Gene

KWMTBOMO11353  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001966

Annotation

ras-like_GTP-binding_protein_Rho1_[Papilio_xuthus]

Location

Bomo_Chr19(-):3965848-3967263      View in EpiBrowser

Full name

Ras-like GTP-binding protein Rho1      

Location in the cell

Cytoplasmic   Reliability : 2.256

CDS

ATGGCTGCGATACGCAAAAAGTTAGTAATCGTCGGTGACGGTGCATGCGGTAAAACATGTCTGCTGATAGTGTTCAGCAAGGATCAATTCCCGGAAGTATACGTGCCGACAGTGTTTGAGAATTACGTTGCCGACATCGAAGTGGATGGAAAACAAGTGGAACTGGCTCTGTGGGATACCGCTGGCCAAGAAGATTACGATCGGCTGCGGCCGCTCTCGTATCCAGATACGGATGTGATCCTCATGTGCTTCTCGGTGGACTCGCCGGATTCGCTCGAGAACATCCCAGAGAAGTGGACCCCTGAGGTAAAGCACTTCTGCCCCAACGTGCCTATTATTTTAGTAGGCAACAAAAAAGACCTCCGCAACGATCCCGCCACCATCAACGAGCTTCGCAAAATGAAGCAAGAGCCTGTGAAACCGCAGGAAGGCCGGGCTATGGCTGAAAAGATTAACGCGTTTGCATATCTGGAATGCTCTGCCAAAAGCAAGGAAGGTGTACGTGAGGTGTTTGAAACAGCAACCAGAGCCGCATTACAGGTCAAGAAGAAGAAGAAGACTAGGTGTTCTCTGCTCAGTCGCGGCGTCAGCCACACAGTGCTTCCTTCCAATACTGACAGCTGA

Protein

MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDPATINELRKMKQEPVKPQEGRAMAEKINAFAYLECSAKSKEGVREVFETATRAALQVKKKKKTRCSLLSRGVSHTVLPSNTDS

Description

Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan (PubMed:10556060, PubMed:25739458). Plays a role in regulating dorsal closure during embryogenesis (PubMed:10556060, PubMed:10323867). During embryogenesis, acts upstream of wash to regulate the developmental migration of tail hemocytes anteriorly along the ventral midline (PubMed:25739458). May have a role in eye development (PubMed:7835340).

Subunit

Interacts with capu (PubMed:10556060). Interacts (via REM repeats) with Pkn (via N-terminus) (PubMed:10323867, PubMed:17507675). Interacts (via N-terminus) with wash (via N-terminus) (PubMed:25739458).

Similarity

Belongs to the aldehyde dehydrogenase family.
Belongs to the small GTPase superfamily. Rho family.

Keywords

Actin-binding   Cell membrane   Complete proteome   Cytoplasm   Cytoskeleton   Developmental protein   GTP-binding   Lipoprotein   Membrane   Methylation   Nucleotide-binding   Prenylation   Reference proteome   Sensory transduction   Vision  

