Gene

KWMTBOMO11350

Pre Gene Modal

BGIBMGA001967

Annotation

PREDICTED:_PX_domain-containing_protein_kinase-like_protein_[Bombyx_mori]

Location

Bomo_Chr19(-):3933443-3943673      View in EpiBrowser

Full name

PX domain-containing protein kinase-like protein      

Alternative Name

Modulator of Na,K-ATPase

Location in the cell

Nuclear   Reliability : 2.223

CDS

ATGGCTTTGTGGCAGAATGCGTCGTCCGTCATATGGAGATTAGACGACACAGCGAAAATTACATGTTTCATAGAAAATGCTCAGAACATTAACAAACACACCGAATACATAATTAGGGTTCAAAGAGGCCCCGTCAAAGAAAATATGTGGAATGTATCTCGTAGATATAGTGATTTTGCATCGCTACACTCATTACTGCTGAAATCCAATATAGATTTGCCTCTCCCACCTAAAAAACTCATAGGAAATATGCAGCCTTCATTTATCGCAGAAAGACAAGTGGCATTGCAGAACTATTTAAATGAAGTGCTGAAACATCAGATATTAGCATTGTCATTGTCAGTGAGAAGTTTTCTAGATCCAAACAACTATTCATTAGCCATCTCAGAGCAATCTCTGCAGACCGTGTCAATAGCCTTGAGGGGAGACTTGCGCTATGAACTAAAAGGACCCATTGCTGATATTGGATGGAGAATAAGGAAACATTATTTTTTGATGTCCGATATTAGTAGCAAGACTAATTGTTTACTTTCGTATCAGCACTACGGTCCGGATAGATATCTCTGCGATAAAGACTTGCAGACTGCCTTCAAGAGCCTACAAAATCTTTCGCACCCTTATATAGACCAAATATTAGCTATACATAATTTAGAAAATGGTGCCTACGTTATTAGAAGGATACACGAGAACGGAAGTCTGAGAGATATATTATACGGTACCGAATACAGTAAACATTATTTAATGAAGTATGGCAACCCGAAAATAAGGAAACCATTCACGACCGGACAAATCGCACACTATGGTTATCAGATATTGCAAGCAATAAAGTTTCTACACGAAAAAGGTCTACCACACGGTCACATCCATCCCGGCAACATCGCAATAGAGAACCAAAGAGCTCTGCTAATGGAGGTCGAGAATTTTGTTATCGGCGTGCCCTGTTTGTACCGGCCCTATCTACTCGAACTGCGGAGGGTGACGACCCCCGAAGACATCGACGTATACTGCTTCGGCAGAACCTTGTACGAGATGACGTTCGCCATCGCACCGGAGGACCCCCACTGCGATTACTTCCCCGACGGAATCAATATGGATTTAGAATCAGTATTACACATGTGCCTTTCAAGTCACGCTTGCAAGCACGGCATGCCGACAGTAGACAGTCTACTCCGGCACCCGTTCTTCTGCCAAGCGCCCCTCAACGGCCTCACGGTGGCGCCGCGCGACGAGAAGATCCACCTCAAGTTCCCCATACAGCTGAAGGAAGAGTTGAAGGCCGCCGTCTCTAGCGCCGAAGCGAGATTAAAACGAGAACAGAAACTGGTGCGAAGCGCAAAGAGAGAAGTCAGGATCCAAGAAATACTCTCTTCAGAAGAGGAAATGAAGAAACAGAAAAAAAGAATGAAAAAGCGCGAGAGCATCTGGAAGTCGACGTCGTCGCTGGCGGACACGGTGCGGAGCGCCAGCACGGCCTCGTCCCCCTCGCCGCCCGCGCCCCGCGAGCGCACCCCGCCGCCCCCGCCACAAGGCGCAGACATGGGTGCCGCGGAGGGAGCGCCGCCCCCCGCCGGCCGCTCCGCGCTGCTGCACGCCATCTGCGCCTTCGACAAGTCCAGACTCGCTCGCGTATCGACTCGGTGA

