Gene

KWMTBOMO11331  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001847

Annotation

PREDICTED:_nicalin-1_[Papilio_polytes]

Location

Bomo_Chr19(+):3414681-3429985      View in EpiBrowser

Full name

Nicalin      

Location in the cell

PlasmaMembrane   Reliability : 2.336

CDS

ATGTGGCTGGATGAAGCAGACGGCTTTGCCGAAATATTCAAAGGCTATTTGCCTTTTTATCTTTTCGTTGCCCTACCTATTTTCATTATAATGTCTCCAGTGAATCCTGTGGCAGCCTCACACGAATTTTCCGTGTACAGAATGCAACAATATGACTTACACACAGTTCCCCATGGTTGTCGTAGTGCCAGCTTCAACTTAGAAGGTCGTTCTTTAACATCATGGAGCACATCACGTCACTGTGTCGTTGCACGCGTACAGGACATAACTTTAGAACAGTTCCTAGAAATCCGCAATAAGGCTGGGGCGTTGTTATTAGTATTACCTAAAAATGAAACTCTTTTGACGCCTGAAGAAAGAGAGCATATTCAATTGCTGGAAATGGCGATGGTACAACAAGAGATCAATGCACCCGTTTACTTTGCTCGTTGGACTCCTGAAATGGAGGACATTCTGGCTGACCTCCAGCATAGTTTTATTACGGATGACAAGTCAGGAACCGCTCTAGAGGCAATGTTCAACACTGTATCATCAAATGGATATCAAATCGTTGTCTCAGCCCCGACTCCACAGAAGCTCGATTCTAAACCAGTCACGTTACACGGCAAACTTATTGGGCGCTCTGGTTCAGCTCAAACCATTGTTATTGCTGCAAATTACGATTCCGCTGCCCTCGTACCGGAAATATCCCAAGGTGCAGATTGTAATGCATCAGGAGCGGTAGCATTACTGGAATTAGCCAGGATATTCTCGCGTATATACTCAACGGCTGGGGGGCGCGGAGCTCCGACTTTGGTCTTTGTGCTGACTTCGGTGGGGCACTCGCTCAACTATTTCGCCACTAAGAAATGGCTAGAAGAACAATTGGACTCCAGTGACGCTTCATTGCTTCAAGACGTGTCGTTCGTGAGCTGCATGGAGTGCGTGTCGCGCGGCCCGGTGCGCATGCACGTGTCCCGCCCCCCGCGCGCGCCCTCCCCCGCGCACTCCTTCCGCGCGCGGCTCGGGGCGCCGCTGCAGCACAAGAAGATCAACCTCGCCGACGAGCTGCTCGCCTGGCACCACGAGAGGTTCAGCATCAGGAGGATGACGGCCTTCACTCTTAGTTCATTGCAGAGTCACAAAGATTCAGGAAGGAGTACAGTGCTGGATACACCGTCTGAAGACAGAATCCAAAATTTAGTATCAAACGTGGCCAGGATAGCACGTGCTCTGGCCTCACATATTTACAACATCACTGATGATGAGAACGATGAGGATGCAGGTTTATATGATGATGTACTGAATGTAGATGAGGCAGCAATAAGATATTGGTACAATTATTTATCATCTCAATCAAGATCGGCTCACATAGTCACAACATCACCAAACGGAGGTGTGACCGGGGCATTAGAAAGAGTATTATCTAGATACATGGAGGTTACCGTGAGCACACACGCCGTCGATAAACGAGAGCCTGAGTATACTCTGTACTCACCCACTAGCGCCACCTTGTACGTTTACAGCGTTAAGCCGGCGGTCTTCGATCTCATTCTAACATTAGCGATAGTTTGTTATTTAGCTGTAGTTTATTTCGCGATACAAGCCTTCCCGCGTTTCTACGAAGAATACGCGAAGATCGTTACGGGCAAGACCAAAGTACAATAG

