Gene

KWMTBOMO11339

Pre Gene Modal

BGIBMGA001973

Annotation

PREDICTED:_lipid_phosphate_phosphohydrolase_1-like_[Amyelois_transitella]

Location

Bomo_Chr19(-):3569836-3578534      View in EpiBrowser

Full name

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial      

Alternative Name

Succinyl-CoA synthetase subunit alpha

Location in the cell

PlasmaMembrane   Reliability : 4.67

CDS

ATGGACAAATTATGTACGAGAATATTTGGATATACAAAATTTCTGTGGTCTAAATCAAACCGATGGCATAAAGGGTTCCTTATATTCGCGCTTATAGAGACGAGAATCTTCCCGGGAGGTCAGGTCGGCTTCCACTGCAACGACCCGGCACTGTCGCATCCGTACACAGGCGATACTATCAGCTGGAAGCTACTGCTGGCCACGGTCATAATCCTACCACTCGTTGTTATGTTAATAGTGGAAAGAAAATACCACACTAATAAGAGGATAAAGCCGAAAGACCAAGCGCTATATTGGTACAGAGAGTACCTTTTCGGAGTGCTCCTCAACTTGATAACGATACAGCTGATGAAGAGCATCGTCGGATCCCCTAGACCGCACTTTTTCGACACGTGTAGCCCTAAGGAGGCATTGACTTGTGAGGGGTCTGAATACATAGAAAGCTACACGTGCACGAAAGCTCACTGGCTCAATCAGTCGGATCGTAGCTTTCCTTCAGGACACACGTCTCTAGCTTTTCATGCTGCTATATATTTAGCTTATTACATATCCAACAGATCGAAGGCAAAATCTGCTTCGATAATAGCGATTCAGTTGGTTTTGCTGACGAGCGCGGCTTTCTGCAGCGTGTCCCGGATGAGCGACCACAGGCACCACTGGTGGGACGTGGTGGCCGGCGCCGCCATCAGTCTGCCCCTGCTCTGGTACACTGTTAGTAGAATTTTTTATTTATTGCTTAGATGGGTGGACGAGCTCACAGCCCACCTAGTGTTAAGTGGTCACTGGAGCCCATGGACATCCACAACGTAA

Protein

MDKLCTRIFGYTKFLWSKSNRWHKGFLIFALIETRIFPGGQVGFHCNDPALSHPYTGDTISWKLLLATVIILPLVVMLIVERKYHTNKRIKPKDQALYWYREYLFGVLLNLITIQLMKSIVGSPRPHFFDTCSPKEALTCEGSEYIESYTCTKAHWLNQSDRSFPSGHTSLAFHAAIYLAYYISNRSKAKSASIIAIQLVLLTSAAFCSVSRMSDHRHHWWDVVAGAAISLPLLWYTVSRIFYLLLRWVDELTAHLVLSGHWSPWTSTT

Description

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

Catalytic Activity

ATP + CoA + succinate = ADP + phosphate + succinyl-CoA
CoA + GTP + succinate = GDP + phosphate + succinyl-CoA

Subunit

Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).

Similarity

Belongs to the succinate/malate CoA ligase alpha subunit family.

Uniprot

A0A2W1B3A1   A0A2H1VPN2   A0A2A4J2W7   A0A2H1WD33   A0A194QW33   A0A212FDZ3   + More
A0A194QEX9   A0A3S2NPQ9   A0A2W1BZB5   A0A2H1V7G8   A0A2A4JB39   A0A2A4J9V6   A0A194R0Z6   A0A212FE60   A0A194QKX8   A0A2A4JDK4   A0A2W1BWN5   A0A194QFB0   A0A0N0PF37   A0A2H1VNK2   H9IX67   A0A1B6DBZ5   A0A1B6G844   A0A1B6DGX1   A0A0P4VTC9   A0A1B6BZ05   A0A1B6KYI6   A0A1B6CUN5   A0A437BRC0   A0A0G3YJ71   A0A2H8TZ89   A0A1B6KJD1   A0A023F1J0   A0A1B6JI62   A0A1W4WFP8   A0A1W4WRV3   A0A1W4WRJ7   A0A2P8ZBP0   A0A026W573   J9K159   A0A2A3E788   A0A3L8E0C8   A0A1B6HH77   A0A154PPE1   E2AJW7   A0A146M6G7   A0A0A9YLC8   A0A146M951   A0A1Y1MN55   D6WT35   A0A212FAY8   A0A1L8DY72   A0A088A7K3   A0A195E411   A0A1Y1MRF5   A0A195AVC0   A0A151X268   A0A1L8DY37   E0W2J4   A0A1L8DY38   A0A182H8E4   A0A0L7R3F4   F4W6H5   A0A1L8DY82   A0A1B0D8B6   A0A1L8DY42   A0A1L8DY28   A0A195FIV6   A0A1Q3FIH3   A0A1Q3FIP4   A0A023ENY9   A0A1L8DY32   A0A1L8DYE2   A0A1L8DYB3   A0A1L8DY94   J3JWD3   A0A310SQX9   A0A1L8DYD3   A0A182YM84   A0A158P2M9   N6U7E8   A0A182WFD5   A0A1B0CLC2   A0A1Y9IUJ3   B0W2X7   U4UMF1   K7IRG6   A0A067R3Z5   N6TYZ0  

