Gene

KWMTBOMO11351  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001853

Annotation

ATP_synthase_[Bombyx_mori]

Location

Bomo_Chr19(+):3945144-3949998      View in EpiBrowser

Full name

ATP synthase subunit alpha       + More
ATP synthase subunit alpha, mitochondrial      

Alternative Name

ATP synthase F1 sector subunit alpha
F-ATPase subunit alpha
Protein bellwether

Location in the cell

Mitochondrial   Reliability : 3.804

CDS

ATGTCGCTGATCTCCGCTCGTATTGCTGGCTCTGTAGCCAGGCGCTTGCCTAATGCTGCTACCCAGGTGTCAAAGGTGGCGGTGCCCGCAGTGGCCGTGGCATCTCGCAAACTACATGTCTCAACCACCCACAAAGCTGCCGAGATCTCCACCATCCTCGAAGAGAGGATCCTTGGAGCCGCGCCCAAGGCTGATCTAGAAGAGACTGGTCGTGTCTTGAGCATTGGTGATGGTATCGCTCGTGTTTATGGCTTGAAGAACATCCAGGCTGAGGAGATGGTGGAGTTCTCCTCAGGCCTCAAGGGAATGGCCCTTAACTTGGAACCTGACAATGTGGGTGTGGTAGTATTTGGTAATGACAAGCTTATCAAGGAAGGAGATATTGTCAAGCGTACTGGTGCTATCGTAGACGTTCCCGTCGGAGAGCAGATCCTTGGGCGTGTAGTAGATGCTTTGGGTAACCCTATTGATGGCAAGGGACCAATCGACACGAAATCCCGTATGAGGGTCGGTATTAAGGCGCCAGGTATCATTCCCCGGGTGTCTGTGCGTGAGCCTATGCAGACTGGTATCAAGGCTGTTGACTCTCTGGTACCAATTGGCCGTGGTCAGCGTGAGTTGATCATTGGTGACCGTCAAACTGGTAAGACTGCCCTGGCCATTGATACGATCATCAACCAGCAGAGATTCAACAAGGGTGAGGATGAGAAGAAGAAGTTGTACTGCATTTATGTTGCCATTGGACAGAAGAGGTCTACTGTAGCTCAAATTGTGAAGAGATTGACTGATGCTGGTGCCATCAACTACACAATCATCGTGTCTGCCACCGCTTCCGATGCTGCTCCCCTGCAATACCTGGCTCCTTACTCTGGTTGTGCCATGGGTGAATTTTTCCGTGATAATGGCAAACACGCCCTTATTATCTACGACGATTTGTCCAAACAAGCCGTAGCCTACCGTCAGATGTCTCTACTGCTGCGTCGTCCCCCCGGCCGTGAGGCTTATCCTGGTGACGTGTTCTATCTTCACTCCCGTCTGCTTGAGCGTGCCGCTAAGATGTCTGACAAAATGGGTGGTGGCTCCCTGACTGCTTTACCTGTCATTGAAACCCAAGCCGGTGATGTGTCAGCTTACATTCCTACCAACGTGATCTCCATCACTGATGGACAGATCTTCTTGGAAACTGAGCTGTTCTACAAAGGTATCCGACCAGCCATCAACGTCGGTCTGTCTGTATCGCGTGTCGGATCTGCTGCTCAGACCAAGGCTATGAAGCAGGTGGCCGGTTCCATGAAGCTGGAATTGGCTCAGTACCGTGAGGTCGCAGCTTTTGCCCAGTTCGGTTCTGACTTGGATGCCGCTACACAGCAGCTGCTCAACAGAGGAATGCGTCTTACTGAGCTCCTCAAGCAAGGACAATATGTGCCCATGGCTATTGAGGAACAGGTCGCCATCATTTACTGCGGTGTCCGCGGTCACCTCGACAAGCTGGACCCCTCCAAAATCACTGCCTTCGAGAAGGAATTCACTCAACACATCAAAACTAGCCACCAGGGTCTTCTCTCCACGATCGCCAAAGACGGTCAGATCACCCCCGAGTCTGACGCCTCCTTGAAGAAGATCGTCACAGACTTCCTAGCTACTTTCACCCAATCGCAGTAA

