIFANAFMARRVDIINPEFKGLPTDWTKNDFKMPKTPPCVISTLCEIKDGLSKEATTMKEYSWKPVIDSFFEKGILKGNSEPTLGILDLGVFDVNLKSLNNLYETYVLSVGEFDERIFLGEQANEQIGMKNKVSGDEISEVIANFGPSGRACPDTPLTGRRYLSRRSEELTPVSEAKNSLARLAATLRHARPQPSPTLLRLFTECGVTDEMINAKLIKPCNGWMEQFGASLKEAHNTPHSETISIRCNMVTCLYYKVFEHIIKEEHRKKPQVSLQMLLSQETYQLTVYACCTEIVLHAYGVNSFKFPRVLQIFKLSAFHFYKIIELVVQAVVDKLSRDVIKHLNAVEEEVLESLVWTSDSPLWDQLSKTPVPASADVSVQDSPFRRTNGLQSPVSTIDRFMSPMAEQAKKQLFKDPIKPGQSLLVQANTTPVKEPAVSANTSQPSQSTSSCETTPTSTPKKNNSLILFFRKFYSLAVVRMNDLCTRLRLTDDELKRKIWTCLEYSIMHQTHLMKDRHLDQILMCSVYVICKVSNNPSSNQVEKTFAEIMRCYRQRPLADNHVYRSVLIKQSTDESSPERGDLINFYNKVYVQCMQNFALRFSGRHRDECSLSPLPTGRCEARSPAGTRVSERHQLYVKPLTDPPPQHHHLTYRFSRSPAKDLQAINSLVWCDTGLGSGVGLKRALEGALDSDPNKRNRAAPAVARKLHHLLSDRQAV

Description

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.

Subunit

Interacts with AATF. Interacts with KDM5A. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (By similarity). Interacts with KMT5B, KMT5C and USP4.

Similarity

Belongs to the retinoblastoma protein (RB) family.

Keywords

Alternative splicing   Cell cycle   Chromatin regulator   Complete proteome   Nucleus   Phosphoprotein   Reference proteome   Repressor   Transcription   Transcription regulation   Tumor suppressor  

Feature

chain  Retinoblastoma-like protein 1
splice variant  In isoform Short.

Uniprot

A0A2A4KAP4   A0A194QES0   A0A0N0PBV8   A0A1B6KSV5   A0A0N0BD75   A0A067QPM2   + More
A0A2A3EA33   A0A0C9S1V4   A0A088A345   A0A195F2H7   E2AA07   E9IWV1   A0A2J7PJ76   A0A1S3I9G5   A0A0X9C1Y3   V3ZXN9   K9J3F9   K7J2L5   A0A3P8RLF2   T1J484   A0A3P8Y5E5   A0A3Q0RN28   A0A3P8ZZU8   A0A3Q1C1I5   A0A3B1JF35   A0A2S2QXQ9   A0A3B4WX80   A0A1W4WTH2   A0A2H8TIK0   A0A336M5G2   A0A3Q2U3X7   A0A1Y1LA14   A0A1Y1LC63   A0A210R2R8   T1K8P0   A0A0K2TLX7   A0A1Y1LDR3   A0A1Y1LHI5   A0A2Y9KN45   A0A2R7WUQ8   A0A1Q3FAJ9   A0A287AAW9   G3TP05   A0A1L8DXE0   A0A0A1WQT9   A0A034WRH1   W8CCW6   H0XAP8   U4UFI4   N6U3F6   A0A2Y9QML1   A0A2Y9DA13   Q3UI58   A0A2J8MKW3   L5JXH6   F1SEM0   A0A2J8MKW4   A0A2Y9IP75   A0A286ZJW1   A0A340WDZ0   A0A2Y9IRQ4   A0A3M6UCC8   A0A287AEE7   A0A2K5URJ7   H9ZBY8   A0A2Y9PMP4   A0A2Y9T7Q3   A0A3Q2HLF0   A0A2K5DHS4   C3XU15   F7IJ08   A0A341BB53   A0A096NSC8   A0A3Q7PE55   A0A2Y9GZE8   F7CLV0   Q64701   A0A3Q7T7T3   Q6PAR4   A0A2U3XQM1   A0A2R9BWX0   F6X9R7   A0A2J8MKX3   A0A2U4CLS0   A0A384B0P2   A0A1U7RD35   G3QRW9   A0A2K6CV71   H2QKB0   A0A2R9BNQ5   A0A2C9K1J5  