Feature

chain  Ras-like GTP-binding protein Rho1
propeptide  Removed in mature form

Uniprot

R4IT84   I4DJ65   A0A059V8B0   A0A1E1WI20   A0A194QVT7   A0A1E1WTV7   + More
A0A194QF24   A0A212F4Y6   A0A2W1BVK8   A0A2A4JRC9   A0A2H1W373   S4PGT9   A0A2M4A2R4   A0A0K8TTA1   A0A1Q3G3F5   A0A182PCC0   Q16K17   Q7PQ08   A0A182GP17   A0A2M3Z004   A0A2M4A338   A0A1Q3FV73   A0A2M3ZFV6   A0A1Q3FUR6   A0A2M4CV70   A0A1Q3FUR4   D6WTQ4   A0A084W2E4   A0A182JCS7   Q16K18   A0A1Q3EUB3   T1E8V6   A0A2M4A307   A7UT88   A0A1Q3FV99   A0A023EID6   T1DF31   A0A1L8E5S2   A0A2P8ZH42   A2I424   A0A2J7R442   A0A067R453   A0A1B6KD41   A0A1B6FA98   A0A0B4J2R0   V9ICS2   A0A1L8E4S2   E9IY49   A0A1W4VCY4   A0A3B0IZQ8   A0A0R3NQ70   B4H6A5   A0A158NRT3   A0A336MZI8   A0A0C9QYS1   A0A2S2NE68   C4WXD0   A0A3L8DGZ4   A0A0L7L5U8   A0A0J7KWC6   A0A0L7RBE8   A0A1J1J844   A0A1L8E531   B5DZ84   A0A1L8E501   A0A154PLQ8   A0A1L8E5B1   A0A1L8E4T5   A0A1I8PXD4   A0A0L0CAX9   A0A1I8PX87   A0A1L8EF16   H9IXI3   B4NMF8   B4HSJ6   B4QHF0   B3NPX6   B3MF51   B4P6R5   P48148   A0A1L8EBB1   A0A1Y1N1U2   A0A067QMA2   A0A2P8Z9R7   A0A0M4E902   A0A1S3D3L3   A0A1L8EB85   A0A1L8EBB8   A0A0M9A1S5   A0A0B4J2N2   J3JXY9   A0A1I8N4C6   A0A1W4WS00   T1PFJ7   A0A0K8U1N5   A0A0A1X2H7   W8BJI0   A0A0P6IZ36   B4J9Y1   B4KQB1  

Pubmed

22651552    24866850    26354079    22118469    28756777    23622113    + More
26369729    17510324    12364791    14747013    17210077    26483478    18362917    19820115    24438588    24945155    24330624    29403074    24845553    20075255    21282665    15632085    17994087    21347285    30249741    26227816    26108605    19121390    22936249    18057021    17550304    7835340    10556060    10731132    12537572    12537569    10323867    17507675    25739458    28004739    22516182    23537049    25315136    25830018    24495485   

EMBL

JQ744276    AGC39042.1    AK401333    BAM17955.1    KJ547698    AHZ89302.1    + More
GDQN01007585    GDQN01004563    JAT83469.1    JAT86491.1    KQ461073    KPJ09587.1    GDQN01000599    JAT90455.1    KQ459053    KPJ04019.1    AGBW02010285    OWR48808.1    KZ149982    PZC75793.1    NWSH01000823    PCG74013.1    ODYU01005766    SOQ46954.1    GAIX01003502    JAA89058.1    GGFK01001803    MBW35124.1    GDAI01000019    JAI17584.1    GFDL01000710    JAV34335.1    CH477981    EAT34628.1    EAT34630.1    EAT34631.1    EAT34632.1    EAT34633.1    EAT34634.1    EAT34635.1    EJY58025.1    AAAB01008900    EAA09459.2    EDO64094.1    EDO64096.1    JXUM01077756    JXUM01077757    JXUM01077758    JXUM01077759    JXUM01077760    JXUM01077761    KQ563026    KXJ74620.1    GGFM01001101    MBW21852.1    GGFK01001858    MBW35179.1    GFDL01003703    JAV31342.1    GGFM01006632    MBW27383.1    GFDL01003705    JAV31340.1    GGFL01005058    MBW69236.1    GFDL01003704    JAV31341.1    KQ971352    EFA07463.2    ATLV01019608    ATLV01019609    KE525275    KFB44388.1    AXCP01003443    EAT34629.1    GFDL01016141    JAV18904.1    GAMD01002423    JAA99167.1    GGFK01001828    MBW35149.1    EDO64093.1    EDO64095.1    GFDL01003702    JAV31343.1    GAPW01004430    JAC09168.1    GALA01000817    JAA94035.1    GFDF01000036    JAV14048.1    PYGN01000059    PSN55824.1    EF070527    ABM55593.1    NEVH01007816    PNF35598.1    KK852908    KDR13982.1    GEBQ01030853    JAT09124.1    GECZ01022661    GECZ01004299    JAS47108.1    JAS65470.1    JR038037    JR038039    JR038040    AEY58088.1    AEY58089.1    AEY58090.1    GFDF01000336    JAV13748.1    GL766908    EFZ14510.1    OUUW01000001    SPP73954.1    CM000071    KRT03186.1    CH479213    EDW33329.1    ADTU01024303    UFQT01002634    SSX33827.1    GBYB01005812    JAG75579.1    GGMR01002902    MBY15521.1    ABLF02019341    AK342566    BAH72550.1    QOIP01000008    RLU19704.1    JTDY01002750    KOB70790.1    LBMM01002618    KMQ94583.1    KQ414617    KOC68189.1    CVRI01000075    CRL08559.1    GFDF01000340    JAV13744.1    EDY69555.2    GFDF01000338    JAV13746.1    KQ434977    KZC12815.1    GFDF01000339    JAV13745.1    GFDF01000341    JAV13743.1    JRES01000655    KNC29578.1    GFDG01001564    JAV17235.1    BABH01018195    BABH01018196    BABH01018197    BABH01018198    CH964282    EDW85547.1    CH480816    EDW48074.1    CM000362    CM002911    EDX07295.1    KMY94157.1    CH954179    EDV55823.1    KQS62476.1    KQS62477.1    CH902619    EDV37679.1    KPU76975.1    KPU76977.1    CM000158    EDW91992.1    KRK00238.1    L38311    AF177871    AF177872    AF177873    AF177874    AE013599    AY119536    BT010085    GFDG01002752    JAV16047.1    GEZM01016123    JAV91368.1    KK853253    KDR09313.1    PYGN01000135    PSN53235.1    CP012524    ALC41296.1    GFDG01002875    JAV15924.1    GFDG01002877    JAV15922.1    KQ435793    KOX74173.1    APGK01056011    BT128111    KB741271    KB630516    KB632114    AEE63072.1    ENN71391.1    ERL83646.1    ERL88926.1    KA647506    KA649092    AFP62135.1    GDHF01031888    GDHF01030837    GDHF01014502    GDHF01011967    GDHF01008356    JAI20426.1    JAI21477.1    JAI37812.1    JAI40347.1    JAI43958.1    GBXI01008931    GBXI01008738    GBXI01001667    JAD05361.1    JAD05554.1    JAD12625.1    GAMC01007650    GAMC01007648    JAB98907.1    GDIQ01002253    JAN92484.1    CH916367    EDW02568.1    CH933808    EDW09239.1    KRG04542.1   