Protein

MSLISARIAGSVARRLPNAATQVSKVAVPAVAVASRKLHVSTTHKAAEISTILEERILGAAPKADLEETGRVLSIGDGIARVYGLKNIQAEEMVEFSSGLKGMALNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGEQILGRVVDALGNPIDGKGPIDTKSRMRVGIKAPGIIPRVSVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTALAIDTIINQQRFNKGEDEKKKLYCIYVAIGQKRSTVAQIVKRLTDAGAINYTIIVSATASDAAPLQYLAPYSGCAMGEFFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMSDKMGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTKAMKQVAGSMKLELAQYREVAAFAQFGSDLDAATQQLLNRGMRLTELLKQGQYVPMAIEEQVAIIYCGVRGHLDKLDPSKITAFEKEFTQHIKTSHQGLLSTIAKDGQITPESDASLKKIVTDFLATFTQSQ

Description

Produces ATP from ADP in the presence of a proton gradient across the membrane.
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).

Catalytic Activity

ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate

Subunit

F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

Similarity

Belongs to the ATPase alpha/beta chains family.

Keywords

ATP synthesis   ATP-binding   Complete proteome   Direct protein sequencing   Hydrogen ion transport   Ion transport   Membrane   Mitochondrion   Mitochondrion inner membrane   Nucleotide-binding   Reference proteome   Transit peptide   Transport  

Feature

chain  ATP synthase subunit alpha, mitochondrial

Uniprot

Q2F5T3   A0A2H1W1X7   S4P2L2   A0A3S2LJ09   A0A194QXA3   A0A194QEQ8   + More
A0A212ELG1   A0A2W1BNE3   A0A2A4JQE0   D6WSI9   A0A2J7Q0B3   A0A034WCI4   A0A0A1WN96   A0A0K8TW13   A0A067QI29   S4VDE6   W8CCY0   A0A182N7Z7   Q7PHI8   A0A182XJA6   A0A182UN55   A0A182LBD1   A0A182HP56   A0A182MRL5   A0A182WAB9   A0A191UR49   A0A084W9J4   Q1HRQ7   A0A182JM63   A0A0V0G2J4   A0A182PHE7   A0A1L8E154   A0A1J1J483   A0A182Q0H6   A0A182RTQ3   A0A0L0CN23   A0A069DZ92   B4MQA2   A0A182K4A3   A0A336N1U6   A0A323TPU0   A0A423TIL1   J3JWJ5   A0A0J9RIM8   A0A1A9XAQ8   A0A1B0BN74   B4I8B0   A0A1W4VDL2   A0A0N7ZCJ7   T1DEX4   B4P5T2   A0A1A9VCE1   A0A2M3YXS3   A0A1A9ZX37   A0A2M3ZZL4   W5J4R5   D3TR42   A0A182FH95   P35381   Q5XUA1   B3NNW0   D3W7E4   A0A171AYN4   A0A023F937   A0A0E3DQZ8   A0A0M4EW76   A0A1Q3FGZ3   A0A154PAS4   U5EZ82   B0W5F2   A0A1B6CGV5   T1PGB4   A0A0N0BIY2   J9JYX3   A0A411G6D1   A0A1B6FR19   A0A1L8EEH9   A0A1Y1LHJ4   R4FQG1   A0A1I8PLE2   A0A1L8EEN1   A0A087ZQI5   A0A1B6KWM9   A0A1L8EHL5   A0A146KQL2   A0A2A3E464   V9IFD6   B3MEJ0   A0A1A9WYG7   A0A3L8DC47   A0A0A9Z2F3   A0A0P5HII0   A0A164NWW6   A0A1D1ZI21   B4KPB8   K7IZG4   B4J414   A0A0L7QXV3   K7IZG5   B4LIV0  

EC Number

7.1.2.2

Pubmed

19121390    23622113    26354079    22118469    28756777    18362917    + More
19820115    25348373    25830018    24845553    24495485    12364791    14747013    17210077    20966253    27538518    27142481    24438588    17204158    17510324    26108605    26334808    17994087    22516182    22936249    17550304    20920257    23761445    20353571    9540069    10731132    12537572    8500545    21384180    25474469    29136191    25315136    28004739    26823975    30249741    25401762    20075255   

