Gene

KWMTBOMO11344

Pre Gene Modal

BGIBMGA001851

Annotation

PREDICTED:_uncharacterized_protein_LOC106140333_[Amyelois_transitella]

Location

Bomo_Chr19(+):3816575-3825383      View in EpiBrowser

Full name

Augmin complex subunit dgt3      

Alternative Name

Dim gamma-tubulin 3

Location in the cell

Cytoplasmic   Reliability : 2.957

CDS

ATGAATGCGTTAGATAAGCTTAGTGACAAGGAATTTATACCATTTCTCCGTACACTTGGGGTGGATACTCGAAACCAGTCATTTGAATGGATGCTAAACAATTCTGAATTTGCTTCAGCTTTAGAATGGATGTACTACCATTTAGACTATAATAATGTATTAAGTGAAACAGAGAAACGAAGATTCGAAGAAATTCAAAAGCGGAATGTACACAAAGATAATGTTCTTTCACAAAATGAAGTTGATGAAAGCATCTCTTTGATCCAAAGTCAGTATCCTGGAATATGTCTTCCAGGAGATGTAGATGCTTTAGCAGAAATGAAGCAGGACATAGAAATGCAAAAGGAAAAATTTAACTTACTGGCCAAACACGAGAGAATTGTCAAAGATCTGATAAAGCAAAAAGAAGGTATAAATGAACAGCTTAATTTGGAAATCACAAAGCTAAACGCGGCACAGCAGCAAATCTGTGATGAAGAGAAGTCTCTAGCTCAAGAATGCATTAGGCTCGCTGATGAAGTGGAAGATATGACCAGTGCAGTTATTGAAGTGGTTGGCAACACAATGGATGTTTATGGGAACTGTGGTGAAAAGGATACAGCACCAAATTACTTTACTTTTGGTCCGTTCGATCAATACAAACAATTGCAAGAGCTTTACCTATCCCACTTTGATTTGTATGTCAGTAAGAAATTCGATCTTAAACAGAATGAAAGCAAAAATTATGATAACGAAGTACTTAGTCAAGCTAAGAACATGGAGAGGCGACTTTCGGAAGCTCTGTCTGAATATATTGATTCAAAAGCAGAATTGTGTGGTGAACAAGCAAAATTAGAATTAGTCGCAAACTACAACAACCCACATTCAAATCAACTCAGCATGAACATACTGGAAGCTCAAACAGCAGTCCAACTTCTAGAACAAGAAGAAGGAATCATAAATCTCCAAATAGAGAACGCTATCAAAGAATTTGTCGAAGACCGCACCCGTATTGTTGAAGAAACTGCACTGAACGCTGCGTTAGCTATAAGAGAAGAAGTCAGCAACGATCTCGCGTACTTGCTGGACACGACGCAGCACGCACTGGTCCTGGATAAAGTACTGTACAGCGCCCTCCGACACGAATTGCACAACATCGAAGAGTTTCTGCTCTTCGCCGCTCAACTCAAGCAATACGTGCTCGATGAAAACGATGCGGTCACCAGCAGGATCTGTTCAATGAACGAAATATGCAGAGAACAAGCCTCGTGCGAGCAGAAACTAGAACATTCAGATGTTTTATTAACATCACTATGCACTGTACTGGGTATCGAACCAACGACGAATGTAATGATCCTTGTGAAAAGCTATAACGATCTTGAAAGAGACATCAAGGAAGCTAAAGAAGGTATCGAAGATGGTTTTAGAGTAAGAGAAGAAAAATTAAGAGAAATTGAACAGTCAATGCGACCGCTAGTGGATTACATCTGGGACGGCTGCACTAAACAACCCAGCAGTACGGACAAAACCGTAGCTGCCCTCGCACACCAACTCGAACACGAGATGAGCAAGACAGACACCAGGATACTGGCTGCCAGTGCGAAGTTTAACTCGATCAAGAACAGCGACAATCAGCTACGGAAACTGTGGCAGTGGTTCCTGACCGATCCGTCAAAACTAATGTCCGTCATTAAAGGCGTACAAAGCGGAAAGTACACGTGA

Protein

MNALDKLSDKEFIPFLRTLGVDTRNQSFEWMLNNSEFASALEWMYYHLDYNNVLSETEKRRFEEIQKRNVHKDNVLSQNEVDESISLIQSQYPGICLPGDVDALAEMKQDIEMQKEKFNLLAKHERIVKDLIKQKEGINEQLNLEITKLNAAQQQICDEEKSLAQECIRLADEVEDMTSAVIEVVGNTMDVYGNCGEKDTAPNYFTFGPFDQYKQLQELYLSHFDLYVSKKFDLKQNESKNYDNEVLSQAKNMERRLSEALSEYIDSKAELCGEQAKLELVANYNNPHSNQLSMNILEAQTAVQLLEQEEGIINLQIENAIKEFVEDRTRIVEETALNAALAIREEVSNDLAYLLDTTQHALVLDKVLYSALRHELHNIEEFLLFAAQLKQYVLDENDAVTSRICSMNEICREQASCEQKLEHSDVLLTSLCTVLGIEPTTNVMILVKSYNDLERDIKEAKEGIEDGFRVREEKLREIEQSMRPLVDYIWDGCTKQPSSTDKTVAALAHQLEHEMSKTDTRILAASAKFNSIKNSDNQLRKLWQWFLTDPSKLMSVIKGVQSGKYT

Description

As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules (PubMed:18443220). The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules (PubMed:17412918).