Proteomes

UP000053240    UP000053268    UP000007151    UP000218220    UP000075885    UP000008820    + More
UP000007062    UP000069940    UP000249989    UP000007266    UP000030765    UP000075880    UP000245037    UP000235965    UP000027135    UP000002358    UP000192221    UP000268350    UP000001819    UP000008744    UP000005205    UP000007819    UP000279307    UP000037510    UP000036403    UP000053825    UP000183832    UP000076502    UP000095300    UP000037069    UP000005204    UP000007798    UP000001292    UP000000304    UP000008711    UP000007801    UP000002282    UP000000803    UP000092553    UP000079169    UP000053105    UP000005203    UP000019118    UP000030742    UP000095301    UP000192223    UP000001070    UP000009192   

PRIDE

H9IXI3    P48148   

Pfam

PF00071   Ras        + More
PF00171   Aldedh

Interpro

IPR003578   Small_GTPase_Rho        + More
IPR005225   Small_GTP-bd_dom       
IPR027417   P-loop_NTPase       
IPR001806   Small_GTPase       
IPR015590   Aldehyde_DH_dom       
IPR016162   Ald_DH_N       
IPR016163   Ald_DH_C       
IPR016160   Ald_DH_CS_CYS       
IPR016161   Ald_DH/histidinol_DH       
IPR029510   Ald_DH_CS_GLU       