EMBL

BABH01018200    DQ311340    ABD36284.1    ODYU01005766    SOQ46956.1    GAIX01011955    + More
JAA80605.1    RSAL01000096    RVE47723.1    KQ461073    KPJ09585.1    KQ459053    KPJ04023.1    AGBW02014073    OWR42307.1    KZ149982    PZC75791.1    NWSH01000823    PCG74029.1    KQ971354    EFA07428.1    NEVH01019983    PNF22023.1    GAKP01007449    JAC51503.1    GBXI01014419    JAC99872.1    GDHF01034079    GDHF01030438    GDHF01025175    JAI18235.1    JAI21876.1    JAI27139.1    KK853579    KDR06557.1    KC792298    AGO59887.1    GAMC01002911    JAC03645.1    AAAB01008900    EAA44524.2    APCN01002921    AXCM01001928    KU365938    KU932311    ANJ04654.1    APA33947.1    ATLV01021825    KE525324    KFB46888.1    DQ440037    CH477847    ABF18070.1    EAT35671.1    GECL01003752    JAP02372.1    GFDF01001782    JAV12302.1    CVRI01000070    CRL07216.1    AXCN02000909    JRES01000264    KNC32844.1    GBGD01001045    JAC87844.1    CH963849    EDW74291.1    UFQT01003371    SSX34933.1    MDVM02000029    PYZ99361.1    QCYY01001676    ROT76288.1    BT127613    AEE62575.1    CM002911    KMY95873.1    JXJN01017231    CH480824    EDW56835.1    GDRN01065788    JAI64640.1    GAMD01003346    JAA98244.1    CM000158    EDW91848.1    GGFM01000300    MBW21051.1    GGFK01000517    MBW33838.1    ADMH02002078    ETN59462.1    CCAG010006562    EZ423894    ADD20170.1    Y07894    AE013599    BT003592    AY737553    AAU84946.1    CH954179    EDV56693.1    GQ848643    ADC55251.1    GEMB01000492    JAS02635.1    GBBI01000721    JAC17991.1    KF818471    QKKF02010319    AIL26069.1    RZF44718.1    CP012524    ALC42287.1    GFDL01008243    JAV26802.1    KQ434846    KZC08318.1    GANO01001263    JAB58608.1    DS231842    EDS35272.1    GEDC01024675    JAS12623.1    KA647180    AFP61809.1    KQ435724    KOX78342.1    ABLF02029687    ABLF02029688    MH365641    QBB01450.1    GECZ01017155    JAS52614.1    GFDG01001745    JAV17054.1    GEZM01055159    GEZM01055158    JAV73104.1    ACPB03006347    GAHY01000414    JAA77096.1    GFDG01001663    JAV17136.1    GEBQ01024142    JAT15835.1    GFDG01000577    JAV18222.1    GDHC01019825    JAP98803.1    KZ288386    PBC26478.1    JR043517    AEY59785.1    CH902619    EDV37610.1    QOIP01000010    RLU17449.1    GBHO01007604    JAG36000.1    GDIQ01227542    JAK24183.1    LRGB01002793    KZS06308.1    GDJX01001320    JAT66616.1    CH933808    EDW09094.1    CH916367    EDW02620.1    KQ414699    KOC63448.1    CH940648    EDW61453.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000053268    UP000007151    UP000218220    + More
UP000007266    UP000235965    UP000027135    UP000075884    UP000007062    UP000076407    UP000075903    UP000075882    UP000075840    UP000075883    UP000075920    UP000030765    UP000008820    UP000075880    UP000075885    UP000183832    UP000075886    UP000075900    UP000037069    UP000007798    UP000075881    UP000247427    UP000283509    UP000092443    UP000092460    UP000001292    UP000192221    UP000002282    UP000078200    UP000092445    UP000000673    UP000092444    UP000069272    UP000000803    UP000008711    UP000291343    UP000092553    UP000076502    UP000002320    UP000095301    UP000053105    UP000007819    UP000015103    UP000095300    UP000005203    UP000242457    UP000007801    UP000091820    UP000279307    UP000076858    UP000009192    UP000002358    UP000001070    UP000053825    UP000008792   