EC Number

6.2.1.4
6.2.1.5

Pubmed

28756777    26354079    22118469    19121390    27129103    25702953    + More
25474469    29403074    24508170    30249741    20798317    26823975    25401762    28004739    18362917    19820115    20566863    26483478    21719571    24945155    22516182    25244985    21347285    23537049    20075255    24845553   

EMBL

KZ150379    PZC71102.1    ODYU01003520    SOQ42412.1    NWSH01003358    PCG66487.1    + More
ODYU01007532    SOQ50384.1    KQ461073    KPJ09519.1    AGBW02008985    OWR51976.1    KQ459053    KPJ04098.1    RSAL01000611    RVE41309.1    KZ149913    PZC78036.1    ODYU01001069    SOQ36793.1    NWSH01002206    PCG68908.1    PCG68907.1    KPJ09516.1    OWR51977.1    KPJ04101.1    NWSH01001933    PCG69634.1    PZC78034.1    KPJ04099.1    LADI01014042    KPJ20781.1    SOQ42415.1    BABH01018212    BABH01018213    GEDC01014094    JAS23204.1    GECZ01029757    GECZ01012517    GECZ01011154    GECZ01005000    JAS40012.1    JAS57252.1    JAS58615.1    JAS64769.1    GEDC01012357    JAS24941.1    GDKW01003444    JAI53151.1    GEDC01030812    JAS06486.1    GEBQ01023475    JAT16502.1    GEDC01020098    JAS17200.1    RSAL01000016    RVE53008.1    KM507106    AKM28430.1    GFXV01007771    MBW19576.1    GEBQ01028442    JAT11535.1    GBBI01003831    JAC14881.1    GECU01008887    JAS98819.1    PYGN01000114    PSN53890.1    KK107474    EZA50179.1    ABLF02039852    ABLF02039853    KZ288347    PBC27575.1    QOIP01000002    RLU26107.1    GECU01033656    JAS74050.1    KQ435012    KZC13765.1    GL440100    EFN66283.1    GDHC01004283    JAQ14346.1    GBHO01033783    GBHO01013264    JAG09821.1    JAG30340.1    GDHC01003057    JAQ15572.1    GEZM01026252    GEZM01026251    JAV87092.1    KQ971354    EFA07160.1    AGBW02009413    OWR50889.1    GFDF01002720    JAV11364.1    KQ979657    KYN19920.1    GEZM01026250    GEZM01026249    JAV87095.1    KQ976731    KYM76183.1    KQ982580    KYQ54478.1    GFDF01002707    JAV11377.1    DS235878    EEB19850.1    GFDF01002721    JAV11363.1    JXUM01029814    KQ560865    KXJ80571.1    KQ414663    KOC65407.1    GL887707    EGI70310.1    GFDF01002715    JAV11369.1    AJVK01004036    GFDF01002716    JAV11368.1    GFDF01002717    JAV11367.1    KQ981523    KYN40333.1    GFDL01007730    JAV27315.1    GFDL01007598    JAV27447.1    GAPW01002933    JAC10665.1    GFDF01002714    JAV11370.1    GFDF01002648    JAV11436.1    GFDF01002646    JAV11438.1    GFDF01002647    JAV11437.1    BT127551    AEE62513.1    KQ761467    OAD57510.1    GFDF01002650    JAV11434.1    ADTU01007015    ADTU01007016    ADTU01007017    ADTU01007018    ADTU01007019    ADTU01007020    ADTU01007021    ADTU01007022    ADTU01007023    APGK01045771    APGK01045772    APGK01045773    KB741039    ENN74517.1    AJWK01017073    DS231829    EDS30336.1    KB632367    ERL93668.1    KK852718    KDR17784.1    APGK01045770    ENN74515.1   