Pubmed

26354079    24845553    20798317    21282665    23254933    20075255    + More
25069045    25329095    15592404    28004739    28812685    25830018    25348373    24495485    23537049    10349636    11042159    11076861    11217851    12466851    16141073    23258410    30382153    25319552    19892987    18563158    17431167    8661722    7490090    16141072    19468303    11571651    15750587    17242355    21183079    15489334    22722832    22398555    16136131    15562597   

EMBL

NWSH01000016    PCG80810.1    KQ459053    KPJ03977.1    KQ460772    KPJ12464.1    + More
GEBQ01025448    JAT14529.1    KQ435878    KOX70054.1    KK853091    KDR11553.1    KZ288322    PBC28152.1    GBYB01014776    JAG84543.1    KQ981864    KYN34294.1    GL437990    EFN69736.1    GL766614    EFZ14956.1    NEVH01024950    PNF16395.1    KP640620    ALB00261.1    KB201489    ESO96313.1    GABZ01003951    JAA49574.1    JH431841    GGMS01013343    MBY82546.1    GFXV01002026    MBW13831.1    UFQT01000185    SSX21268.1    AADN05000479    GEZM01061429    JAV70492.1    GEZM01061433    JAV70488.1    NEDP02000731    OWF55242.1    CAEY01001879    HACA01009548    CDW26909.1    GEZM01061431    JAV70490.1    GEZM01061434    JAV70487.1    KK855619    PTY23299.1    GFDL01010496    JAV24549.1    AEMK02000106    GFDF01003022    JAV11062.1    GBXI01013271    JAD01021.1    GAKP01002172    JAC56780.1    GAMC01002981    JAC03575.1    AAQR03049853    AAQR03049854    AAQR03049855    AAQR03049856    AAQR03049857    AAQR03049858    AAQR03049859    AAQR03049860    AAQR03049861    AAQR03049862    KB632333    ERL92744.1    APGK01051096    KB741181    ENN73092.1    AK147064    BAE27648.1    NBAG03000253    PNI60164.1    KB031072    ELK04164.1    PNI60163.1    RCHS01001807    RMX51301.1    AQIA01008744    AQIA01008745    AQIA01008746    AQIA01008747    AQIA01008748    AQIA01008749    JU476650    AFH33454.1    GG666464    EEN68389.1    AHZZ02000391    AHZZ02000392    JSUE03004419    U33320    U27177    U27178    AK156055    AL669828    BC060124    AAH60124.1    AJFE02112947    AJFE02112948    AJFE02112949    AJFE02112950    AJFE02112951    AJFE02112952    AJFE02112953    AJFE02112954    AJFE02112955    AJFE02112956    PNI60162.1    CABD030116688    CABD030116689    CABD030116690    CABD030116691    CABD030116692    CABD030116693    CABD030116694    CABD030116695    CABD030116696    CABD030116697    AACZ04052783    GABC01010197    GABF01009275    GABF01009274    GABF01009273    GABD01007608    GABD01007607    GABE01009801    JAA01141.1    JAA12870.1    JAA25492.1    JAA34938.1    PNI60161.1   

Proteomes

UP000218220    UP000053268    UP000053240    UP000053105    UP000027135    UP000242457    + More
UP000005203    UP000078541    UP000000311    UP000235965    UP000085678    UP000030746    UP000002358    UP000265080    UP000265140    UP000261340    UP000257160    UP000018467    UP000261360    UP000192223    UP000000539    UP000242188    UP000015104    UP000248482    UP000008227    UP000007646    UP000005225    UP000030742    UP000019118    UP000248480    UP000010552    UP000265300    UP000275408    UP000233100    UP000248483    UP000248484    UP000002281    UP000233020    UP000001554    UP000008225    UP000252040    UP000028761    UP000286641    UP000248481    UP000006718    UP000000589    UP000286640    UP000245341    UP000240080    UP000245320    UP000261681    UP000189706    UP000001519    UP000233120    UP000002277    UP000076420   

