Gene

KWMTBOMO11330

Pre Gene Modal

BGIBMGA001977

Annotation

PREDICTED:_sodium/potassium/calcium_exchanger_Nckx30C-like_[Bombyx_mori]

Location

Bomo_Chr19(-):3408602-3409650      View in EpiBrowser

Full name

Sodium/potassium/calcium exchanger Nckx30C      

Alternative Name

Na(+)/K(+)/Ca(2+)-exchange protein Nckx30C

Location in the cell

PlasmaMembrane   Reliability : 4.97

CDS

ATGGGAGGCGCGCTCGTGCTCGCGCTGCTGGCGGCGGCGCGCGCCGGCGACCCCAACGCCACCCAGCTGCCCAACGCCACCCAGCTGCCGAACGCCACTGAAGATGCAAAGACGCCGCTCTTCCCGCCCGACGTTTTCAGCGAGGAGCAGCGGCGGTCCGGCGCGGTGCTGCTGCACGTGCTCGGCATGGGCTACATGTTCGTCGCGCTCGCCATCGTCTGCGATGAGTTCTTCGTGCCCGCGCTCGACGTCATCATAGAGCGGCTCGAGATCCGCGACGACGTCGCCGGCGCCACGTTTATGGCGGCCGGGGGCTCCGCCCCGGAGCTGTTCACCTCCGTCATCGGCGTGTTCGTGTCGTTCGACGACGTCGGCATCGGGACGATCGTCGGCTCCGCGGTCTTCAACATCCTGTTCGTGATCGGTGCCTGCGCGATGTTCTCCCGCACGACGCTGTCGCTCACCTGGTGGCCGCTGTTCCGCGACTGCACCTTCTACTCGATCAGCCTGCTAGTGTTGATATACTGTTTCCGGGACAACAGGATCTACTGGCAGGAGGCGCTGGTGTTGTTCTCGCTCTACGGCGCGTACGTCATGTTCATGAGGTGGAACCAGCCGGTCGAGAGGGCCTTCAAGAAGCTCATCTACAAGAACAAGGTGACCAGGGTCAGGAGTACAGATCAGCTGATGCCGACGGTGAGCTCGCCCGCACATCCCTTGCATGCGATACAGTTAGTCTTTGGCGCAGATTTGATTAGCACGTAA

Protein

MGGALVLALLAAARAGDPNATQLPNATQLPNATEDAKTPLFPPDVFSEEQRRSGAVLLHVLGMGYMFVALAIVCDEFFVPALDVIIERLEIRDDVAGATFMAAGGSAPELFTSVIGVFVSFDDVGIGTIVGSAVFNILFVIGACAMFSRTTLSLTWWPLFRDCTFYSISLLVLIYCFRDNRIYWQEALVLFSLYGAYVMFMRWNQPVERAFKKLIYKNKVTRVRSTDQLMPTVSSPAHPLHAIQLVFGADLIST

Description

May function in the removal and maintenance of calcium homeostasis during signaling in the adult and in signaling events during embryogenesis and patterning of imaginal disks. Transports one Ca(2+) and 1 K(+) in exchange for 4 Na(+).

Similarity

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.

Keywords

Alternative splicing   Antiport   Calcium   Calcium transport   Complete proteome   Glycoprotein   Ion transport   Membrane   Potassium   Potassium transport   Reference proteome   Repeat   RNA editing   Sodium   Sodium transport   Symport   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Sodium/potassium/calcium exchanger Nckx30C
splice variant  In isoform E and isoform F.