Protein

MWLDEADGFAEIFKGYLPFYLFVALPIFIIMSPVNPVAASHEFSVYRMQQYDLHTVPHGCRSASFNLEGRSLTSWSTSRHCVVARVQDITLEQFLEIRNKAGALLLVLPKNETLLTPEEREHIQLLEMAMVQQEINAPVYFARWTPEMEDILADLQHSFITDDKSGTALEAMFNTVSSNGYQIVVSAPTPQKLDSKPVTLHGKLIGRSGSAQTIVIAANYDSAALVPEISQGADCNASGAVALLELARIFSRIYSTAGGRGAPTLVFVLTSVGHSLNYFATKKWLEEQLDSSDASLLQDVSFVSCMECVSRGPVRMHVSRPPRAPSPAHSFRARLGAPLQHKKINLADELLAWHHERFSIRRMTAFTLSSLQSHKDSGRSTVLDTPSEDRIQNLVSNVARIARALASHIYNITDDENDEDAGLYDDVLNVDEAAIRYWYNYLSSQSRSAHIVTTSPNGGVTGALERVLSRYMEVTVSTHAVDKREPEYTLYSPTSATLYVYSVKPAVFDLILTLAIVCYLAVVYFAIQAFPRFYEEYAKIVTGKTKVQ

Description

May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

Similarity

Belongs to the nicastrin family.

Uniprot

A0A2H1W3D9   A0A194QEX6   A0A194QVM3   A0A2W1BJ60   H9IX64   A0A212FNS3   + More
A0A437B1X3   S4NMA1   A0A1B6EWH8   A0A1B6LNK9   A0A026WTX8   A0A0L7KU27   A0A1Y1MDA6   K7IV63   A0A151IL08   E2AIS2   D6WSR0   A0A151WEL7   A0A151IVJ8   A0A195BES7   A0A158NNP9   A0A2J7QK95   A0A0C9RN96   A0A0L7RC92   A0A067R2G1   A0A310SF45   A0A1W4XB13   A0A087ZYD4   A0A154P742   F4X363   A0A195FH69   J3JUX1   A0A2A3E6I6   A0A0J7P331   A0A0A9XWJ6   A0A023F0P4   K1R1W9   A0A224XHN6   A0A2T7NEJ3   A0A2S2QJB6   A0A433TU00   A0A0L8H611   J9JX24   A0A023ETX0   A0A2S2PB97   T1JL86   A0A087UN08   A0A0P6F1L9   Q177H2   A0A147BV28   A0A131XZW9   C3YBA6   A0A0N8BB37   A0A0P4Y5M3   A0A0P5H2V8   A0A182FNY0   A0A2M4BJ54   A0A0P5VZE4   A0A182YHR2   A0A182XAW1   A0A182V7H0   W8BQR4   A0A182HSR1   Q7QCB7   A0A1Q3FAZ1   A0A1Q3FBK8   A0A131XCD4   A0A182U0M6   B0W936   A0A084VCX8   U5EYI1   E9FRQ1   A0A2M3Z7E3   A0A131YK52   A0A023FZZ2   A0A401SEA9   W5JIC9   V9KIE2   L7M6Z4   A0A182LET4   A0A1E1X949   A0A1E1XUB3   A0A023FPQ0   L7M878   A0A3B3ZSQ8   W5M914   V4CLX7   A0A1L8E295   A0A2M4AFL0   A0A2M4AFM9   A0A182M8Z5   A0A182NRM6   A0A401NQ32   A0A182R055   A0A182JYH5   A0A182RS58   A0A182VWV8  

Pubmed

26354079    28756777    19121390    22118469    23622113    24508170    + More
30249741    26227816    28004739    20075255    20798317    18362917    19820115    21347285    24845553    21719571    22516182    25401762    26823975    25474469    22992520    24945155    17510324    29652888    18563158    25244985    24495485    12364791    14747013    17210077    28049606    24438588    21292972    26830274    30297745    20920257    23761445    24402279    25576852    20966253    28503490    29209593    25463417    23254933   