PRIDE

Q2F5T3    P35381    D3W7E4    A0A087ZQI5   

Pfam

PF02874   ATP-synt_ab_N        + More
PF00006   ATP-synt_ab
PF00306   ATP-synt_ab_C

Interpro

IPR027417   P-loop_NTPase        + More
IPR033732   ATP_synth_F1_a       
IPR020003   ATPase_a/bsu_AS       
IPR005294   ATP_synth_F1_asu       
IPR000194   ATPase_F1/V1/A1_a/bsu_nucl-bd       
IPR000793   ATP_synth_asu_C       
IPR038376   ATP_synth_asu_C_sf       
IPR036121   ATPase_F1/V1/A1_a/bsu_N_sf       
IPR023366   ATP_synth_asu-like_sf       
IPR004100   ATPase_F1/V1/A1_a/bsu_N       

SUPFAM

SSF52540   SSF52540        + More
SSF50615   SSF50615       

Gene 3D

1.20.150.20     2.40.30.20    

CDD

cd01132  F1_ATPase_alpha

ProteinModelPortal

Q2F5T3   A0A2H1W1X7   S4P2L2   A0A3S2LJ09   A0A194QXA3   A0A194QEQ8   + More
A0A212ELG1   A0A2W1BNE3   A0A2A4JQE0   D6WSI9   A0A2J7Q0B3   A0A034WCI4   A0A0A1WN96   A0A0K8TW13   A0A067QI29   S4VDE6   W8CCY0   A0A182N7Z7   Q7PHI8   A0A182XJA6   A0A182UN55   A0A182LBD1   A0A182HP56   A0A182MRL5   A0A182WAB9   A0A191UR49   A0A084W9J4   Q1HRQ7   A0A182JM63   A0A0V0G2J4   A0A182PHE7   A0A1L8E154   A0A1J1J483   A0A182Q0H6   A0A182RTQ3   A0A0L0CN23   A0A069DZ92   B4MQA2   A0A182K4A3   A0A336N1U6   A0A323TPU0   A0A423TIL1   J3JWJ5   A0A0J9RIM8   A0A1A9XAQ8   A0A1B0BN74   B4I8B0   A0A1W4VDL2   A0A0N7ZCJ7   T1DEX4   B4P5T2   A0A1A9VCE1   A0A2M3YXS3   A0A1A9ZX37   A0A2M3ZZL4   W5J4R5   D3TR42   A0A182FH95   P35381   Q5XUA1   B3NNW0   D3W7E4   A0A171AYN4   A0A023F937   A0A0E3DQZ8   A0A0M4EW76   A0A1Q3FGZ3   A0A154PAS4   U5EZ82   B0W5F2   A0A1B6CGV5   T1PGB4   A0A0N0BIY2   J9JYX3   A0A411G6D1   A0A1B6FR19   A0A1L8EEH9   A0A1Y1LHJ4   R4FQG1   A0A1I8PLE2   A0A1L8EEN1   A0A087ZQI5   A0A1B6KWM9   A0A1L8EHL5   A0A146KQL2   A0A2A3E464   V9IFD6   B3MEJ0   A0A1A9WYG7   A0A3L8DC47   A0A0A9Z2F3   A0A0P5HII0   A0A164NWW6   A0A1D1ZI21   B4KPB8   K7IZG4   B4J414   A0A0L7QXV3   K7IZG5   B4LIV0  

PDB

2W6J     E-value=0,     Score=2215

KEGG

692926    K02132 F-type H+-transporting ATPase subunit alpha | (RefSeq) ATP synthase

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0046933   GO:0005524   GO:0015986   GO:0045261   GO:0006754   GO:0006811   GO:0043531   GO:0000275   GO:0005886   GO:1902769   GO:0022900   GO:0019915   GO:0005739   GO:0015992   GO:0046034   GO:0032559   GO:0004812   GO:0006418   GO:0003824   GO:1902600  

Subcellular location

Cell membrane  
Mitochondrion inner membrane  

Length:

553

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02359

Exp number, first 60 AAs:

0.00165

Total prob of N-in:

0.00157

outside

1  -  553

 

 

Pi

264.121357

Theta

209.321834

Tajima's D

1.042591

CLR

0.001077

CSRT

0.666816659167042

Interpretation

Uncertain