Uniprot

H9IXJ4   A0A194QF37   A0A194QVF9   A0A0L7KUS8   A0A2H1W357   A0A2A4JD35   + More
A0A2A4JE91   A0A2W1BH04   A0A084W5S1   A0A2P8Y702   A0A139WEA9   A0A182SS77   E0VH76   E9IU77   A0A182MDE3   A0A182P8M6   A0A0J7L5J3   A0A182RM94   A0A182F1X8   D6WTN1   A0A0M4E185   A0A1A9V8A8   A0A182JHM3   A0A2J7QS14   A0A182Y3A8   A0A0M9A1V2   A0A0L0CN71   A0A1A9Z9H2   A0A1B0AWZ3   A0A1A9WKA2   A0A1A9Y531   A0A1B0CYD8   A0A0M4EFC2   A0A139WE20   A0A336MEF1   V9IIE1   A0A0C9QWL2   A0A0Q9XG79   A0A154PLV3   A0A182QHL5   A0A195D9U8   A0A158NDL2   A0A088A2K6   A0A195F3K2   A0A0J9QYZ2   A0A195BQQ7   B4N1D0   A0A3L8DY02   A0A3F2YYY2   A0A0Q9WZ09   A0A2A3EIL4   A0A2C9GPU7   A0A3F2YUQ2   A0A0Q9WRF4   A0A3F2Z0A8   A0A3F2Z0Z2   A0A0Q9WRQ2   A0A195CL90   A0A3F2Z204   T1H1Q5   B4KID4   B4Q866   B4JZG9   A0A0Q9XHN3   A0A0Q9X695   A0A0Q9X686   B4G7Y3   A0A1B0G3N5   A0A0Q5W9R4   B4LQC7   A0A0R1DSM4   A0A3B0KKJ5   A0A1S4G840   A0A0R3NS30   Q29NB7   A0A3B0KBX9   A0A0N7ZCU7   A0A0R3NSA6   A0A0R3NS33   T1I780   A0A146M504   A0A0P8XHG6   A0A0P8XHB2   A0A0R3NZ27   B3MUY0   A0A0R3NRS6   A0A0N8NZG7   A0A0P8XHJ2   A0A1W4W9J1   A0A0P8Y5A8   A0A1W4VXP2   B4HW94   A0A0J9R090   A0A1W4VXQ1   A0A0J9R0A1   B3N8H2   A0A0Q5WH41   Q9U6A0-2   A0A0Q5WJ87  

Pubmed

19121390    26354079    26227816    28756777    24438588    29403074    + More
18362917    19820115    20566863    21282665    25244985    26108605    17994087    21347285    22936249    30249741    12364791    20966253    17550304    15632085    26823975    23185243    18057021    10545508    10731132    12537572    12537569    17018572   

EMBL

BABH01018254    KQ459053    KPJ04092.1    KQ461073    KPJ09523.1    JTDY01005670    + More
KOB66769.1    ODYU01006003    SOQ47467.1    NWSH01001896    PCG69759.1    PCG69760.1    KZ150054    PZC74342.1    ATLV01020690    KE525305    KFB45565.1    PYGN01000853    PSN40025.1    KQ971355    KYB26197.1    DS235161    EEB12732.1    GL765847    EFZ15880.1    AXCM01004093    LBMM01000649    KMQ97891.1    EFA07201.2    CP012523    ALC39078.1    NEVH01011881    PNF31365.1    KQ435793    KOX74223.1    JRES01000147    KNC33793.1    JXJN01004965    AJVK01000030    ALC39105.1    KYB26193.1    UFQT01000871    SSX27751.1    JR049242    AEY60908.1    GBYB01005067    JAG74834.1    CH933807    KRG03758.1    KQ434977    KZC12861.1    AXCN02000807    KQ981082    KYN09695.1    ADTU01012708    ADTU01012709    ADTU01012710    ADTU01012711    ADTU01012712    ADTU01012713    KQ981820    KYN35160.1    CM002910    KMY89312.1    KQ976424    KYM88296.1    CH963920    EDW78103.2    QOIP01000002    RLU25321.1    AAAB01008964    KRF98814.1    KZ288252    PBC31026.1    APCN01000789    KRF98815.1    KRF98816.1    KQ977600    KYN01468.1    CAQQ02195219    EDW13431.2    CM000361    EDX04388.1    CH916379    EDV94091.1    KRG03761.1    KRG03760.1    KRG03759.1    CH479180    EDW28481.1    CCAG010019552    CH954177    KQS70391.1    CH940649    EDW63377.2    CM000157    KRJ97971.1    OUUW01000010    SPP85671.1    CH379060    KRT03818.1    EAL33425.2    SPP85670.1    GDRN01060039    JAI65440.1    KRT03820.1    KRT03817.1    ACPB03001745    GDHC01004772    JAQ13857.1    CH902624    KPU74278.1    KPU74271.1    KRT03814.1    EDV33045.1    KRT03815.1    KRT03819.1    KPU74276.1    KPU74272.1    KPU74273.1    KPU74277.1    CH480818    EDW52289.1    KMY89309.1    KMY89308.1    KMY89319.1    EDV58395.1    KQS70388.1    KQS70389.1    AF190455    AE014134    AY094674    BT099704    KQS70393.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000037510    UP000218220    UP000030765    + More
UP000245037    UP000007266    UP000075901    UP000009046    UP000075883    UP000075885    UP000036403    UP000075900    UP000069272    UP000092553    UP000078200    UP000075880    UP000235965    UP000076408    UP000053105    UP000037069    UP000092445    UP000092460    UP000091820    UP000092443    UP000092462    UP000009192    UP000076502    UP000075886    UP000078492    UP000005205    UP000005203    UP000078541    UP000078540    UP000007798    UP000279307    UP000242457    UP000075840    UP000075882    UP000075903    UP000075920    UP000078542    UP000076407    UP000015102    UP000000304    UP000001070    UP000008744    UP000092444    UP000008711    UP000008792    UP000002282    UP000268350    UP000001819    UP000015103    UP000007801    UP000192221    UP000001292    UP000000803   