PRIDE

Q3UI58    F1SEM0    Q64701   

Pfam

PF01858   RB_A        + More
PF01857   RB_B
PF11934   DUF3452
PF08934   Rb_C

Interpro

IPR028310   RBL1        + More
IPR002720   RB_A       
IPR028309   RB_fam       
IPR024599   RB_N       
IPR036915   Cyclin-like_sf       
IPR002719   RB_B       
IPR013763   Cyclin-like       
IPR015030   RB_C       
IPR028308   RB2       

SUPFAM

SSF47954   SSF47954       

CDD

cd00043  CYCLIN

ProteinModelPortal

A0A2A4KAP4   A0A194QES0   A0A0N0PBV8   A0A1B6KSV5   A0A0N0BD75   A0A067QPM2   + More
A0A2A3EA33   A0A0C9S1V4   A0A088A345   A0A195F2H7   E2AA07   E9IWV1   A0A2J7PJ76   A0A1S3I9G5   A0A0X9C1Y3   V3ZXN9   K9J3F9   K7J2L5   A0A3P8RLF2   T1J484   A0A3P8Y5E5   A0A3Q0RN28   A0A3P8ZZU8   A0A3Q1C1I5   A0A3B1JF35   A0A2S2QXQ9   A0A3B4WX80   A0A1W4WTH2   A0A2H8TIK0   A0A336M5G2   A0A3Q2U3X7   A0A1Y1LA14   A0A1Y1LC63   A0A210R2R8   T1K8P0   A0A0K2TLX7   A0A1Y1LDR3   A0A1Y1LHI5   A0A2Y9KN45   A0A2R7WUQ8   A0A1Q3FAJ9   A0A287AAW9   G3TP05   A0A1L8DXE0   A0A0A1WQT9   A0A034WRH1   W8CCW6   H0XAP8   U4UFI4   N6U3F6   A0A2Y9QML1   A0A2Y9DA13   Q3UI58   A0A2J8MKW3   L5JXH6   F1SEM0   A0A2J8MKW4   A0A2Y9IP75   A0A286ZJW1   A0A340WDZ0   A0A2Y9IRQ4   A0A3M6UCC8   A0A287AEE7   A0A2K5URJ7   H9ZBY8   A0A2Y9PMP4   A0A2Y9T7Q3   A0A3Q2HLF0   A0A2K5DHS4   C3XU15   F7IJ08   A0A341BB53   A0A096NSC8   A0A3Q7PE55   A0A2Y9GZE8   F7CLV0   Q64701   A0A3Q7T7T3   Q6PAR4   A0A2U3XQM1   A0A2R9BWX0   F6X9R7   A0A2J8MKX3   A0A2U4CLS0   A0A384B0P2   A0A1U7RD35   G3QRW9   A0A2K6CV71   H2QKB0   A0A2R9BNQ5   A0A2C9K1J5  

PDB

4ELL     E-value=8.93549e-43,     Score=440

KEGG

101736780    K04681 retinoblastoma-like protein 1 | (RefSeq) retinoblastoma-like protein 2

PATHWAY

04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0051726   GO:0005634   GO:0006357   GO:0005667   GO:0051302   GO:0016021   GO:0005654   GO:0043550   GO:1990841   GO:0000122   GO:2000773   GO:0008134   GO:0010629   GO:2000134   GO:0030154   GO:0001012   GO:0001102   GO:0007346   GO:0000785   GO:0006325   GO:0007049   GO:0006313   GO:0007018   GO:0030286   GO:0046034   GO:0032559   GO:0004812   GO:0006418   GO:0003824  

PANTHER

PTHR13742:SF20   PTHR13742   PTHR13742:SF8  

Subcellular location

Nucleus  

Length:

918

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0751199999999997

Exp number, first 60 AAs:

0.00221

Total prob of N-in:

0.00311

outside

1  -  918

 

 

Pi

177.435306

Theta

164.278261

Tajima's D

-0.453147

CLR

1.168116

CSRT

0.254287285635718

Interpretation

Uncertain