Subunit

Component of the augmin complex composed of dgt2, dgt3, dgt4, dgt5, dgt6, msd1, msd5 and wac (PubMed:18443220, PubMed:19369198). The complex interacts directly or indirectly with microtubules and is required for centrosome-independent generation of spindle microtubules (PubMed:18443220).

Miscellaneous

The name 'dim gamma-tubulin 3' derives from the decreased gamma-tubulin staining of the spindle pole seen following RNAi-mediated knockdown of dgt3 in S2 cells.

Similarity

Belongs to the HAUS3 family.

Keywords

Cell cycle   Cell division   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Microtubule   Mitosis   Reference proteome  

Feature

chain  Augmin complex subunit dgt3

Uniprot

H9IX68   A0A2H1V7G7   A0A437BRC1   A0A212F8D5   A0A194QF46   S4P959   + More
A0A2A4IUQ7   A0A194QX29   A0A2W1BXS6   A0A1Q3EZH2   B0W1T6   A0A1A9V8M3   A0A1A9ZVI3   A0A182IY75   Q9W2P0   A0A182R7Y5   A0A1B0BZF0   B3NK17   B4I7H4   A0A088A2E3   B3MIB1   A0A182F3A3   A0A2A3E9W7   B4QFJ9   A0A182VTD5   W5JAR4   A0A1I8NTR8   B4NN47   A0A182M1E3   B4P9K2   A0A084VCP9   A0A034W5R0   A0A182U5K7   A0A182NAJ6   A0A182Q5I3  

Pubmed

19121390    22118469    26354079    23622113    28756777    10731132    + More
12537572    12537569    17412918    18443220    19369198    17994087    22936249    20920257    23761445    17550304    24438588    25348373   

EMBL

BABH01018210    ODYU01001069    SOQ36795.1    RSAL01000016    RVE53007.1    AGBW02009752    + More
OWR49997.1    KQ459053    KPJ04102.1    GAIX01003874    JAA88686.1    NWSH01006793    PCG63236.1    KQ461073    KPJ09515.1    KZ149913    PZC78037.1    GFDL01014344    JAV20701.1    DS231823    EDS26637.1    AE013599    BT099935    AY058678    AAL13907.1    ACX36511.1    JXJN01023106    CH954179    EDV55383.1    CH480824    EDW56549.1    CH902619    EDV35956.1    KZ288311    PBC28510.1    CM000362    CM002911    EDX07991.1    KMY95376.1    ADMH02001784    ETN61091.1    CH964282    EDW85786.1    AXCM01009230    CM000158    EDW91322.1    ATLV01010838    KE524620    KFB35743.1    GAKP01008898    JAC50054.1    AXCN02002196   

Proteomes

UP000005204    UP000283053    UP000007151    UP000053268    UP000218220    UP000053240    + More
UP000002320    UP000078200    UP000092445    UP000075880    UP000000803    UP000075900    UP000092460    UP000008711    UP000001292    UP000005203    UP000007801    UP000069272    UP000242457    UP000000304    UP000075920    UP000000673    UP000095300    UP000007798    UP000075883    UP000002282    UP000030765    UP000075902    UP000075884    UP000075886   

PRIDE

H9IX68    Q9W2P0   

Pfam

PF14932   HAUS-augmin3

Interpro

IPR032733   HAUS3_N        + More
IPR026206   HAUS3       

ProteinModelPortal

H9IX68   A0A2H1V7G7   A0A437BRC1   A0A212F8D5   A0A194QF46   S4P959   + More
A0A2A4IUQ7   A0A194QX29   A0A2W1BXS6   A0A1Q3EZH2   B0W1T6   A0A1A9V8M3   A0A1A9ZVI3   A0A182IY75   Q9W2P0   A0A182R7Y5   A0A1B0BZF0   B3NK17   B4I7H4   A0A088A2E3   B3MIB1   A0A182F3A3   A0A2A3E9W7   B4QFJ9   A0A182VTD5   W5JAR4   A0A1I8NTR8   B4NN47   A0A182M1E3   B4P9K2   A0A084VCP9   A0A034W5R0   A0A182U5K7   A0A182NAJ6   A0A182Q5I3  

KEGG

101740343    no KO assigned | (RefSeq) HAUS augmin-like complex subunit 3

GO

GO:0051225   GO:0070652   GO:0051301   GO:0005874   GO:0007052   GO:0007088   GO:0005819   GO:0005737  

PANTHER

PTHR19378  

Subcellular location

  

Length:

566

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0107

Exp number, first 60 AAs:

0.00039

Total prob of N-in:

0.00151

outside

1  -  566

 

 

Pi

319.739087

Theta

168.886156

Tajima's D

2.142512

CLR

0.101487

CSRT

0.896205189740513

Interpretation

Uncertain