Gene

KWMTBOMO11354  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001966

Annotation

aldehyde_dehydrogenase_isoform_2_[Bombyx_mori]

Location

Bomo_Chr19(-):3971546-3992303      View in EpiBrowser

Full name

Aldehyde dehydrogenase      

Location in the cell

Cytoplasmic   Reliability : 1.875

CDS

ATGACAGTCGGGAATCTTACAACATCCAAACAAAAGACGATGTCAGCTGCTGAGGCCGTCCAAAAAGCTCGAGACACTTTCAATCGCGGCACAACCAGGCCGATAGAATGGCGCCGTCAGCAGCTCAAGAATTTGTTAAGAATGTACGAGGAAAACCAAAACGTCATGGTGGAGGCCCTACACAAGGATCTCAGACGAAGCAAAATGGAAGCCATTCTACTCGAAGTCGACTACTTGATCAATGATTTGAGGAACACTCTGCATTATTTGGATGAGTGGACTAAGCCGGAACATCCTCCAAAAGGCTTCGTGAACATTCTAGACGAGGTGGTTATATACAATGACCCGTACGGCGTCGTCCTCGTAATAGGCGCCTGGAACTATCCCTTGCAGCTGCTGCTTTTGCCGATGGCCGGAGCCATCGCTGCCGGGAACACGGTTATCGTGAAACCCAGCGAACTATCAGTCGCCTGCTCGAACTTTGTTGTCGAAAATCTACCGAAATATTTGGATAATGATGCTTTCATCGTATTCGAAGGAGGTCCGCAAGAGACCACTGAGTTGCTCAAACAGAGGTTTGACTACATCTTCTACACTGGAGGCACTAACGTCGGTAGAATTGTTTACGAAGCCGCCACCAAAAATCTCACGCCTGTCACATTGGAACTTGGCGGCAAAAGCCCAGTTTACGTAGATAACACGGTGGACATAGTTGTGACGGCAAAACGAATTCTCTGGGGTAAATTTATAAACGTGGGCCAAACTTGCATTGCTCCCGACTACGTACTGTGCACGAAGGAGGTACAGAACAAGTTTCTGGAGGCCTCCAAGAAAGTCCTGAAGGAATGGTACGGAGAGGACCCACAGAAATCCCCCGATCTATGCCGTATCATAAATAACAGGCACTTCAGCCGTCTGCAGCAGCTGATAGAATCGAGCAAGAACAAAATAGCCATCGGTGGTTGTTACGACTCTAACGACAGATATATAGAGCCCACAATATTGGCCAACGTCACGCCGGCCGACAAAGTGATGGAAGACGAGATATTCGGTCCCATCTTACCAATAGTTTGTATTGAAAACGCTTACGAGGCCATCAAATTTATAAATGAAAGGGAACATCCGCTAGTGCTTTACGTGTTCAGCAATCAATACAACATACAAAAGTTATTCACTGAACAGACTCGCTCTGGAAGCATTAGTATCAACGACACGATCATGTTTTACGGCGTTGAAACTCTACCGTTTGGTGGTGTGGGTAACAGCGGTATAGGTGCGTACCACGGAAAGAAGACTATCGATACATTCACACACAAAAAGAGTTGCCTCAAGAAGAACTTCGCTGCTATTGGAGAGAAACTGGCTTCAGGCCGCTACCCTCCTTACACAGAAGGAAACTTGAAATTCATAACGGCACTAATGAAGAAACGTCACGGGCCCTCGCTAAAGTATCTGCCACACTTCATGGCCTTCGCTCTCGGAGCTGCTATATCTTACGGTATCTTCGCATGGCAAAAGATGGCGTCCGATGATTCTTAA

Protein

MTVGNLTTSKQKTMSAAEAVQKARDTFNRGTTRPIEWRRQQLKNLLRMYEENQNVMVEALHKDLRRSKMEAILLEVDYLINDLRNTLHYLDEWTKPEHPPKGFVNILDEVVIYNDPYGVVLVIGAWNYPLQLLLLPMAGAIAAGNTVIVKPSELSVACSNFVVENLPKYLDNDAFIVFEGGPQETTELLKQRFDYIFYTGGTNVGRIVYEAATKNLTPVTLELGGKSPVYVDNTVDIVVTAKRILWGKFINVGQTCIAPDYVLCTKEVQNKFLEASKKVLKEWYGEDPQKSPDLCRIINNRHFSRLQQLIESSKNKIAIGGCYDSNDRYIEPTILANVTPADKVMEDEIFGPILPIVCIENAYEAIKFINEREHPLVLYVFSNQYNIQKLFTEQTRSGSISINDTIMFYGVETLPFGGVGNSGIGAYHGKKTIDTFTHKKSCLKKNFAAIGEKLASGRYPPYTEGNLKFITALMKKRHGPSLKYLPHFMAFALGAAISYGIFAWQKMASDDS