Protein

MALWQNASSVIWRLDDTAKITCFIENAQNINKHTEYIIRVQRGPVKENMWNVSRRYSDFASLHSLLLKSNIDLPLPPKKLIGNMQPSFIAERQVALQNYLNEVLKHQILALSLSVRSFLDPNNYSLAISEQSLQTVSIALRGDLRYELKGPIADIGWRIRKHYFLMSDISSKTNCLLSYQHYGPDRYLCDKDLQTAFKSLQNLSHPYIDQILAIHNLENGAYVIRRIHENGSLRDILYGTEYSKHYLMKYGNPKIRKPFTTGQIAHYGYQILQAIKFLHEKGLPHGHIHPGNIAIENQRALLMEVENFVIGVPCLYRPYLLELRRVTTPEDIDVYCFGRTLYEMTFAIAPEDPHCDYFPDGINMDLESVLHMCLSSHACKHGMPTVDSLLRHPFFCQAPLNGLTVAPRDEKIHLKFPIQLKEELKAAVSSAEARLKREQKLVRSAKREVRIQEILSSEEEMKKQKKRMKKRESIWKSTSSLADTVRSASTASSPSPPAPRERTPPPPPQGADMGAAEGAPPPAGRSALLHAICAFDKSRLARVSTR

Description

Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.

Similarity

Belongs to the protein kinase superfamily.

Keywords

Actin-binding   Alternative splicing   Cell membrane   Complete proteome   Cytoplasm   Membrane   Reference proteome  

Feature

chain  PX domain-containing protein kinase-like protein
splice variant  In isoform 3.

Uniprot

H9IXI4   A0A2H1W1P7   A0A2A4JQQ0   A0A2W1BSQ6   A0A194QWA4   A0A3S2NXD8   + More
A0A212ELF5   A0A194QF29   A0A2J7PZP6   A0A2J7PZN0   D6WQ78   A0A067QV47   A0A1Y1LI12   V9IAU7   A0A2A3ER94   A0A088A0Q9   A0A0C9QC73   A0A0C9RGN4   A0A0J7KQX6   A0A0C9Q9W3   A0A232F530   K7J816   A0A1W4WMQ9   E9IVE1   A0A151XHQ6   F4X7A4   A0A195FGQ5   E1ZW46   E2C009   A0A026WUI1   A0A195B1E4   A0A158ND63   A0A0L7QX31   A0A151ICB2   A0A195DJF0   U4UJH9   A0A1B6CZC3   N6URM8   A0A1B6G353   A0A3B3QXH9   A0A3Q1B738   A0A3P9A4A9   A0A3Q1CCD9   H2MYY7   A0A2D0PLG0   A0A3Q1B4P4   A0A0B8RU11   A0A3P8UCA9   A0A3B4VAU0   W5UJE9   E6ZGF0   A0A2T7NTX1   G1KLK4   A0A1U8C6N2   A0A3Q0CXX7   A0A1U7QYL6   A0A3Q0D3E4   A0A2U9BE91   Q6DFG1   A0A147AH73   A0A3B4DG86   A0A087XLM7   A0A3Q2VL46   U3F7W1   A0A1W4Z8Q0   A0A3Q1IIN0   A0A2D4JWI2   A0A0L8G5U9   A0A1U7QN72   A0A3B3XQ31   A0A3B3YYT2   A0A3P8WQH2   A0A096MDR5   A0A3Q0D1E0   A0A0L8G5U6   I3IV85   A0A1W4ZHV7   A0A0N8K0L4   A0A1B6KY41   A0A3B4H5P6   A0A0F8CH29   A0A1V4JIC7   A0A2D4P8G2   Q8BX57-2   A0A2I4BSP6   W5KBV6   F1SGJ0   A0A3P9NX70   A0A1V4JJJ7   A0A1V4JIF3   A0A1S3K5R6   A0A2Y9N5S6   A0A2Y9N2L0   A0A2Y9NGP3   A0A2U4CCC9   A0A2U4CCC3   A0A2U4CCF3   A0A226PH43   A0A2Y9NAG6   A0A2K6RMV6  