EMBL

ODYU01006003    SOQ47466.1    KQ459053    KPJ04093.1    KQ461073    KPJ09522.1    + More
KZ150054    PZC74341.1    BABH01018251    BABH01018252    BABH01018253    BABH01018254    AGBW02004770    OWR55377.1    RSAL01000205    RVE44369.1    GAIX01014371    JAA78189.1    GECZ01027491    JAS42278.1    GEBQ01014771    JAT25206.1    KK107106    QOIP01000002    EZA59423.1    RLU25848.1    JTDY01005670    KOB66768.1    GEZM01036586    JAV82580.1    AAZX01001200    KQ977151    KYN05292.1    GL439874    EFN66661.1    KQ971354    EFA05879.1    KQ983238    KYQ46247.1    KQ980895    KYN11743.1    KQ976509    KYM82687.1    ADTU01000325    NEVH01013275    PNF28998.1    GBYB01008556    GBYB01008560    JAG78323.1    JAG78327.1    KQ414616    KOC68448.1    KK853060    KDR11903.1    KQ769179    OAD52925.1    KQ434829    KZC07749.1    GL888609    EGI59044.1    KQ981606    KYN39577.1    BT127036    AEE61998.1    KZ288369    PBC26779.1    LBMM01000238    KMR03323.1    GBHO01020351    GBHO01020349    GBHO01020348    GBRD01015144    GBRD01015143    GBRD01015142    GDHC01017288    JAG23253.1    JAG23255.1    JAG23256.1    JAG50682.1    JAQ01341.1    GBBI01003677    JAC15035.1    JH818095    EKC37504.1    GFTR01007108    JAW09318.1    PZQS01000013    PVD19594.1    GGMS01008646    MBY77849.1    RQTK01000184    RUS85048.1    KQ419065    KOF84726.1    ABLF02014212    GAPW01000800    JAC12798.1    GGMR01013839    MBY26458.1    JH432114    KK120653    KFM78747.1    GDIQ01054315    JAN40422.1    CH477376    EAT42305.1    GEGO01001012    JAR94392.1    GEFM01004520    JAP71276.1    GG666497    EEN62263.1    GDIQ01195163    JAK56562.1    GDIP01233283    LRGB01002568    JAI90118.1    KZS07100.1    GDIQ01233391    JAK18334.1    GGFJ01003958    MBW53099.1    GDIP01093053    JAM10662.1    GAMC01002950    JAC03606.1    APCN01000326    AAAB01008859    EAA07525.4    GFDL01010382    JAV24663.1    GFDL01010162    JAV24883.1    GEFH01004831    JAP63750.1    DS231862    EDS39733.1    ATLV01010990    KE524630    KFB35822.1    GANO01000284    JAB59587.1    GL732523    EFX90447.1    GGFM01003686    MBW24437.1    GEDV01008893    JAP79664.1    GBBL01000987    JAC26333.1    BEZZ01000215    GCC28680.1    ADMH02001312    ETN63043.1    JW865237    AFO97754.1    GACK01004988    JAA60046.1    GFAC01003406    JAT95782.1    GFAA01000557    JAU02878.1    GBBK01001662    JAC22820.1    GACK01004987    JAA60047.1    AHAT01011146    AHAT01011147    KB200049    ESP03325.1    GFDF01001257    JAV12827.1    GGFK01006107    MBW39428.1    GGFK01006127    MBW39448.1    AXCM01002097    BFAA01000014    GCB62993.1    AXCN02000007   

Proteomes

UP000053268    UP000053240    UP000005204    UP000007151    UP000283053    UP000053097    + More
UP000279307    UP000037510    UP000002358    UP000078542    UP000000311    UP000007266    UP000075809    UP000078492    UP000078540    UP000005205    UP000235965    UP000053825    UP000027135    UP000192223    UP000005203    UP000076502    UP000007755    UP000078541    UP000242457    UP000036403    UP000005408    UP000245119    UP000271974    UP000053454    UP000007819    UP000054359    UP000008820    UP000001554    UP000076858    UP000069272    UP000076408    UP000076407    UP000075903    UP000075840    UP000007062    UP000075902    UP000002320    UP000030765    UP000000305    UP000287033    UP000000673    UP000075882    UP000261520    UP000018468    UP000030746    UP000075883    UP000075884    UP000288216    UP000075886    UP000075881    UP000075900    UP000075920   