Similarity

Belongs to the aldehyde dehydrogenase family.
Belongs to the NDK family.

Uniprot

Q2F5I9   Q2F5J0   H9IXI3   A0A2W1BQ95   A0A3S2LZM4   A0A2H1W1Q4   + More
A0A194RB61   A0A1L8D714   A0A194QVM6   A0A212F520   A0A1Q3FLE4   A0A1Q3FL55   A0A1Q3FKX3   M9T154   B0W5G6   A0A2A4JQY4   A0A1Q3FL16   M9T6D2   M9SYR6   A0A1Q3FKY1   A0A1Q3FL24   A0A2J7RN02   A0A2J7RMZ6   A0A2J7RN13   K7J3Y9   A0A2J7RMZ1   M9T4M3   Q16MV5   A0A023EUE7   A0A182N808   A0A182UNC1   A0A1S4GNY9   A0A182H762   A0A1S4FVG5   M9T0L1   Q7PQ09   A0A182ISI2   A0A182LBE0   U5EUY4   A0A182JTN8   A0A232F9B4   A0A182WAA8   A0A1L8DZT0   A0A084W9K4   A0A1Q3FL79   A0A1L8E0A1   A0A453YRU6   A7UT82   A0A1L8E005   A0A1Q3FLE5   A0A182LSR1   A0A453YRN7   A0A182RTP2   A0A2M3Z8G5   S4PB99   A0A2M4BL12   A0A2M4BKP9   A7UT81   W5J9E3   D2SNX0   A0A2M4AKZ2   A0A453YJT1   A0A2M4CNA2   A0A2M4CNL1   A0A453YJI2   W8BT84   A0A0A1WJM9   W8B5M1   A0A1B6CUY8   A0A0C9RAF2   A0A182PHD7   A0A1B6CPG8   A0A1I8PAD2   A0A1B6E8W0   A0A1W4V0G7   A0A158NEB0   A0A1B6CRG9   A0A0A1WVN3   A0A1W4VCR3   A0A195CCD8   A0A151J6X4   A0A1I8MCL6   A0A0A1X9V8   A0A1W4VE28   A0A0B4KEE1   E3CTS3   A0A1J1I8P8   Q7JR61   A0A034VVW2   A0A034VXI2   A4UZ69   A0A0C4FEI5   A0A034VXI8   T1PLC3   A0A034VVW7   T1PCX5   Q8IGH3   A0A0B4KF99   A0A0B4KEL0   A1Z6Z4  

Pubmed

19121390    28756777    26354079    22118469    23639754    20075255    + More
17510324    24945155    12364791    26483478    14747013    17210077    20966253    28648823    24438588    23622113    20920257    23761445    20074338    24495485    25830018    21347285    25315136    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25348373   