SUPFAM

SSF52540   SSF52540        + More
SSF53720   SSF53720       

Gene 3D

3.40.309.10     3.40.605.10    

ProteinModelPortal

R4IT84   I4DJ65   A0A059V8B0   A0A1E1WI20   A0A194QVT7   A0A1E1WTV7   + More
A0A194QF24   A0A212F4Y6   A0A2W1BVK8   A0A2A4JRC9   A0A2H1W373   S4PGT9   A0A2M4A2R4   A0A0K8TTA1   A0A1Q3G3F5   A0A182PCC0   Q16K17   Q7PQ08   A0A182GP17   A0A2M3Z004   A0A2M4A338   A0A1Q3FV73   A0A2M3ZFV6   A0A1Q3FUR6   A0A2M4CV70   A0A1Q3FUR4   D6WTQ4   A0A084W2E4   A0A182JCS7   Q16K18   A0A1Q3EUB3   T1E8V6   A0A2M4A307   A7UT88   A0A1Q3FV99   A0A023EID6   T1DF31   A0A1L8E5S2   A0A2P8ZH42   A2I424   A0A2J7R442   A0A067R453   A0A1B6KD41   A0A1B6FA98   A0A0B4J2R0   V9ICS2   A0A1L8E4S2   E9IY49   A0A1W4VCY4   A0A3B0IZQ8   A0A0R3NQ70   B4H6A5   A0A158NRT3   A0A336MZI8   A0A0C9QYS1   A0A2S2NE68   C4WXD0   A0A3L8DGZ4   A0A0L7L5U8   A0A0J7KWC6   A0A0L7RBE8   A0A1J1J844   A0A1L8E531   B5DZ84   A0A1L8E501   A0A154PLQ8   A0A1L8E5B1   A0A1L8E4T5   A0A1I8PXD4   A0A0L0CAX9   A0A1I8PX87   A0A1L8EF16   H9IXI3   B4NMF8   B4HSJ6   B4QHF0   B3NPX6   B3MF51   B4P6R5   P48148   A0A1L8EBB1   A0A1Y1N1U2   A0A067QMA2   A0A2P8Z9R7   A0A0M4E902   A0A1S3D3L3   A0A1L8EB85   A0A1L8EBB8   A0A0M9A1S5   A0A0B4J2N2   J3JXY9   A0A1I8N4C6   A0A1W4WS00   T1PFJ7   A0A0K8U1N5   A0A0A1X2H7   W8BJI0   A0A0P6IZ36   B4J9Y1   B4KQB1  

PDB

5C2K     E-value=4.99852e-96,     Score=892

KEGG

101739657    K04513 Ras homolog gene family, member A | (RefSeq) ras-like GTP-binding protein Rho1

PATHWAY

04144    Endocytosis - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)
04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005525   GO:0003924   GO:0007264   GO:0032153   GO:0030950   GO:0008360   GO:0051017   GO:0032956   GO:0005737   GO:0019901   GO:0043231   GO:0007266   GO:0016477   GO:0007015   GO:0030334   GO:0005938   GO:0016021   GO:0042249   GO:0034334   GO:0035298   GO:0035149   GO:0035099   GO:0007435   GO:0050770   GO:0007377   GO:0008347   GO:0032456   GO:0046663   GO:0044291   GO:0007405   GO:0045179   GO:0090254   GO:0016324   GO:0006897   GO:0008045   GO:0071896   GO:0007422   GO:1904059   GO:0016476   GO:0007298   GO:0090251   GO:0070451   GO:0051493   GO:0071902   GO:0007368   GO:1903475   GO:0090090   GO:0001745   GO:0019900   GO:0035277   GO:0007349   GO:0030589   GO:0007374   GO:0007480   GO:0007395   GO:0090303   GO:1901739   GO:0045199   GO:0035317   GO:0070593   GO:0051489   GO:0035159   GO:0035006   GO:0007370   GO:0070252   GO:0031532   GO:0035202   GO:0042060   GO:0045184   GO:0016620   GO:0009611   GO:0005886   GO:0010004   GO:0000281   GO:0007391   GO:0034613   GO:0007411   GO:0007601   GO:0007424   GO:0005829   GO:0003779   GO:0030036   GO:0048812   GO:0048813   GO:0030866   GO:0005856   GO:0046933   GO:0005524   GO:0015992   GO:0046034   GO:0032559   GO:0004812   GO:0006418   GO:0003824  

Subcellular location

Cell membrane  
Cytoplasm  
Cytoskeleton  

Length:

207

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0684599999999999

Exp number, first 60 AAs:

0.0683

Total prob of N-in:

0.16359

outside

1  -  207

 

 

Pi

220.167328

Theta

164.756308

Tajima's D

0.863267

CLR

0.881787

CSRT

0.621318934053297

Interpretation

Uncertain