Pubmed

19121390    28756777    26354079    22118469    18362917    19820115    + More
24845553    28004739    28648823    20075255    21282665    21719571    20798317    24508170    30249741    21347285    23537049    29240929    25069045    17554307    25476704    23127152    28071753    23915248    24487278    25186727    25835551    16135750    16141072    15489334    21183079    25329095    30723633    24621616    25362486   

EMBL

BABH01018200    BABH01018201    ODYU01005766    SOQ46957.1    NWSH01000823    PCG74028.1    + More
KZ149982    PZC75790.1    KQ461073    KPJ09584.1    RSAL01000034    RVE51423.1    AGBW02014073    OWR42308.1    KQ459053    KPJ04024.1    NEVH01020333    PNF21792.1    PNF21791.1    KQ971354    EFA06114.1    KK852981    KDR12927.1    GEZM01054974    JAV73289.1    JR037082    AEY57571.1    KZ288201    PBC33561.1    GBYB01000884    JAG70651.1    GBYB01012267    JAG82034.1    LBMM01004213    KMQ92696.1    GBYB01000004    JAG69771.1    NNAY01000991    OXU25588.1    GL766194    EFZ15493.1    KQ982116    KYQ59944.1    GL888828    EGI57716.1    KQ981560    KYN39865.1    GL434776    EFN74555.1    GL451712    EFN78705.1    KK107102    QOIP01000005    EZA59613.1    RLU22381.1    KQ976690    KYM78107.1    ADTU01012423    KQ414705    KOC63177.1    KQ978060    KYM97730.1    KQ980800    KYN12942.1    KB632331    ERL92628.1    GEDC01018573    JAS18725.1    APGK01019272    KB740098    ENN81392.1    GECZ01012948    GECZ01003675    JAS56821.1    JAS66094.1    GBSH01002145    JAG66881.1    JT417147    AHH42274.1    FQ310506    CBN80667.1    PZQS01000009    PVD24611.1    CP026248    AWP02293.1    BC076777    AAH76777.1    GCES01008524    JAR77799.1    AYCK01023250    GAEP01000799    JAB54022.1    IACL01013140    LAB00829.1    KQ423675    KOF72412.1    KOF72411.1    AERX01018480    AERX01018481    AERX01018482    JARO02002523    KPP72465.1    GEBQ01023618    JAT16359.1    KQ040939    KKF32833.1    LSYS01007300    OPJ71949.1    IACN01057743    LAB53569.1    DQ095196    DQ095197    AK048910    AK152058    AK152789    AK153067    AK156146    AK157364    AK169565    AK170361    AK150413    AK150337    BC016131    AAH16131.1    AAZ04665.1    BAC33489.1    BAE29537.1    BAE34065.1    BAE41231.1    BAE41744.1    AEMK02000086    DQIR01314807    HDC70285.1    OPJ71947.1    OPJ71948.1    AWGT02000081    OXB78707.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000283053    UP000007151    UP000053268    + More
UP000235965    UP000007266    UP000027135    UP000242457    UP000005203    UP000036403    UP000215335    UP000002358    UP000192223    UP000075809    UP000007755    UP000078541    UP000000311    UP000008237    UP000053097    UP000279307    UP000078540    UP000005205    UP000053825    UP000078542    UP000078492    UP000030742    UP000019118    UP000261540    UP000257160    UP000265140    UP000001038    UP000221080    UP000265080    UP000261420    UP000245119    UP000001646    UP000189706    UP000246464    UP000261440    UP000028760    UP000264840    UP000192224    UP000265040    UP000053454    UP000261480    UP000265120    UP000005207    UP000034805    UP000261460    UP000190648    UP000000589    UP000192220    UP000018467    UP000008227    UP000242638    UP000085678    UP000248483    UP000245320    UP000198419    UP000233200   