EMBL

DQ311434    ABD36378.1    DQ311433    ABD36377.1    BABH01018195    BABH01018196    + More
BABH01018197    BABH01018198    KZ149982    PZC75794.1    RSAL01000096    RVE47726.1    ODYU01005766    SOQ46953.1    KQ460436    KPJ14729.1    GEYN01000005    JAV02124.1    KQ461073    KPJ09588.1    AGBW02010285    OWR48809.1    GFDL01006739    JAV28306.1    GFDL01006822    JAV28223.1    GFDL01006784    JAV28261.1    KC243495    AGI96738.1    DS231842    EDS35286.1    NWSH01000823    PCG74014.1    GFDL01006797    JAV28248.1    KC243497    AGI96740.1    KC243496    AGI96739.1    GFDL01006808    JAV28237.1    GFDL01006833    JAV28212.1    NEVH01002546    PNF42206.1    PNF42205.1    PNF42209.1    AAZX01001008    PNF42204.1    KC243498    AGI96741.1    CH477847    EAT35690.1    GAPW01001052    JAC12546.1    AAAB01008900    JXUM01115632    JXUM01115633    JXUM01115634    JXUM01115635    JXUM01115636    JXUM01115637    KQ565901    KXJ70553.1    KC243499    AGI96742.1    EAA09458.5    GANO01001252    JAB58619.1    NNAY01000677    OXU27049.1    GFDF01002091    JAV11993.1    ATLV01021829    KE525324    KFB46898.1    GFDL01006718    JAV28327.1    GFDF01002092    JAV11992.1    EDO64087.1    GFDF01002097    JAV11987.1    GFDL01006711    JAV28334.1    AXCM01000363    GGFM01004040    MBW24791.1    GAIX01004711    JAA87849.1    GGFJ01004543    MBW53684.1    GGFJ01004505    MBW53646.1    EDO64086.1    ADMH02002078    ETN59470.1    EZ407255    ACX53811.1    GGFK01008096    MBW41417.1    APCN01002922    GGFL01002628    MBW66806.1    GGFL01002739    MBW66917.1    GAMC01014141    JAB92414.1    GBXI01015674    JAC98617.1    GAMC01014142    JAB92413.1    GEDC01019998    JAS17300.1    GBYB01005250    JAG75017.1    GEDC01022024    JAS15274.1    GEDC01002929    JAS34369.1    ADTU01013229    ADTU01013230    ADTU01013231    ADTU01013232    GEDC01021307    JAS15991.1    GBXI01011400    JAD02892.1    KQ978023    KYM97896.1    KQ979851    KYN18822.1    GBXI01006777    JAD07515.1    AE013599    AGB93305.1    BT125739    ADP21878.1    CVRI01000041    CRK95326.1    BT003248    BT003252    AAF59248.2    AAO25009.1    GAKP01012368    GAKP01012359    JAC46584.1    GAKP01012367    GAKP01012365    JAC46585.1    AAM68900.3    BT126071    AAM68894.5    ADY17770.1    GAKP01012370    GAKP01012362    GAKP01012361    JAC46590.1    KA649572    AFP64201.1    GAKP01012371    GAKP01012364    GAKP01012363    JAC46589.1    KA646611    AFP61240.1    BT001784    AAN71539.1    AGB93308.1    AGB93306.1    AAM68899.3   

Proteomes

UP000005204    UP000283053    UP000053240    UP000007151    UP000002320    UP000218220    + More
UP000235965    UP000002358    UP000008820    UP000075884    UP000075903    UP000069940    UP000249989    UP000007062    UP000075880    UP000075882    UP000075881    UP000215335    UP000075920    UP000030765    UP000075883    UP000075900    UP000000673    UP000075840    UP000075885    UP000095300    UP000192221    UP000005205    UP000078542    UP000078492    UP000095301    UP000000803    UP000183832   

PRIDE

Q2F5I9    Q2F5J0    H9IXI3    Q7JR61    A4UZ69    A0A0C4FEI5    + More
Q8IGH3    A1Z6Z4   

Pfam

PF00171   Aldedh        + More
PF00071   Ras
PF00789   UBX
PF08059   SEP
PF00334   NDK
PF13281   DUF4071
PF00069   Pkinase

Interpro

IPR016161   Ald_DH/histidinol_DH        + More
IPR012394   Aldehyde_DH_NAD(P)       
IPR016163   Ald_DH_C       
IPR016162   Ald_DH_N       
IPR029510   Ald_DH_CS_GLU       
IPR015590   Aldehyde_DH_dom       
IPR001806   Small_GTPase       
IPR027417   P-loop_NTPase       
IPR003578   Small_GTPase_Rho       
IPR005225   Small_GTP-bd_dom       
IPR016160   Ald_DH_CS_CYS       
IPR001012   UBX_dom       
IPR029071   Ubiquitin-like_domsf       
IPR036241   NSFL1C_SEP_dom_sf       
IPR012989   SEP_domain       
IPR023005   Nucleoside_diP_kinase_AS       
IPR036850   NDK-like_dom_sf       
IPR034907   NDK-like_dom       
IPR001564   Nucleoside_diP_kinase       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR025136   DUF4071       
IPR017441   Protein_kinase_ATP_BS       
IPR000719   Prot_kinase_dom       