Proteomes

UP000218220    UP000053240    UP000007151    UP000053268    UP000283053    UP000005204    + More
UP000192223    UP000245037    UP000053097    UP000007819    UP000242457    UP000279307    UP000076502    UP000000311    UP000007266    UP000005203    UP000078492    UP000078540    UP000075809    UP000009046    UP000069940    UP000249989    UP000053825    UP000007755    UP000092462    UP000078541    UP000076408    UP000005205    UP000019118    UP000075920    UP000092461    UP000002320    UP000030742    UP000002358    UP000027135   

PRIDE

H9IX67   

Pfam

PF01569   PAP2        + More
PF00549   Ligase_CoA
PF02629   CoA_binding

Interpro

IPR036938   P_Acid_Pase_2/haloperoxi_sf        + More
IPR000326   P_Acid_Pase_2/haloperoxidase       
IPR003781   CoA-bd       
IPR005810   CoA_lig_alpha       
IPR033847   Citrt_syn/SCS-alpha_CS       
IPR017440   Cit_synth/succinyl-CoA_lig_AS       
IPR036291   NAD(P)-bd_dom_sf       
IPR016102   Succinyl-CoA_synth-like       
IPR005811   CoA_ligase       

SUPFAM

SSF48317   SSF48317        + More
SSF51735   SSF51735       
SSF52210   SSF52210       

Gene 3D

3.40.50.261    

ProteinModelPortal

A0A2W1B3A1   A0A2H1VPN2   A0A2A4J2W7   A0A2H1WD33   A0A194QW33   A0A212FDZ3   + More
A0A194QEX9   A0A3S2NPQ9   A0A2W1BZB5   A0A2H1V7G8   A0A2A4JB39   A0A2A4J9V6   A0A194R0Z6   A0A212FE60   A0A194QKX8   A0A2A4JDK4   A0A2W1BWN5   A0A194QFB0   A0A0N0PF37   A0A2H1VNK2   H9IX67   A0A1B6DBZ5   A0A1B6G844   A0A1B6DGX1   A0A0P4VTC9   A0A1B6BZ05   A0A1B6KYI6   A0A1B6CUN5   A0A437BRC0   A0A0G3YJ71   A0A2H8TZ89   A0A1B6KJD1   A0A023F1J0   A0A1B6JI62   A0A1W4WFP8   A0A1W4WRV3   A0A1W4WRJ7   A0A2P8ZBP0   A0A026W573   J9K159   A0A2A3E788   A0A3L8E0C8   A0A1B6HH77   A0A154PPE1   E2AJW7   A0A146M6G7   A0A0A9YLC8   A0A146M951   A0A1Y1MN55   D6WT35   A0A212FAY8   A0A1L8DY72   A0A088A7K3   A0A195E411   A0A1Y1MRF5   A0A195AVC0   A0A151X268   A0A1L8DY37   E0W2J4   A0A1L8DY38   A0A182H8E4   A0A0L7R3F4   F4W6H5   A0A1L8DY82   A0A1B0D8B6   A0A1L8DY42   A0A1L8DY28   A0A195FIV6   A0A1Q3FIH3   A0A1Q3FIP4   A0A023ENY9   A0A1L8DY32   A0A1L8DYE2   A0A1L8DYB3   A0A1L8DY94   J3JWD3   A0A310SQX9   A0A1L8DYD3   A0A182YM84   A0A158P2M9   N6U7E8   A0A182WFD5   A0A1B0CLC2   A0A1Y9IUJ3   B0W2X7   U4UMF1   K7IRG6   A0A067R3Z5   N6TYZ0  

KEGG

101736953    K01080 phosphatidate phosphatase [EC:3.1.3.4] | (RefSeq) putative phosphatidate phosphatase

PATHWAY

00561    Glycerolipid metabolism - Bombyx mori (domestic silkworm)
00564    Glycerophospholipid metabolism - Bombyx mori (domestic silkworm)
00565    Ether lipid metabolism - Bombyx mori (domestic silkworm)
00600    Sphingolipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0016787   GO:0009142   GO:0004550   GO:0006104   GO:0048037   GO:0006099   GO:0006105   GO:0004775   GO:0004776   GO:0005739   GO:0005829   GO:0000166   GO:0008195  

Subcellular location

Mitochondrion  

Length:

269

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

119.90859

Exp number, first 60 AAs:

19.68908

Total prob of N-in:

0.87378

POSSIBLE N-term signal

sequence

inside

1  -  24

TMhelix

25  -  44

outside

45  -  58

TMhelix

59  -  81

inside

82  -  190

TMhelix

191  -  213

outside

214  -  222

TMhelix

223  -  245

inside

246  -  269

 

 

Pi

189.490707

Theta

202.149049

Tajima's D

1.467868

CLR

0.080778

CSRT

0.779611019449028

Interpretation

Uncertain