PRIDE

H9IXJ4    Q9U6A0   

Pfam

PF01699   Na_Ca_ex

Interpro

IPR004481   K/Na/Ca-exchanger        + More
IPR004837   NaCa_Exmemb       
IPR030243   NCKX30C-like       

ProteinModelPortal

H9IXJ4   A0A194QF37   A0A194QVF9   A0A0L7KUS8   A0A2H1W357   A0A2A4JD35   + More
A0A2A4JE91   A0A2W1BH04   A0A084W5S1   A0A2P8Y702   A0A139WEA9   A0A182SS77   E0VH76   E9IU77   A0A182MDE3   A0A182P8M6   A0A0J7L5J3   A0A182RM94   A0A182F1X8   D6WTN1   A0A0M4E185   A0A1A9V8A8   A0A182JHM3   A0A2J7QS14   A0A182Y3A8   A0A0M9A1V2   A0A0L0CN71   A0A1A9Z9H2   A0A1B0AWZ3   A0A1A9WKA2   A0A1A9Y531   A0A1B0CYD8   A0A0M4EFC2   A0A139WE20   A0A336MEF1   V9IIE1   A0A0C9QWL2   A0A0Q9XG79   A0A154PLV3   A0A182QHL5   A0A195D9U8   A0A158NDL2   A0A088A2K6   A0A195F3K2   A0A0J9QYZ2   A0A195BQQ7   B4N1D0   A0A3L8DY02   A0A3F2YYY2   A0A0Q9WZ09   A0A2A3EIL4   A0A2C9GPU7   A0A3F2YUQ2   A0A0Q9WRF4   A0A3F2Z0A8   A0A3F2Z0Z2   A0A0Q9WRQ2   A0A195CL90   A0A3F2Z204   T1H1Q5   B4KID4   B4Q866   B4JZG9   A0A0Q9XHN3   A0A0Q9X695   A0A0Q9X686   B4G7Y3   A0A1B0G3N5   A0A0Q5W9R4   B4LQC7   A0A0R1DSM4   A0A3B0KKJ5   A0A1S4G840   A0A0R3NS30   Q29NB7   A0A3B0KBX9   A0A0N7ZCU7   A0A0R3NSA6   A0A0R3NS33   T1I780   A0A146M504   A0A0P8XHG6   A0A0P8XHB2   A0A0R3NZ27   B3MUY0   A0A0R3NRS6   A0A0N8NZG7   A0A0P8XHJ2   A0A1W4W9J1   A0A0P8Y5A8   A0A1W4VXP2   B4HW94   A0A0J9R090   A0A1W4VXQ1   A0A0J9R0A1   B3N8H2   A0A0Q5WH41   Q9U6A0-2   A0A0Q5WJ87  

PDB

5HYA     E-value=2.50073e-05,     Score=112

KEGG

101737519    K13750 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 | (RefSeq) sodium/pot

GO

GO:0016021   GO:0055085   GO:0007601   GO:0008273   GO:0005887   GO:0006874   GO:0005262   GO:0070588   GO:0048749   GO:0015293   GO:0006814   GO:0006816   GO:0006516   GO:0008270   GO:0005515   GO:0042555   GO:0006260   GO:0006811   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR10846   PTHR10846:SF44  

Subcellular location

Membrane  

SignalP

Position:   1 - 15,         Likelihood:  0.789579

 

 

Length:

254

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

100.61053

Exp number, first 60 AAs:

4.65947

Total prob of N-in:

0.72704

inside

1  -  56

TMhelix

57  -  79

outside

80  -  98

TMhelix

99  -  121

inside

122  -  125

TMhelix

126  -  148

outside

149  -  157

TMhelix

158  -  177

inside

178  -  181

TMhelix

182  -  201

outside

202  -  254

 

 

Pi

195.351764

Theta

187.012815

Tajima's D

0.136908

CLR

27.912961

CSRT

0.3996800159992

Interpretation

Uncertain