SUPFAM

SSF53720   SSF53720        + More
SSF52540   SSF52540       
SSF54236   SSF54236       
SSF102848   SSF102848       
SSF54919   SSF54919       
SSF56112   SSF56112       

Gene 3D

3.40.309.10     3.40.605.10     3.30.420.210     3.30.70.141    

ProteinModelPortal

Q2F5I9   Q2F5J0   H9IXI3   A0A2W1BQ95   A0A3S2LZM4   A0A2H1W1Q4   + More
A0A194RB61   A0A1L8D714   A0A194QVM6   A0A212F520   A0A1Q3FLE4   A0A1Q3FL55   A0A1Q3FKX3   M9T154   B0W5G6   A0A2A4JQY4   A0A1Q3FL16   M9T6D2   M9SYR6   A0A1Q3FKY1   A0A1Q3FL24   A0A2J7RN02   A0A2J7RMZ6   A0A2J7RN13   K7J3Y9   A0A2J7RMZ1   M9T4M3   Q16MV5   A0A023EUE7   A0A182N808   A0A182UNC1   A0A1S4GNY9   A0A182H762   A0A1S4FVG5   M9T0L1   Q7PQ09   A0A182ISI2   A0A182LBE0   U5EUY4   A0A182JTN8   A0A232F9B4   A0A182WAA8   A0A1L8DZT0   A0A084W9K4   A0A1Q3FL79   A0A1L8E0A1   A0A453YRU6   A7UT82   A0A1L8E005   A0A1Q3FLE5   A0A182LSR1   A0A453YRN7   A0A182RTP2   A0A2M3Z8G5   S4PB99   A0A2M4BL12   A0A2M4BKP9   A7UT81   W5J9E3   D2SNX0   A0A2M4AKZ2   A0A453YJT1   A0A2M4CNA2   A0A2M4CNL1   A0A453YJI2   W8BT84   A0A0A1WJM9   W8B5M1   A0A1B6CUY8   A0A0C9RAF2   A0A182PHD7   A0A1B6CPG8   A0A1I8PAD2   A0A1B6E8W0   A0A1W4V0G7   A0A158NEB0   A0A1B6CRG9   A0A0A1WVN3   A0A1W4VCR3   A0A195CCD8   A0A151J6X4   A0A1I8MCL6   A0A0A1X9V8   A0A1W4VE28   A0A0B4KEE1   E3CTS3   A0A1J1I8P8   Q7JR61   A0A034VVW2   A0A034VXI2   A4UZ69   A0A0C4FEI5   A0A034VXI8   T1PLC3   A0A034VVW7   T1PCX5   Q8IGH3   A0A0B4KF99   A0A0B4KEL0   A1Z6Z4  

PDB

1AD3     E-value=7.36504e-134,     Score=1223

KEGG

692988    K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] | (RefSeq) aldehyde dehydrogenase

PATHWAY

00010    Glycolysis / Gluconeogenesis - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
00071    Fatty acid degradation - Bombyx mori (domestic silkworm)
00280    Valine, leucine and isoleucine degradation - Bombyx mori (domestic silkworm)
00310    Lysine degradation - Bombyx mori (domestic silkworm)
00330    Arginine and proline metabolism - Bombyx mori (domestic silkworm)
00340    Histidine metabolism - Bombyx mori (domestic silkworm)
00380    Tryptophan metabolism - Bombyx mori (domestic silkworm)
00410    beta-Alanine metabolism - Bombyx mori (domestic silkworm)
00561    Glycerolipid metabolism - Bombyx mori (domestic silkworm)
00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016620   GO:0006081   GO:0016021   GO:0005525   GO:0007264   GO:0003924   GO:0016491   GO:0004028   GO:0006183   GO:0004550   GO:0006241   GO:0006228   GO:0004672   GO:0005524   GO:0004030   GO:0008152   GO:0046034   GO:0032559   GO:0004812   GO:0006418   GO:0003824   GO:0055114  

Length:

512

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

28.4855

Exp number, first 60 AAs:

0

Total prob of N-in:

0.20096

outside

1  -  483

TMhelix

484  -  503

inside

504  -  512

 

 

Pi

239.719481

Theta

159.681371

Tajima's D

1.156803

CLR

0.405759

CSRT

0.705564721763912

Interpretation

Uncertain