PRIDE

H9IXI4    Q8BX57   

Pfam

PF07714   Pkinase_Tyr        + More
PF00787   PX
PF00069   Pkinase
PF02205   WH2

Interpro

IPR001245   Ser-Thr/Tyr_kinase_cat_dom        + More
IPR011009   Kinase-like_dom_sf       
IPR000719   Prot_kinase_dom       
IPR001683   Phox       
IPR036871   PX_dom_sf       
IPR003124   WH2_dom       
IPR037903   MONaKA_PX       

SUPFAM

SSF64268   SSF64268        + More
SSF56112   SSF56112       

Gene 3D

3.30.1520.10    

CDD

cd06871  PX_MONaKA

ProteinModelPortal

H9IXI4   A0A2H1W1P7   A0A2A4JQQ0   A0A2W1BSQ6   A0A194QWA4   A0A3S2NXD8   + More
A0A212ELF5   A0A194QF29   A0A2J7PZP6   A0A2J7PZN0   D6WQ78   A0A067QV47   A0A1Y1LI12   V9IAU7   A0A2A3ER94   A0A088A0Q9   A0A0C9QC73   A0A0C9RGN4   A0A0J7KQX6   A0A0C9Q9W3   A0A232F530   K7J816   A0A1W4WMQ9   E9IVE1   A0A151XHQ6   F4X7A4   A0A195FGQ5   E1ZW46   E2C009   A0A026WUI1   A0A195B1E4   A0A158ND63   A0A0L7QX31   A0A151ICB2   A0A195DJF0   U4UJH9   A0A1B6CZC3   N6URM8   A0A1B6G353   A0A3B3QXH9   A0A3Q1B738   A0A3P9A4A9   A0A3Q1CCD9   H2MYY7   A0A2D0PLG0   A0A3Q1B4P4   A0A0B8RU11   A0A3P8UCA9   A0A3B4VAU0   W5UJE9   E6ZGF0   A0A2T7NTX1   G1KLK4   A0A1U8C6N2   A0A3Q0CXX7   A0A1U7QYL6   A0A3Q0D3E4   A0A2U9BE91   Q6DFG1   A0A147AH73   A0A3B4DG86   A0A087XLM7   A0A3Q2VL46   U3F7W1   A0A1W4Z8Q0   A0A3Q1IIN0   A0A2D4JWI2   A0A0L8G5U9   A0A1U7QN72   A0A3B3XQ31   A0A3B3YYT2   A0A3P8WQH2   A0A096MDR5   A0A3Q0D1E0   A0A0L8G5U6   I3IV85   A0A1W4ZHV7   A0A0N8K0L4   A0A1B6KY41   A0A3B4H5P6   A0A0F8CH29   A0A1V4JIC7   A0A2D4P8G2   Q8BX57-2   A0A2I4BSP6   W5KBV6   F1SGJ0   A0A3P9NX70   A0A1V4JJJ7   A0A1V4JIF3   A0A1S3K5R6   A0A2Y9N5S6   A0A2Y9N2L0   A0A2Y9NGP3   A0A2U4CCC9   A0A2U4CCC3   A0A2U4CCF3   A0A226PH43   A0A2Y9NAG6   A0A2K6RMV6  

PDB

5GW1     E-value=1.54999e-07,     Score=134

KEGG

101736025    K17543 PX domain-containing protein kinase-like protein | (RefSeq) PX domain-containing protein kina

GO

GO:0005524   GO:0035091   GO:0004672   GO:0003779   GO:0016301   GO:0043271   GO:0005737   GO:0042391   GO:0032780   GO:0005886   GO:0005815   GO:0005829   GO:0032991   GO:0050804   GO:0006954   GO:0005634   GO:0008022   GO:0016021   GO:0006468   GO:0006435   GO:0000166   GO:0004812   GO:0006418   GO:0003824  

Subcellular location

Cytoplasm  
Cell membrane  

Length:

546

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00171

Exp number, first 60 AAs:

5e-05

Total prob of N-in:

0.00180

outside

1  -  546

 

 

Pi

268.932138

Theta

170.982455

Tajima's D

1.29044

CLR

0.240662

CSRT

0.738013099345033

Interpretation

Uncertain