PRIDE

H9IX64   

Pfam

PF04389   Peptidase_M28        + More
PF13358   DDE_3
PF00155   Aminotran_1_2

Interpro

IPR007484   Peptidase_M28        + More
IPR016574   Nicalin       
IPR038717   Tc1-like_DDE_dom       
IPR015422   PyrdxlP-dep_Trfase_dom1       
IPR015421   PyrdxlP-dep_Trfase_major       
IPR004839   Aminotransferase_I/II       
IPR015424   PyrdxlP-dep_Trfase       
IPR001917   Aminotrans_II_pyridoxalP_BS       
IPR011282   2am3keto_CoA_ligase       
IPR018247   EF_Hand_1_Ca_BS       

SUPFAM

SSF53383   SSF53383       

Gene 3D

3.40.640.10     3.90.1150.10    

ProteinModelPortal

A0A2H1W3D9   A0A194QEX6   A0A194QVM3   A0A2W1BJ60   H9IX64   A0A212FNS3   + More
A0A437B1X3   S4NMA1   A0A1B6EWH8   A0A1B6LNK9   A0A026WTX8   A0A0L7KU27   A0A1Y1MDA6   K7IV63   A0A151IL08   E2AIS2   D6WSR0   A0A151WEL7   A0A151IVJ8   A0A195BES7   A0A158NNP9   A0A2J7QK95   A0A0C9RN96   A0A0L7RC92   A0A067R2G1   A0A310SF45   A0A1W4XB13   A0A087ZYD4   A0A154P742   F4X363   A0A195FH69   J3JUX1   A0A2A3E6I6   A0A0J7P331   A0A0A9XWJ6   A0A023F0P4   K1R1W9   A0A224XHN6   A0A2T7NEJ3   A0A2S2QJB6   A0A433TU00   A0A0L8H611   J9JX24   A0A023ETX0   A0A2S2PB97   T1JL86   A0A087UN08   A0A0P6F1L9   Q177H2   A0A147BV28   A0A131XZW9   C3YBA6   A0A0N8BB37   A0A0P4Y5M3   A0A0P5H2V8   A0A182FNY0   A0A2M4BJ54   A0A0P5VZE4   A0A182YHR2   A0A182XAW1   A0A182V7H0   W8BQR4   A0A182HSR1   Q7QCB7   A0A1Q3FAZ1   A0A1Q3FBK8   A0A131XCD4   A0A182U0M6   B0W936   A0A084VCX8   U5EYI1   E9FRQ1   A0A2M3Z7E3   A0A131YK52   A0A023FZZ2   A0A401SEA9   W5JIC9   V9KIE2   L7M6Z4   A0A182LET4   A0A1E1X949   A0A1E1XUB3   A0A023FPQ0   L7M878   A0A3B3ZSQ8   W5M914   V4CLX7   A0A1L8E295   A0A2M4AFL0   A0A2M4AFM9   A0A182M8Z5   A0A182NRM6   A0A401NQ32   A0A182R055   A0A182JYH5   A0A182RS58   A0A182VWV8  

KEGG

101741324    no KO assigned | (RefSeq) nicalin

GO

GO:0009966   GO:0016021   GO:0005789   GO:0016740   GO:0030170   GO:0009058   GO:0006567   GO:0016874   GO:0008890   GO:0004177   GO:0048484   GO:1900176  

PANTHER

PTHR31826  

Length:

548

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

45.0801899999999

Exp number, first 60 AAs:

21.79434

Total prob of N-in:

0.68378

POSSIBLE N-term signal

sequence

inside

1  -  11

TMhelix

12  -  34

outside

35  -  504

TMhelix

505  -  527

inside

528  -  548

 

 

Pi

32.13905

Theta

220.720345

Tajima's D

-2.203019

CLR

0.075476

CSRT

0.00659967001649917

Interpretation

Uncertain